T. Hayashi

Publication List Details

Period

1958 - 2009

Number

273

Co-Authors

Double walled carbon nanotubes as ultrafast optical switches (2009)

Kamaraju, N, Kumar, Sunil, Kim, Y A, Hayashi, T, Muramatsu, H, Endo, M, ...

Pristine and molybdenum filled double walled carbon nanotubes (DWNTs) suspended in D2O show excellent ultrafast optical switching properties investigated through femtosecond Z-scan and degenerate...

Controlled growth of one-dimensional clusters of molybdenum atoms using double-walled carbon nanotube templating (2009)

Tao, Y, Muramatsu, H, Hayashi, T, Kim, YA, Shimamoto, D, Endo, M, ...

Copyright (2009) American Institute of Physics. This article may be downloaded for personal use only. Any other use requires prior permission of the author and the American Institute of Physics.

ABSTRACTS (2009)

Abdelwahab, A., Gardner, M., Parkash, R., Basta, M., Sapp, J., Veltmann, C., ...

Introduction: Scar-related ventricular tachycardia (VT) is often unmappable. Data regarding the outcomes of ablation for mappable vs unmappable VT are lacking. Methods: Catheter ablation of...

Raman study on electrochemical lithium insertion into multiwalled carbon nanotubes (2008)

Kim, YA, Kojima, M, Muramatsu, H, Shimamoto, D, Hayashi, T, Endo, M, ...

This is the pre-peer reviewed version of the following article: JOURNAL OF RAMAN SPECTROSCOPY 39(9): 1183-1188, 2008, which has been published in final form...

A triple quantum dot in a single wall carbon nanotube (2008)

Grove-Rasmussen, K., Jørgensen, H. I., Hayashi, T., Lindelof, P. E., Fujisawa, T.

A top-gated single wall carbon nanotube is used to define three coupled quantum dots in series between two electrodes. The additional electron number on each quantum dot is controlled by top-gate...

Robust, Conducting, and Transparent Polymer Composites using Surface-Modified and Individualized Double-Walled Carbon Nanotubes (2008)

Jung, YC, Shimamoto, D, Muramatsu, H, Kim, YA, Hayashi, T, Endo, M, ...

This is the pre-peer reviewed version of the following article: ADVANCED MATERIALS. 20(23):4509-4512 (2008), which has been published in final form at 10.1002/adma.200801659.

ITER design review: Tritium issues. (2008)

Murdoch, D., Beloglazov, S., Boucquey, P., Chung, H., Glugla, M., Hayashi, T., ...

8th Internat.Conf.on Tritium Science and Technology, Rochester, N.Y., September 16-21, 2007

Analytical Expression for the Tunneling Time in Symmetrical Rectangular Double-Barrier Structures (2007)

H. Yamamoto, K. Miyamoto, T. Hayashi

An analytical expression for the electron tunneling time has been derived for symmetrical rectangular double-barrier structures. It gives values of the tunneling time equal to those calculated by the...

The Kyoto 3d Spectrograph (2007)

Ohtani Ishigaki, T. Ishigaki, T. Hayashi, S. Ozaki, T. Hattori, K. Aoki

During observations, the etalon temperature is stabilized within 1.0 degree. (4) Microlens-Array (MLA) Intergal Field Spectrocopy: An object field is devided into 7x11 square small fields by using a...

Discovery of a WZ Sge-Type Dwarf Nova, SDSS J102146.44+234926.3: Unprecedented Infrared Activity during a Rebrightening Phase (2007)

Uemura, M., Arai, A., Krajci, T., Pavlenko, E., Shugarov, S. Yu., Katysheva, N. A., ...

Several SU UMa-type dwarf novae, in particular, WZ Sge-type stars tend to exhibit rebrightenings after superoutbursts. The rebrightening phenomenon is problematic for the disk instability theory of...

Enhanced thermal conductivity of carbon fiber/phenolic resin composites by the introduction of carbon nanotubes (2007)

Kim, YA, Kamio, S, Tajiri, T, Hayashi, T, Song, SM, Endo, M, ...

Copyright (2007) American Institute of Physics. This article may be downloaded for personal use only. Any other use requires prior permission of the author and the American Institute of Physics. The...

Extending the linearity range of eddy-current displacement sensor with magnetoplated wire (2007)

Mizuno, T, Enoki, S, Hayashi, T, Asahina, T, Shinagawa, H

“This material is presented to ensure timely dissemination of scholarly and technical work. Copyright and all rights therein are retained by authors or by other copyright holders. All persons...

Laminin-alpha4 and integrin-linked kinase mutations cause human cardiomyopathy via simultaneous defects in cardiomyocytes and endothelial cells (2007)

Knoll, R., Postel, R., Wang, J., Kratzner, R., Hennecke, G., Vacaru, A. M., ...

BACKGROUND: Extracellular matrix proteins, such as laminins, and endothelial cells are known to influence cardiomyocyte performance; however, the underlying molecular mechanisms remain poorly...

A successful IVF-pregnancy in a patient who underwent conservative surgery followed by a regimen of cisplatin, vinblastine and peplomycin to treat an advanced ovarian mixed germ cell tumour: A Case Report (2007)

Kitajima, Y., Endo, T., Hayashi, T., Ishioka, S., Baba, T., Honnma, H., ...

Mixed germ cell tumours of the ovary, one type of malignant ovarian germ cell tumours (MOGCTs), are rare gynaecologic cancers usually affecting young women. We report the case of a patient with an...

Recent progress in ITER tritium plant systems design and layout. (2007)

Glugla, M., Beloglazov, S., Carlson, B., Cho, S., Cristescu, I.R., Cristescu, I., ...

8th Internat.Conf.on Tritium Science and Technology, Rochester, N.Y., September 16-21, 2007

Resonance Raman study of linear carbon chains formed by the heat treatment of double-wall carbon nanotubes (2006)

Fantini, C, Cruz, E, Jorio, A, Terrones, M, Terrones, H, Van Lier, G, ...

We study the resonance behavior of the unusual Raman feature known as the coalescence-inducing mode CIM, observed at 1850 cm^-1, in samples of double-wall carbon nanotubes annealed at high...

Inelastic collision processes of low energy protons in liquid water (2006)

Date, H., Sutherland, K.L., Hayashi, T., Matsuzaki, Y., Kiyanagi, Y., 伊達, 広行

Production probabilities of ions and excited particle species along the proton beam track in liquid water are estimated around the Bragg peak region, taking into account charge-changing processes and...

Inelastic collision processes of low energy protons in liquid water (2006)

Date, H., Sutherland, K.L., Hayashi, T., Matsuzaki, Y., Kiyanagi, Y.

Production probabilities of ions and excited particle species along the proton beam track in liquid water are estimated around the Bragg peak region, taking into account charge-changing processes and...

Inelastic collision processes of low energy protons in liquid water (2006)

Date, H., Sutherland, K.L., Hayashi, T., Matsuzaki, Y., Kiyanagi, Y.

Production probabilities of ions and excited particle species along the proton beam track in liquid water are estimated around the Bragg peak region, taking into account charge-changing processes and...

A successful IVF-pregnancy in a patient who underwent conservative surgery followed by a regimen of cisplatin, vinblastine and peplomycin to treat an advanced ovarian mixed germ cell tumour: A Case Report (2006)

Kitajima, Y., Endo, T., Hayashi, T., Ishioka, S., Baba, T., Honnma, H., ...

Mixed germ cell tumours of the ovary, one type of malignant ovarian germ cell tumours (MOGCTs), are rare gynaecologic cancers usually affecting young women. We report the case of a patient with an...

A successful IVF-pregnancy in a patient who underwent conservative surgery followed by a regimen of cisplatin, vinblastine and peplomycin to treat an advanced ovarian mixed germ cell tumour: A Case Report (2006)

Kitajima, Y., Endo, T., Hayashi, T., Ishioka, S., Baba, T., Honnma, H., ...

Mixed germ cell tumours of the ovary, one type of malignant ovarian germ cell tumours (MOGCTs), are rare gynaecologic cancers usually affecting young women. We report the case of a patient with an...

Pauli spin blockade in cotunneling transport through a double quantum dot (2005)

Liu, H. W., Fujisawa, T., Hayashi, T., Hirayama, Y.

We study spin correlation in a double quantum dot containing a few electrons in each dot (around 10). Clear current rectification with negative differential conductance is observed in the cotunneling...

