Susumu Kobayashi

Caenorhabditis elegans galectins LEC-6 and LEC-1 recognize a chemically synthesized Gal{beta}1-4Fuc disaccharide unit which is present in Protostomia glycoconjugates (2009)

Takeuchi, Tomoharu, Nishiyama, Kazusa, Sugiura, Ken-ichi, Takahashi, Miki, Yamada, Atsushi, Kobayashi, Susumu, ...

Galβ1-4GlcNAc is thought to be a common disaccharide unit preferentially recognized by vertebrate galectins. Eight-amino-acid residues conserved in proteins belonging to the galectin family have...

PAPER Special Section on VLSI Design and CAD Algorithms A VLSI Scan-Chain Optimization Algorithm for Multiple Scan-Paths (2007)

Susumu Kobayashi, Masato Edahiro, Mikio Kubo

pape preGL ts an algorithm forthe scanchain optimizationproble in multipleLC[I detip meti dology. The prop ose algorithm, which consists of fourphaseG firstdet1I mine pairs of scan-in and scan-out...

BIM Mediates EGFR Tyrosine Kinase Inhibitor-Induced Apoptosis in Lung Cancers with Oncogenic EGFR Mutations (2007)

Daniel B. Costa, Balázs Halmos, Amit Kumar, Susan T. Schumer, Mark S. Huberman, Titus J. Boggon, ...

BackgroundEpidermal growth factor receptor (EGFR) mutations are present in the majority of patients with non-small cell lung cancer (NSCLC) responsive to the EGFR tyrosine kinase inhibitors (TKIs)...

BIM mediates EGFR tyrosine kinase inhibitor-induced apoptosis in lung cancers with oncogenic EGFR mutations. (2007)

Costa, Daniel B, Halmos, Bal Zs, Kumar, Amit, Schumer, Susan T, Huberman, Mark S, Boggon, Titus J, ...

BACKGROUND: Epidermal growth factor receptor (EGFR) mutations are present in the majority of patients with non-small cell lung cancer (NSCLC) responsive to the EGFR tyrosine kinase inhibitors (TKIs)...

Differential Effects of Gefitinib and Cetuximab on Non–small-cell Lung Cancers Bearing Epidermal Growth Factor Receptor Mutations (2005)

Mukohara, Toru, Engelman, Jeffrey A., Hanna, Nasser H., Yeap, Beow Y., Kobayashi, Susumu, Lindeman, Neal, ...

Background: Many patients with non–small-cell lung cancer (NSCLC) who achieve radiographic responses to treatment with the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors...

Clerocidin alkylates DNA through its epoxide function: evidence for a fine tuned mechanism of action (2003)

Richter, Sara, Gatto, Barbara, Fabris, Daniele, Takao, Ken-ichi, Kobayashi, Susumu, Palumbo, Manlio

Clerocidin (CL) is an effective topoisomerase II‐poison, which has been shown to produce DNA depurination and strand breaks per se at the guanine (G) level. To elucidate the roles played by the...

3-D eddy current analysis in moving conductor of permanent magnet type of retarder using moving coordinate system (1999)

Muramatsu, Kazuhiro, Takahashi, Norio, Hashio, Tomohiro, Yamada, Chuji, Kobayashi, Susumu, Kuwahara, Tohru

A 3-D DC steady state eddy current analysis of a permanent magnet type of retarder which rotates at high speed is carried out using a moving coordinate system. The method of DC steady-state analysis...

3-D eddy current analysis in moving conductors of permanent magnet type retarders using moving coordinate system (1997)

Muramatsu, Kazuhiro, Takahashi, Norio, Hashino, Tomohiro, Yamada, Chuji, Kobayashi, Susumu, Kuwahara, Tohru

A 3-D DC steady state eddy current analysis of a permanent magnet type retarder which rotates at high speed is carried out using a moving coordinate system. The method of DC steady state analysis...

Inhibition of human immunodeficiency virus (HIV-1) replication by synthetic oligo-RNA derivatives (1989)

Shibahara, Susumu, Mukai, Sachiko, Morisawa, Hirokazu, Nakashima, Hideki, Kobayashi, Susumu, Yamamoto, Naoki

Several synthetic 2'-0-methyl-RNA oligomers and their derivatives have been evaluated for inhibitory effect against HIV-induced cytopathic effect and expression of the virus specific antigen in...

Hydrolysis of Platelet Activating Factor and Its Methylated Analogs by Acetylhydrolases (1988)

Yanoshita, Ryohei, Kudo, Ichiro, Ikizawa, Koichi, Chang, Hyuen Wook, Kobayashi, Susumu, Ohno, Masaji, ...

We examined the substrate specificity of PAF-degrading enzymes from various sources using platelet activating factor (PAF) and its synthetic analogs. The results were as follows: 1) Tissue-originated...

Desenvolvimento de um sistema de crescimento epitaxial de silicio por redução de tetracloreto de silicio (1987)

Susumu Kobayashi

Foi desenvolvido um sistema de crescimento epitaxial de silício que opera com tetracloreto de silício. O sistema foi inteiramente projetado e construído no Laboratório de Eletrônica e...

Clerocidin alkylates DNA through its epoxide function: evidence for a fine tuned mechanism of action

Richter, Sara, Gatto, Barbara, Fabris, Daniele, Takao, Ken-ichi, Kobayashi, Susumu, Palumbo, Manlio

Clerocidin (CL) is an effective topoisomerase II-poison, which has been shown to produce DNA depurination and strand breaks per se at the guanine (G) level. To elucidate the roles played by the...

