Scientific Commons: T. D. Sakore

A crystalline end product produced by the hydrolytic cleavage of an RNA-like fragment by an organometallointercalator: 1,10-phenanthroline-platinum(II)-ethylenediamine-cytidine 3' monophosphate.

Vijay-Kumar, S, Sakore, T D, Sobell, H M

1,10-Phenanthroline-platinum(II)-ethylenediamine ( PEPt ) forms a crystalline complex with cytidine-3'-phosphate (3'-CMP) and its structure has been determined by X-ray crystallography. 3'-CMP...

Mutagen-nucleic acid intercalative binding: structure of a 9-aminoacridine: 5-iodocytidylyl(3'-5')guanosine crystalline complex.

Sakore, T D, Jain, S C, Tsai, C C, Sobell, H M

9-Aminoacridine forms a crystalline complex with the dinucleoside monophosphate, 5-iodocytidylyl(3'-5')guanosine. We have solved the three-dimensional structure of this complex by x-ray...

Stereochemistry of a Curare Alkaloid: O,O′,N-Trimethyl-d-Tubocurarine

Sobell, Henry M., Sakore, T. D., Tavale, S. S., Canepa, F. G., Pauling, Peter, Petcher, Trevor J.

The three-dimensional structure of O,O′,N-trimethyl-d-tubocurarine, a neuromuscular blocking agent, has been determined by x-ray crystallography. This may help to provide insight into its...

Organization of DNA in chromatin.

Sobell, H M, Tsai, C C, Gilbert, S G, Jain, S C, Sakore, T D

Conformational changes in DNA that accompany drug intercalation have led us to ask if DNA first bends or "kinks" to accept an intercalative drug or dye. Kinking is made possible by altering the...