Electrical pump-and-probe study of spin singlet-triplet relaxation in a quantum dot (2005)

Sasaki, S., Fujisawa, T., Hayashi, T., Hirayama, Y.

Spin relaxation from a triplet excited state to a singlet ground state in a semiconductor quantum dot is studied by employing an electrical pump-and-probe method. Spin relaxation occurs via...

Boson and Fermion Brownian Motion (2005)

Kobryn, A. E., Hayashi, T., Arimitsu, T.

Dynamics of quantum systems which are perturbed by linear coupling to the reservoir stochastically can be studied in terms of quantum stochastic differential equations (for example, quantum...

A search for deeply bound kaonic nuclear states (2005)

Suzuki, T., Bhang, H., Franklin, G., Gomikawa, K., Hayano, R. S., Hayashi, T., ...

We have measured proton and neutron energy spectra by stopping negative kaons on liquid helium4. Two distinct peak structures were found on both spectra, which were assigned to the formation of new...

I. THEORY OF STRONGLY CORRELATED ELECTRON SYSTEMS (2005)

Professors Toshihiro Kawakatsu, Yoshio Kuramoto, Riichiro Saito, Komajiro Niizeki, Hiroaki Kusunose, Tatsuya Nakajima, ...

1. Octupole order in Ce0.7La0.3B6 probed by resonant X-ray scattering The azimuthal angle dependence observed in the resonant X-ray scattering in phase IV of Ce0.7La0.3B6 is analyzed...

Genetic linkage maps of Japanese and European pears aligned to the apple consensus map (2004)

Yamamoto, T., Kimura, T., Saito, T., Kotobuki, K., Matsuta, N., Liebhard, R., ...

Genetic linkage maps of the Japanese pear (Pyrus pyrifolia Nakai) cultivar `Housui¿ and the European pear (Pyrus communis L.) cultivar `Bartlett¿ were constructed based on Amplified Fragment Length...

Confinement characteristics of the quasi-axisymmetric stellarator CHS-qa (2004)

Okamura, S., Matsuoka, K., Nishimura, S., Isobe, M., Suzuki, C., Shimuzu, A., ...

A low aspect ratio stellarator CHS-qa with a quasi-axisymmetric configuration has been designed at NIFS, whose main objective is the experimental study of confinement improvement. The high beta...

A Study of the Distribution of Star-Forming Regions in Luminous Infrared Galaxies by Means of H$\alpha$ Imaging Observations (2003)

Hattori, T., Yoshida, M., Ohtani, H., Sugai, H., Ishigaki, T., Sasaki, M., ...

We performed H-alpha imaging observations of 22 luminous infrared galaxies to investigate how the distribution of star-forming regions in these galaxies is related to galaxy interactions. Based on...

Indication of a strange tribaryon S^+ from the ^4He(stopped K^-,n) reaction (2003)

Iwasaki, M., Suzuki, T., Bhang, H., Franklin, G., Gomikawa, K., Hayano, R. S., ...

We measured the neutron time-of-flight spectrum in the ^4He(stopped K^-, n) reaction by stopping negative kaons in a superfluid helium target. A clear enhancement was observed in the neutron...

Quantum stochastic differential equations for boson and fermion systems -- Method of Non-Equilibrium Thermo Field Dynamics (2003)

Kobryn, A. E., Hayashi, T., Arimitsu, T.

A unified canonical operator formalism for quantum stochastic differential equations, including the quantum stochastic Liouville equation and the quantum Langevin equation both of the It\^o and the...

Design of the ITER tritium plant, confinement and detritiation facilities. (2003)

Yoshida, H., Glugla, M., Hayashi, T., Lässer, R., Murdoch, D., Nishi, M., ...

Proc.of the 6th Internat.Symp.on Fusion Nuclear Technology (ISFNT-6), San Diego, Calif., April 7-12, 2002

Non-Anomalous Flavor Symmetries and $SU(6) \times SU(2)_R$ Model (2002)

Abe, Y., Hattori, C., Hayashi, T., Ito, M., Matsuda, M., Matsunaga, M., ...

We introduce the flavor symmetry ${\bf Z}_M \times {\bf Z}_N \times D_4$ into the $SU(6) \times SU(2)_R$ string-inspired model. The cyclic group ${\bf Z}_M$ and the dihedral group $D_4$ are R...

Self-trapped states and the related luminescence in PbCl$_2$ crystals (2002)

Iwanaga, M., Shirai, M., Tanaka, K., Hayashi, T.

We have comprehensively investigated localized states of photoinduced electron-hole pairs with electron-spin-resonance technique and photoluminescence (PL) in a wide temperature range of 5-200 K. At...

Response of coupled chaotic circuits to sinusoidal input signal (2002)

Hayashi, T., Nishio, Y., Hasler, M., Ushida, A.

In this study, synchronization state of the coupled chaotic circuit is investigated when a sinusoidal input signal is added by both of computer simulations and circuit experiments. It is confirmed...

Complete Nucleotide Sequence of the Coturnix chinensis (Blue-Breasted Quail) Mitochondorial Genome and a Phylogenetic Analysis With Related Species (2002)

Nishibori, M., Tsudzuki, M., Hayashi, T., Yamamoto, Y., Yasue, H.

Coturnix chinensis (blue-breasted quail) has been classically grouped in Galliformes Phasianidae Coturnix, based on morphologic features and biochemical evidence. Since the blue-breasted quail has...

The analytical system of the ITER tritium fuel processing plant. (2002)

Lässer, R., Glugla, M., Schuster, P., Hayashi, T., Yoshida, H.

Proc.of the 6th Internat.Conf.on Tritium Science and Technology, Tsukuba, J, November 11-16, 2001

The storage and delivery system of the ITER tritium fuel processing plant. (2002)

Lässer, R., Dörr, L., Glugla, M., Penzhorn, R.D., Hayashi, T., Murdoch, D.K., ...

Proc.of the 6th Internat.Conf.on Tritium Science and Technology, Tsukuba, J, November 11-16, 2001

Topological Obstruction in Block-spin Transformations (2000)

Fujiwara, T., Hayashi, T., Suzuki, H., Wu, K.

Block-spin transformations from a fine lattice to a coarse one are shown to give rise to a one-to-one correspondence between the zero-modes of the Ginsparg-Wilson Dirac operators. The index is then...

Energy-Efficient Initialization Protocols for Ad-hoc Radio Networks (2000)

J. L. Bordim, J. Cui, T. Hayashi, K. Nakano, S. Olariu

. The main contribution of this work is to propose energyefficient randomized initialization protocols for ad-hoc radio networks (ARN, for short). First, we show that if the number n of stations is...

Increased digitalis-like immunoreactive substances in patients with hypertrophic cardiomyopathy (2000)

Hayashi, T, Ijiri, Y, Toko, H, Shimomura, H, Okabe, M, Terasaki, F, ...

Aims Although increased digitalis-like immunoreactive substances have been found in cases of hypertension and heart failure, no information is available about digitalis-like immunoreactive substances...

The tritium fuel cycle of ITER-FEAT. (2000)

Glugla, M., Busigin, A., Dörr, L., Haange, R., Hayashi, T., Kveton, O., ...

21st Symp.on Fusion Technology (SOFT), Madrid, E, September 11-15, 2000

Spin-Vacancy-Induced Long-Range Order in a New Haldane-Gap Antiferromagnet (1999)

Uchiyama, Y., Sasago, Y., Tsukada, I., Uchinokura, K., Zheludev, A., Hayashi, T., ...

Magnetic susceptibility, high-field magnetization and inelastic neutron scattering experiments are used to study the magnetic properties of a new S=1 quasi-1-dimensional antiferromagnet PbNi2V2O8....

3D MHD Study of Helias and Heliotron. (1998)

Hayashi, T., Sato, T., Lotz, W., Merkel, P., Nuehrenberg, J., Schwenn, U.

Properties of magnetic islands induced by the finite pressure effect are numerically analyzed for three-dimensional magnetohydrostatic equilibria of Helias and l = 2 heliotron/torsatron types. For...

Process and Properties of PM Al-Si-X Alloys. (1998)

Takeda, Y., Odani, Y., Hayashi, T., Akechi, K.

Alloys are needed by the automotive, home appliance, and other civil industries to replace cast iron and steel products; high strength, wear resistance, high modulus of elasticity, thermal expansion,...

Microstructure and Mechanical Properties of P/M Al-Si-X Alloy. (1998)

Takeda, Y., Odani, Y., Hayashi, T., Akechi, K.

