T. Hansen

Publication List Details

Period

1996 - 2009

Number

83

Co-Authors

Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity (online first) (2009)

Thorleifsson, G., Walters, G.B., Gudbjartsson, D.F., Steinhorsdottir, V., Sulem, P., Helgadottir, A., ...

besity results from the interaction of genetic and environmental factors. To search for sequence variants that affect variation in two common measures of obesity, weight and body mass index (BMI),...

In vivo study with quartz-containing ceramic dusts: Inflammatory effects of two factory samples in lungs after intratracheal instillation in a 28-day study with rats (2009)

Creutzenberg, O., Ziemann, C., Hansen, T., Ernst, H., Jackson, P., Cartlidge, D., ...

As various quartz polymorphs react differently in lungs, a differentiation of effects is needed while setting occupational exposure levels. The objective of this European Collective Research Project...

In vivo study with quartz-containing ceramic dusts: Inflammatory effects of two factory samples in lungs after intratracheal instillation in a 28-day study with rats (2009)

Creutzenberg, O., Ziemann, C., Hansen, T., Ernst, H., Jackson, P., Cartlidge, D., ...

As various quartz polymorphs react differently in lungs, a differentiation of effects is needed while setting occupational exposure levels. The objective of this European Collective Research Project...

Identification of novel variants in the hepatocyte nuclear factor-1alpha gene in South Indian patients with maturity onset diabetes of young. (2009)

Radha, V, Ek, J, Anuradha, S, Hansen, T, Pedersen, O, Mohan, V

CONTEXT: Mutations in the HNF 1A gene are the most common cause of maturity-onset diabetes of the young (MODY) in most populations. India currently has the largest number of people with diabetes in...

Magnetic order in CaFe1-xCoxAsF (x = 0, 0.06, 0.12) superconductor compounds (2008)

Xiao, Y., Su, Y., Mittal, R., Chatterji, T., Hansen, T., Kumar, C. M. N., ...

A Neutron Powder Diffraction (NPD) experiment has been performed to investigate the structural phase transition and magnetic order in CaFe1-xCoxAsF superconductor compounds (x = 0, 0.06, 0.12). The...

Magnetic Ordering and Negative Thermal Expansion in PrFeAsO (2008)

Kimber, S. A. J., Argyriou, D. N., Yokaichiya, F., Habicht, K., Gerischer, S., Hansen, T., ...

We report the structure and magnetism of PrOFeAs, one of the parent phases of the newly discovered Fe-As superconductors, as measured by neutron powder diffraction. In common with other REOFeAs...

CaCrO3: an anomalous antiferromagnetic metallic oxide (2008)

Komarek, A. C., Streltsov, S. V., Isobe, M., Moeller, T., Hoelzel, M., Senyshyn, A., ...

Combining infrared reflectivity, transport, susceptibility and several diffraction techniques, we find compelling evidence that CaCrO3 is a rare case of a metallic and antiferromagnetic...

Toxicity of a quartz with occluded surfaces in a 90-day intratracheal instillation study in rats (2008)

Creutzenberg, O., Hansen, T., Ernst, H., Muhle, H., Oberdörster, G., Hamilton, R.

This 90-day study was aimed at characterizing the differences in biological activity between a crystalline ground reference quartz (DQ12) and a quartz with occluded surfaces ( quartz isolate)...

Designing New Guides And Instruments Using Mcstas (2007)

E. Farhi, T. Hansen, A. Wildes, R. Ghosh, K. Lefmann

With the increasing complexity of modern neutron scattering instruments, the need for powerful tools to optimize their geometry and physical performances (ux, resolution, divergence, etc.) has become...

A variant in CDKAL1 influences insulin response and risk of type 2 diabetes (2007)

Steinthorsdottir, V., Thorleifsson, G., Reynisdottir, I., Benediktsson, R., Jonsdottir, T., Walters, G.B., ...

We conducted a genome-wide association study for type 2 diabetes (T2D) in Icelandic cases and controls, and we found that a previously described variant in the transcription factor 7-like 2 gene...

A variant in CDKAL1 influences insulin response and risk of type 2 diabetes (2007)

Wijmenga, C., Jorgensen, T., Hofker, M.H., Pedersen, O., Chan, J.C., ...

We conducted a genome-wide association study for type 2 diabetes (T2D) in Icelandic cases and controls, and we found that a previously described variant in the transcription factor 7-like 2 gene...

The environmental carcinogen 3-nitrobenzanthrone and its main metabolite 3-aminobenzanthrone enhance formation of reactive oxygen intermediates in human A549 lung epithelial cells (2007)

Hansen, T., Seidel, A., Borlak, J.

The environmental contaminant 3-nitrobenzanthrone (3-NBA) is highly mutagenic and a suspected human carcinogen. We aimed to evaluate whether 3-NBA is able to deregulate critical steps in cell cycle...

The environmental carcinogen 3-nitrobenzanthrone and its main metabolite 3-aminobenzanthrone enhance formation of reactive oxygen intermediates in human A549 lung epithelial cells (2007)

Hansen, T., Seidel, A., Borlak, J.

