Vascular-Targeted Radioimmunotherapy with the Alpha-Particle Emitter 211At (2002)
S. J. Kennel, S. Mirzadeh, W. C. Eckelman, T. A. Waldmann, K. Garmestani, A. T. Yordanov, ...
Kennel, S. J., Mirzadeh, S., Eckelman, W. C., Waldmann, T. A., Garmestani, K., Yordanov, A. T., Stabin, M. G. and Brechbiel, M. W. Vascular-Targeted Radioimmunotherapy with the Alpha-Particle Emitter...
Vereb, G., Matkó, J., Vámosi, G., Ibrahim, S. M., Magyar, E., Varga, S., ...
Immunogold staining and electron microscopy show that IL-2 receptor α-subunits exhibit nonrandom surface distribution on human T lymphoma cells. Analysis of interparticle distances reveals that this...
Junghans, R. P., Carrasquillo, J. A., Waldmann, T. A.
In patients with malignancies and immune disorders expressing Tac (α chain of the interleukin 2 receptor; CD25), physiologic shedding of this receptor may lead to high blood levels of the soluble...
Bamford, R N, Battiata, A P, Burton, J D, Sharma, H, Waldmann, T A
We reported previously that the human T-cell lymphotrophic virus type I (HTLV-I)-associated adult T-cell leukemia line HuT-102 produces a cytokine designated interleukin (IL) T that requires...
Richardson, J H, Sodroski, J G, Waldmann, T A, Marasco, W A
The experimental manipulation of peptide growth hormones and their cellular receptors is central to understanding the pathways governing cellular signaling and growth control. Previous work has shown...
Roessler, E, Grant, A, Ju, G, Tsudo, M, Sugamura, K, Waldmann, T A
The interleukin 2 (IL-2) receptor (IL-2R) is a multisubunit receptor that includes three major IL-2 binding subunits, the IL-2R alpha, beta, and gamma chains. We have detected and analyzed...
Burton, J D, Bamford, R N, Peters, C, Grant, A J, Kurys, G, Goldman, C K, ...
In early phases of human T-cell lymphotrophic virus I-induced adult T-cell leukemia (ATL), the malignant cell proliferation is associated with an autocrine process involving coordinate expression of...
Bamford, R N, Grant, A J, Burton, J D, Peters, C, Kurys, G, Goldman, C K, ...
Late-phase human T-cell lymphotropic virus I-associated adult T-cell leukemia cells express IL-2 receptors (IL-2R) but no longer produce IL-2. We have reported that the IL-2-independent adult T-cell...
Grant, A J, Roessler, E, Ju, G, Tsudo, M, Sugamura, K, Waldmann, T A
Interleukin 2 (IL-2)-mediated signaling through its high-affinity receptor involves a complex interrelationship between IL-2 and two IL-2-binding chains, IL-2R alpha and beta chains. Previously with...
Horak, I D, Gress, R E, Lucas, P J, Horak, E M, Waldmann, T A, Bolen, J B
Addition of interleukin 2 (IL-2) to IL-2-dependent T cells results in tyrosine protein kinase signal transduction events even though the IL-2 receptor alpha and beta chains lack intrinsic enzymatic...
Burton, J, Goldman, C K, Rao, P, Moos, M, Waldmann, T A
Previously, using flow cytometric resonance energy transfer and lateral diffusion measurements, we demonstrated that a 95-kDa protein identified by two monoclonal antibodies (OKT27 and OKT27b)...
Panyi, G., Bagdány, M., Bodnár, A., Vámosi, G., Szentesi, G., Jenei, A., ...
Distribution and lateral organization of Kv1.3 potassium channels and CD3 molecules were studied by using electron microscopy, confocal laser scanning microscopy, and fluorescence resonance energy...
Dynamic, yet structured: The cell membrane three decades after the Singer–Nicolson model
Vereb, G., Szöllősi, J., Matkó, J., Nagy, P., Farkas, T., Vígh, L., ...
The fluid mosaic membrane model proved to be a very useful hypothesis in explaining many, but certainly not all, phenomena taking place in biological membranes. New experimental data show that the...
Oh-Ishi, T, Goldman, C K, Misiti, J, Waldmann, T A
The role of interleukin 2 (IL-2) in the activation of suppressor T cells was investigated by using the monoclonal antibody anti-Tac, which blocks the binding of IL-2 to the 55-kDa peptide of the...
