T. Hashimoto

Publication List Details

Period

1957 - 2009

Number

264

Co-Authors

Proceedings of The 13th International Symposium on Artificial Life and Robotics (AROB08), M. Sugisaka and H. Tanaka (Eds.), (2008) Minimum Nomic, a Tool for Studying Rule Dynamics (2009)

M. Hatakeyama, T. Hashimoto

We propose a kind of self-amendment game, Minimum Nomic, as a model to study rule dynamics. Nomic is a game in which changing the rule of game is a move. Minimum Nomic is a reduced version of the...

Proceedings of The 13th International Symposium on Artificial Life and Robotics (AROB08), M. Sugisaka and H. Tanaka (Eds.), (2008) The Diversification of Proto-Cells Driven by Membrane Permselectivity (2009)

M. Hatakeyama, T. Hashimoto

We consider how permselectivity as a function of the membrane is related to the cell evolution with an abstract proto-cell model. We construct an autopoietic proto-cell model having primitive...

Discrimination with error margin between two states - Case of general occurrence probabilities - (2009)

Sugimoto, H., Hashimoto, T., Horibe, M., Hayashi, A.

We investigate a state discrimination problem which interpolates minimum-error and unambiguous discrimination by introducing a margin for the probability of error. We closely analyze discrimination...

Locality and nonlocality in quantum pure-state identification problems (2008)

Ishida, Y., Hashimoto, T., Horibe, M., Hayashi, A.

Suppose we want to identify an input state with one of two unknown reference states, where the input state is guaranteed to be equal to one of the reference states. We assume that no classical...

State discrimination with error margin and its locality (2008)

Hayashi, A., Hashimoto, T., Horibe, M.

There are two common settings in a quantum-state discrimination problem. One is minimum-error discrimination where a wrong guess (error) is allowed and the discrimination success probability is...

Proceedings of 10th Conference on Artificial Life and Robotics (AROB05) (CD-ROM) 1 Outwit game – a dynamical systems game for market dynamics (2008)

M. Konno, T. Hashimoto

A dynamical systems game model of market, called Outwit Game, is proposed. In the game, individual behavior in a market is abstracted as orienting majority and orienting minority. We suppose that...

Proceedings of 10th Conference on Artificial Life and Robotics (AROB05) (CD-ROM) 1 Rule ecology dynamics for studying dynamical and interactional nature of social institutions (2008)

T. Hashimoto, M. Nishibe

In this paper, we address a new concept to view a social system as consisting of diversified institutions interacting with each other and dynamically changing through actions of individuals in a...

Proceedings of 10th Conference on Artificial Life and Robotics (AROB05) (CD-ROM) 1 Models of individuals for constructive approach to dynamic view of language and society (2008)

T. Hashimoto, T. Sato, A. Masumi

In order to understand dynamic nature of our world and ourselves, we propose three models of individuals that can be used in multi-agent systems for dynamic linguistic or social simulations. They are...

Barrier and porous anodic oxides on InSb (2008)

Suleiman, A, Hashimoto, T, Skeldon, P, Thompson, GE, Echeverria, F, Graham, MJ, ...

Anodizing of InSb at 5 mA cm−2 in sodium tungstate electrolyte is shown to produce barrier-type amorphous oxide at relatively low voltages, to about 40 V, and porous-type amorphous oxide at...

Behaviour of copper during alkaline corrosion of Al–Cu alloys (2008)

Liu, Y, Arenas, MA, Garcia-Vergara, SJ, Hashimoto, T, Skeldon, P, Thompson, GE, ...

Enrichment of copper beneath amorphous anodic films on relatively dilute, solid-solution Al–Cu alloys is necessary before copper can be oxidized and incorporated into the oxide layer. A similar...

DECIGO pathfinder (2008)

Ando, M., Kawamura, Seiji, Nakamura, T., Tsubono, K., Tanaka, T., Funaki, I., ...

DECIGO pathfinder (DPF) is a milestone satellite mission for DECIGO (DECi-hertz Interferometer Gravitational wave Observatory) which is a future space gravitational wave antenna. DECIGO is expected...

The Japanese space gravitational wave antenna: DECIGO (2008)

Kawamura, Seiji, Ando, M., Nakamura, T., Tsubono, K., Tanaka, T., Funaki, I., ...

DECi-hertz Interferometer Gravitational wave Observatory (DECIGO) is the future Japanese space gravitational wave antenna. DECIGO is expected to open a new window of observation for gravitational...

The Japanese space gravitational wave antenna - DECIGO (2008)

Kawamura, Seiji, Ando, M., Nakamura, T., Tsubono, K., Tanaka, T., Funaki, I., ...

DECi-hertz Interferometer Gravitational wave Observatory (DECIGO) is the future Japanese space gravitational wave antenna. The goal of DECIGO is to detect gravitational waves from various kinds of...

Clinical features of haemophagocytic syndrome in patients with systemic autoimmune diseases: analysis of 30 cases (2008)

Fukaya, S., Yasuda, S., Hashimoto, T., Oku, K., Kataoka, H., Horita, T., ...

Objectives. Haemophagocytic syndrome (HPS) is known as a relatively rare complication in autoimmune diseases. Here we analysed the clinical features of HPS in patients with systemic autoimmune...

Nonlocality in unambiguous pure-state identification without classical knowledge (2007)

Hayashi, A., Ishida, Y., Hashimoto, T., Horibe, M.

For two bipartite pure states, we consider the problem of unambiguous identification without classical knowledge on the states. The optimal success probability by means of local operations and...

Local Quantum Pure-state Identification without Classical Knowledge (2007)

Ishida, Y., Hashimoto, T., Horibe, M., Hayashi, A.

Suppose we want to distinguish two quantum pure states. We consider the case in which no classical knowledge on the two states is given and only a pair of samples of the two states is available. This...

Finite (2007)

K. Takayama, K. Koremoto, T. Hashimoto, H. Mitobe

fringe analysis of two dimensional and axially-symmetric flows

Lentiviral gene replacement therapy of retinas in a mouse model for Usher syndrome type 1B (2007)

Hashimoto, T., Gibbs, D., Lillo, C., Azarian, S. M., Zhang, X-M, Legacki, E., ...

One of the most disabling forms of retinal degeneration occurs in Usher syndrome, since it affects patients who already suffer from deafness. Mutations in the myosin VIIa gene (MYO7A) cause a major...

Childhood epidermolysis bullosa acquisita with autoantibodies against the noncollagenous 1 and 2 domains of type VII collagen : case report and review of the literature (2006)

Mayuzumi, M., Akiyama, M., Nishie, W., Ukae, S., Abe, M., Sawamura, D., ...

Epidermolysis bullosa acquisita (EBA) is an acquired subepidermal bullous disease characterized by IgG autoantibodies to type VII collagen, a major component of anchoring fibrils. Most patients with...

Phase selection of microcrystalline GaN synthesized in supercritical ammonia (2006)

Hashimoto, T, Fujito, K, Sharma, R, Letts, E R, Fini, P T, Speck, J S, ...

Microcrystalline GaN was synthesized in supercritical ammonia with acidic, neutral, and basic mineralizers. For both acidic and neutral mineralizers, a mixture of wurtzite GaN and zinc-blende GaN was...

Stationary quantum Markov process for the Wigner function (2006)

Hashimoto, T., Horibe, M., Hayashi, A.

As a stochastic model for quantum mechanics we present a stationary quantum Markov process for the time evolution of the Wigner function on a lattice phase space Z_N x Z_N with N odd. By introducing...

