Sylvia L. F. Pender

Matrix metalloproteinase-3 production by gut IgG plasma cells in chronic inflammatory bowel disease. (2007)

Gordon, John N., Pickard, Karen M., Di Sabatino, Antonio, Prothero, Joanna D., Pender, Sylvia L.F., Goggin, Patrick M., ...

Background: In both ulcerative colitis (UC) and Crohn's disease (CD) there is a marked increase in mucosal IgG plasma cells (PC), although their precise role is not well established. In this study we...

Functional modulation of Crohn's disease myofibroblasts by anti-tumor necrosis factor antibodies (2007)

Di Sabatino, Antonio Di, Pender, Sylvia L.F., Jackson, Claire L., Prothero, Joanna D., Gordon, John N., Picariello, Lucia, ...

BACKGROUND & AIMS: Infliximab induces immune cell apoptosis by outside-to-inside signaling through transmembrane tumor necrosis factor-alpha (mTNF). However, in inflamed gut, myofibroblasts also...

Role of macrophage metalloelastase in gut inflammation. [Issue: Inflammatory Bowel Disease: Genetics, Barrier Function, Immunologic Mechanisms and Microbial] (2006)

Pender, Sylvia L.F., Li, C.K.F., Di Sabatino, A., MacDonald, T.T., Buckley, M.G.

Matrix metalloproteinases (MMPs) are involved in a number of physiological and pathologic processes including the inflammation found in IBD. We have shown that MMP-3 is upregulated in Crohn's disease...

Impaired immunity to intestinal bacterial infection in stromelysin-1 (matrix metalloproteinase-3)-deficient mice (2004)

Li, Chris K.F., Pender, Sylvia L.F., Pickard, Karen M., Chance, Victoria, Holloway, Judith A., Huett, Alan, ...

Infection of mice with the intestinal bacterial pathogen Citrobacter rodentium results in colonic mucosal hyperplasia and a local Th1 inflammatory response similar to that seen in mouse models of...

Up-regulation of collagen and tissue inhibitors of matrix metalloproteinase in colonic diverticular disease (2004)

Mimura, Toshiki, Bateman, Adrian C., Lee, Ronald L., Johnson, Penelope A., McDonald, Peter J., Talbot, Ian C., ...

Purpose: Thickening of the muscularis propria is a key pathologic feature of colonic diverticulosis but its cause is unknown. This study was designed to investigate the role of collagens, matrix...

Matrix metalloproteinases and the gut - new roles for old enzymes (2004)

Pender, Sylvia L. F., MacDonald, Thomas T

Matrix metalloproteinases (MMPs) are a family of neutral proteases with the ability to degrade all components of extracellular matrix. To date, more than 24 different human MMPs have been identified....

Interferon-alpha drives T cell-mediated immunopathology in the intestine (2001)

Monteleone, Giovanni, Pender, Sylvia L. F., Wathen, Neville C., MacDonald, Thomas T.

The ability of interferon (IFN)-alpha to induce autoimmunity and exacerbate Th1 diseases is well known. We have recently described enhanced expression of IFN-alpha in the mucosa of patients with...

Costimulatory molecules in the developing human gastrointestinal tract: a pathway for fetal allergen priming (2001)

Jones, Catherine A., Vance, Gillian H., Power, Lynsey L., Pender, Sylvia L.F., MacDonald, Thomas T., Warner, John O.

Background: Antigen-specific responses can be detected in umbilical cord blood mononuclear cells. The fetal immune system must therefore attain a level of maturity compatible with the initiation of...

Matrix metalloproteinases and their inhibitors in the nasal mucosa of patients with perennial allergic rhinitis (2001)

Shaida, Azhar, Kenyon, Guy, Devalia, Jagdish, Davies, Robert J., MacDonald, Thomas T., Pender, Sylvia L.F.

Background: Allergic rhinitis and asthma show many similarities in their epithelial and inflammatory responses to allergens. However, one notable difference is that disruption and desquamation of the...

Ligation of α4β1 Integrin on Human Intestinal Mucosal Mesenchymal Cells Selectively Up-Regulates Membrane Type-1 Matrix Metalloproteinase and Confers a Migratory Phenotype

Pender, Sylvia L. F., Salmela, Mikko T., Monteleone, Giovanni, Schnapp, Denni, McKenzie, Catriona, Spencer, Jo, ...

Human intestinal lamina propria mesenchymal cells show high surface expression of the α4β1 integrin. Ligation of α4β1 on mesenchymal cell lines with an activating monoclonal anti-α4 antibody or...