Expression of cholesteryl glucoside by heat shock in human fibroblasts

Kunimoto, Shohko, Kobayashi, Tetsuyuki, Kobayashi, Susumu, Murakami-Murofushi, Kimiko

ABSTRACT We investigated the heat-induced alteration of glycolipids in human cultured cells, TIG-3 fibroblasts, to show the expression of steryl glucoside by heat shock. A glycolipid band was...

Absence of the transcription factor CCAAT enhancer binding protein α results in loss of myeloid identity in bcr/abl-induced malignancy

Wagner, Katharina, Zhang, Pu, Rosenbauer, Frank, Drescher, Bettina, Kobayashi, Susumu, Radomska, Hanna S., ...

The lineage-determining transcription factor CCAAT enhancer binding protein α (C/EBPα) is required for myeloid differentiation. Decreased function or expression of C/EBPα is often found in human...

Clerocidin alkylates DNA through its epoxide function: evidence for a fine tuned mechanism of action

Richter, Sara, Gatto, Barbara, Fabris, Daniele, Takao, Ken-ichi, Kobayashi, Susumu, Palumbo, Manlio

Clerocidin (CL) is an effective topoisomerase II-poison, which has been shown to produce DNA depurination and strand breaks per se at the guanine (G) level. To elucidate the roles played by the...

Expression of cholesteryl glucoside by heat shock in human fibroblasts

Kunimoto, Shohko, Kobayashi, Tetsuyuki, Kobayashi, Susumu, Murakami-Murofushi, Kimiko

ABSTRACT We investigated the heat-induced alteration of glycolipids in human cultured cells, TIG-3 fibroblasts, to show the expression of steryl glucoside by heat shock. A glycolipid band was...

Absence of the transcription factor CCAAT enhancer binding protein α results in loss of myeloid identity in bcr/abl-induced malignancy

Wagner, Katharina, Zhang, Pu, Rosenbauer, Frank, Drescher, Bettina, Kobayashi, Susumu, Radomska, Hanna S., ...

The lineage-determining transcription factor CCAAT enhancer binding protein α (C/EBPα) is required for myeloid differentiation. Decreased function or expression of C/EBPα is often found in human...

千葉大学病院において生体部分肝移植手術を実施した8症例

小林, 進, コバヤシ, ススム, Kobayashi, Susumu, 落合, 武徳, オチアイ, タケノリ, Ochiai, Takenori, ...

千葉大学医学部附属病院において2000年3月から, 2003年8月まで8例の生体部分肝移植手術を施行した。5例が18歳未満(7ヶ月, 4歳, 12歳, 13歳,...

千葉大学病院において生体部分肝移植手術を実施した8症例

小林, 進, 落合, 武徳, 堀, 誠司, 宮内, 英聡, 清水, 孝徳, 千葉, 聡, ...

千葉大学医学部附属病院において2000年3月から, 2003年8月まで8例の生体部分肝移植手術を施行した。5例が18歳未満(7ヶ月, 4歳, 12歳, 13歳,...

Hemangiopericytoma of the Greater Omentum

Shiba, Hiroaki, Misawa, Takeyuki, Kobayashi, Susumu, Yokota, Tokuyasu, Son, Kyonsu, Yanaga, Katsuhiko

A 41-year-old Chinese woman was admitted to our hospital with epigastric pain. Computed tomography detected a heterogeneous enhancement tumor fed by the left gastroepiploic artery in the left lower...

A distal single nucleotide polymorphism alters long-range regulation of the PU.1 gene in acute myeloid leukemia

Steidl, Ulrich, Steidl, Christian, Ebralidze, Alexander, Chapuy, Björn, Han, Hye-Jung, Will, Britta, ...

Targeted disruption of a highly conserved distal enhancer reduces expression of the PU.1 transcription factor by 80% and leads to acute myeloid leukemia (AML) with frequent cytogenetic aberrations in...

BIM Mediates EGFR Tyrosine Kinase Inhibitor-Induced Apoptosis in Lung Cancers with Oncogenic EGFR Mutations

Costa, Daniel B, Halmos, Balázs, Kumar, Amit, Schumer, Susan T, Huberman, Mark S, Boggon, Titus J, ...

Susumu Kobayashi and colleagues provide evidence that the polypeptide BIM is involved in tyrosine kinase inhibitor (TKI)-induced apoptosis in sensitiveEGFR-mutant cells and suggest that induction of...

Caspases Are Activated in a Branched Protease Cascade and Control Distinct Downstream Processes in Fas-induced Apoptosis

Hirata, Hirokazu, Takahashi, Atsushi, Kobayashi, Susumu, Yonehara, Shin, Sawai, Hirofumi, Okazaki, Toshiro, ...

Two novel synthetic tetrapeptides, VEID-CHO and DMQD-CHO, could selectively inhibit caspase-6 and caspase-3, respectively. We used these inhibitors to dissect the pathway of caspase activation in...

CDDO induces granulocytic differentiation of myeloid leukemic blasts through translational up-regulation of p42 CCAAT enhancer–binding protein alpha

Koschmieder, Steffen, D'Alò, Francesco, Radomska, Hanna, Schöneich, Christine, Chang, Ji Suk, Konopleva, Marina, ...

2-Cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO) induces differentiation and apoptosis of tumor cells in vitro and in vivo. Here we assessed the effects of CDDO on CCAAT enhancer–binding...

Phosphorylation of CCAAT/Enhancer-binding Protein α Regulates GLUT4 Expression and Glucose Transport in Adipocytes*

Cha, Hyuk C., Oak, Nikhil R., Kang, Sona, Tran, Tuan-Ahn, Kobayashi, Susumu, Chiang, Shian-Huey, ...

The transcription factor CCAAT/enhancer-binding protein α (C/EBPα) is required during adipogenesis for development of insulin-stimulated glucose uptake. Modes for regulating this function of...