The Japanese space gravitational wave antenna - DECIGO (2006)

Kawamura, Seiji, Nakamura, T., Ando, M., Seto, N., Tsubono, K., Numata, K., ...

DECi-hertz Interferometer Gravitational wave Observatory (DECIGO) is the future Japanese space gravitational wave antenna. It aims at detecting various kinds of gravitational waves between 1 mHz and...

The impact of cardiovascular risk factors on the age-related excess risk of coronary heart disease (2006)

Huxley, R, Barzi, F, Lam, TH, Lawes, CMM, Wong, JW, Woodward, M, ...

Purpose Differences in cardiovascular risk factor levels have been suggested to contribute to the age-related excess risk of coronary heart disease (CHD). The aim of this study was to reliably...

The impact of cardiovascular risk factors on the age-related excess risk of coronary heart disease (2006)

Huxley, R, Barzi, F, Lam, TH, Lawes, CMM, Wong, JW, Woodward, M, ...

Purpose Differences in cardiovascular risk factor levels have been suggested to contribute to the age-related excess risk of coronary heart disease (CHD). The aim of this study was to reliably...

Optimal estimation of a physical observable's expectation value for pure states (2005)

Hayashi, A., Horibe, M., Hashimoto, T.

We study the optimal way to estimate the quantum expectation value of a physical observable when a finite number of copies of a quantum pure state are presented. The optimal estimation is determined...

Unambiguous pure state identification without classical knowledge (2005)

Hayashi, A., Horibe, M., Hashimoto, T.

We study how to unambiguously identify a given quantum pure state with one of the two reference pure states when no classical knowledge on the reference states is given but a certain number of copies...

Flow fields of a large-angle, spiked blunt cone at hypersonic Mach numbers (2005)

Gopalan, J, Menezes, V, Reddy, KPJ, Hashimoto, T, Sun, M, Saito, T, ...

The flow fields around a large apex angle. spiked blunt cone have been analyzed at a hypersonic Mach number through experiments in a free piston-driven shock tunnel and the results, are compared with...

Quantum pure-state identification (2005)

Hayashi, A., Horibe, M., Hashimoto, T.

We address a problem of identifying a given pure state with one of two reference pure states, when no classical knowledge on the reference states is given, but a certain number of copies of them are...

Mean king's problem with mutually unbiased bases and orthogonal Latin squares (2005)

Hayashi, A., Horibe, M., Hashimoto, T.

The mean king's problem with maximal mutually unbiased bases (MUB's) in general dimension d is investigated. It is shown that a solution of the problem exists if and only if the maximal number (d+1)...

Smoking, quitting, and the risk of cardiovascular disease among women and men in the Asia-Pacific region (2005)

Woodward, M., Lam, T. H., Barzi, Federica, Patel, Ashvin K., Gu, D. F., Rodgers, A., ...

Published by Oxford University Press on behalf of the International Epidemiological Association © The Author 2005; all rights reserved.

Smoking, quitting, and the risk of cardiovascular disease among women and men in the Asia-Pacific region (2005)

Woodward, M., Lam, T. H., Barzi, Federica, Patel, Ashvin K., Gu, D. F., Rodgers, A., ...

Published by Oxford University Press on behalf of the International Epidemiological Association © The Author 2005; all rights reserved.

Reexamination of optimal quantum state estimation of pure states (2004)

Hayashi, A., Hashimoto, T., Horibe, M.

A direct derivation is given for the optimal mean fidelity of quantum state estimation of a d-dimensional unknown pure state with its N copies given as input, which was first obtained by M. Hayashi...

Extended Quantum Color Coding (2004)

Hayashi, A., Hashimoto, T., Horibe, M.

The quantum color coding scheme proposed by Korff and Kempe (quant-ph/0405086) is easily extended so that the color coding quantum system is allowed to be entangled with an extra auxiliary quantum...

Limits on the neutrino magnetic moment using 1496 days of Super-Kamiokande-I solar neutrino data (2004)

Ashie, Y, Fukuda, S, Fukuda, Y, Ishihara, K, Itow, Y, ...

A search for a nonzero neutrino magnetic moment has been conducted using 1496 live days of solar neutrino data from Super-Kamiokande-I. Specifically, we searched for distortions to the energy...

Body mass index and cardiovascular disease in the Asia-Pacific Region: an overview of 33 cohorts involving 310 000 participants (2004)

Mhurchu, CN, Rodgers, A, Pan, WH, Gu, DF, Woodward, M, Parag, V, ...

Background Few prospective data from the Asia-Pacific region are available relating body mass index (BMI) to the risks of stroke and ischaemic heart disease (IHD). Our objective was to assess the...

Blood glucose and risk of cardiovascular disease in the Asia Pacific region (2004)

Lawes, CMM, Parag, V, Bennett, DA, Suh, I, Lam, TH, Whitlock, G, ...

OBJECTIVE - To assess the shape and strength of the association between usual blood glucose and cardiovascular disease (CVD) in Asian and Australasian cohorts and to determine the impact of adjusting...

Body mass index and cardiovascular disease in the Asia-Pacific Region: an overview of 33 cohorts involving 310 000 participants (2004)

Mhurchu, CN, Rodgers, A, Pan, WH, Gu, DF, Parag, V, Lin, R, ...

Background Few prospective data from the Asia-Pacific region are available relating body mass index (BMI) to the risks of stroke and ischaemic heart disease (IHD). Our objective was to assess the...

Blood glucose and risk of cardiovascular disease in the Asia Pacific region (2004)

Lawes, CMM, Parag, V, Bennett, DA, Suh, I, Whitlock, G, Barzi, F, ...

OBJECTIVE - To assess the shape and strength of the association between usual blood glucose and cardiovascular disease (CVD) in Asian and Australasian cohorts and to determine the impact of adjusting...

Quantum Markov Process on a Lattice (2003)

Hashimoto, T., Horibe, M., Hayashi, A.

We develop a systematic description of Weyl and Fano operators on a lattice phase space. Introducing the so-called ghost variable even on an odd lattice, odd and even lattices can be treated in a...

Expression of the Flk1 receptor and its ligand VEGF in the developing chick central nervous system (2003)

Hashimoto, T, Zhang, X M, Yang, X J

The receptor tyrosine kinase Flk1 is known to mediate signals of vascular endothelial growth factor (VEGF) during vasculogenesis and hematopoiesis. We demonstrate by in situ hybridization that in...

Visualization of Unsteady Shock Oscillations in the High-Enthalpy Flow Field around Double Cones (2003)

Jagadeesh, G, Hashimoto, T, Naitou, K, Sun, M, Takayama, K

The presence of an adverse pressure gradient, shock/shock interaction and shock wave/boundary layer interaction often induces flow separation around bodies. However, the effect of dissociated flow on...

Visualization of Unsteady Shock Oscillations in the High-Enthalpy Flow Field around Double Cones (2003)

Jagadeesh, G, Hashimoto, T, Naitou, K, Sun, M, Takayama, K

The presence of an adverse pressure gradient, shock/shock interaction and shock wave/boundary layer interaction often induces flow separation around bodies. However, the effect of dissociated flow on...

Remote State Preparation without Oblivious Conditions (2002)

Hayashi, A., Hashimoto, T., Horibe, M.

In quantum teleportation, neither Alice nor Bob acquires any classical knowledge on teleported states. The teleportation protocol is said to be oblivious to both parties. In remote state preparation...

Evaluation of Environmental Dose Rate at JCO Using Luminescence from Quartz Stimulated by Blue Light (2001)

Hong, D.G., Galloway, R.B., Takano, M., Hashimoto, T.

The environmental dose due to the recent nuclear accident at JCO, Japan, was estimated using luminescence optically stimulated from unheated quartz. Two methods originally developed for dating...