Air-atomized Si-2024 is shown to have an extended eutectic silicon content of 17% and have a simple mixture of fine eutectic silicon crystals and an aluminum matrix; the addition of Fe and/or Ni is...

Al-Fe-X Alloys Consolidated by Powder Forging Without Lateral Flow. (1998)

Kondoh, K., Kaji, T., Hayashi, T., Takeda, Y.

This paper presents a study of Al-8 wt%Fe alloys consolidated by powder forging without lateral flow. Results of tensile tests at room temperature and at 373-573 K show that UTS was 402 MPa, higher...

Similarity and Difference between Magnetic- and Nonmagnetic-Impurity Effects in Spin-Peierls Cuprate CuGeO_3 (1998)

Koide, N., Uchiyama, Y., Hayashi, T., Masuda, T., Sasago, Y., Uchinokura, K., ...

We have measured the magnetic susceptibility of single-crystal Cu_{1-x}Ni_xGeO_3 to study doping effects of the magnetic impurity (Ni^{2+} has S=1 spin) on the inorganic spin-Peierls (SP) material...

TEMPERATURE GRADIENT CHAMBERS FOR RESEARCH ON GLOBAL ENVIRONMENT CHANGE : I. THERMAL ENVIRONMENT IN A LARGE CHAMBER (1995)

Okada, M., Hamasaki, T., Hayashi, T.

Simple and low-cost temperature gradient chambers (TGC) have been developed to study the effects of temperature on field crops. Providing a continuous one-way air flow along the long axis of the TGC,...

Neutron Electric Dipole Momento in Two-Higgs-Doublet Model (1994)

Hayashi, T., Koide, Y., Matsuda, M., Tanimoto, M.

The effect of the "chromo-electric" dipole moment on the electric dipole moment(EDM) of the neutron is studied in the two-Higgs-doublet model. The Weinberg's operator $O_{3g}=GG\t G$ and the operator...

Penguin-Diagram Induced $B \rightarrow K_X\phi$ Decays in the Standard Model and in the Two-Higgs-Doublet Model (1993)

Davies, A. J., Hayashi, T., Matsuda, M., Tanimoto, M.

We systematically analyse the gluonic penguin-induced charmless decays $B \ra K_X\phi$($K_X$ denotes the meson state $s\bar q \;(q=u\ {\rm or}\ d)$ ), in the standard model and the two-Higgs-doublet...

Mhd-Theoretical Aspects of Stellarators (1993)

Nuhrenberg, J., Merkel, P., Schwab, C., Schwenn, U., Cooper, A., Hayashi, T., ...

Development and results of the MHD description of stellarators over the past half-decade are reviewed. Major events were the acceleration of convergence of those equilibrium codes which assume nested...

Fabrication and Evaluation of a High Density Multi Fiber Plastic Connector, (1983)

Tachigami,S., Ohtake,A., Hayashi,T., Iso,T., Shirasawa,T.

This connector is made by direct-molding a five-fiber tape using transfer-molding machine, so that it may be small in size, high in precision, low in cost, and easy to assemble. This connector has...

MORPHOLOGY OF FINE CRYSTALLITES FORMED BY GAS-EVAPORATION TECHNIQUE. FACE CENTRED METALS (Al, Co, Ni, Cu, Pd, In, Ag, Au AND Pb), SILICON AND GERMANIUM (1977)

Hayashi, T., Saito, Y., Yatsuya, S., Mihama, K., Uyeda, R.

Co, Ni, Cu, Pd, Ag and Au showed clean-cut habits : 1) Octahedra. 2) Shapes derived from 1) with odd or even number of twin planes. 3) Triangular bipyramids. 4) Triangular plates. 5) Decahedra or...

MORPHOLOGY OF FINE CRYSTALLITES FORMED BY GAS-EVAPORATION TECHNIQUE. FACE CENTRED METALS (Al, Co, Ni, Cu, Pd, In, Ag, Au AND Pb), SILICON AND GERMANIUM (1977)

Hayashi, T., Saito, Y., Yatsuya, S., Mihama, K., Uyeda, R.

Co, Ni, Cu, Pd, Ag and Au showed clean-cut habits : 1) Octahedra. 2) Shapes derived from 1) with odd or even number of twin planes. 3) Triangular bipyramids. 4) Triangular plates. 5) Decahedra or...

MORPHOLOGY OF FINE CRYSTALLITES FORMED BY GAS-EVAPORATION TECHNIQUE. FACE CENTRED METALS (Al, Co, Ni, Cu, Pd, In, Ag, Au AND Pb), SILICON AND GERMANIUM (1977)

Hayashi, T., Saito, Y., Yatsuya, S., Mihama, K., Uyeda, R.

Co, Ni, Cu, Pd, Ag and Au showed clean-cut habits : 1) Octahedra. 2) Shapes derived from 1) with odd or even number of twin planes. 3) Triangular bipyramids. 4) Triangular plates. 5) Decahedra or...

Basal release of nitric oxide from aortic rings is greater in female rabbits than in male rabbits: implications for atherosclerosis.

Hayashi, T, Fukuto, J M, Ignarro, L J, Chaudhuri, G

Estradiol is known to exert a protective effect against the development of atherosclerosis, but the mechanism of this hormonal action is unknown. One of the early events in the development of...

A Xyloglucan-Specific Endo-1,4-[beta]-Glucanase Isolated from Auxin-Treated Pea Stems.

Matsumoto, T., Sakai, F., Hayashi, T.

A xyloglucan-specific endo-1,4-[beta]-glucanase was isolated from the apoplast fraction of auxin-treated pea (Pisum sativum) stems, in which both the rate of stem elongation and the amount of...

Involvement of Phenolic Esters in Cell Aggregation of Suspension-Cultured Rice Cells.

Kato, Y., Yamanouchi, H., Hinata, K., Ohsumi, C., Hayashi, T.

Fluorescence microscopy of rice (Oryza sativa L.) callus sections showed that all of the walls fluoresced blue in water (pH 5.8) and green in ammonia (pH 10.0), both characteristics of feruloyl...

In vitro antibacterial properties of T-5575 and T-5578 novel parenteral 2-carboxypenams.

Watanabe, Y, Minami, S, Hayashi, T, Araki, H, Kitayama, R, Ochiai, H

T-5575 and T-5578, novel 2-carboxypenams in which a carboxyl group has been introduced into the C-2 beta position of the nucleus, were evaluated for their in vitro antibacterial properties. The...

In vitro and in vivo activities of sedecamycin against Treponema hyodysenteriae.

Hayashi, T, Suenaga, I, Narukawa, N, Yamazaki, T

Sedecamycin (lankacidin A), one of the lankacidin-group antibiotics, showed potent activity against Treponema hyodysenteriae. The MICs of sedecamycin against 79 field isolates of T. hyodysenteriae...

Protective effect of piperacillin against nephrotoxicity of cephaloridine and gentamicin in animals.

Hayashi, T, Watanabe, Y, Kumano, K, Kitayama, R, Yasuda, T, Saikawa, I, ...

The protective effect of piperacillin against the nephrotoxicity of cephaloridine and gentamicin was examined in experimental animals. In rabbits, piperacillin was infused at a dose of 1 mg/kg (body...

Protective effect of piperacillin against the nephrotoxicity of cisplatin in rats.

Hayashi, T, Watanabe, Y, Kumano, K, Kitayama, R, Muratani, T, Yasuda, T, ...

The protective effect of piperacillin against the nephrotoxicity of cisplatin was compared with that of fosfomycin in Fischer 344 rats. Blood urea nitrogen, serum creatinine, and morphological...

Binding of the 68-kilodalton protein of Mycobacterium avium to alpha(v)beta3 on human monocyte-derived macrophages enhances complement receptor type 3 expression.

Hayashi, T, Rao, S P, Catanzaro, A

Attachment to and uptake by host cells are important early events in the pathogenesis of intracellular organisms such as Mycobacterium avium. Monocyte-derived macrophages (MDM) are known to express...

Apoptosis of human monocytes and macrophages by Mycobacterium avium sonicate.

Hayashi, T, Catanzaro, A, Rao, S P

Mycobacterium avium is an intracellular organism which multiplies predominantly within human macrophages. This organism has previously been shown to induce apoptosis in human macrophages. With a view...

Efficacy of NY-198 against experimental Legionnaires disease.

Kohno, S, Yamaguchi, K, Dohtsu, Y, Koga, H, Hayashi, T, Hirota, M, ...

