Sylvie Darche

The TL MHC class Ib molecule has only marginal effects on the activation, survival and trafficking of mouse small intestinal intraepithelial lymphocytes (2004)

Pardigon, Nathalie, Darche, Sylvie, Kelsall, Brian, Bennink, Jack R., Yewdell, Jonathan W.

Thymus leukemia antigen (TL) is an MHC class Ib molecule that is highly conserved in rats and mice with no obvious human homolog. TL is expressed in mouse small intestinal epithelial cells and is...

Comparative analysis of the CD8+ T cell repertoires of H-2 class I wild-type/HLA-A2.1 and H-2 class I knockout/HLA-A2.1 transgenic mice (2002)

Firat, Hüseyin, Cochet, Madeleine, Rohrlich, Pierre-Simon, Garcia-Pons, Francisco, Darche, Sylvie, Danos, Olivier, ...

HHD transgenic mice which express HLA‐A2.1 monochain molecules in a H‐2 class I– context have an improved capacity to develop HLA‐A2.1‐restricted cytotoxic T lymphocyte (CTL)...

Quantitative titration of nucleic acids by enzymatic amplification reactions run to saturation (1993)

Pannetier, Christophe, Delassus, Sylvie, Darche, Sylvie, Saucier, Cécile, Kourilsky, Philippe

In vitro enzymatic amplification of nucleic acids by PCR or other techniques is a very sensftive method to detect rare DNA segments. We present here a protocol that allows the rapid, sensitive and...

CD11c- and CD11b-expressing mouse leukocytes transport single Toxoplasma gondii tachyzoites to the brain

Courret, Nathalie, Darche, Sylvie, Sonigo, Pierre, Milon, Geneviève, Buzoni-Gâtel, Dominique, Tardieux, Isabelle

The protozoan parasite Toxoplasma gondii enters hosts through the intestinal mucosa and colonizes distant tissues such as the brain, where its progeny persists for a lifetime. We investigated the...

Extrathymic T Cell Lymphopoiesis: Ontogeny and Contribution to Gut Intraepithelial Lymphocytes in Athymic and Euthymic Mice

Guy-Grand, Delphine, Azogui, Orly, Celli, Susanna, Darche, Sylvie, Nussenzweig, Michel C., Kourilsky, Philippe, ...

In the absence of thymopoiesis, T lymphocytes are nevertheless present, mainly in the gut epithelium. Ontogeny of the extrathymic pathway and the extent of its involvement in euthymic mice are...