Chemical potential response of meson masses at finite temperature (2000)

Hashimoto, T., Hioki, S., Liu, Y., Matsufuru, H., Miyamura, O., ...

We study the response of meson masses to the chemical potential ($\partial{m}/\partial{\mu}$) at high temperature and at zero chemical potential on $N_f=2$ lattice with staggered fermions....

Wigner Functions on a Lattice (2000)

Takami, A., Hashimoto, T., Horibe, M., Hayashi, A.

The Wigner functions on the one dimensional lattice are studied. Contrary to the previous claim in literature, Wigner functions exist on the lattice with any number of sites, whether it is even or...

Meson Correlators in Finite Temperature Lattice QCD (2000)

De Forcrand, Philippe, García-Pérez, M, Hashimoto, T, Hioki, S, Matsufuru, H, Miyamura, O, ...

We analyze temporal and spatial meson correlators in quenched lattice QCD at T>0. Below T_c we observe little change in the meson properties as compared with T=0. Above T_c we observe new features:...

Meson Correlators in Finite Temperature Lattice QCD (2000)

Collaboration, QCD-TARO, De Forcrand, Ph., Perez, M. Garcia, Hashimoto, T., Hioki, S., Matsufuru, H., ...

We analyze temporal and spatial meson correlators in quenched lattice QCD at T>0. Below T_c we observe little change in the meson properties as compared with T=0. Above T_c we observe new features:...

Determinant of a new fermionic action on a lattice - (II) (2000)

Takami, A., Hashimoto, T., Horibe, M., Hayashi, A.

We investigate the fermion determinant of a new action on a $(1+D)$-dimensional lattice for SU(2) gauge groups. This action possesses the discrete chiral symmetry and provides $2^D$-component...

Determinant of a new fermionic action on a lattice - (I) (2000)

Takami, A., Hashimoto, T., Horibe, M., Hayashi, A.

We investigate, analytically and numerically, the fermion determinant of a new action on a (1+1)-dimensional Euclidean lattice. In this formulation the discrete chiral symmetry is preserved and the...

Effects of Chemical Potential on Hadron Masses in the Phase Transition Region (1999)

Perez, M. Garcia, Hashimoto, T., Hioki, S., Liu, Y., Matsufuru, H., ...

We study the response of hadron masses with respect to chemical potential at $\mu=0$. Our preliminary results of the pion channel show that $\partial m/\partial \mu$ in the confinement phase is...

Renormalization group flow of SU(3) lattice gauge theory - Numerical studies in a two coupling space (1999)

De Forcrand, Ph., Pérez, M. García, Hashimoto, T., Hioki, S., Matsufuru, H., Miyamura, O., ...

We investigate the renormalization group (RG) flow of SU(3) lattice gauge theory in a two coupling space with couplings $\beta_{11}$ and $\beta_{12}$ corresponding to $1\times 1$ and $1\times 2$...

A Study of Meson Correlators at Finite Temperature (1999)

Perez, M. Garcia, Hashimoto, T., Hioki, S., Katayama, R., Matsufuru, H., ...

We present results for mesonic propagators in temporal and spatial directions at T below and above the deconfining transition in quenched QCD. Anisotropic lattices are used to get enough information...

Monte Carlo Renormalization Group analysis of QCD in two dimensional coupling space (1999)

Perez, M. Garcia, Hashimoto, T., Hioki, S., Matsufuru, H., Miyamura, O., ...

We report our results of the Monte Carlo Renormalization Group analysis in two dimensional coupling space. The qualitative features of the RG flow are described with a phenomenological RG equation....

Mesons Above The Deconfining Transition (1999)

Perez, M. Garcia, Hashimoto, T., Hioki, S., Matsufuru, H., Miyamura, O., ...

We analyze temporal and spatial meson correlators in quenched lattice QCD at T>0. Above T_c we find different masses and (spatial) screening masses, signals of plasma formation, and indication of...

SCATTERING OF LIGHT BY FILMS HAVING NONRANDOM ORIENTATION FLUCTUATIONS - II. (1998)

Hashimoto,T., Stein,R. S.

The theory for scattering of light from films in which the orientation correlation between two scattering elements depends upon the angle beta between the optic axes and the vector connecting the two...

Characterization of L-leucine Induced Germination of Trichophyton mentagrophytes microspores. (1998)

Hashimoto,T., Wu,C. D. R., Blumenthal,H. J.

L-Leucine and several amino acids proved to be effective germination inducers of microspores of Trichophyton mentagrophytes. During germination phase darkening and swelling occurred concomitantly...

Effects of Chemical Potential on Hadron Masses at Finite Temperature (1998)

Perez, M. Garcia, Hashimoto, T., Hioki, S., Matsufuru, H., Miyamura, O., ...

We study the effects of the chemical potential on the $\rho$ meson mass at finite temperature. Our preliminary results show that some effects are seen in the vicinity of the phase transition point....

Finite Temperature QCD on Anisotropic Lattices (1998)

Perez, M. Garcia, Hashimoto, T., Hioki, S., Matsufuru, H., Miyamura, O., ...

We present results for mesonic propagators in temporal and spatial direction and for topological properties at T below and above the deconfining transition in quenched QCD. We use anisotropic...

Scaling Analysis of Improved Actions for Pure SU(3) Gauge Theory (1998)

De Forcrand, Philippe, García-Pérez, M, Hashimoto, T, Hioki, S, Matsufuru, H, Miyamura, O, ...

We have explored the behaviour of some improved actions based on a nonperturbative renormalization group (RG) analysis in coupling space. We calculate the RG flow in two-coupling space...

Scaling Analysis of Improved Actions for Pure SU(3) Gauge Theory (1998)

Peréz, M. Garc{\'\i}a, Hashimoto, T., Hioki, S., Matsufuru, H., Miyamura, O., ...

We have explored the behaviour of some improved actions based on a nonperturbative renormalization group (RG) analysis in coupling space. We calculate the RG flow in two-coupling space...

Study of P Influenced to Magnetic Characteristics of Mn-Zn Ferrites for Power Applications (1997)

Otobe, S., Hashimoto, T., Takei, H., Maeda, T.

We examined that influence of P which changes magnetic characteristics of Mn-Zn ferrites for power applications. As quantity of P increase, larger size grains were formed in the microstructure of...

Study of P Influenced to Magnetic Characteristics of Mn-Zn Ferrites for Power Applications (1997)

Otobe, S., Hashimoto, T., Takei, H., Maeda, T.

We examined that influence of P which changes magnetic characteristics of Mn-Zn ferrites for power applications. As quantity of P increase, larger size grains were formed in the microstructure of...

Study of P Influenced to Magnetic Characteristics of Mn-Zn Ferrites for Power Applications (1997)

Otobe, S., Hashimoto, T., Takei, H., Maeda, T.

We examined that influence of P which changes magnetic characteristics of Mn-Zn ferrites for power applications. As quantity of P increase, larger size grains were formed in the microstructure of...

Finite Temperature Gauge Theory on Anisotropic Lattices (1996)

Fujisaki, M., Okuda, M., Tago, Y., Hashimoto, T., Hioki, S., Matsufuru, H., ...

The finite temperature transition of QCD can be seen as a change in the structure of the hadrons and as a symmetry breaking transition -- a change in the structure of the vacuum. These phenomena are...

Search for Effective Lattice Action of Pure QCD (1996)

DeForcrand, Ph., Fujisaki, M., Hashimoto, T., Hioki, S., Matsufuru, H., Miyamura, O., ...