The in vitro and in vivo effects of NY-198 against Legionella pneumophila were compared with those of ciprofloxacin. The MIC of NY-198 against 15 standard reference strains of Legionella of various...

Analysis of functional domains of Rts1 RepA by means of a series of hybrid proteins with P1 RepA.

Tabuchi, A, Ohnishi, M, Hayashi, T, Terawaki, Y

The RepA protein of the plasmid Rts1, consisting of 288 amino acids, is a trans-acting protein essential for initiation of plasmid replication. To study the functional domains of RepA, hybrid...

Mechanism of action of the antiherpesvirus biflavone ginkgetin.

Hayashi, K, Hayashi, T, Morita, N

Screening of plant extracts found that a biflavone from Cephalotaxus drupacea, which was found to be ginkgetin, is active against herpes simplex virus type 1 (HSV-1). This compound caused...

Identification of the lipopolysaccharide core region as the receptor site for a cytotoxin-converting phage, phi CTX, of Pseudomonas aeruginosa.

Yokota, S, Hayashi, T, Matsumoto, H

A temperate phage, phi CTX, is a cytotoxin-converting phage of Pseudomonas aeruginosa. In this study, we characterized the lipopolysaccharide (LPS) structures of phi CTX-resistant mutants derived...

Haloalkaliphilic maltotriose-forming alpha-amylase from the archaebacterium Natronococcus sp. strain Ah-36.

Kobayashi, T, Kanai, H, Hayashi, T, Akiba, T, Akaboshi, R, Horikoshi, K

A haloalkaliphilic archaebacterium, Natronococcus sp. strain Ah-36, produced extracellularly a maltotriose-forming amylase. The amylase was purified to homogeneity by ethanol precipitation,...

Function of the N-terminal half of RepA in activation of Rts1 ori.

Terawaki, Y, Itoh, Y, Zeng, H, Hayashi, T, Tabuchi, A

The RepA protein of the Rts1 plasmid, consisting of 288 amino acids, is a trans-acting protein essential for replication. A mutant repA gene, repA delta C143, carrying a deletion that removed the 143...

Effects of mutations in the repA gene of plasmid Rts1 on plasmid replication and autorepressor function.

Terawaki, Y, Nozue, H, Zeng, H, Hayashi, T, Kamio, Y, Itoh, Y

We constructed a system in which wild-type RepA or RepAcop1 protein was supplied in trans in various amounts to coexisting mini-Rts1 plasmids by clones of the repA or repAcop1 gene under the control...

Site-directed mutations in the repA C-terminal region of plasmid Rts1: pleiotropic effects on the replication and autorepressor functions.

Zeng, H, Hayashi, T, Terawaki, Y

We induced site-directed mutations near the 3' terminus of the gene repA, which encodes the protein of 288 amino acid residues essential for plasmid Rts1 replication, and obtained seven repA mutants....

Differentiation of human immunodeficiency virus type 1 (HIV-1) infections with HIV-2-cross-reacting antibody from mixed infections with HIV-1 and HIV-2 by serological absorption test.

Imai, M, Hayashi, T, Kondo, M, Saito, T, Ito, A, Hayami, M, ...

The interpretation of dual seroreactivity with human immunodeficiency virus type 1 (HIV-1) and HIV-2 in blood samples is a serious problem facing AIDS researchers worldwide. Some samples of sera from...

Prior enrichment of human immunodeficiency virus DNA with probe DNA particles for efficient PCR diagnosis.

Tano, H, Fan, K, Kitajima, M A, Kasai, K, Tamatsukuri, S, Furuichi, Y, ...

We report here a novel method by which one can recover human immunodeficiency virus (HIV) DNA in a small volume (approximately 50 microliters) of solution from 8 ml of crude cell lysate which...

CA150, a nuclear protein associated with the RNA polymerase II holoenzyme, is involved in Tat-activated human immunodeficiency virus type 1 transcription.

Suñé, C, Hayashi, T, Liu, Y, Lane, W S, Young, R A, Garcia-Blanco, M A

Maximal human immunodeficiency virus type 1 (HIV-1) gene expression requires specific cellular factors in addition to the virus-encoded trans-activator protein Tat and the RNA element TAR. We...

Removal of bacteria from water by adhesion to cross-linked poly(vinylpyridinium halide).

Kawabata, N, Hayashi, T, Matsumoto, T

Cross-linked poly(vinylpyridinium halide) was found to have a novel and remarkable ability to remove bacteria from water. For example, when 10 g (wet weight) of cross-linked...

Role of intestinal excretion in the effect of subcutaneously administered sedecamycin on cecal infection caused by Treponema hyodysenteriae in mice.

Hayashi, T, Okada, J, Kondo, S, Yamazaki, T

The therapeutic effects of subcutaneously administered sedecamycin on experimental Treponema hyodysenteriae infection in mice were evaluated. Sedecamycin was more active than tiamulin and lincomycin....

Pneumopathogenicity of a Sendai virus protease-activation mutant, TCs, which is sensitive to trypsin and chymotrypsin.

Itoh, M, Ming, T D, Hayashi, T, Mochizuki, Y, Homma, M

A protease-activation mutant of Sendai virus, TCs, was isolated from a trypsin-resistant mutant, TR-5. TCs was activated in vitro by both trypsin and chymotrypsin. TCs was, however, less sensitive to...

Monoclonal antibodies against the native urease of Helicobacter pylori: synergistic inhibition of urease activity by monoclonal antibody combinations.

Nagata, K, Mizuta, T, Tonokatu, Y, Fukuda, Y, Okamura, H, Hayashi, T, ...

Monoclonal antibodies (MAbs) against the native urease of Helicobacter pylori NCTC 11637 were found to clearly inhibit the urease activity. Interestingly, synergistic inhibition by two MAbs...

High-performance liquid chromatographic analysis of bacterial fatty acid composition for chemotaxonomic characterization of oral streptococci.

Tsuchiya, H, Sato, M, Kato, M, Namikawa, I, Hayashi, T, Tatsumi, M, ...

A high-performance liquid chromatographic method was developed to analyze the fatty acid composition of bacterial lipids. After saponification of lipids extracted from bacteria, the liberated fatty...

Thermal stability of type I and type III procollagens from normal human fibroblasts and from a patient with osteogenesis imperfecta.

Peltonen, L, Palotie, A, Hayashi, T, Prockop, D J

Type I and type III procollagens were isolated from the medium of human fibroblast cultures in amounts adequate for examination by circular dichroism. Type I procollagen had a spectrum similar to...

Differentiation-inducing factor purified from conditioned medium of mitogen-treated spleen cell cultures stimulates bone resorption.

Abe, E, Tanaka, H, Ishimi, Y, Miyaura, C, Hayashi, T, Nagasawa, H, ...

Spleen cells treated with mitogens produce a potent bone-resorbing factor called osteoclast-activating factor (OAF). To examine the relationship between the bone-resorbing factor and other protein...

Cloning and sequence analysis of cDNA for human renin precursor.

Imai, T, Miyazaki, H, Hirose, S, Hori, H, Hayashi, T, Kageyama, R, ...

The primary structure of human renin precursor has been deduced from its cDNA sequence. A library of cDNA clones was constructed from human kidney poly(A)+ RNA by applying the vector/primer method of...

Structure of the human renin gene.

Miyazaki, H, Fukamizu, A, Hirose, S, Hayashi, T, Hori, H, Ohkubo, H, ...

The human renin gene was isolated from a Charon 4A human genomic library and characterized. The gene spans about 11.7 kilobases and consists of 10 exons and 9 introns that map at points that could be...

Activation and fusion induced by 1 alpha,25-dihydroxyvitamin D3 and their relation in alveolar macrophages.

Abe, E, Shiina, Y, Miyaura, C, Tanaka, H, Hayashi, T, Kanegasaki, S, ...

1 alpha,25-Dihydroxyvitamin D3 [1 alpha,25-(OH)2D3] induces fusion of murine alveolar macrophages. This effect was observed in growth medium containing 5% human serum but not in the medium with 5%...

Synaptic vesicle membrane fusion complex: action of clostridial neurotoxins on assembly.

Hayashi, T, McMahon, H, Yamasaki, S, Binz, T, Hata, Y, Südhof, T C, ...

Clostridial neurotoxins inhibit neurotransmitter release by selective and specific intracellular proteolysis of synaptobrevin/VAMP, synaptosomal-associated protein of 25 kDa (SNAP-25) or syntaxin....

