Beaty, T. H, Hetmanski, J. B, Fallin, M. D, Park, J. W, Sull, J. W, McIntosh, I, ...
Isolated oral clefts, including cleft lip with/without cleft palate (CL/P) and cleft palate (CP), have a complex and heterogeneous etiology. Case-parent trios from three populations were used to...
Segregation analysis of plasma apolipoprotein B levels in familial combined hyperlipidemia (1997)
Stalenhoef, A.F.H., Beaty, T.H., Demacker, P.N.M., Drongelen, J. Van, Bredie, S.J.H.
LIANG, K. Y., BEATY, T. H., COHEN, B. H.
A regression model for estimating covariate effects on odds ratios to test for familial aggregation of common disease in first-degree relatives of cases and controls is presented and illustrated by...
IMPAIRED PULMONARY FUNCTION AS A RISK FACTOR FOR MORTALITY (1982)
BEATY, T. H., COHEN, B. H., NEWILL, C. A., MENKERS, H. A., DIAMOND, E. L., CHEN, C. J.
Prospective follow-up information obtained between 1976 and 1981 on mortality among 2539 individuals showed that pulmonary function impairment is a risk factor for short-term mortality, even when...
Discriminating among single locus models using small pedigrees (1980)
Simulated small pedigrees (2 parents, 4 offspring) were used to illustrate the applications and limitations of a “model choice” approach designed to detect genetic heterogeneity in familial...
Mendelian inheritance of familial prostate cancer.
Carter, B S, Beaty, T H, Steinberg, G D, Childs, B, Walsh, P C
Previous studies have demonstrated familial clustering of prostate cancer. To define the nature of this familial aggregation and to assess whether Mendelian inheritance can explain prostate cancer...
Nestadt, G., Lan, T., Samuels, J., Riddle, M., Bienvenu III, O. J., Liang, K. Y., ...
Evidence from twin and family studies supports a genetic etiology for obsessive-compulsive disorder (OCD). The purpose of this study was to test whether a major gene is implicated in a proportion of...
Inheritance of congenital esotropia.
Maumenee, I H, Alston, A, Mets, M B, Flynn, J T, Mitchell, T N, Beaty, T H
Liang, K Y, Huang, C Y, Beaty, T H
Recent advances in molecular biology have enhanced the opportunity to conduct multipoint mapping for complex diseases. Concurrently, one sees a growing interest in the use of quantitative traits in...
Beaty, T. H., Prenger, V. L., Virgil, D. G., Lewis, B., Kwiterovich, P. O., Bachorik, P. S.
The St. Thomas Hospital (STH) rabbit has been previously shown to have a Mendelian form of hypertriglyceridemia, accompanied by accelerated atherosclerosis, and these animals may serve as a useful...
Haplotype Diversity in 11 Candidate Genes Across Four Populations
Beaty, T. H., Fallin, M. D., Hetmanski, J. B., McIntosh, I., Chong, S. S., Ingersoll, R., ...
Analysis of haplotypes based on multiple single-nucleotide polymorphisms (SNP) is becoming common for both candidate gene and fine-mapping studies. Before embarking on studies of haplotypes from...
Coresh, J, Beaty, T H, Kwiterovich, P O, Antonarakis, S E
Previous studies suggest that plasma apolipoprotein B-100 (apoB) level is strongly influenced by genetic factors. Characterizing alleles that influence plasma apoB level would help define genetic...
Prenger, V L, Beaty, T H, Kwiterovich, P O
Plasma levels of two lipoprotein risk factors, high-density lipoprotein-cholesterol (HDL-C) and apolipoprotein A-1 (apo A-1), have been shown to be negatively associated with the risk of developing...
Etiologic heterogeneity in the familial aggregation of congenital cardiovascular malformations.
Maestri, N E, Beaty, T H, Boughman, J A
Recent data indicate that there is increased risk of congenital cardiovascular malformations (CCVM) within families of probands diagnosed with congenital cardiovascular malformations that are due to...
Multipoint mapping studies of the beta-globin, insulin, and c-Ha-ras-1 loci on 11p.
Meyers, D A, Beaty, T H, Maestri, N E, Antonarakis, S E, Kazazian, H H
Evidence that autoimmunity in man is a Mendelian dominant trait.
Bias, W B, Reveille, J D, Beaty, T H, Meyers, D A, Arnett, F C
Family studies of autoimmune diseases are consistent with multifactorial etiology. However, familial occurrence of the autoimmune trait as defined by the presence of autoimmune disease and/or high...
Genetic analysis of juvenile periodontitis in families ascertained through an affected proband.
Beaty, T H, Boughman, J A, Yang, P, Astemborski, J A, Suzuki, J B
Data from 28 families ascertained through a proband with juvenile periodontitis were used to test a series of Mendelian models of inheritance that included both autosomal and X-linked transmission....