We study a coupling flow of pure QCD gauge system by using the Monte Carlo Renormalization Group method. A rough location of the renormalized trajectory in two coupling space is obtained. Also we...

A lattice fermion without doubling (1996)

Hayashi, A., Hashimoto, T., Horibe, M., Yamamoto, H.

A free fermion without doubler is formulated on 1+D dimensional discrete Minkowski space-time. The action is not hermitian but causes no harm. In 1+3 dimensional massless case the equation describes...

Diastolic mitral annular motion in normal subjects and patients with coronary artery disease (1995)

OHTE, N., NARITA, H., HASHIMOTO, T., KOBAYASHI, K., AKITA, S., FUJINAMI, T.

The purpose of this study was to evaluate the characteristics of mitral annular motion during diastole in 28 normal subjects, 40 patients with prior myocardial infarction (MI), and 23 patients with...

Systematic study of autocorrelation time in pure SU(3) lattice gauge theory (1993)

Akemi, K., DeForcrand, Ph., Fujisaki, M., Hashimoto, T., Hioki, S., Miyamura, O., ...

Results of our autocorrelation measurement performed on Fujitsu AP1000 are reported. We analyze (i) typical autocorrelation time, (ii) optimal mixing ratio between overrelaxation and pseudo-heatbath...

Scaling Study of Pure Gauge Lattice QCD by Monte Carlo Renormalization Group Method (1993)

Akemi, K., DeForcrand, Ph., Fujisaki, M., Hashimoto, T., Hege, H. C., Hioki, S., ...

The scaling behavior of pure gauge SU(3) in the region $\beta=5.85 - 7.60$ is examined by a Monte Carlo Renormalization Group analysis. The coupling shifts induced by factor 2 blocking are measured...

Intermittency and Phase Transition (1992)

Nakamura, E. R., Kudo, K., Hashimoto, T., Yoneda, I.

On the basis of a lattice gas model and the convolution formula with cell construction scheme, we demonstrate that intermittency in the rapidity-space with respect to the scaled moments comes from a...

Autocorrelation in Updating Pure SU(3) Lattice Gauge Theory by the use of Overrelaxed Algorithms (1992)

Akemi, K., DeForcrand, Ph., Fujisaki, M., Hashimoto, T., Hege, H. C., Hioki, S., ...

We measure the sweep-to-sweep autocorrelations of blocked loops below and above the deconfinement transition for SU(3) on a $16^4$ lattice using 20000-140000 Monte-Carlo updating sweeps. A divergence...

ACETALDEHYDE-INDUCED ALTERATIONS IN METABOLISM OF MONOAMINES IN MOUSE BRAIN (1989)

HASHIMOTO, T., UEHA, T., KURIYAMA, T., KATSURA, M., KURIYAMA, K.

The effects of single and repeated inhalations of acetaldehyde (AcAl) on spontaneous activity and the metabolisms of cerebral monoamines and neuroactive amino acids were investigated. Both single and...

Die Windgeschwindigkeit an der Kühlerfrontfläche bei den in Kraftfahrzeugen eingebauten wassergekühlten Motoren (1966)

Masuda, T., Saito, H., Hashimoto, T.

Untersuchung der Besonderheiten der Motorkühlung bei PKW mit Frontmotor (bei unterschiedlichen Geschwindigkeiten, bei Berg- und Talfahrt) - Art der Fahrzeuge und Kühler, der Meßstellen und...

Two tropinone reductases with different stereospecificities are short-chain dehydrogenases evolved from a common ancestor.

Nakajima, K, Hashimoto, T, Yamada, Y

In the biosynthetic pathway of tropane alkaloids, tropinone reductase (EC 1.1.1.236) (TR)-I and TR-II, respectively, reduce a common substrate, tropinone, stereospecifically to the stereoisomeric...

Metabolic engineering of medicinal plants: transgenic Atropa belladonna with an improved alkaloid composition.

Yun, D J, Hashimoto, T, Yamada, Y

The tropane alkaloid scopolamine is a medicinally important anticholinergic drug present in several solanaceous plants. Hyoscyamine 6 beta-hydroxylase (EC 1.14.11.11) catalyzes the oxidative...

The retinoblastoma gene functions as a growth and tumor suppressor in human bladder carcinoma cells.

Takahashi, R, Hashimoto, T, Xu, H J, Hu, S X, Matsui, T, Miki, T, ...

The product of the human retinoblastoma gene (RB) is a nuclear phosphoprotein that is thought to function as a tumor suppressor. Mutations of RB frequently occur in human bladder carcinoma. To...

Species-dependent expression of the hyoscyamine 6 beta-hydroxylase gene in the pericycle.

Kanegae, T, Kajiya, H, Amano, Y, Hashimoto, T, Yamada, Y

The tropane alkaloid scopolamine is synthesized in the pericycle of branch roots in certain species of the Solanaceae. The enzyme responsible for the synthesis of scopolamine from hyoscyamine is...

Gene expression in tobacco low-nicotine mutants.

Hibi, N, Higashiguchi, S, Hashimoto, T, Yamada, Y

Two nuclear genes, Nic1 and Nic2, regulate nicotine levels in tobacco. nic1 and nic2 are semidominant mutations in Burley 21 that reduce leaf nicotine levels and the activities of multiple enzymes in...

Cloning of the aldehyde reductase gene from a red yeast, Sporobolomyces salmonicolor, and characterization of the gene and its product.

Kita, K, Matsuzaki, K, Hashimoto, T, Yanase, H, Kato, N, Chung, M C, ...

An NADPH-dependent aldehyde reductase (ALR) isolated from a red yeast, Sporobolomyces salmonicolor, catalyzes the reduction of a variety of carbonyl compounds. To investigate its primary structure,...

Enhanced killing of Candida albicans by cultured peritoneal exudate cells treated with SM-1213, a synthetic immunomodulator.

Morrison, C J, Gordon, P, Hashimoto, T

The effect of SM-1213 [1,2-O-isopropylidene-3-O-3'-(N', N'-dimethylamino-n-propyl)-D-glucofuranose] on the candidastatic and candidacidal capacity of guinea pig peritoneal exudate cells was...

Efficacy of BRL 25000 against Serratia marcescens, Enterobacter cloacae, and Citrobacter freundii in urinary tract infections.

Nakazawa, H, Hashimoto, T, Nishiura, T, Mitsuhashi, S

Synergism between amoxicillin and clavulanic acid was not expected against cephalosporinase-producing bacterial strains because clavulanic acid has little inhibitory action on cephalosporinases....

Cloning and sequencing of two tandem genes involved in degradation of 2,3-dihydroxybiphenyl to benzoic acid in the polychlorinated biphenyl-degrading soil bacterium Pseudomonas sp. strain KKS102.

Kimbara, K, Hashimoto, T, Fukuda, M, Koana, T, Takagi, M, Oishi, M, ...

Two genes involved in the degradation of biphenyl were isolated from a gene library of a polychlorinated biphenyl-degrading soil bacterium, Pseudomonas sp. strain KKS102, by using a broad-host-range...

"Nonfibrillar" chitin associated with walls and septa of Trichophyton mentagrophytes arthrospores.

Pollack, J H, Lange, C F, Hashimoto, T

Two morphologically distinct forms of chitin were found in the arthrospore walls and septa of Trichophyton mentagrophytes. Two-thirds of the total wall chitin was the microfibrillar and...

Carotenogenesis associated with arthrosporulation of Trichophyton mentagrophytes.

Hashimoto, T, Pollack, J H, Blumenthal, H J

Carotenoid pigments were demonstrated in arthrospores of the dermatophyte Trichophyton mentagrophytes but were absent from hyphae and microconidia of this fungus. Incubation at higher temperatures...