Disassembly of the reconstituted synaptic vesicle membrane fusion complex in vitro.

Hayashi, T, Yamasaki, S, Nauenburg, S, Binz, T, Niemann, H

The interaction of the presynaptic membrane proteins SNAP-25 and syntaxin with the synaptic vesicle protein synaptobrevin (VAMP) plays a key role in the regulated exocytosis of neurotransmitters....

In Vitro and In Vivo Antibacterial Activity of T-1220, a New Semisynthetic Penicillin

Ueo, K., Fukuoka, Y., Hayashi, T., Yasuda, T., Taki, H., Tai, M., ...

T-1220, sodium 6-[d-(-)-α-(4-ethyl-2,3-dioxo-1-piperazinylcarbonyl-amino)- α-phenylacetamido] penicillanate, is a new semisynthetic penicillin derivative that possesses a broad spectrum of in vitro...

UDP-Glucose: (1→3)-β-Glucan Synthases from Mung Bean and Cotton: Differential Effects of Ca2+ and Mg2+ on Enzyme Properties and on Macromolecular Structure of the Glucan Product

Hayashi, T., Read, S. M., Bussell, J., Thelen, M., Brown, R. M., ...

A re-examination of the kinetic properties of UDP-glucose: (1→3)-β-glucan (callose) synthases from mung bean seedlings (Vigna radiata) and cotton fibers (Gossypium hirsutum) shows that these...

Specific activity of phosphatidylinositol 3-kinase is increased by insulin stimulation.

Okamoto, M, Hayashi, T, Kono, S, Inoue, G, Kubota, M, Okamoto, M, ...

We investigated whether phosphatidylinositol 3-kinase (PI3K) is phosphorylated and whether its specific activity is increased by insulin stimulation in vivo using Fao cells and antibodies raised...

Biosynthesis of pentosyl lipids by pea membranes.

Hayashi, T, Maclachlan, G

Pea membranes were incubated with UDP-[14C]xylose or UDP-[14C]arabinose and sequentially extracted with chloroform/methanol/water (10:10:3, by vol.) and sodium dodecyl sulphate (2%, w/v). An active...

Regulation of the human protein C inhibitor gene expression in HepG2 cells: role of Sp1 and AP2.

Hayashi, T, Usui, M, Nishioka, J, Zhang, Z X, Suzuki, K

Protein C inhibitor (PCI) is the plasma inhibitor of activated protein C, which is the main protease of the anticoagulant protein C pathway. In this study the transcriptional regulation of human PCI...

A spectrum of mutations in the second gene for autosomal dominant polycystic kidney disease (PKD2).

Veldhuisen, B, Saris, J J, De Haij, S, Hayashi, T, Reynolds, D M, Mochizuki, T, ...

Recently the second gene for autosomal dominant polycystic kidney disease (ADPKD), located on chromosome 4q21-q22, has been cloned and characterized. The gene encodes an integral membrane protein,...

Production of R-(-)-Ketoprofen from an Amide Compound by Comamonas acidovorans KPO-2771-4

Yamamoto, K., Otsubo, K., Matsuo, A., Hayashi, T., Fujimatsu, I., Komatsu, K.

R-(-)-2-(3(prm1)-Benzoylphenyl)propionic acid [R-(-)-ketoprofen] was produced from racemic 2-(3(prm1)-benzoylphenyl)propionamide (keto-amide) by the isolated bacterial strain Comamonas acidovorans...

A novel blocker-PCR method for detection of rare mutant alleles in the presence of an excess amount of normal DNA.

Seyama, T, Ito, T, Hayashi, T, Mizuno, T, Nakamura, N, Akiyama, M

A novel polymerase chain reaction method was developed to preferentially amplify a segment of DNA containing a base substitution mutation. This technique uses a pair of dideoxynucleotide-labeled...

Clinicopathologic comparisons between estrogen receptor-positive and -negative hepatocellular carcinomas.

Nagasue, N, Kohno, H, Chang, Y C, Yamanoi, A, Nakamura, T, Yukaya, H, ...

During the past 8 years, estrogen receptors (ERs) in the cytosol of hepatocellular carcinoma (HCC) were assayed in 66 unselected patients without preceding treatments on whom radical hepatic...

Inhibition of gap junctional intercellular communication in normal human breast epithelial cells after treatment with pesticides, PCBs, and PBBs, alone or in mixtures.

Kang, K S, Wilson, M R, Hayashi, T, Chang, C C, Trosko, J E

Chemical pollutants in the Great Lakes have found their way through the food chain into humans because of their environmental persistence and lipophilicity. Some epidemiological studies have claimed...

Epidemiologic studies on possible health effects of intake of pyrolyzates of foods, with reference to mortality among Japanese Seventh-Day Adventists.

Kuratsune, M, Ikeda, M, Hayashi, T

To elucidate the effect of intake of mutagenic and/or carcinogenic pyrolysis products of proteins and amino acids on carcinogenesis in man, we have undertaken two epidemiologic cohort studies: one...

Androgen receptor in hepatocellular carcinoma as a prognostic factor after hepatic resection.

Nagasue, N, Chang, Y C, Hayashi, T, Galizia, G, Kohno, H, Nakamura, T, ...

Androgen receptors (AR) in the cytosol of hepatocellular carcinoma (HCC) were assayed in 45 unselected patients in whom radical hepatic resection was performed. Thirty-one patients had detectable...

Homeless and housed families in Los Angeles: a study comparing demographic, economic, and family function characteristics.

Wood, D, Valdez, R B, Hayashi, T, Shen, A

We studied 196 homeless and 194 housed poor families in Los Angeles, California to gain an understanding of events that precipitate family homelessness. Both homeless and housed poor mothers averaged...

Change in Genetic Variance under Selection in a Self-Fertilizing Population

Hayashi, T., Ukai, Y.

In this study we show how the genetic variance of a quantitative trait changes in a self-fertilizing population under repeated cycles of truncation selection, with the analysis based on the...

Empirical Bayes procedure for estimating genetic distance between populations and effective population size.

Kitada, S, Hayashi, T, Kishino, H

We developed an empirical Bayes procedure to estimate genetic distances between populations using allele frequencies. This procedure makes it possible to describe the skewness of the genetic distance...

Basal release of nitric oxide from aortic rings is greater in female rabbits than in male rabbits: implications for atherosclerosis.

Hayashi, T, Fukuto, J M, Ignarro, L J, Chaudhuri, G

Estradiol is known to exert a protective effect against the development of atherosclerosis, but the mechanism of this hormonal action is unknown. One of the early events in the development of...

A Xyloglucan-Specific Endo-1,4-[beta]-Glucanase Isolated from Auxin-Treated Pea Stems.

Matsumoto, T., Sakai, F., Hayashi, T.

A xyloglucan-specific endo-1,4-[beta]-glucanase was isolated from the apoplast fraction of auxin-treated pea (Pisum sativum) stems, in which both the rate of stem elongation and the amount of...

Involvement of Phenolic Esters in Cell Aggregation of Suspension-Cultured Rice Cells.

Kato, Y., Yamanouchi, H., Hinata, K., Ohsumi, C., Hayashi, T.

Fluorescence microscopy of rice (Oryza sativa L.) callus sections showed that all of the walls fluoresced blue in water (pH 5.8) and green in ammonia (pH 10.0), both characteristics of feruloyl...

In vitro antibacterial properties of T-5575 and T-5578 novel parenteral 2-carboxypenams.

Watanabe, Y, Minami, S, Hayashi, T, Araki, H, Kitayama, R, Ochiai, H

T-5575 and T-5578, novel 2-carboxypenams in which a carboxyl group has been introduced into the C-2 beta position of the nucleus, were evaluated for their in vitro antibacterial properties. The...

In vitro and in vivo activities of sedecamycin against Treponema hyodysenteriae.

Hayashi, T, Suenaga, I, Narukawa, N, Yamazaki, T

Sedecamycin (lankacidin A), one of the lankacidin-group antibiotics, showed potent activity against Treponema hyodysenteriae. The MICs of sedecamycin against 79 field isolates of T. hyodysenteriae...

Protective effect of piperacillin against nephrotoxicity of cephaloridine and gentamicin in animals.

Hayashi, T, Watanabe, Y, Kumano, K, Kitayama, R, Yasuda, T, Saikawa, I, ...

The protective effect of piperacillin against the nephrotoxicity of cephaloridine and gentamicin was examined in experimental animals. In rabbits, piperacillin was infused at a dose of 1 mg/kg (body...