Davey, M P, Bertness, V, Nakahara, K, Johnson, J P, McBride, O W, Waldmann, T A, ...
We describe a t(14;14)(q11;q32) translocation in a patient with T-cell chronic lymphocytic leukemia and ataxia-telangiectasia (AT). By using a battery of joining (J)-segment probes from the T-cell...
Begley, C G, Aplan, P D, Davey, M P, Nakahara, K, Tchorz, K, Kurtzberg, J, ...
We have studied a leukemic stem-cell line, DU.528, that is able to differentiate into myeloid and lymphoid cells. The leukemic cells have a translocation between chromosomes 1 and 14,...
Greenberg, S J, Ehrlich, G D, Abbott, M A, Hurwitz, B J, Waldmann, T A, Poiesz, B J
Twenty-one patients with multiple sclerosis, chronic progressive type, were examined for DNA sequences homologous to a human retrovirus. Genomic DNA from peripheral blood mononuclear cells was...
Metabolism of human immunoglobulin D (IgD).
Rogentine, G N, Rowe, D S, Bradley, J, Waldmann, T A, Fahey, J L
Strober, W., Wochner, R. D., Carbone, P. P., Waldmann, T. A.
Intestinal lymphangiectasia is a disease characterized by dilated intestinal lymphatics, protein-losing enteropathy, hypoalbuminemia, and edema. The immunologic status of 18 patients with intestinal...
A humanized antibody that binds to the interleukin 2 receptor.
Queen, C, Schneider, W P, Selick, H E, Payne, P W, Landolfi, N F, Duncan, J F, ...
The anti-Tac monoclonal antibody is known to bind to the p55 chain of the human interleukin 2 receptor and to inhibit proliferation of T cells by blocking interleukin 2 binding. However, use of...
Begley, C G, Aplan, P D, Denning, S M, Haynes, B F, Waldmann, T A, Kirsch, I R
We have identified the human gene, SCL. We discovered this gene because of its involvement in a chromosomal translocation associated with the occurrence of a stem cell leukemia manifesting myeloid...
Tsudo, M, Goldman, C K, Bongiovanni, K F, Chan, W C, Winton, E F, Yagita, M, ...
There are at least two interleukin 2 (IL-2) binding peptides: one is the Mr 55,000 peptide (p55) reactive with the anti-Tac monoclonal antibody, and the other is a Mr 75,000 non-Tac IL-2 binding...
Szöllösi, J, Damjanovich, S, Goldman, C K, Fulwyler, M J, Aszalos, A A, Goldstein, G, ...
Two monoclonal antibodies (OKT27 and OKT27b) have been produced that react with distinct epitopes of a 95-kDa peptide. The T27 antigen is widely distributed, being expressed on B lymphocytes,...
Deletional rearrangement in the human T-cell receptor alpha-chain locus.
De Villartay, J P, Lewis, D, Hockett, R, Waldmann, T A, Korsmeyer, S J, Cohen, D I
The antigen-specific receptor on the surface of mature T lymphocytes is a heterodimer consisting of polypeptides termed alpha and beta. In the course of characterizing human T-cell tumors with an...
Tsudo, M, Kozak, R W, Goldman, C K, Waldmann, T A
There are at least two forms of cellular receptors for interleukin 2 (IL-2); one with a very high affinity and the other with a lower affinity. We identified a non-Tac IL-2 binding peptide with a...
Kozak, R W, Atcher, R W, Gansow, O A, Friedman, A M, Hines, J J, Waldmann, T A
Anti-Tac, a monoclonal antibody directed to the human interleukin 2 (IL-2) receptor, has been successfully conjugated to the alpha-particle-emitting radionuclide bismuth-212 by use of a bifunctional...
Only high-affinity receptors for interleukin 2 mediate internalization of ligand.
Weissman, A M, Harford, J B, Svetlik, P B, Leonard, W L, Depper, J M, Waldmann, T A, ...
Interleukin 2 (IL-2) receptors are expressed on activated T cells and in select T-cell leukemias. Recently, it has been demonstrated that at least two classes of receptor for IL-2 exist with markedly...
The metabolism of albumin and IgG was investigated in two siblings, products of a first-cousin marriage, a female aged 34 yr and a male aged 17, who had a marked reduction in their respective serum...
Buckley, R H, Gilbertsen, R B, Schiff, R I, Ferreira, E, Sanal, S O, Waldmann, T A
Surface markers typical of T and B lymphocytes were present on varying proportions of peripheral blood lymphocytes from three infants with severe combined immunodeficiency disease. Despite this,...