Isolation and characterization of the rodlet layer of Trichophyton mentagrophytes microconidial wall.

Hashimoto, T, Wu-Yuan, C D, Blumenthal, H J

The rodlet layer of the microconidial wall of Trichophyton mentagrophytes was isolated and partially characterized. The purified microconidial walls were first extracted with urea (8M),...

Isolation of temperature-sensitive mutants of R plasmid by in vitro mutagenesis with hydroxylamine.

Hashimoto, T, Sekiguchi, M

Temperature-sensitive mutants were isolated from a tetracycline resistance plasmid, pSC101, after mutagenesis with hydroxylamine. They were divided into three classes according to their growth...

Architecture and chemistry of microconidial walls of Trichophyton mentagrophytes.

Wu-Yuan, C D, Hashimoto, T

The ultrastructure and chemical composition of the walls of Trichophyton mentagrophytes microconidia were investigated with particular emphasis on the localization of the major structural components...

Ethanol contamination in commercial buffers: ethanol contaminating tris-maleate and other commercial buffers induces germ tube formation in Candida albicans.

Pollack, J H, Hashimoto, T

Evidence is presented for the presence of trace amounts of ethanol in certain commercial buffers. It was shown that germ tube formation occurring in Candida albicans suspended in the buffers was due...

Survival and resistance of Trichophyton mentagrophytes arthrospores.

Hashimoto, T, Blumenthal, H J

The effects of several physical and chemical agents on the survival of Trichophyton mentagrophytes arthrospores were investigated. Although arthrospores of this dermatophyte were highly resistant to...

Appendage Development in Clostridium bifermentans

Samsonoff, William A., Hashimoto, T., Conti, S. F.

The appendages of Clostridium bifermentans UK-A 1003 spores were shown to originate from a substance located just exterior to the outer forespore membrane. The dense spore coat develops along the...

Presence of Nuclear Bodies in Some Minicells of Escherichia coli

Tudor, J., Hashimoto, T., Conti, S. F.

Electron microscopy of serial sections of Escherichia coli K-12 (P678-54) revealed that some “minicells” contain nuclear bodies.

Facultatively Parasitic Strain of Bdellovibrio bacteriovorus1

Diedrich, D. L., Denny, C. F., Hashimoto, T., Conti, S. F.

A strain of Bdellovibrio bacteriovorus (designated strain UKi2) was isolated which was capable of growing either saprophytically in host-free medium or endoparasitically in Escherichia coli B/r. It...

Ultrastructure and Cell Division of a Facultatively Parasitic Strain of Bdellovibrio bacteriovorus1

Burnham, Jeffrey C., Hashimoto, T., Conti, S. F.

Some aspects of cell development and division of Bdellovibrio bacteriovorus strain UKi2 were examined by use of electron microscopic techniques. Under saprophytic and parasitic conditions of growth,...

Ultrastructural Changes Associated with Germination and Outgrowth of an Appendage-Bearing Clostridial Spore

Samsonoff, William A., Hashimoto, T., Conti, S. F.

The sequence of events occurring during the germination and outgrowth of appendage-bearing spores of Clostridium bifermentans was studied by phase-contrast and electron microscopy. The mature spore...

Electron Microscopic Observations on the Penetration of Bdellovibrio bacteriovorus into Gram-negative Bacterial Hosts1

Burnham, Jeffrey C., Hashimoto, T., Conti, S. F.

The progressive stages in Bdellovibrio bacteriovorus penetration into two strains of Escherichia coli were examined by use of electron microscopic techniques. The initial change observed in the...

In vitro study of contact-mediated killing of Candida albicans hyphae by activated murine peritoneal macrophages in a serum-free medium.

Hashimoto, T

Activated peritoneal macrophages obtained from Listeria-immune mice were demonstrated to kill nonphagocytosable Candida albicans hyphae by contact-mediated mechanisms in a serum-free synthetic...

Identification of Pseudomonas aeruginosa by using a disk of phenanthroline and 9-chloro-9-[4-(diethylamino)phenyl]-9,10-dihydro-10-phenylacridine hydrochloride and by cell agglutination testing with monoclonal antibodies.

Fujita, S, Tonohata, A, Matsuoka, T, Okado, N, Hashimoto, T

To establish a simple identification procedure for Pseudomonas aeruginosa, we developed a disk consisting of phenanthroline and 9-chloro-9-[4-(diethylamino)phenyl]-9,10-dihydro-10- phenylacridine...

Detection of serum Candida antigens by enzyme-linked immunosorbent assay and a latex agglutination test with anti-Candida albicans and anti-Candida krusei antibodies.

Fujita, S, Hashimoto, T

Serum samples from 197 patients with and without candidiasis were assayed for Candida albicans mannan and Candida krusei mannan by an enzyme-linked immunosorbent assay (ELISA) and a latex...

Effect of chilling on the survival of Bacteroides fragilis.

Hagen, J C, Wood, W S, Hashimoto, T

Factors affecting the susceptibility of Bacteroides fragilis subsp. fragilis to low temperature were examined. Predetermined numbers of cells were spread on agar media or suspended in enriched...

Effect of temperature on survival of Bacteroides fragilis subsp. fragilis and Escherichia coli in pus.

Hagen, J C, Wood, W S, Hashimoto, T

Approximately 40 to 60% of Bacteroides fragilis subsp. fragilis in pus from experimental intra-abdominal abscesses lost their viability within 24 h when stored at refrigeration temperature (4 degrees...

Combined antibacterial activity of amoxicillin with clavulanic acid against ampicillin-resistant strains.

Matsuura, M, Nakazawa, H, Hashimoto, T, Mitsuhashi, S

Strains of bacteria resistant to beta-lactam antibiotics have been increasing in number and are becoming troublesome in clinical medicine. The in vitro antibacterial activity of amoxicillin combined...

Morphogenesis of Ascospores in Saccharomyces cerevisiae

Guth, E., Hashimoto, T., Conti, S. F.

Ultrastructural changes associated with ascospore formation in Saccharomyces cerevisiae were investigated by using freeze-etching and thin-sectioning techniques. The first nuclear division (meiosis...

Identification of a novel exonic mutation at -13 from 5' splice site causing exon skipping in a girl with mitochondrial acetoacetyl-coenzyme A thiolase deficiency.

Fukao, T, Yamaguchi, S, Wakazono, A, Orii, T, Hoganson, G, Hashimoto, T

We identified a novel exonic mutation which causes exon skipping in the mitochondrial acetoacetyl-CoA thiolase (T2) gene from a girl with T2 deficiency (GK07). GK07 is a compound heterozygote; the...

Mitochondrial trifunctional protein deficiency. Catalytic heterogeneity of the mutant enzyme in two patients.

Kamijo, T, Wanders, R J, Saudubray, J M, Aoyama, T, Komiyama, A, Hashimoto, T

We examined the enzyme protein and biosynthesis of human trifunctional protein harboring enoyl-CoA hydratase, 3-hydroxyacyl-CoA dehydrogenase, and 3-ketoacyl-CoA thiolase activity in cultured skin...

Purification of human very-long-chain acyl-coenzyme A dehydrogenase and characterization of its deficiency in seven patients.

Aoyama, T, Souri, M, Ushikubo, S, Kamijo, T, Yamaguchi, S, Kelley, R I, ...

Mitochondrial very-long-chain acyl-coenzyme A dehydrogenase (VLCAD) was purified from human liver. The molecular masses of the native enzyme and the subunit were estimated to be 154 and 70 kD,...