Protective effect of piperacillin against the nephrotoxicity of cisplatin in rats.

Hayashi, T, Watanabe, Y, Kumano, K, Kitayama, R, Muratani, T, Yasuda, T, ...

The protective effect of piperacillin against the nephrotoxicity of cisplatin was compared with that of fosfomycin in Fischer 344 rats. Blood urea nitrogen, serum creatinine, and morphological...

Binding of the 68-kilodalton protein of Mycobacterium avium to alpha(v)beta3 on human monocyte-derived macrophages enhances complement receptor type 3 expression.

Hayashi, T, Rao, S P, Catanzaro, A

Attachment to and uptake by host cells are important early events in the pathogenesis of intracellular organisms such as Mycobacterium avium. Monocyte-derived macrophages (MDM) are known to express...

Apoptosis of human monocytes and macrophages by Mycobacterium avium sonicate.

Hayashi, T, Catanzaro, A, Rao, S P

Mycobacterium avium is an intracellular organism which multiplies predominantly within human macrophages. This organism has previously been shown to induce apoptosis in human macrophages. With a view...

Efficacy of NY-198 against experimental Legionnaires disease.

Kohno, S, Yamaguchi, K, Dohtsu, Y, Koga, H, Hayashi, T, Hirota, M, ...

The in vitro and in vivo effects of NY-198 against Legionella pneumophila were compared with those of ciprofloxacin. The MIC of NY-198 against 15 standard reference strains of Legionella of various...

Analysis of functional domains of Rts1 RepA by means of a series of hybrid proteins with P1 RepA.

Tabuchi, A, Ohnishi, M, Hayashi, T, Terawaki, Y

The RepA protein of the plasmid Rts1, consisting of 288 amino acids, is a trans-acting protein essential for initiation of plasmid replication. To study the functional domains of RepA, hybrid...

Mechanism of action of the antiherpesvirus biflavone ginkgetin.

Hayashi, K, Hayashi, T, Morita, N

Screening of plant extracts found that a biflavone from Cephalotaxus drupacea, which was found to be ginkgetin, is active against herpes simplex virus type 1 (HSV-1). This compound caused...

Identification of the lipopolysaccharide core region as the receptor site for a cytotoxin-converting phage, phi CTX, of Pseudomonas aeruginosa.

Yokota, S, Hayashi, T, Matsumoto, H

A temperate phage, phi CTX, is a cytotoxin-converting phage of Pseudomonas aeruginosa. In this study, we characterized the lipopolysaccharide (LPS) structures of phi CTX-resistant mutants derived...

Haloalkaliphilic maltotriose-forming alpha-amylase from the archaebacterium Natronococcus sp. strain Ah-36.

Kobayashi, T, Kanai, H, Hayashi, T, Akiba, T, Akaboshi, R, Horikoshi, K

A haloalkaliphilic archaebacterium, Natronococcus sp. strain Ah-36, produced extracellularly a maltotriose-forming amylase. The amylase was purified to homogeneity by ethanol precipitation,...

Function of the N-terminal half of RepA in activation of Rts1 ori.

Terawaki, Y, Itoh, Y, Zeng, H, Hayashi, T, Tabuchi, A

The RepA protein of the Rts1 plasmid, consisting of 288 amino acids, is a trans-acting protein essential for replication. A mutant repA gene, repA delta C143, carrying a deletion that removed the 143...

Effects of mutations in the repA gene of plasmid Rts1 on plasmid replication and autorepressor function.

Terawaki, Y, Nozue, H, Zeng, H, Hayashi, T, Kamio, Y, Itoh, Y

We constructed a system in which wild-type RepA or RepAcop1 protein was supplied in trans in various amounts to coexisting mini-Rts1 plasmids by clones of the repA or repAcop1 gene under the control...

Site-directed mutations in the repA C-terminal region of plasmid Rts1: pleiotropic effects on the replication and autorepressor functions.

Zeng, H, Hayashi, T, Terawaki, Y

We induced site-directed mutations near the 3' terminus of the gene repA, which encodes the protein of 288 amino acid residues essential for plasmid Rts1 replication, and obtained seven repA mutants....

Differentiation of human immunodeficiency virus type 1 (HIV-1) infections with HIV-2-cross-reacting antibody from mixed infections with HIV-1 and HIV-2 by serological absorption test.

Imai, M, Hayashi, T, Kondo, M, Saito, T, Ito, A, Hayami, M, ...

The interpretation of dual seroreactivity with human immunodeficiency virus type 1 (HIV-1) and HIV-2 in blood samples is a serious problem facing AIDS researchers worldwide. Some samples of sera from...

Prior enrichment of human immunodeficiency virus DNA with probe DNA particles for efficient PCR diagnosis.

Tano, H, Fan, K, Kitajima, M A, Kasai, K, Tamatsukuri, S, Furuichi, Y, ...

We report here a novel method by which one can recover human immunodeficiency virus (HIV) DNA in a small volume (approximately 50 microliters) of solution from 8 ml of crude cell lysate which...

CA150, a nuclear protein associated with the RNA polymerase II holoenzyme, is involved in Tat-activated human immunodeficiency virus type 1 transcription.

Suñé, C, Hayashi, T, Liu, Y, Lane, W S, Young, R A, Garcia-Blanco, M A

Maximal human immunodeficiency virus type 1 (HIV-1) gene expression requires specific cellular factors in addition to the virus-encoded trans-activator protein Tat and the RNA element TAR. We...

Removal of bacteria from water by adhesion to cross-linked poly(vinylpyridinium halide).

Kawabata, N, Hayashi, T, Matsumoto, T

Cross-linked poly(vinylpyridinium halide) was found to have a novel and remarkable ability to remove bacteria from water. For example, when 10 g (wet weight) of cross-linked...

Role of intestinal excretion in the effect of subcutaneously administered sedecamycin on cecal infection caused by Treponema hyodysenteriae in mice.

Hayashi, T, Okada, J, Kondo, S, Yamazaki, T

The therapeutic effects of subcutaneously administered sedecamycin on experimental Treponema hyodysenteriae infection in mice were evaluated. Sedecamycin was more active than tiamulin and lincomycin....

Pneumopathogenicity of a Sendai virus protease-activation mutant, TCs, which is sensitive to trypsin and chymotrypsin.

Itoh, M, Ming, T D, Hayashi, T, Mochizuki, Y, Homma, M

A protease-activation mutant of Sendai virus, TCs, was isolated from a trypsin-resistant mutant, TR-5. TCs was activated in vitro by both trypsin and chymotrypsin. TCs was, however, less sensitive to...

Monoclonal antibodies against the native urease of Helicobacter pylori: synergistic inhibition of urease activity by monoclonal antibody combinations.

Nagata, K, Mizuta, T, Tonokatu, Y, Fukuda, Y, Okamura, H, Hayashi, T, ...

Monoclonal antibodies (MAbs) against the native urease of Helicobacter pylori NCTC 11637 were found to clearly inhibit the urease activity. Interestingly, synergistic inhibition by two MAbs...

High-performance liquid chromatographic analysis of bacterial fatty acid composition for chemotaxonomic characterization of oral streptococci.

Tsuchiya, H, Sato, M, Kato, M, Namikawa, I, Hayashi, T, Tatsumi, M, ...

A high-performance liquid chromatographic method was developed to analyze the fatty acid composition of bacterial lipids. After saponification of lipids extracted from bacteria, the liberated fatty...

A novel blocker-PCR method for detection of rare mutant alleles in the presence of an excess amount of normal DNA.

Seyama, T, Ito, T, Hayashi, T, Mizuno, T, Nakamura, N, Akiyama, M

A novel polymerase chain reaction method was developed to preferentially amplify a segment of DNA containing a base substitution mutation. This technique uses a pair of dideoxynucleotide-labeled...

Thermal stability of type I and type III procollagens from normal human fibroblasts and from a patient with osteogenesis imperfecta.

Peltonen, L, Palotie, A, Hayashi, T, Prockop, D J

Type I and type III procollagens were isolated from the medium of human fibroblast cultures in amounts adequate for examination by circular dichroism. Type I procollagen had a spectrum similar to...

Differentiation-inducing factor purified from conditioned medium of mitogen-treated spleen cell cultures stimulates bone resorption.

Abe, E, Tanaka, H, Ishimi, Y, Miyaura, C, Hayashi, T, Nagasawa, H, ...

Spleen cells treated with mitogens produce a potent bone-resorbing factor called osteoclast-activating factor (OAF). To examine the relationship between the bone-resorbing factor and other protein...