Inheritance of total serum IgE (basal levels) in man.
Meyers, D A, Beaty, T H, Freidhoff, L R, Marsh, D G
Since allergic individuals with atopic allergy tend to have higher total serum IgE levels than do nonallergic subjects, family studies of total serum IgE levels are necessary in delineating the...
Beaty, T H, Kwiterovich, P O, Khoury, M J, White, S, Bachorik, P S, Smith, H H, ...
We previously reported the finding of phytosterolemia, xanthomatosis, and hyperapobetalipoproteinemia (hyperapoB) in five siblings in a large Amish pedigree ascertained through a 13-year-old boy who...
Mendelian inheritance of familial prostate cancer.
Carter, B S, Beaty, T H, Steinberg, G D, Childs, B, Walsh, P C
Previous studies have demonstrated familial clustering of prostate cancer. To define the nature of this familial aggregation and to assess whether Mendelian inheritance can explain prostate cancer...
Beaty, T. H., Prenger, V. L., Virgil, D. G., Lewis, B., Kwiterovich, P. O., Bachorik, P. S.
The St. Thomas Hospital (STH) rabbit has been previously shown to have a Mendelian form of hypertriglyceridemia, accompanied by accelerated atherosclerosis, and these animals may serve as a useful...
Nestadt, G., Lan, T., Samuels, J., Riddle, M., Bienvenu III, O. J., Liang, K. Y., ...
Evidence from twin and family studies supports a genetic etiology for obsessive-compulsive disorder (OCD). The purpose of this study was to test whether a major gene is implicated in a proportion of...
Inheritance of congenital esotropia.
Maumenee, I H, Alston, A, Mets, M B, Flynn, J T, Mitchell, T N, Beaty, T H
Liang, K Y, Huang, C Y, Beaty, T H
Recent advances in molecular biology have enhanced the opportunity to conduct multipoint mapping for complex diseases. Concurrently, one sees a growing interest in the use of quantitative traits in...
Haplotype Diversity in 11 Candidate Genes Across Four Populations
Beaty, T. H., Fallin, M. D., Hetmanski, J. B., McIntosh, I., Chong, S. S., Ingersoll, R., ...
Analysis of haplotypes based on multiple single-nucleotide polymorphisms (SNP) is becoming common for both candidate gene and fine-mapping studies. Before embarking on studies of haplotypes from...
Coresh, J, Beaty, T H, Kwiterovich, P O, Antonarakis, S E
Previous studies suggest that plasma apolipoprotein B-100 (apoB) level is strongly influenced by genetic factors. Characterizing alleles that influence plasma apoB level would help define genetic...
Prenger, V L, Beaty, T H, Kwiterovich, P O
Plasma levels of two lipoprotein risk factors, high-density lipoprotein-cholesterol (HDL-C) and apolipoprotein A-1 (apo A-1), have been shown to be negatively associated with the risk of developing...
Etiologic heterogeneity in the familial aggregation of congenital cardiovascular malformations.
Maestri, N E, Beaty, T H, Boughman, J A
Recent data indicate that there is increased risk of congenital cardiovascular malformations (CCVM) within families of probands diagnosed with congenital cardiovascular malformations that are due to...
Multipoint mapping studies of the beta-globin, insulin, and c-Ha-ras-1 loci on 11p.
Meyers, D A, Beaty, T H, Maestri, N E, Antonarakis, S E, Kazazian, H H
Evidence that autoimmunity in man is a Mendelian dominant trait.
Bias, W B, Reveille, J D, Beaty, T H, Meyers, D A, Arnett, F C
Family studies of autoimmune diseases are consistent with multifactorial etiology. However, familial occurrence of the autoimmune trait as defined by the presence of autoimmune disease and/or high...
Genetic analysis of juvenile periodontitis in families ascertained through an affected proband.
Beaty, T H, Boughman, J A, Yang, P, Astemborski, J A, Suzuki, J B
Data from 28 families ascertained through a proband with juvenile periodontitis were used to test a series of Mendelian models of inheritance that included both autosomal and X-linked transmission....
Inheritance of total serum IgE (basal levels) in man.
Meyers, D A, Beaty, T H, Freidhoff, L R, Marsh, D G
Since allergic individuals with atopic allergy tend to have higher total serum IgE levels than do nonallergic subjects, family studies of total serum IgE levels are necessary in delineating the...
Beaty, T H, Kwiterovich, P O, Khoury, M J, White, S, Bachorik, P S, Smith, H H, ...
We previously reported the finding of phytosterolemia, xanthomatosis, and hyperapobetalipoproteinemia (hyperapoB) in five siblings in a large Amish pedigree ascertained through a 13-year-old boy who...