Absorption of pathogenic autoantibodies by the extracellular domain of pemphigus vulgaris antigen (Dsg3) produced by baculovirus.

Amagai, M, Hashimoto, T, Shimizu, N, Nishikawa, T

Pemphigus vulgaris (PV) is an autoimmune blistering disease, in which autoantibodies against PV antigen (PVA or Dsg3) play a pathogenic role in inducing blister formation. Bacterial fusion proteins...

Peroxisomal beta-oxidation enzyme proteins in adrenoleukodystrophy: distinction between X-linked adrenoleukodystrophy and neonatal adrenoleukodystrophy.

Chen, W W, Watkins, P A, Osumi, T, Hashimoto, T, Moser, H W

Very long chain fatty acids, which accumulate in plasma and tissues in X-linked adrenoleukodystrophy (ALD), neonatal ALD, and the Zellweger cerebrohepatorenal syndrome, are degraded by the...

Human peroxisomal 3-oxoacyl-coenzyme A thiolase deficiency.

Schram, A W, Goldfischer, S, Van Roermund, C W, Brouwer-Kelder, E M, Collins, J, Hashimoto, T, ...

We investigated the peroxisomal beta-oxidation system in liver from a patient with clinical features similar to those in the cerebrohepatorenal (Zellweger) syndrome and with elevated levels in body...

Yeast ribosomal proteins: XIII. Saccharomyces cerevisiae YL8A gene, interrupted with two introns, encodes a homolog of mammalian L7.

Mizuta, K, Hashimoto, T, Otaka, E

We isolated and sequenced a gene, YL8A, encoding ribosomal protein YL8 of Saccharomyces cerevisiae. It is one of the two duplicated genes encoding YL8 and is located on chromosome VII while the other...

Complete nucleotide sequence of cDNA and deduced amino acid sequence of rat liver catalase.

Furuta, S, Hayashi, H, Hijikata, M, Miyazawa, S, Osumi, T, Hashimoto, T

We have isolated five cDNA clones for rat liver catalase (hydrogen peroxide:hydrogen peroxide oxidoreductase, EC 1.11.1.6). These clones overlapped with each other and covered the entire length of...

Transcription regulation of peroxisomal fatty acyl-CoA oxidase and enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase in rat liver by peroxisome proliferators.

Reddy, J K, Goel, S K, Nemali, M R, Carrino, J J, Laffler, T G, Reddy, M K, ...

The structurally diverse peroxisome proliferators ciprofibrate, clofibrate, and bis(2-ethylhexyl) phthalate [(EtHx)2 greater than Pht] increase the activities of hepatic catalase and peroxisomal...

Yeast ribosomal proteins: XII. YS11 of Saccharomyces cerevisiae is a homologue to E. coli S4 according to the gene analysis.

Mizuta, K, Hashimoto, T, Suzuki, K, Otaka, E

We isolated and sequenced a gene, YS11A, encoding ribosomal protein YS11 of Saccharomyces cerevisiae. YS11A is one of two functional copies of the YS11 gene, located on chromosome XVI and transcribed...

Production of human monoclonal anti-basement membrane zone (BMZ) antibodies from a patient with bullous pemphigoid (BP) by Epstein-Barr virus transformation. Analyses of the heterogeneity of anti-BMZ antibodies in BP sera using them.

Sugi, T, Hashimoto, T, Hibi, T, Nishikawa, T

We established three lymphoblastoid cell lines from a bullous pemphigoid (BP) patient's peripheral blood by means of EBV transformation, which produced human monoclonal anti-basement membrane zone...

Molecular cloning and sequence of the complementary DNA encoding human mitochondrial acetoacetyl-coenzyme A thiolase and study of the variant enzymes in cultured fibroblasts from patients with 3-ketothiolase deficiency.

Fukao, T, Yamaguchi, S, Kano, M, Orii, T, Fujiki, Y, Osumi, T, ...

Complementary DNAs encoding the precursor of human hepatic mitochondrial acetoacetyl-CoA thiolase (T2) (EC 2.3.1.9) were cloned and sequenced. The cDNA inserts in these clones were 1,518 bases in...

A position-dependent silencer plays a major role in repressing alpha-fetoprotein expression in human hepatoma.

Nakabayashi, H, Hashimoto, T, Miyao, Y, Tjong, K K, Chan, J, Tamaoki, T

A large percentage of human hepatomas produce alpha-fetoprotein (AFP), but the levels of AFP expression vary greatly among hepatomas. To understand the molecular basis for this variation, we analyzed...

A human alpha-fetoprotein enhancer-binding protein, ATBF1, contains four homeodomains and seventeen zinc fingers.

Morinaga, T, Yasuda, H, Hashimoto, T, Higashio, K, Tamaoki, T

We have isolated a full-length cDNA encoding a protein (ATBF1) that binds to an AT-rich motif in the human alpha-fetoprotein gene enhancer. The amino acid sequence deduced from the cDNA revealed that...

Peroxisome targeting signal of rat liver acyl-coenzyme A oxidase resides at the carboxy terminus.

Miyazawa, S, Osumi, T, Hashimoto, T, Ohno, K, Miura, S, Fujiki, Y

To identify the topogenic signal of peroxisomal acyl-coenzyme A oxidase (AOX) of rat liver, we carried out in vitro import experiments with mutant polypeptides of the enzyme. Full-length AOX and...

Biosynthesis and maturation of peroxisomal beta-oxidation enzymes in fibroblasts in relation to the Zellweger syndrome and infantile Refsum disease.

Schram, A W, Strijland, A, Hashimoto, T, Wanders, R J, Schutgens, R B, ...

The biosynthesis of the peroxisomal enzymes acyl-CoA oxidase, 3-oxoacyl-CoA thiolase (acetyl-CoA acyl-transferase, EC 2.3.1.16), and catalase (EC 1.11.1.6) was studied in cultured skin fibroblasts...

Factors affecting germination of Trichophyton mentagrophytes arthrospores.

Hashimoto, T, Blumenthal, H J

Nutritional and environmental factors affecting germination of Trichophyton mentagrophytes arthrospores were investigated. Germination of dormant arthrospores occurred only in rich complex media such...

Defect in biosynthesis of mitochondrial acetoacetyl-coenzyme A thiolase in cultured fibroblasts from a boy with 3-ketothiolase deficiency.

Yamaguchi, S, Orii, T, Sakura, N, Miyazawa, S, Hashimoto, T

The etiology of 3-ketothiolase deficiency has been attributed to a defect of mitochondrial acetoacetyl-CoA thiolase because the acetoacetyl-CoA thiolase activity in related materials is not activated...

Identification of three mutant alleles of the gene for mitochondrial acetoacetyl-coenzyme A thiolase. A complete analysis of two generations of a family with 3-ketothiolase deficiency.

Fukao, T, Yamaguchi, S, Orii, T, Schutgens, R B, Osumi, T, Hashimoto, T

3-Ketothiolase deficiency (3KTD) stems from a deficiency of mitochondrial acetoacetyl-coenzyme A thiolase (T2). We analyzed the molecular basis of 3KTD in two generations of a family. A boy (patient...

The need for primary quality control of commercially available immunoassay kits.

Hashimoto, T, Matsubara, F

Discrepancies among three commercially available luteinising hormone (LH) radioimmunoassay RIA kits, all calibrated against the second-IRP-HMG (World Health Organisation International Laboratory for...

Antibodies against desmoglein 3 (pemphigus vulgaris antigen) are present in sera from patients with paraneoplastic pemphigus and cause acantholysis in vivo in neonatal mice.

