International Union of Pharmacology. XXIII. The (2008)
Angiotensin Ii Receptors, M. De Gasparo, K. J. Catt, T. Inagami, J. W. Wright, Th. Unger
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Mifune, M., Ohtsu, H., Suzuki, H., Nakashima, H., Brailoiu, E., Dun, N. J., ...
A G protein-coupled receptor agonist, angiotensin II (AngII), induces epidermal growth factor (EGF) receptor (EGFR) transactivation possibly through metalloprotease- dependent, heparin-binding EGF...
Mifune, M., Ohtsu, H., Suzuki, H., Nakashima, H., Brailoiu, E., Dun, N. J., ...
A G protein-coupled receptor agonist, angiotensin II (AngII), induces epidermal growth factor (EGF) receptor (EGFR) transactivation possibly through metalloprotease- dependent, heparin-binding EGF...
Angiotensin II-mediated vascular smooth muscle cell growth signaling (2000)
The mechanism by which Ang II stimulates the growth of vascular smooth muscle cells was investigated by measuring the phosphorylation of mitogen-activated protein kinases ERK 1 and ERK 2. Ca2+...
Cloning, Expression and Regulation of Angiotensin II Receptors (1994)
Inagami, T., Iwai, N., Sasaki, K., Yamano, Y., Bardhan, S., Chaki, S., ...
Angiotensin II isoform 1 (AT1) receptor cDNAs were cloned by expression cloning from bovine adrenal and rat vascular smooth muscles. Human AT1 receptor was also cloned. Seven transmembrane structures...
Kitami, Y, Inui, H, Uno, S, Inagami, T
PDGF has been shown to contribute to hypertrophy in vascular smooth muscle cells (VSMC). PDGF-AA differentially promotes protein synthesis in VSMC from spontaneously hypertensive rats (SHR) but not...
Niimura, F, Labosky, P A, Kakuchi, J, Okubo, S, Yoshida, H, Oikawa, T, ...
Elevated levels of endogenous angiotensin can cause hypertensive nephrosclerosis as a result of the potent vasopressor action of the peptide. We have produced by gene targeting mice homozygous for a...
Mizuno, K, Hoffman, L H, McKenzie, J C, Inagami, T
Renin has been identified biochemically and immunohistochemically in the adrenal gland. We examined the subcellular distribution and behavior of adrenal renin. By differential centrifugation of...
Badr, K F, Murray, J J, Breyer, M D, Takahashi, K, Inagami, T, Harris, R C
We investigated the actions of endothelin in anesthetized rats and cultured mesangial cells. Intravenous infusion of endothelin (10 pmol/min) decreased renal blood flow by 44% at 20 min without...
Clearance of atrial natriuretic factor by lung, liver, and kidney in human subjects and the dog.
Hollister, A S, Rodeheffer, R J, White, F J, Potts, J R, Imada, T, Inagami, T
We determined human and canine plasma clearance of atrial natriuretic factor (ANF) by lung, liver, and kidney from arteriovenous differences in plasma ANF and measured organ plasma flow. Human...
The multiple physiologic functions of angiotensin II(AII) are generally supposed to be mediated by the peptide generated in the blood circulation. In addition to this extracellular mechanism of AII...
Markedly elevated specific renin levels in the adrenal in genetically hypertensive rats.
The specific renin (EC 3.4.99.19) activity in the adrenal of spontaneously hypertensive rats was determined by a method that is capable of distinguishing renin from nonspecific renin-like activity of...
Amino acid sequence of mouse submaxillary gland renin.
Misono, K S, Chang, J J, Inagami, T
The complete amino acid sequences of the heavy chain and light chain of mouse submaxillary gland renin have been determined. The heavy chain consists of 288 amino acid residues having a Mr of 31,036...
Okamura, T, Clemens, D L, Inagami, T
The mechanism of formation of various peptide hormones in neuronal cells in the brain is not clear. The question of whether brain angiotensin II is formed by an extracellular mechanism as in the...
