Synchronization of active mechanical oscillators by an inertial load (2003)
Motivated by the operation of myogenic (self-oscillatory) insect flight muscle, we study a model consisting of a large number of identical oscillatory contractile elements joined in a chain, whose...
Active traveling wave in the cochlea (2003)
A sound stimulus entering the inner ear excites a deformation of the basilar membrane which travels along the cochlea towards the apex. It is well established that this wavelike disturbance is...
Physical basis of two-tone interference in hearing (2001)
Julicher, F., Andor, D., Duke, T.
The cochlea uses active amplification to capture faint sounds. It has been proposed that the amplifier comprises a set of self-tuned critical oscillators: each hair cell contains a force-generating...
Spiral Defects in Motility Assays: A Measure of Motor Protein Force (1995)
Bourdieu, L., Duke, T., Elowitz, M. B., Winkelmann, D. A., Leibler, S., Libchaber, A.
In a commonly used motility assay, cytoskeletal filaments are observed as they glide over a surface coated with motor proteins. Defects in the motion frequently interrupt the flow of filaments....
Trapping of branched DNA in microfabricated structures.
Volkmuth, W D, Duke, T, Austin, R H, Cox, E C
We have observed electrostatic trapping of tribranched DNA molecules undergoing electrophoresis in a microfabricated pseudo-two-dimensional array of posts. Trapping occurs in a unique transport...
Motor protein mechanics: a stochastic model with minimal mechanochemical coupling.
A stochastic model for the action of motor proteins such as kinesin is presented. The mechanical components of the enzyme are 1) two identical head domains that bind to discrete sites on a...
Caulkett, N A, Duke, T, Bailey, J V
Systolic blood pressure measurement obtained with a pulse oximeter has been compared to values obtained by other indirect methods in man. Direct pressure measurement is subject to less error than...
Intravenous regional anesthesia (Bier block) in a dog.
Webb, A A, Cantwell, S L, Duke, T, Adkins, E
Intravenous regional anesthesia was used in an adult dog as part of a balanced approach to general anesthesia for amputation of the 4th digit of its right hind limb. It allowed the concentration of...
Hall, T L, Duke, T, Townsend, H G, Caulkett, N A, Cantwell, S L
The median effective dosage (ED50) for induction of anesthesia with propofol was determined by using the up-and-down method in 31 unpremedicated cats, in 30 cats premedicated with butorphanol, 0.4...
Trapping of branched DNA in microfabricated structures.
Volkmuth, W D, Duke, T, Austin, R H, Cox, E C
We have observed electrostatic trapping of tribranched DNA molecules undergoing electrophoresis in a microfabricated pseudo-two-dimensional array of posts. Trapping occurs in a unique transport...
Motor protein mechanics: a stochastic model with minimal mechanochemical coupling.
A stochastic model for the action of motor proteins such as kinesin is presented. The mechanical components of the enzyme are 1) two identical head domains that bind to discrete sites on a...
Caulkett, N A, Duke, T, Bailey, J V
Systolic blood pressure measurement obtained with a pulse oximeter has been compared to values obtained by other indirect methods in man. Direct pressure measurement is subject to less error than...
Intravenous regional anesthesia (Bier block) in a dog.
Webb, A A, Cantwell, S L, Duke, T, Adkins, E
Intravenous regional anesthesia was used in an adult dog as part of a balanced approach to general anesthesia for amputation of the 4th digit of its right hind limb. It allowed the concentration of...
Hall, T L, Duke, T, Townsend, H G, Caulkett, N A, Cantwell, S L
The median effective dosage (ED50) for induction of anesthesia with propofol was determined by using the up-and-down method in 31 unpremedicated cats, in 30 cats premedicated with butorphanol, 0.4...
Cooperativity of myosin molecules through strain-dependent chemistry.
There is mounting evidence that the myosin head domain contains a lever arm which amplifies small structural changes that occur at the nucleotide-binding site. The mechanical work associated with...
Activation of the L-arginine nitric oxide pathway in severe sepsis
Duke, T., South, M., Stewart, A.
Accepted 6 September 1996
The management of sick young infants at primary health centres in a rural developing country
Duke, T, Oa, O, Mokela, D, Oswyn, G, Hwaihwanje, I, Hawap, J
Aims: To investigate the epidemiology of illness among young infants at remote health clinics in a rural developing country, and to determine risk factors for mortality that might be used as triggers...
Duke, T, Blaschke, A, Sialis, S, Bonkowsky, J
Aims: To determine, in sick neonates and children requiring admission to a hospital in the highlands of Papua New Guinea: (1) the incidence and severity of hypoxaemia; (2) the proportion with...
Chloramphenicol or ceftriaxone, or both, as treatment for meningitis in developing countries?
Duke, T, Michael, A, Mokela, D, Wal, T, Reeder, J
Aims: To determine in children with meningitis whether there is any difference in mortality and neurological sequelae using chloramphenicol as first line treatment, with a change to ceftriaxone if...
Tibballs, J, Kinney, S, Duke, T, Oakley, E, Hennessy, M
Aims: To determine the impact of a paediatric medical emergency team (MET) on cardiac arrest, mortality, and unplanned admission to intensive care in a paediatric tertiary care hospital.
Pak3 inhibits local actin filament formation to regulate global cell polarity
Asano, Y., Jiménez-Dalmaroni, A., Liverpool, T. B., Marchetti, M. C., Giomi, L., Kiger, A., ...
Lamellipodia are broad actin-based structures that define the protruding edge of many motile animal cells. Here we identify a Drosophila homolog of the p21-activated kinases (Paks) as a novel...