The environmental contaminant 3-nitrobenzanthrone (3-NBA) is highly mutagenic and a suspected human carcinogen. We aimed to evaluate whether 3-NBA is able to deregulate critical steps in cell cycle...

In vivo animal models (2007)

Braun, A., Hansen, T., Hoymann, H.G., Muhle, H.

The lung is a preferential site of drug delivery for new pharmaceuticals and particular biopharmaceuticals. Standard models for efficacy testing and the standard toxicology battery often fail to...

Importance of DNA-adduct formation and gene expression profiling of disease candidate genes in rats exposed to bitumen fumes (2007)

Halter, R., Hansen, T., Seidel, A., Ziemann, C., Borlak, J.

The equivocal experimental and epidemiological evidence of bitumen fumes and the possible mechanisms of toxicity remain uncertain. This study therefore aimed at investigating the genotoxicity of...

IL6 gene promoter polymorphisms and type 2 diabetes: joint analysis of individual participants' data from 21 studies (2006)

Huth, C., Heid, I.M., Vollmert, C., Gieger, C., Grallert, H., Wolford, J.K., ...

Several lines of evidence indicate a causal role of the cytokine interleukin (IL)-6 in the development of type 2 diabetes in humans. Two common polymorphisms in the promoter of the IL-6 encoding gene...

Proposal for a histopathological consensus classification of the periprosthetic interface membrane (2006)

Morawietz, L., Schröder, J. H., Dynybil, C., Perka, C., Skwara, A., ...

AIMS: The introduction of clearly defined histopathological criteria for a standardised evaluation of the periprosthetic membrane, which can appear in cases of total joint arthroplasty revision...

Primary rat alveolar epithelial cells for use in biotransformation and toxicity studies (2006)

Hansen, T., Blickwede, M., Borlak, J.

The alveolar epithelium may function as a barrier for airborne xenobiotics, and in vitro models mimicking this barrier are useful for metabolism and toxicity studies. To gain insight into the...

Metabolism of verapamil in cultures of rat alveolar epithelial cells and pharmacokinetics after administration by intravenous and inhalation routes (2005)

Borlak, J., Blickwede, M., Hansen, T., Koch, W., Walles, M., Levsen, K.

Administration of therapeutic entities by inhalation opens new possibilities for drug entry into systemic circulation, but this requires passage through the alveolar epithelium. Little is known about...

A prevalent amino acid polymorphism at codon 98 (Ala98Val) of the hepatocyte nuclear factor-1alpha is associated with maturity-onset diabetes of the young and younger age at onset of. (2005)

Anuradha, S, Radha, V, Deepa, R, Hansen, T, Carstensen, B, Pedersen, O, ...

OBJECTIVE: Among Europeans, mutations in the hepatocyte nuclear factor-1alpha (HNF1alpha) gene are associated with the most common form of maturity-onset diabetes of the young (MODY)3. In Asian...

Formation of convective cells in the scrape-off layer of the CASTOR tokamak (2004)

Stöckel, J., Devynck, P., Gunn, J., Martines, E., Bonhomme, G., Van Oost, G., ...

Understanding of the scrape-off layer (SOL) physics in tokamaks requires diagnostics with sufficient temporal and spatial resolution. This contribution describes results of experiments performed in...

Formation of convective cells in the scrape-off layer of the CASTOR tokamak (2004)

Stöckel, J., Devynck, P., Gunn, J., Martines, E., Bonhomme, G., Van Oost, G., ...

Understanding of the scrape-off layer (SOL) physics in tokamaks requires diagnostics with sufficient temporal and spatial resolution. This contribution describes results of experiments performed in...

Daphnia population growth but not moulting is a substantial phosphorus drain for phytoplankton (2003)

Sommer, F., Santer, B., Jamieson, C., Hansen, T., Sommer, U.

1. Negative effects of zooplankton on the availability of phosphorus (P) for phytoplankton as a result of the retention of nutrients in zooplankton biomass and the sedimentation of exoskeletal...

DNA adducts in cultures of polychlorinated biphenyl-treated human hepatocytes (2003)

Borlak, J., Hock, A., Hansen, T., Richter, E.

Polychlorinated biphenyls (PCBs) are persistent environmental chemicals that accumulate at the apex of food chains. Several scientific committees support its designation as a human carcinogen, even...

Coordinated Cluster and ground-based instrument observations of transient changes in the magnetopause boundary layer during an interval of predominantly northward IMF: relation to reconnection pulses and FTE signatures (2001)

Lockwood, M., Fazakerley, A., Opgenoorth, H., Moen, J., Van Eyken, A. P., Dunlop, M., ...

We study a series of transient entries into the low-latitude boundary layer (LLBL) of all four Cluster spacecraft during an outbound pass through the mid-afternoon magnetopause ( [ XGSM, YGSM, ZGSM ]...

Coordinated Cluster, ground-based instrumentation and low-altitude satellite observations of transient poleward-moving events in the ionosphere and in the tail lobe (2001)

Lockwood, M., Opgenoorth, H., Van Eyken, A. P., Fazakerley, A., Denig, W., ...

