Syeed Hussain

Evidence for ‘lock and key’ character in an anti-phosphonate hydrolytic antibody catalytic site augmented by non-reaction centre recognition: variation in substrate selectivity between an anti-phosphonate antibody, an anti-phosphate antibody and two hydrolytic enzymes

Sonkaria, Sanjiv, Boucher, Guillaume, FLóREZ-ÁLVAREZ, José, Said, Bilal, Hussain, Syeed, Ostler, Elizabeth L., ...

The substrate selectivities of an anti-phosphonate and an anti-phosphate kinetically homogeneous polyclonal catalytic antibody preparation and two hydrolytic enzymes were compared by using...

Variation in the pH-dependent pre-steady-state and steady-state kinetic characteristics of cysteine-proteinase mechanism: evidence for electrostatic modulation of catalytic-site function by the neighbouring carboxylate anion.

Hussain, Syeed, Pinitglang, Surapong, Bailey, Tamara S F, Reid, James D, Noble, Michael A, Resmini, Marina, ...

The acylation and deacylation stages of the hydrolysis of N -acetyl-Phe-Gly methyl thionoester catalysed by papain and actinidin were investigated by stopped-flow spectral analysis. Differences in...

Improvement in hydrolytic antibody activity by change in haptenic structure from phosphate to phosphonate with retention of a common leaving-group determinant: evidence for the 'flexibility' hypothesis.

Gul, Sheraz, Sonkaria, Sanjiv, Pinitglang, Surapong, Florez-Alvarez, José, Hussain, Syeed, Thomas, Emrys W, ...

To investigate the hypothesis that decreased hapten flexibility may lead to increased catalytic antibody activity, we used two closely related immunogens differing only in the flexibility of the...

Isomerization of the uncomplexed actinidin molecule: kinetic accessibility of additional steps in enzyme catalysis provided by solvent perturbation.

Reid, James D, Hussain, Syeed, Bailey, Tamara S F, Sonkaria, Sanjiv, Sreedharan, Suneal K, Thomas, Emrys W, ...

The effects of increasing the content of the aprotic dipolar organic co-solvent acetonitrile on the observed first-order rate constant (k(obs)) of the pre-steady state acylation phases of the...

Evidence for ‘lock and key’ character in an anti-phosphonate hydrolytic antibody catalytic site augmented by non-reaction centre recognition: variation in substrate selectivity between an anti-phosphonate antibody, an anti-phosphate antibody and two hydrolytic enzymes

Sonkaria, Sanjiv, Boucher, Guillaume, FLóREZ-ÁLVAREZ, José, Said, Bilal, Hussain, Syeed, Ostler, Elizabeth L., ...

The substrate selectivities of an anti-phosphonate and an anti-phosphate kinetically homogeneous polyclonal catalytic antibody preparation and two hydrolytic enzymes were compared by using...

Variation in the pH-dependent pre-steady-state and steady-state kinetic characteristics of cysteine-proteinase mechanism: evidence for electrostatic modulation of catalytic-site function by the neighbouring carboxylate anion.

Hussain, Syeed, Pinitglang, Surapong, Bailey, Tamara S F, Reid, James D, Noble, Michael A, Resmini, Marina, ...

The acylation and deacylation stages of the hydrolysis of N -acetyl-Phe-Gly methyl thionoester catalysed by papain and actinidin were investigated by stopped-flow spectral analysis. Differences in...

Improvement in hydrolytic antibody activity by change in haptenic structure from phosphate to phosphonate with retention of a common leaving-group determinant: evidence for the 'flexibility' hypothesis.

Gul, Sheraz, Sonkaria, Sanjiv, Pinitglang, Surapong, Florez-Alvarez, José, Hussain, Syeed, Thomas, Emrys W, ...

To investigate the hypothesis that decreased hapten flexibility may lead to increased catalytic antibody activity, we used two closely related immunogens differing only in the flexibility of the...

Isomerization of the uncomplexed actinidin molecule: kinetic accessibility of additional steps in enzyme catalysis provided by solvent perturbation.

Reid, James D, Hussain, Syeed, Bailey, Tamara S F, Sonkaria, Sanjiv, Sreedharan, Suneal K, Thomas, Emrys W, ...

The effects of increasing the content of the aprotic dipolar organic co-solvent acetonitrile on the observed first-order rate constant (k(obs)) of the pre-steady state acylation phases of the...