Immunohistochemical localization of renin in luteinizing hormone-producing cells of rat pituitary.
Naruse, K, Takii, Y, Inagami, T
The location of renin (EC 3.4.99.19) in rat pituitary was determined by the peroxidase-antiperoxidase immunohistochemical technique. By using antisera prepared with purified rat renal renin, an...
Matsusaka, T, Nishimura, H, Utsunomiya, H, Kakuchi, J, Niimura, F, Inagami, T, ...
We have developed chimeric mice carrying 'regional' null mutation of the angiotensin type 1A (AT1A) receptor, the AT1 receptor subtype exclusively present in mouse juxtaglomerular (JG) cells. The...
Tsuchida, S, Matsusaka, T, Chen, X, Okubo, S, Niimura, F, Nishimura, H, ...
Rodents are the unique species carrying duplicated angiotensin (Ang) type 1 (AT1) receptor genes, Agtr1a and Agtr1b. After separately generating Agtr1a and Agtr1b null mutant mice by gene targeting,...
Angiotensin induces the urinary peristaltic machinery during the perinatal period.
Miyazaki, Y, Tsuchida, S, Nishimura, H, Pope, J C, Harris, R C, McKanna, J M, ...
The embryonic development of mammalian kidneys is completed during the perinatal period with a dramatic increase in urine production, as the burden of eliminating nitrogenous metabolic waste shifts...
Kambayashi, Y, Takahashi, K, Bardhan, S, Inagami, T
A novel protein [designated protein tyrosine phosphatase-like protein (PTPLP)] which is distantly related to receptor-type protein tyrosine phosphatases (PTPases) was cloned from a rat...
1. Isoionic chemical modification of amino groups of trypsin (EC 3.4.21.4) was studied for the purpose of obtaining a well-defined modified trypsin with minimum changes in physicochemical properties...
N-Terminal amino acid sequence of the -subunit of human pituitary luteinizing hormone.
Inagami, T, Murakami, K, Puett, D, Hartree, A S, Nureddin, A
Differential response of renin secretion to vasoconstrictors in the isolated perfused rat kidney.
Scholz, H, Kaissling, B, Inagami, T, Kurtz, A
1. We have examined whether an increase of renal vascular resistance is generally accompanied by an inhibition of renin secretion. The effects of vasoconstriction produced by angiotensin II (Ang II),...
Kitami, Y, Inui, H, Uno, S, Inagami, T
PDGF has been shown to contribute to hypertrophy in vascular smooth muscle cells (VSMC). PDGF-AA differentially promotes protein synthesis in VSMC from spontaneously hypertensive rats (SHR) but not...
Niimura, F, Labosky, P A, Kakuchi, J, Okubo, S, Yoshida, H, Oikawa, T, ...
Elevated levels of endogenous angiotensin can cause hypertensive nephrosclerosis as a result of the potent vasopressor action of the peptide. We have produced by gene targeting mice homozygous for a...
Mizuno, K, Hoffman, L H, McKenzie, J C, Inagami, T
Renin has been identified biochemically and immunohistochemically in the adrenal gland. We examined the subcellular distribution and behavior of adrenal renin. By differential centrifugation of...
Badr, K F, Murray, J J, Breyer, M D, Takahashi, K, Inagami, T, Harris, R C
We investigated the actions of endothelin in anesthetized rats and cultured mesangial cells. Intravenous infusion of endothelin (10 pmol/min) decreased renal blood flow by 44% at 20 min without...
Clearance of atrial natriuretic factor by lung, liver, and kidney in human subjects and the dog.
Hollister, A S, Rodeheffer, R J, White, F J, Potts, J R, Imada, T, Inagami, T
We determined human and canine plasma clearance of atrial natriuretic factor (ANF) by lung, liver, and kidney from arteriovenous differences in plasma ANF and measured organ plasma flow. Human...