The Sézary syndrome: a malignant proliferation of helper T cells.
Broder, S, Edelson, R L, Lutzner, M A, Nelson, D L, MacDermott, R P, Durm, M E, ...
The Sézary syndrome is a frequently lethal disease characterized by circulating malignant cells of thymus-derived (T)-cell origin. The capacity of circulating malignant lymphocytes from patients...
Developmental hierarchy of immunoglobulin gene rearrangements in human leukemic pre-B-cells.
Korsmeyer, S J, Hieter, P A, Ravetch, J V, Poplack, D G, Waldmann, T A, Leder, P
We have used a special class of human acute lymphocytic leukemias, the common "non-T/non-B" cell type, to define a hierarchy of genetic rearrangements that occur during the earliest stages of B-cell...
Green, J E, Begley, C G, Wagner, D K, Waldmann, T A, Jay, G
Three lines of transgenic mice carrying the human T-cell lymphotropic virus type 1 tax gene have previously been reported to develop neurofibromas composed of perineural fibroblasts (S. H. Hinrichs,...
Korsmeyer, S J, Greene, W C, Cossman, J, Hsu, S M, Jensen, J P, Neckers, L M, ...
The origin and exact stage of differentiation of the neoplastic cells that comprise hairy cell leukemia have remained uncertain. As Ig heavy and light chain genes must both undergo a DNA...
Davey, M P, Bongiovanni, K F, Kaulfersch, W, Quertermous, T, Seidman, J G, Hershfield, M S, ...
The use of probes to genes (IG and TCRB) encoding immunoglobulins (IG) and the beta chain of the T-cell antigen receptor (TCRB), respectively, have become a sensitive means to assess clonality and...
Tsudo, M, Kozak, R W, Goldman, C K, Waldmann, T A
The interleukin 2 (IL-2) receptor system plays a key role in the T-cell immune response. Although IL-2 binding was reported to be restricted to the Tac peptide, we have identified an IL-2 binding...
Characterization of the human receptor for T-cell growth factor.
Leonard, W J, Depper, J M, Robb, R J, Waldmann, T A, Greene, W C
Anti-Tac monoclonal antibody has been identified as a putative antibody against the receptor for T-cell growth factor (TCGF). We now show that: (i) TCGF blocks 85% of 3H-labeled anti-Tac binding to...
Cyclosporin A inhibits T-cell growth factor gene expression at the level of mRNA transcription.
Krönke, M, Leonard, W J, Depper, J M, Arya, S K, Wong-Staal, F, Gallo, R C, ...
Cyclosporin A (CsA) is a potent immunosuppressive agent, now gaining wide application in human organ transplantation. The immunosuppressive activity of CsA is at least in part due to inhibition of...
Interleukin 2 (IL-2) augments transcription of the IL-2 receptor gene.
Depper, J M, Leonard, W J, Drogula, C, Krönke, M, Waldmann, T A, Greene, W C
We demonstrate that purified interleukin 2 (IL-2) can directly upregulate IL-2 receptor expression on phytohemagglutinin-activated T lymphocytes maintained in culture until IL-2 receptor expression...
FitzGerald, D J, Waldmann, T A, Willingham, M C, Pastan, I
An immunotoxin was constructed with an activity that discriminated between two T cell lines based on the expression of the T cell growth factor (TCGF) receptor on their cell surface. A toxic protein...
Waldmann, T A, Broder, S, Goldman, C K, Frost, K, Korsmeyer, S J, Medici, M A
The pathogenesis of the immunoglobulin deficiency of 20 patients with ataxia telangiectasia was studied using an in vitro immunoglobulin biosynthesis system. 10 patients had no detectable IgA in...
Korsmeyer, S J, Arnold, A, Bakhshi, A, Ravetch, J V, Siebenlist, U, Hieter, P A, ...
We have explored the relationship among immunoglobulin gene rearrangement, cytoplasmic immunoglobulin production, and cell surface antigen expression within 37 cases of acute lymphocytic leukemia....
Waldmann, T A, Greene, W C, Sarin, P S, Saxinger, C, Blayney, D W, Blattner, W A, ...
Adult T cell leukemia (ATL) and Sézary leukemia are malignant proliferations of T lymphocytes that share similar cell morphology and clinical features. ATL is associated with HTLV (human T cell...
Identification of a novel receptor/signal transduction pathway for IL-15/T in mast cells.
