Sleep-wake disturbances in sporadic Creutzfeldt-Jakob disease. (2006)
Landolt, H P, Glatzel, M, Blättler, T, Achermann, P, Roth, C, Mathis, J, ...
BACKGROUND: The prevalence and characteristics of sleep-wake disturbances in sporadic Creutzfeldt-Jakob disease (sCJD) are poorly understood. METHODS: Seven consecutive patients with definite sCJD...
Hugel, B, Martínez, M C, Kunzelmann, C, Blättler, T, Aguzzi, A, Freyssinet, J M
Because expressed at a significant level at the membrane of human T cells, we made the hypothesis that the cellular prion protein (PrPc) could behave as a receptor, and be responsible for signal...
Shmerling, D, Hegyi, I, Fischer, M B, Blättler, T, Brandner, S, Götz, J, ...
The physiological role of prion protein (PrP) remains unknown. Mice devoid of PrP develop normally but are resistant to scrapie; introduction of a PrP transgene restores susceptibility to the...
Raeber, A J, Klein, M A, Frigg, R, Brandner, S, Blättler, T, Aguzzi, A
Prion disease or transmissible spongiform encephalopathies are caused by novel pathogens termed prions. Unlike classical infectious agents such as viruses or bacteria, prions lack an independent...
Use of brain grafts to study the pathogenesis of prion diseases. (1998)
Aguzzi, A, Klein, M A, Musahl, C, Raeber, A J, Blättler, T, Hegyi, I, ...
For the study of prion neurotoxicity, we used neural-grafting techniques: mice devoid of the normal host prion protein (Prnp% mice) received a neural graft and were intracerebrally infected with...
PrP-expressing tissue required for transfer of scrapie infectivity from spleen to brain. (1997)
Blättler, T, Brandner, S, Raeber, A J, Klein, M A, Voigtländer, T, Weissmann, C, ...
Much available evidence points to a pathological isoform of the prion protein PrP being the infectious agent that causes transmissible spongiform encephalopathies, but the mechanisms controlling the...
Tracking prions: the neurografting approach. (1997)
Aguzzi, A, Blättler, T, Klein, M A, Räber, A J, Hegyi, I, Frigg, R, ...
The physical nature of the agent that causes transmissible spongiform encephalopathies (the 'prion'), is the subject of passionate controversy. Investigation of it has benefited tremendously from the...
Neurotoxicity and neuroinvasiveness of prions. (1997)
Aguzzi, A, Raeber, A, Blättler, T, Flechsig, E, Klein, M, Weissmann, C, ...
Brandner, S, Raeber, A, Sailer, A, Blättler, T, Fischer, M B, Weissmann, C, ...
Mice devoid of PrPC (Prnp%) are resistant to scrapie and do not allow propagation of the infectious agent (prion). PrPC-expressing neuroectodermal tissue grafted into Prnp% brains but not the...