Fluorescence in Situ Hybridization and Digital Imaging (2009)
Sven Perner, Silke Brüderlein, Cornelia Hasel, Irena Waibel, Ra Holdenried, ...
Telomere length analysis has aroused considerable interest in biology and oncology. However, most published data are pan-genomic Southern-blot-based estimates. We developed T/C-FISH...
Estrogen-Dependent Signaling in a Molecularly Distinct Subclass of Aggressive Prostate Cancer (2008)
Setlur, Sunita R., Mertz, Kirsten D., Hoshida, Yujin, Demichelis, Francesca, Lupien, Mathieu, Perner, Sven, ...
Background The majority of prostate cancers harbor gene fusions of the 5′-untranslated region of the androgen-regulated transmembrane protease serine 2 (TMPRSS2) promoter with erythroblast...
Characterizing the cancer genome in lung adenocarcinoma (2007)
Weir, Barbara A., Woo, Michele S., Getz, Gad, Perner, Sven, Ding, Li, Beroukhim, Rameen, ...
Somatic alterations in cellular DNA underlie almost all human cancers(1). The prospect of targeted therapies(2) and the development of high-resolution, genome-wide approaches(3-8) are now spurring...
Characterizing the cancer genome in lung adenocarcinoma (2007)
Weir, Barbara A., Woo, Michele S., Getz, Gad, Perner, Sven, Ding, Li, Beroukhim, Rameen, ...
Mertz, Kirsten D., Setlur, Sunita R., Dhanasekaran, Saravana M., Demichelis, Francesca, Perner, Sven, Tomlins, Scott, ...
Recent studies have established that a significant fraction of prostate cancers harbor a signature gene fusion between the 5′ region of androgen-regulated TMPRSS2 and an ETS family transcription...
Perner, Sven, Brüderlein, Silke, Hasel, Cornelia, Waibel, Irena, Holdenried, Alexandra, Ciloglu, Neslisah, ...
Telomere length analysis has aroused considerable interest in biology and oncology. However, most published data are pan-genomic Southern-blot-based estimates. We developed T/C-FISH...
EML4-ALK Fusion Lung Cancer: A Rare Acquired Event
Perner, Sven, Wagner, Patrick L, Demichelis, Francesca, Mehra, Rohit, LaFargue, Christopher J, Moss, Benjamin J, ...
A recurrent gene fusion between EML4 and ALK in 6.7% of non-small cell lung cancers (NSCLCs) and NKX2-1 (TTF1, TITF1) high-level amplifications in 12% of adenocarcinomas of the lung were...
Beroukhim, Rameen, Getz, Gad, Nghiemphu, Leia, Barretina, Jordi, Hsueh, Teli, Linhart, David, ...
Comprehensive knowledge of the genomic alterations that underlie cancer is a critical foundation for diagnostics, prognostics, and targeted therapeutics. Systematic efforts to analyze cancer genomes...
N-myc Downstream Regulated Gene 1 (NDRG1) Is Fused to ERG in Prostate Cancer12
Pflueger, Dorothee, Rickman, David S, Sboner, Andrea, Perner, Sven, LaFargue, Christopher J, Svensson, Maria A, ...
A step toward the molecular classification of prostate cancer was the discovery of recurrent erythroblast transformation-specific rearrangements, most commonly fusing the androgen-regulated TMPRSS2...