Tagaya, Y, Burton, J D, Miyamoto, Y, Waldmann, T A
Interleukin-15/T(IL-15) is a growth factor that utilizes IL-2 receptor (IL-2R) components in addition to its private binding protein IL-15R(alpha) in T-cells. Here, we report that IL-15 induces mast...
Protein-losing enteropathy and malabsorption in regional enteritis: cure by limited ileal resection.
Antigen-induced activation of resting T-cells induces the synthesis of interleukin-2 (IL-2), as well as the expression of specific cell surface receptors for this lymphokine. There are at least two...
Vereb, G., Matkó, J., Vámosi, G., Ibrahim, S. M., Magyar, E., Varga, S., ...
Immunogold staining and electron microscopy show that IL-2 receptor α-subunits exhibit nonrandom surface distribution on human T lymphoma cells. Analysis of interparticle distances reveals that this...
Junghans, R. P., Carrasquillo, J. A., Waldmann, T. A.
In patients with malignancies and immune disorders expressing Tac (α chain of the interleukin 2 receptor; CD25), physiologic shedding of this receptor may lead to high blood levels of the soluble...
Bamford, R N, Battiata, A P, Burton, J D, Sharma, H, Waldmann, T A
We reported previously that the human T-cell lymphotrophic virus type I (HTLV-I)-associated adult T-cell leukemia line HuT-102 produces a cytokine designated interleukin (IL) T that requires...
Richardson, J H, Sodroski, J G, Waldmann, T A, Marasco, W A
The experimental manipulation of peptide growth hormones and their cellular receptors is central to understanding the pathways governing cellular signaling and growth control. Previous work has shown...
Roessler, E, Grant, A, Ju, G, Tsudo, M, Sugamura, K, Waldmann, T A
The interleukin 2 (IL-2) receptor (IL-2R) is a multisubunit receptor that includes three major IL-2 binding subunits, the IL-2R alpha, beta, and gamma chains. We have detected and analyzed...
Burton, J D, Bamford, R N, Peters, C, Grant, A J, Kurys, G, Goldman, C K, ...
In early phases of human T-cell lymphotrophic virus I-induced adult T-cell leukemia (ATL), the malignant cell proliferation is associated with an autocrine process involving coordinate expression of...
Bamford, R N, Grant, A J, Burton, J D, Peters, C, Kurys, G, Goldman, C K, ...
Late-phase human T-cell lymphotropic virus I-associated adult T-cell leukemia cells express IL-2 receptors (IL-2R) but no longer produce IL-2. We have reported that the IL-2-independent adult T-cell...
Grant, A J, Roessler, E, Ju, G, Tsudo, M, Sugamura, K, Waldmann, T A
Interleukin 2 (IL-2)-mediated signaling through its high-affinity receptor involves a complex interrelationship between IL-2 and two IL-2-binding chains, IL-2R alpha and beta chains. Previously with...
Horak, I D, Gress, R E, Lucas, P J, Horak, E M, Waldmann, T A, Bolen, J B
Addition of interleukin 2 (IL-2) to IL-2-dependent T cells results in tyrosine protein kinase signal transduction events even though the IL-2 receptor alpha and beta chains lack intrinsic enzymatic...
Burton, J, Goldman, C K, Rao, P, Moos, M, Waldmann, T A
Previously, using flow cytometric resonance energy transfer and lateral diffusion measurements, we demonstrated that a 95-kDa protein identified by two monoclonal antibodies (OKT27 and OKT27b)...
Panyi, G., Bagdány, M., Bodnár, A., Vámosi, G., Szentesi, G., Jenei, A., ...
Distribution and lateral organization of Kv1.3 potassium channels and CD3 molecules were studied by using electron microscopy, confocal laser scanning microscopy, and fluorescence resonance energy...
Dynamic, yet structured: The cell membrane three decades after the Singer–Nicolson model
Vereb, G., Szöllősi, J., Matkó, J., Nagy, P., Farkas, T., Vígh, L., ...
The fluid mosaic membrane model proved to be a very useful hypothesis in explaining many, but certainly not all, phenomena taking place in biological membranes. New experimental data show that the...
Oh-Ishi, T, Goldman, C K, Misiti, J, Waldmann, T A
The role of interleukin 2 (IL-2) in the activation of suppressor T cells was investigated by using the monoclonal antibody anti-Tac, which blocks the binding of IL-2 to the 55-kDa peptide of the...