Sylvestre Grizot

Efficient targeting of a SCID gene by an engineered single-chain homing endonuclease (2009)

Grizot, Sylvestre, Smith, Julianne, Daboussi, Fayza, Prieto, Jesús, Redondo, Pilar, Merino, Nekane, ...

Sequence-specific endonucleases recognizing long target sequences are emerging as powerful tools for genome engineering. These endonucleases could be used to correct deleterious mutations or to...

A combinatorial approach to create artificial homing endonucleases cleaving chosen sequences

Smith, Julianne, Grizot, Sylvestre, Arnould, Sylvain, Duclert, Aymeric, Epinat, Jean-Charles, Chames, Patrick, ...

Meganucleases, or homing endonucleases (HEs) are sequence-specific endonucleases with large (>14 bp) cleavage sites that can be used to induce efficient homologous gene targeting in cultured cells...

Structure of colicin I receptor bound to the R-domain of colicin Ia: implications for protein import

Buchanan, Susan K, Lukacik, Petra, Grizot, Sylvestre, Ghirlando, Rodolfo, Ali, Maruf M U, Barnard, Travis J, ...

Colicin Ia is a 69 kDa protein that kills susceptible Escherichia coli cells by binding to a specific receptor in the outer membrane, colicin I receptor (70 kDa), and subsequently translocating its...

Crystal structure of I-DmoI in complex with its target DNA provides new insights into meganuclease engineering

Marcaida, María José, Prieto, Jesús, Redondo, Pilar, Nadra, Alejandro D., Alibés, Andreu, Serrano, Luis, ...

Homing endonucleases, also known as meganucleases, are sequence-specific enzymes with large DNA recognition sites. These enzymes can be used to induce efficient homologous gene targeting in cells and...

Efficient targeting of a SCID gene by an engineered single-chain homing endonuclease

Grizot, Sylvestre, Smith, Julianne, Daboussi, Fayza, Prieto, Jesús, Redondo, Pilar, Merino, Nekane, ...

Sequence-specific endonucleases recognizing long target sequences are emerging as powerful tools for genome engineering. These endonucleases could be used to correct deleterious mutations or to...