Cloning and sequence analysis of cDNA for human renin precursor.

Imai, T, Miyazaki, H, Hirose, S, Hori, H, Hayashi, T, Kageyama, R, ...

The primary structure of human renin precursor has been deduced from its cDNA sequence. A library of cDNA clones was constructed from human kidney poly(A)+ RNA by applying the vector/primer method of...

Structure of the human renin gene.

Miyazaki, H, Fukamizu, A, Hirose, S, Hayashi, T, Hori, H, Ohkubo, H, ...

The human renin gene was isolated from a Charon 4A human genomic library and characterized. The gene spans about 11.7 kilobases and consists of 10 exons and 9 introns that map at points that could be...

Activation and fusion induced by 1 alpha,25-dihydroxyvitamin D3 and their relation in alveolar macrophages.

Abe, E, Shiina, Y, Miyaura, C, Tanaka, H, Hayashi, T, Kanegasaki, S, ...

1 alpha,25-Dihydroxyvitamin D3 [1 alpha,25-(OH)2D3] induces fusion of murine alveolar macrophages. This effect was observed in growth medium containing 5% human serum but not in the medium with 5%...

Synaptic vesicle membrane fusion complex: action of clostridial neurotoxins on assembly.

Hayashi, T, McMahon, H, Yamasaki, S, Binz, T, Hata, Y, Südhof, T C, ...

Clostridial neurotoxins inhibit neurotransmitter release by selective and specific intracellular proteolysis of synaptobrevin/VAMP, synaptosomal-associated protein of 25 kDa (SNAP-25) or syntaxin....

Disassembly of the reconstituted synaptic vesicle membrane fusion complex in vitro.

Hayashi, T, Yamasaki, S, Nauenburg, S, Binz, T, Niemann, H

The interaction of the presynaptic membrane proteins SNAP-25 and syntaxin with the synaptic vesicle protein synaptobrevin (VAMP) plays a key role in the regulated exocytosis of neurotransmitters....

In Vitro and In Vivo Antibacterial Activity of T-1220, a New Semisynthetic Penicillin

Ueo, K., Fukuoka, Y., Hayashi, T., Yasuda, T., Taki, H., Tai, M., ...

T-1220, sodium 6-[d-(-)-α-(4-ethyl-2,3-dioxo-1-piperazinylcarbonyl-amino)- α-phenylacetamido] penicillanate, is a new semisynthetic penicillin derivative that possesses a broad spectrum of in vitro...

UDP-Glucose: (1→3)-β-Glucan Synthases from Mung Bean and Cotton: Differential Effects of Ca2+ and Mg2+ on Enzyme Properties and on Macromolecular Structure of the Glucan Product

Hayashi, T., Read, S. M., Bussell, J., Thelen, M., Brown, R. M., ...

A re-examination of the kinetic properties of UDP-glucose: (1→3)-β-glucan (callose) synthases from mung bean seedlings (Vigna radiata) and cotton fibers (Gossypium hirsutum) shows that these...

Specific activity of phosphatidylinositol 3-kinase is increased by insulin stimulation.

Okamoto, M, Hayashi, T, Kono, S, Inoue, G, Kubota, M, Okamoto, M, ...

We investigated whether phosphatidylinositol 3-kinase (PI3K) is phosphorylated and whether its specific activity is increased by insulin stimulation in vivo using Fao cells and antibodies raised...

Biosynthesis of pentosyl lipids by pea membranes.

Hayashi, T, Maclachlan, G

Pea membranes were incubated with UDP-[14C]xylose or UDP-[14C]arabinose and sequentially extracted with chloroform/methanol/water (10:10:3, by vol.) and sodium dodecyl sulphate (2%, w/v). An active...

Change in Genetic Variance under Selection in a Self-Fertilizing Population

Hayashi, T., Ukai, Y.

In this study we show how the genetic variance of a quantitative trait changes in a self-fertilizing population under repeated cycles of truncation selection, with the analysis based on the...

Regulation of the human protein C inhibitor gene expression in HepG2 cells: role of Sp1 and AP2.

Hayashi, T, Usui, M, Nishioka, J, Zhang, Z X, Suzuki, K

Protein C inhibitor (PCI) is the plasma inhibitor of activated protein C, which is the main protease of the anticoagulant protein C pathway. In this study the transcriptional regulation of human PCI...

Clinicopathologic comparisons between estrogen receptor-positive and -negative hepatocellular carcinomas.

Nagasue, N, Kohno, H, Chang, Y C, Yamanoi, A, Nakamura, T, Yukaya, H, ...

During the past 8 years, estrogen receptors (ERs) in the cytosol of hepatocellular carcinoma (HCC) were assayed in 66 unselected patients without preceding treatments on whom radical hepatic...

Production of R-(-)-Ketoprofen from an Amide Compound by Comamonas acidovorans KPO-2771-4

Yamamoto, K., Otsubo, K., Matsuo, A., Hayashi, T., Fujimatsu, I., Komatsu, K.

R-(-)-2-(3(prm1)-Benzoylphenyl)propionic acid [R-(-)-ketoprofen] was produced from racemic 2-(3(prm1)-benzoylphenyl)propionamide (keto-amide) by the isolated bacterial strain Comamonas acidovorans...

Homeless and housed families in Los Angeles: a study comparing demographic, economic, and family function characteristics.

Wood, D, Valdez, R B, Hayashi, T, Shen, A

We studied 196 homeless and 194 housed poor families in Los Angeles, California to gain an understanding of events that precipitate family homelessness. Both homeless and housed poor mothers averaged...

Empirical Bayes procedure for estimating genetic distance between populations and effective population size.

Kitada, S, Hayashi, T, Kishino, H

We developed an empirical Bayes procedure to estimate genetic distances between populations using allele frequencies. This procedure makes it possible to describe the skewness of the genetic distance...

Inhibition of gap junctional intercellular communication in normal human breast epithelial cells after treatment with pesticides, PCBs, and PBBs, alone or in mixtures.

Kang, K S, Wilson, M R, Hayashi, T, Chang, C C, Trosko, J E

Chemical pollutants in the Great Lakes have found their way through the food chain into humans because of their environmental persistence and lipophilicity. Some epidemiological studies have claimed...

Epidemiologic studies on possible health effects of intake of pyrolyzates of foods, with reference to mortality among Japanese Seventh-Day Adventists.

Kuratsune, M, Ikeda, M, Hayashi, T

To elucidate the effect of intake of mutagenic and/or carcinogenic pyrolysis products of proteins and amino acids on carcinogenesis in man, we have undertaken two epidemiologic cohort studies: one...

Androgen receptor in hepatocellular carcinoma as a prognostic factor after hepatic resection.

Nagasue, N, Chang, Y C, Hayashi, T, Galizia, G, Kohno, H, Nakamura, T, ...

Androgen receptors (AR) in the cytosol of hepatocellular carcinoma (HCC) were assayed in 45 unselected patients in whom radical hepatic resection was performed. Thirty-one patients had detectable...

A spectrum of mutations in the second gene for autosomal dominant polycystic kidney disease (PKD2).

Veldhuisen, B, Saris, J J, De Haij, S, Hayashi, T, Reynolds, D M, Mochizuki, T, ...

Recently the second gene for autosomal dominant polycystic kidney disease (ADPKD), located on chromosome 4q21-q22, has been cloned and characterized. The gene encodes an integral membrane protein,...

Lactic dehydrogenase virus infection enhances parasite egg production and inhibits eosinophil and mast cell responses in mice infected with the nematode Nippostrongylus brasiliensis.

Morimoto, M, Yamada, M, Arizono, N, Hayashi, T

The effects of lactic dehydrogenase virus (LDV) infection on the protective immune responses to the nematode Nippostrongylus brasiliensis were studied. Mice with chronic LDV infection showed...

Prevalence of joint pain is higher among women in rural Japan than urban Japanese-American women in Hawaii

Aoyagi, K., Ross, P., Huang, C., Wasnich, R., Hayashi, T., Takemoto, T.

OBJECTIVE—Environmental factors such as farming contribute to the frequency of joint symptoms. The purpose of this study is to explore the possible role of environment (lifestyle), by comparing the...

The potential role of BAX and BCL-2 expression in diffuse alveolar damage.

Guinee, D., Brambilla, E., Fleming, M., Hayashi, T., Rahn, M., Koss, M., ...