During the interval between 8:00–9:30 on 14 January 2001, the four Cluster spacecraft were moving from the central magnetospheric lobe, through the dusk sector mantle, on their way towards...

Coordinated Cluster and ground-based instrument observations of transient changes in the magnetopause boundary layer during an interval of predominantly northward IMF: relation to reconnection pulses and FTE signatures (2001)

Lockwood, M., Fazakerley, A., Opgenoorth, H., Moen, J., Van Eyken, A. P., Dunlop, M., ...

We study a series of transient entries into the low-latitude boundary layer (LLBL) of all four Cluster spacecraft during an outbound pass through the mid-afternoon magnetopause ( [ XGSM, YGSM, ZGSM ]...

Coordinated Cluster, ground-based instrumentation and low-altitude satellite observations of transient poleward-moving events in the ionosphere and in the tail lobe (2001)

Lockwood, M., Opgenoorth, H., Van Eyken, A. P., Fazakerley, A., Denig, W., ...

During the interval between 8:00–9:30 on 14 January 2001, the four Cluster spacecraft were moving from the central magnetospheric lobe, through the dusk sector mantle, on their way towards...

Cytochrome P450 enzyme activity and protein expression in primary porcine enterocyte and hepatocyte cultures (2000)

Hansen, T., Borlak, J., Bader, A.

1. A method for the isolation and cultivation of porcine hepatocytes and porcine duodenal enterocytes for the investigation of drug oxidation reactions has been established. 2. Hepatocytes as well as...

Metabolism and DNA-binding of 3-nitrobenzanthrone in primary rat alveolar type II cells, in human fetal bronchial, rat epithelial and mesenchymal cell lines (2000)

Borlak, J., Hansen, T., Kumar, S., Sikka, H.C., Frank, H., ...

3-Nitrobezanthrone (NBA) is a suspected human carcinogen and has been identified is diesel exhaust and in airborne particulates. Human exposure to NBA is thought to occur primarily via the...

Primary porcine enterocyte and hepatocyte cultures to study drug oxidation reactions (2000)

Bader, A., Hansen, T., Kirchner, G., Allmeling, C., Haverich, A., Borlak, J.

1. Primary porcine hepatocytes and enterocytes were isolated and cultured in Williams' E medium for up to 10 days to investigate potential organ differences in the metabolism of the immunosuppressive...

Mutations in the hepatocyte nuclear factor-1 alpha gene in maturity-onset diabetes of the young (MODY3) (1996)

Yamagata, K, Oda, N, Kaisaki, PJ, Menzel, S, Furuta, H, Vaxillaire, M, ...

THE disease non-insulin-dependent (type 2) diabetes mellitus (NIDDM) is characterized by abnormally high blood glucose resulting from a relative deficiency of insulin(1). It affects about 2% of the...

TESTING OPTIMALITY WITH EXPERIMENTAL EVOLUTION: LYSIS TIME IN A BACTERIOPHAGE

Heineman, Richard H, Bull, James J, Hansen, T

Optimality models collapse the vagaries of genetics into simple trade-offs to calculate phenotypes expected to evolve by natural selection. Optimality approaches are commonly criticized for this...

Primary porcine enterocyte and hepatocyte cultures to study drug oxidation reactions

Bader, A, Hansen, T, Kirchner, G, Allmeling, C, Haverich, A, Borlak, J T

Primary porcine hepatocytes and enterocytes were isolated and cultured in Williams' E medium for up to 10 days to investigate potential organ differences in the metabolism of the immunosuppressive...

Sulfolobus acidocaldarius inorganic pyrophosphatase: structure, thermostability, and effect of metal ion in an archael pyrophosphatase.

Leppänen, V. M., Nummelin, H., Hansen, T., Lahti, R., Schäfer, G., Goldman, A.

The first crystal structure of an inorganic pyrophosphatase (S-PPase) from an archaebacterium, the thermophile Sulfolobus acidocaldarius, has been solved by molecular replacement and refined to an...

Evidence of an association between genetic variation of the coactivator PGC-1ß and obesity

Andersen, G, Wegner, L, Yanagisawa, K, Rose, C, Lin, J, Glumer, C, ...

Background: Peroxisome proliferator activated receptor-γ coactivator-1ß (PGC-1ß) is a recently identified homologue of the tissue specific coactivator PGC-1α, a coactivator of transcription...

Norwegian local tax policy

T Hansen

A broad outline of the main elements of the Norwegian local tax system is first given. This is followed by a discussion of some of the changes that have taken place in the relative distribution of...

Autosomal dominant optic atrophy associated with hearing impairment and impaired glucose regulation caused by a missense mutation in the WFS1 gene

Eiberg, H, Hansen, L, Kjer, B, Hansen, T, Pedersen, O, Bille, M, ...

Autosomal dominant optic atrophy (ADOA) is genetically heterogeneous, with OPA1 on 3q28 being the most prevalently mutated gene. Additional loci are OPA3, OPA4, and OPA5, located at 19q13.2, 18q12.2,...