T. Andrew Binkowski

Protein Functional Surfaces: Global Shape Matching and Local Spatial Alignments of Ligand Binding Sites (2008)

Binkowski, T Andrew, Joachimiak, Andrzej

Abstract Background Protein surfaces comprise only a fraction of the total residues but are the most conserved functional features of proteins. Surfaces performing identical functions are found in...

Identifying Surfaces of Proteins (2008)

T. Andrew Binkowski, Andrzej Joachimiak

Proteins function by interacting with other molecules, but their functional surfaces often involve only a small number of key residues. As structural genomics efforts continue to populate the protein...

Liang J: Order independent structural alignment of circularly permuted proteins (2008)

T. Andrew Binkowski, Bhaskar Dasgupta, Jie Liang

Abstract–Circular permutation connects the N and C termini of a protein and concurrently cleaves elsewhere in the chain, providing an important mechanism for generating novel protein fold and...

Liang J: Order independent structural alignment of circularly permuted proteins (2007)

T. Andrew Binkowski, Bhaskar Dasgupta

Abstract–Circular permutation connects the N and C termini of a protein and concurrently cleaves elsewhere in the chain, providing an important mechanism for generating novel protein fold and...

pvSOAR: Detecting similar surface patterns of pocket and void surfaces of amino acid residues on proteins (2007)

T. Andrew Binkowski, Patrick Freeman, Jie Liang

Detecting similar protein surfaces provides an important route for discovering unrecognized or novel functional relationship between proteins. The webserver pvSOAR (pocket and void Surfaces Of Amino...

in (2005)

T. Andrew Binkowski, Andrzej Joachimiak, Jie Liang

surface analysis for function annotation

Order independent structural alignment of circularly permuted proteins (2004)

Binkowski, T. Andrew, DasGupta, Bhaskar, Liang, Jie

Circular permutation connects the N and C termini of a protein and concurrently cleaves elsewhere in the chain, providing an important mechanism for generating novel protein fold and functions....

topoSNP: a topographic database of non-synonymous single nucleotide polymorphisms with and without known disease association (2004)

Nathan O. Stitziel, T. Andrew Binkowski, Yan Yuan Tseng, Jie Liang, Simon Kasif

The database of topographic mapping of Single Nucleotide Polymorphism (topoSNP) provides an online resource for analyzing non-synonymous SNPs (nsSNPs) that can be mapped onto known 3D structures of...

pvSOAR: Detecting similar surface patterns of pocket and void surfaces of amino acid residues on proteins (2004)

T. Andrew Binkowski, Patrick Freeman, Jie Liang

Detecting similar protein surfaces provides an important route for discovering unrecognized or novel functional relationship between proteins. The web server pvSOAR (pocket and void Surfaces Of Amino...

pvSOAR: detecting similar surface patterns of pocket and void surfaces of amino acid residues on proteins (2004)

Binkowski, T. Andrew, Freeman, Patrick, Liang, Jie

Detecting similar protein surfaces provides an important route for discovering unrecognized or novel functional relationship between proteins. The web server pvSOAR (pocket and void Surfaces Of Amino...

topoSNP: a topographic database of non-synonymous single nucleotide polymorphisms with and without known disease association (2004)

Stitziel, Nathan O., Binkowski, T. Andrew, Tseng, Yan Yuan, Kasif, Simon, Liang, Jie

The database of topographic mapping of Single Nucleotide Polymorphism (topoSNP) provides an online resource for analyzing non‐synonymous SNPs (nsSNPs) that can be mapped onto known 3D structures...

CASTp: Computed atlas of surface topography of proteins (2003)

T. Andrew Binkowski, Shapor Naghibzadeh, Jie Liang

Computed atlas of surface topography of proteins (CASTp) provides an online resource for locating, delineating, and measuring concave surface regions on three-dimensional structures of proteins....

Higher-order interhelical spatial interactions in membrane proteins (2003)

Larisa Adamian, Ronald Jackups, T. Andrew Binkowski, Jie Liang

Membrane proteins play essential cellular roles, including signal transduction, proton pumping, ion transport, and light harvesting. Although transmembrane (TM) helices can be predicted

Inferring Functional Relationships of Proteins from Local Sequence and Spatial Surface Patterns (2003)

T. Andrew Binkowski, Larisa Adamian, Jie Liang

es, and for further inquiries on evolutionary origins of structural elements important for protein function. q 2003 Elsevier Ltd. All rights reserved. Keywords: protein surface; surface pattern;...

CASTp: Computed Atlas of Surface Topography of proteins (2003)

Binkowski, T. Andrew, Naghibzadeh, Shapor, Liang, Jie

Computed Atlas of Surface Topography of proteins (CASTp) provides an online resource for locating, delineating and measuring concave surface regions on three-dimensional structures of proteins. These...

CASTp: Computed Atlas of Surface Topography of proteins

Binkowski, T. Andrew, Naghibzadeh, Shapor, Liang, Jie

Computed Atlas of Surface Topography of proteins (CASTp) provides an online resource for locating, delineating and measuring concave surface regions on three-dimensional structures of proteins. These...

topoSNP: a topographic database of non-synonymous single nucleotide polymorphisms with and without known disease association

Stitziel, Nathan O., Binkowski, T. Andrew, Tseng, Yan Yuan, Kasif, Simon, Liang, Jie

The database of topographic mapping of Single Nucleotide Polymorphism (topoSNP) provides an online resource for analyzing non-synonymous SNPs (nsSNPs) that can be mapped onto known 3D structures of...

pvSOAR: detecting similar surface patterns of pocket and void surfaces of amino acid residues on proteins

Binkowski, T. Andrew, Freeman, Patrick, Liang, Jie

Detecting similar protein surfaces provides an important route for discovering unrecognized or novel functional relationship between proteins. The web server pvSOAR (pocket and void Surfaces Of Amino...

CASTp: Computed Atlas of Surface Topography of proteins

Binkowski, T. Andrew, Naghibzadeh, Shapor, Liang, Jie

Computed Atlas of Surface Topography of proteins (CASTp) provides an online resource for locating, delineating and measuring concave surface regions on three-dimensional structures of proteins. These...

topoSNP: a topographic database of non-synonymous single nucleotide polymorphisms with and without known disease association

Stitziel, Nathan O., Binkowski, T. Andrew, Tseng, Yan Yuan, Kasif, Simon, Liang, Jie

The database of topographic mapping of Single Nucleotide Polymorphism (topoSNP) provides an online resource for analyzing non-synonymous SNPs (nsSNPs) that can be mapped onto known 3D structures of...

pvSOAR: detecting similar surface patterns of pocket and void surfaces of amino acid residues on proteins

Binkowski, T. Andrew, Freeman, Patrick, Liang, Jie

Detecting similar protein surfaces provides an important route for discovering unrecognized or novel functional relationship between proteins. The web server pvSOAR (pocket and void Surfaces Of Amino...

Protein surface analysis for function annotation in high-throughput structural genomics pipeline

Binkowski, T. Andrew, Joachimiak, Andrzej, Liang, Jie

Structural genomics (SG) initiatives are expanding the universe of protein fold space by rapidly determining structures of proteins that were intentionally selected on the basis of low sequence...