Apoptosis of type II pneumocytes has been identified in diffuse alveolar damage (DAD), is associated with p53 and WAF1 expression, and may be of pathogenetic importance. BAX, a homologue of BCL-2, is...

Immunohistochemical study of metalloproteinases and their tissue inhibitors in the lungs of patients with diffuse alveolar damage and idiopathic pulmonary fibrosis.

Hayashi, T., Stetler-Stevenson, W. G., Fleming, M. V., Fishback, N., Koss, M. N., Liotta, L. A., ...

Immunohistochemical and confocal microscopic studies of the localization of matrix metalloproteinases (MMPs), their tissue inhibitors (TIMPs), and type IV collagen were made in lung tissues from...

Association of p53 and WAF1 expression with apoptosis in diffuse alveolar damage.

Guinee, D., Fleming, M., Hayashi, T., Woodward, M., Zhang, J., Walls, J., ...

Little is known about alterations in cell cycle regulatory proteins such as p53 and WAF1 in diffuse alveolar damage (DAD). We hypothesized that up-regulation of p53 and WAF1 in type II pneumocytes in...

Regulation of enzyme levels in the blood. Influence of environmental and genetic factors on enzyme clearance.

Hayashi, T., Salata, K., Kingman, A., Notkins, A. L.

Since its discovery, lactic dehydrogenase virus (LDV) has remained unique as a model of long-term enzyme elevation due to impairment of enzyme clearance. The present study shows that mice inoculated...

Argon plasma coagulation for successful treatment of early gastric cancer with intramucosal invasion

Sagawa, T, Takayama, T, Oku, T, Hayashi, T, Ota, H, Okamoto, T, ...

Background: In recent years, there has been an increasing number of cases of early gastric cancer (T1, NX) with intramucosal invasion, which are untreatable by surgical or endoscopic mucosal...

A novel chain of basement membrane-associated collagen as revealed by biochemical and immunohistochemical characterizations of the epitope recognized by a monoclonal antibody against human placenta basement membrane collagen.

Kino, J., Adachi, E., Yoshida, T., Asamatsu, C., Nakajima, K., Yamamoto, K., ...

Biochemical and immunohistochemical characterizations of the epitope recognized by a monoclonal antibody, JK-132, originally produced against human type IV collagen showed that it was distinct from...

Familial atrial standstill caused by amyloidosis.

Maeda, S, Tanaka, T, Hayashi, T

Three of nine siblings were affected by atrial standstill. Clinical, electrophysiological, and histological findings in two of these cases were studied. Electrophysiological studies showed persistent...

QT dispersion and left ventricular morphology in patients with hypertrophic cardiomyopathy

Sakata, K, Shimizu, M, Ino, H, Yamaguchi, M, Terai, H, Hayashi, K, ...

Objective: To evaluate the relation between QT variables and disproportion of left ventricular wall hypertrophy in patients with hypertrophic cardiomyopathy.

Angiotensin II receptor blockade prevents microangiopathy and preserves diastolic function in the diabetic rat heart

Hayashi, T, Sohmiya, K, Ukimura, A, Endoh, S, Mori, T, Shimomura, H, ...

Background: Cardiac microangiopathy may be involved in the development of heart failure in diabetes mellitus.

Acute myocardial infarction caused by thrombotic occlusion at a stent site two years after conventional stent implantation

Hayashi, T, Kimura, A, Ishikawa, K

Two cases of acute myocardial infarction caused by thrombotic occlusion at the conventional stented site two years after stenting are described. Late thrombotic stent occlusion may be caused by...

Localization of type V collagen and type IV collagen in human cornea, lung, and skin. Immunohistochemical evidence by anti-collagen antibodies characterized by immunoelectroblotting.

Konomi, H., Hayashi, T., Nakayasu, K., Arima, M.

Tissue distribution of Type V collagen in comparison with Type IV collagen was investigated by indirect immunofluorescence microscopy. Affinity-purified rat antibodies to Type IV and Type V collagens...

A case of solitary pulmonary lymphangioma

Nagayasu, T, Hayashi, T, Ashizawa, K, Muraoka, M, Tagawa, T, Akamine, S, ...

Solitary pulmonary lymphangiomas are rare benign lesions thought to result from the development of abnormally proliferating lymphatic vessels. This report describes a case of solitary pulmonary...

In vivo tumouricidal effects of LAD-1 monoclonal antibody on murine RL-male-1 lymphoma mediated by enhanced phagocytosis

Ito, M, Omoto, S, Kato, Y, Hayashi, T, Mori, N, Fujii, Y R

We have reported previously that the LAD-4 monoclonal antibody (mAb) directed against a fibronectin receptor (FNR) on RL-male-1 T lymphoma cells in BALB/c mice partially inhibited their migration to...

Gastric organ culture. A model for reepithelialization.

Hayashi, T., Papla, B., Stemmermann, G. N.

The in vitro organ culture system is useful in the study of the mechanics of gastric reepithelialization, cell migration and exfoliation. Reepithelialization is apparently effected by actively motile...

Effect of the NMDA-antagonist, MK 801, on benzodiazepine-opioid interactions at the spinal and supraspinal level in rats.

Luger, T J, Lorenz, I H, Grabner-Weiss, C, Hayashi, T

1. Benzodiazepines potentiate morphine antinociception at the spinal level via GABAergic mechanisms. At the supraspinal level, the inhibitory effect of midazolam on morphine antinociception cannot be...

The Sigma Receptor: Evolution of the Concept in Neuropsychopharmacology

Hayashi, T, Su, TP

Although originally proposed as a subtype of opioid receptors, the sigma receptor is now confirmed to be a non-opioid receptor that binds diverse classes of psychotropic drugs. Sigma receptors are...

JC virus regulatory region rearrangements in the brain of a long surviving patient with progressive multifocal leukoencephalopathy

Yogo, Y, Matsushima-Ohno, T, Hayashi, T, Sugimoto, C, Sakurai, M, Kanazawa, I

JC virus (JCV) infection of oligodendrocytes causes demyelination in brains of patients with with progressive multifocal leukoencephalopathy (PML). Expansion of demyelination throughout the brain is...

Job strain, social support in the workplace, and haemoglobin A1c in Japanese men

Kawakami, N, Akachi, K, Shimizu, H, Haratani, T, Kobayashi, F, Ishizaki, M, ...

OBJECTIVES—To examine the association between job strain (defined in the model of job demands and job control) and social support at the workplace with levels of glycosylated haemoglobin A1c...

Comparison of the pattern of atrophy of the corpus callosum in frontotemporal dementia, progressive supranuclear palsy, and Alzheimer's disease

Yamauchi, H., Fukuyama, H., Nagahama, Y., Katsumi, Y., Hayashi, T., Oyanagi, C., ...

OBJECTIVES—The loss of the neurons in layer 3, one of the groups of cortical neurons most vulnerable in various degenerative brain diseases, results in axonal degeneration leading to atrophy of the...

Possible association between heavy computer users and glaucomatous visual field abnormalities: a cross sectional study in Japanese workers

Tatemichi, M., Nakano, T., Tanaka, K., Hayashi, T., Nawa, T., Miyamoto, T., ...

Study objective: To study the association between computer use and visual field abnormalities (VFA) and to assess whether heavy computer users have an increased risk of glaucoma.

Attitude toward imprecise information

Gajdos, T., Hayashi, T.

This paper presents an axiomatic model of decision making under uncertainty which incorporates objective but imprecise information. Information is assumed to take the form of a...

Restructuring of items within a product line: a case study of Japanese multinational enterprises in the electric machinery industry

T Hayashi

Through an examination of the intrafirm division of labour between the parent companies of Japanese multinational enterprises (MNEs) and their Asian affiliates in the electric machinery industry, it...

Probing intermolecular couplings in liquid water with two-dimensional infrared photon echo spectroscopy

Paarmann, A., Hayashi, T., Mukamel, S., Miller, R. J.D.

Two-dimensional infrared photon echo and pump probe studies of the OH stretch vibration provide a sensitive probe of the correlations and couplings in the hydrogen bond network of liquid water. The...

Cisplatin-incorporating polymeric micelles (NC-6004) can reduce nephrotoxicity and neurotoxicity of cisplatin in rats

Uchino, H, Matsumura, Y, Negishi, T, Koizumi, F, Hayashi, T, Honda, T, ...

In spite of the clinical usefulness of cisplatin (CDDP), there are many occasions in which it is difficult to continue the administration of CDDP due to its nephrotoxicity and neurotoxicity. We...