Amagai, M, Nishikawa, T, Nousari, H C, Anhalt, G J, Hashimoto, T

Paraneoplastic pemphigus (PNP) is an autoimmune blistering disease that occurs in association with underlying neoplasms. Patients with PNP develop characteristic IgG autoantibodies directed against...

Biliary and urinary excretion rates and serum concentration changes of four bilirubin photoproducts in Gunn rats during total darkness and low or high illumination.

Onishi, S, Ogino, T, Yokoyama, T, Isobe, K, Itoh, S, Yamakawa, T, ...

On cycled exposure of Gunn rats to total darkness and low and high illumination, biliary excretion rates of (EZ)- and (ZE)-bilirubin and (EZ)-cyclobilirubin increased up to approx. 10-fold from the...

Release of Ca2+ from a non-mitochondrial store site in peritoneal macrophages treated with saponin by inositol 1,4,5-trisphosphate.

Hirata, M, Suematsu, E, Hashimoto, T, Hamachi, T, Koga, T

The effects of inositol 1,4,5-trisphosphate, prepared from human erythrocyte ghosts, on Ca2+ release from intracellular store sites were studied in saponin-treated guinea pig peritoneal macrophages....

Evidence for differential activation of arachidonic acid metabolism in formylpeptide- and macrophage-activation-factor-stimulated guinea-pig macrophages.

Homma, Y, Hashimoto, T, Nagai, Y, Takenawa, T

Alterations of phospholipid and arachidonic acid metabolism were studied by treatment of guinea-pig peritoneal-exudate macrophages with chemotactic peptide, formylmethionyl-leucylphenylalanine...

Thyromimetic effect of peroxisomal proliferators in rat liver.

Hertz, R, Aurbach, R, Hashimoto, T, Bar-Tana, J

Amphipathic carboxylates, of varying hydrophobic backbones, which act as peroxisomal proliferators (aryloxyalkanoic acids, methyl-substituted dicarboxylic acid) induce in euthyroid or...

Conditioning effect in single human motoneurones: a new method using the unitary H reflex.

Shindo, M, Yanagawa, S, Morita, H, Hashimoto, T

1. A new method for the study of spinal reflexes using single motor units is described. 2. The excitability of a motoneurone is assessed as the 'critical firing stimulus' (CFS), which is the...

Hypotonic stimulation induced Ca2+ release from IP3-sensitive internal stores in a green monkey kidney cell line.

Ishii, T, Hashimoto, T, Ohmori, H

1. Hypotonic stimulation (180 +/- 5 mosmol l-1) increased [Ca2+]i in fura-2-loaded Green monkey kidney cells (COS-7 cells) and depolarized the membrane. 2. COS-7 cells were depolarized up to -3.5 +/-...

Release of Ca2+ is the crucial step for the potentiation of IPSCs in the cultured cerebellar Purkinje cells of the rat.

Hashimoto, T, Ishii, T, Ohmori, H

1. Spontaneous inhibitory postsynaptic currents (IPSCs) and evoked IPSCs were recorded by a whole-cell patch-recording technique from cultured Purkinje cells of the rat. The size of spontaneous...

Kinetics of biliary excretion of the main two bilirubin photoproducts after injection into Gunn rats.

Onishi, S, Kawade, N, Itoh, S, Isobe, K, Sugiyama, S, Hashimoto, T, ...

The kinetics of biliary excretion of the main two photoproducts after injection into Gunn rats were examined. The photoproducts that are obtained from experiments in vitro consist of unknown pigment,...

Inositol 1,4,5-trisphosphate activates pharmacomechanical coupling in smooth muscle of the rabbit mesenteric artery.

Hashimoto, T, Hirata, M, Itoh, T, Kanmura, Y, Kuriyama, H

To clarify the nature of the noradrenaline (NA)-induced contraction, the effects of NA on inositol phospholipid metabolism and the actions of inositol 1,4,5-trisphosphate (InsP3) on skinned muscle of...

Peroxisome proliferator-induced acyl-CoA thioesterase from rat liver cytosol: molecular cloning and functional expression in Chinese hamster ovary cells.

Engberg, S T, Aoyama, T, Alexson, S E, Hashimoto, T, Svensson, L T

We have isolated and cloned a cDNA that codes for one of the peroxisome proliferator-induced acyl-CoA thioesterases of rat liver. The deduced amino acid sequence corresponds to the major induced...

Molecular cloning and characterization of a mitochondrial peroxisome proliferator-induced acyl-CoA thioesterase from rat liver.

Svensson, L T, Engberg, S T, Aoyama, T, Usuda, N, Alexson, S E, Hashimoto, T

We have previously reported the purification and characterization of the peroxisome proliferator-induced very-long-chain acyl-CoA thioesterase (MTE-I) from rat liver mitochondria [L.T. Svensson, S.E....

Peroxisomal bifunctional protein deficiency revisited: resolution of its true enzymatic and molecular basis.

Van Grunsven, E G, Van Berkel, E, Mooijer, P A, Watkins, P A, Moser, H W, Suzuki, Y, ...

In the past few years, many patients have been described who have a defect of unknown origin in the peroxisomal beta-oxidation pathway. Complementation analysis has been done by various groups to...

Application of log-linear model in inference on karyotypic evolution in chronic myelocytic leukemia.

Hashimoto, T, Ohtaki, M, Kamada, N, Yamamoto, H, Munaka, M

Relationships among additional chromosome abnormalities in chronic myelocytic leukemia (CML) with translocation 9;22 [Philadelphia chromosome (Ph1)-positive CML] were analyzed by log-linear models on...

D-3-hydroxyacyl-CoA dehydratase/D-3-hydroxyacyl-CoA dehydrogenase bifunctional protein deficiency: a newly identified peroxisomal disorder.

Suzuki, Y, Jiang, L L, Souri, M, Miyazawa, S, Fukuda, S, Zhang, Z, ...

Peroxisomal beta-oxidation proceeds from enoyl-CoA through D-3-hydroxyacyl-CoA to 3-ketoacyl-CoA by the D-3-hydroxyacyl-CoA dehydratase/D-3-hydroxy-acyl-CoA dehydrogenase bifunctional protein...

Existence of both IL-1 alpha and beta in normal human amniotic fluid: unique high molecular weight form of IL-1 beta.

Tamatani, T, Tsunoda, H, Iwasaki, H, Kaneko, M, Hashimoto, T, Onozaki, K

We investigated the possible existence of IL-1 in human amniotic fluid (AF). Since AF from most full-term deliveries appeared to contain an inhibitor(s) for thymocyte proliferation, AFs were...

Cloning of human very-long-chain acyl-coenzyme A dehydrogenase and molecular characterization of its deficiency in two patients.

Aoyama, T, Souri, M, Ueno, I, Kamijo, T, Yamaguchi, S, Rhead, W J, ...

Two overlapping cDNA clones (1,991 bp and 736 bp, respectively) encoding the precursor of human mitochondrial very-long-chain acyl-coenzyme A dehydrogenase (VLCAD) were cloned and sequenced. The cDNA...

A comparison of lipid variables as predictors of cardiovascular disease in the Asia Pacific Region

Barzi, F, Patel, A, Woodward, M, Lawes, CMM, Ohkubo, T, Gu, D, ...

PURPOSE: Many guidelines advocate measurement of total or low density lipoprotein cholesterol (LDL), high density lipoprotein cholesterol (HDL), and triglycerides (TG) to determine treatment...

Smoking, quitting, and the risk of cardiovascular disease among women and men in the Asia-Pacific region

Woodward, M, Lam, TH, Barzi, F, Patel, A, Gu, D, Rodgers, A, ...