The multiple physiologic functions of angiotensin II(AII) are generally supposed to be mediated by the peptide generated in the blood circulation. In addition to this extracellular mechanism of AII...
Markedly elevated specific renin levels in the adrenal in genetically hypertensive rats.
The specific renin (EC 3.4.99.19) activity in the adrenal of spontaneously hypertensive rats was determined by a method that is capable of distinguishing renin from nonspecific renin-like activity of...
Amino acid sequence of mouse submaxillary gland renin.
Misono, K S, Chang, J J, Inagami, T
The complete amino acid sequences of the heavy chain and light chain of mouse submaxillary gland renin have been determined. The heavy chain consists of 288 amino acid residues having a Mr of 31,036...
Okamura, T, Clemens, D L, Inagami, T
The mechanism of formation of various peptide hormones in neuronal cells in the brain is not clear. The question of whether brain angiotensin II is formed by an extracellular mechanism as in the...
Immunohistochemical localization of renin in luteinizing hormone-producing cells of rat pituitary.
Naruse, K, Takii, Y, Inagami, T
The location of renin (EC 3.4.99.19) in rat pituitary was determined by the peroxidase-antiperoxidase immunohistochemical technique. By using antisera prepared with purified rat renal renin, an...
Matsusaka, T, Nishimura, H, Utsunomiya, H, Kakuchi, J, Niimura, F, Inagami, T, ...
We have developed chimeric mice carrying 'regional' null mutation of the angiotensin type 1A (AT1A) receptor, the AT1 receptor subtype exclusively present in mouse juxtaglomerular (JG) cells. The...
Tsuchida, S, Matsusaka, T, Chen, X, Okubo, S, Niimura, F, Nishimura, H, ...
Rodents are the unique species carrying duplicated angiotensin (Ang) type 1 (AT1) receptor genes, Agtr1a and Agtr1b. After separately generating Agtr1a and Agtr1b null mutant mice by gene targeting,...
Angiotensin induces the urinary peristaltic machinery during the perinatal period.
Miyazaki, Y, Tsuchida, S, Nishimura, H, Pope, J C, Harris, R C, McKanna, J M, ...
The embryonic development of mammalian kidneys is completed during the perinatal period with a dramatic increase in urine production, as the burden of eliminating nitrogenous metabolic waste shifts...
Kambayashi, Y, Takahashi, K, Bardhan, S, Inagami, T
A novel protein [designated protein tyrosine phosphatase-like protein (PTPLP)] which is distantly related to receptor-type protein tyrosine phosphatases (PTPases) was cloned from a rat...
1. Isoionic chemical modification of amino groups of trypsin (EC 3.4.21.4) was studied for the purpose of obtaining a well-defined modified trypsin with minimum changes in physicochemical properties...
N-Terminal amino acid sequence of the -subunit of human pituitary luteinizing hormone.
Inagami, T, Murakami, K, Puett, D, Hartree, A S, Nureddin, A
Differential response of renin secretion to vasoconstrictors in the isolated perfused rat kidney.
Scholz, H, Kaissling, B, Inagami, T, Kurtz, A
1. We have examined whether an increase of renal vascular resistance is generally accompanied by an inhibition of renin secretion. The effects of vasoconstriction produced by angiotensin II (Ang II),...
Immunohistochemical localization of renin in renal tumors.
Tomita, T., Poisner, A., Inagami, T.
Immunoperoxidase staining for renin was performed with renal tumors, including juxtaglomerular (JG) tumor, Wilms' tumors, renal adenocarcinomas, renal oncocytomas, and cortical adenomas. Compared...
Cantin, M., Gutkowska, J., Lacasse, J., Ballak, M., Ledoux, S., Inagami, T., ...
Partial ligation of the rat aorta between the renal arteries induces acute hypertension with atrophy of the left (ischemic) kidney, intense stimulation of juxtaglomerular cell (JGC) secretory...