Background Although smoking is a major risk factor for cardiovascular disease, it has been suggested that Asians may be less susceptible to the adverse effects of smoking than Caucasians. This may...

Does sex matter in the associations between classic risk factors and fatal coronary heart disease in populations from the Asia-Pacific region?

Huxley, R, Woodward, M, Barzi, F, Wong, JW, Pan, WH, Patel, A, ...

Background: There is much interest in promoting healthy heart awareness among women. However, little is known about the reasons behind the lower rates of heart disease among women compared with men,...

Coronary risk prediction for those with and without diabetes

Woodward, M, Barzi, E, Lam, TH, Jamrozik, K, Ueshima, H, Patel, A, ...

Background Coronary risk prediction 'engines' are now in common use, and their worth is well proven. There remains the question of how to deal with a prior diagnosis of diabetes. Design An individual...

Body mass index and risk of diabetes mellitus in the Asia-Pacific region

Mhurchu, CN, Parag, V, Nakamura, M, Patel, A, Rodgers, A, Lam, TH, ...

Few prospective data from the Asia Pacific region are available relating body mass index to the risk of diabetes. Our objective was to provide reliable age, sex and region specific estimates of the...

Immunocytochemical localization of peroxisomal enzymes in human liver biopsies.

Litwin, J. A., Völkl, A., Müller-Höcker, J., Hashimoto, T., Fahimi, H. D.

The immunocytochemical localization of catalase and three enzymes of the peroxisomal lipid beta-oxidation system--acyl-CoA oxidase, the bifunctional protein enoyl-CoA hydratase, 3-hydroxyacyl-CoA...

Temporary corneal oedema after acute intake of alcohol.

Shiono, T, Asano, Y, Hashimoto, T, Mizuno, K

A 65-year-old man had diffuse, bilateral corneal oedema after acute intake of alcohol. Three days later the total opacification began to clear from the peripheral area towards the centre of the...

Recombinant granulocyte-macrophage colony-stimulating factor (GM-CSF) or tumour necrosis factor-alpha (TNF-alpha) activate human alveolar macrophages to inhibit growth of Mycobacterium avium complex.

Suzuki, K, Lee, W J, Hashimoto, T, Tanaka, E, Murayama, T, Amitani, R, ...

We investigated the effects of certain macrophage-active cytokines on the phagocytosis and growth inhibition of Mycobacterium avium complex (MAC) by human alveolar macrophages (AM). We also evaluated...

Abnormal T cell responses to bacterial superantigens in Behçet's disease (BD)

Hirohata, S, Hashimoto, T

This study examines the nature of T cell hypersensitivity in BD. Highly purified T cells from 32 BD patients, from 29 rheumatoid arthritis (RA) patients and from 14 healthy individuals were cultured...

Induction of keratinocyte IL-8 expression and secretion by IgG autoantibodies as a novel mechanism of epidermal neutrophil recruitment in a pemphigus variant

O'toole, E A, Mak, L L, Guitart, J, Woodley, D T, Hashimoto, T, Amagai, M, ...

A subset of pemphigus herpetiformis, a rare pemphigus variant, is characterized histopathologically by subcorneal acantholysis and neutrophilic infiltration. The mechanism of neutrophil infiltration...

Molecular characterization of mitochondrial trifunctional protein deficiency: formation of the enzyme complex is important for stabilization of both alpha- and beta-subunits.

Ushikubo, S., Aoyama, T., Kamijo, T., Wanders, R. J., Rinaldo, P., Vockley, J., ...

Mitochondrial trifunctional protein (TP) is an enzyme complex with three activities: enoyl-CoA hydratase, 3-hydroxyacyl-CoA dehydrogenase, and 3-ketoacyl-CoA thiolase. Studies on defects in this...

Mutation analysis of very-long-chain acyl-coenzyme A dehydrogenase (VLCAD) deficiency: identification and characterization of mutant VLCAD cDNAs from four patients.

Souri, M., Aoyama, T., Orii, K., Yamaguchi, S., Hashimoto, T.

Very-long-chain acyl-coenzyme A dehydrogenase (VLCAD) deficiency is a newly identified disease. A 105-bp deletion in the VLCAD cDNA in two patients has been reported, and detailed molecular...

The cardiovascular effects of xamoterol, a beta 1-adrenoceptor partial agonist, in healthy volunteers at rest.

Hashimoto, T, Shiina, A, Toyo-Oka, T, Hosoda, S, Kondo, K

The cardiovascular effects of three single intravenous doses of a beta 1-adrenoceptor partial agonist, xamoterol (0.025, 0.05 and 0.1 mg kg-1) and placebo were studied in six healthy volunteers at...

Receptor-coupled shortening of alpha-toxin-permeabilized single smooth muscle cells from the guinea-pig stomach.

Ono, T., Mita, M., Suga, O., Hashimoto, T., Oishi, K., Uchida, M. K.

1. Isolated single smooth muscle cells from the fundus of the guinea-pig stomach were permeabilized by use of Staphylococcus aureus alpha-toxin. Receptor-coupled shortening of individual cells was...

Protein kinase C-independent sensitization of contractile proteins to Ca2+ in alpha-toxin-permeabilized smooth muscle cells from the guinea-pig stomach.

Oishi, K., Mita, M., Ono, T., Hashimoto, T., Uchida, M. K.

Involvement of protein kinase C in receptor-operated Ca2+ sensitization of cell shortening was investigated by use of alpha-toxin-permeabilized smooth muscle cells from the fundus of the guinea-pig....

All-or-none augmentation of Ca2+ sensitivity in alpha-toxin-permeabilized single smooth muscle cells from guinea-pig taenia caecum.

Mita, M., Hashimoto, T.

1. Isolated smooth muscle cells from guinea-pig taenia caecum were permeabilized by use of Staphylococcus aureus alpha-toxin, and the sarcoplasmic reticulum Ca2+ store was depleted by exposure to 0.1...

A role for inositol 1,4,5-trisphosphate in the initiation of agonist-induced contractions of dog tracheal smooth muscle.

Hashimoto, T., Hirata, M., Ito, Y.

To elucidate the role of inositol 1,4,5-trisphosphate (Ins-P3) in the initiation of agonist-induced contraction of the smooth muscle cells of the dog trachea, we investigated the effects of...

Increased ictal perfusion of the thalamus in paroxysmal kinesigenic dyskinesia

Shirane, S, Sasaki, M, Kogure, D, Matsuda, H, Hashimoto, T

The ictal and interictal cerebral blood flow (CBF) were evaluated in a patient with right unilateral short lasting paroxysmal kinesigenic dyskinesia, by means of single photon emission computed...

Event based and time based prospective memory in Parkinson's disease

Katai, S, Maruyama, T, Hashimoto, T, Ikeda, S

Background: Patients with Parkinson's disease have been reported to have retrospective memory impairment, while prospective memory, which is memory for actions to be performed in the future, has not...

Novel amyloid precursor protein gene missense mutation (D678N) in probable familial Alzheimer's disease

Wakutani, Y, Watanabe, K, Adachi, Y, Wada-Isoe, K, Urakami, K, Ninomiya, H, ...

Subject: The proband was a women of 72. Symptoms of dementia that fulfilled the criteria for probable Alzheimer's disease appeared at about 60 years of age, and slowly worsened over more than 10...

Effect of oral mexiletine on the cough response to capsaicin and tartaric acid

Fujimura, M., Kamio, Y., Myou, S., Hashimoto, T.

BACKGROUND—The effect of the orally active local anaesthetic mexiletine on the cough response to two different tussive agents, a C-fibre ending stimulator capsaicin and a chemostimulant tartaric...