T. Inoue

Realization and Analysis of a Mask-Programmable I2L Multivalued Logic Circuit, (9999)

Taniguchi,K., Inoue,T., Ueno,F.

This paper presents a new mask-programmable I2L multivalued logic circuit. The proposed logic circuit is a variable operational circuit using the ROM structure. The sensitivity analysis is given for...

The Biofilter System--Use of Aquatic Plants for Water Purification, (9999)

Mishima, T., Inoue, T.

This paper describes a mechanical system for cultivating aquatic plants (waterhyacinth, watercress) in rivers and lakes that are severely polluted, for the purpose of water purification. The system...

REPORT ON 6TH U.S.-JAPAN JOINT SEMINAR ON NANOSCALE TRANSPORT PHENOMENA.SCIENCE AND ENGINEERING (2009)

T. Borca-tasciuc, D. G. Cahill, G. Chen, H. Daiguji, C. Dames, K. Fushinobu, ...

The objective of this U.S.-Japan joint seminar series is to provide a cross-disciplinary and

E-Cadherin regulates neural stem cell self-renewal (2009)

Karpowicz, P., Willaime-Morawek, S., Balenci, L., DeVeale, B., Inoue, T.

E-Cadherin, a cell adhesion protein, has been shown to take part in the compartmentalization, proliferation, survival, and differentiation of cells. E-Cadherin is expressed in the adult and embryonic...

Ground-state electric quadrupole moment of 31Al (2008)

Nagae, D., Ueno, H., Kameda, D., Takemura, M., Asahi, K., Takase, K., ...

Ground-state electric quadrupole moment of 31Al (I =5/2+, T_1/2 = 644(25) ms) has been measured by means of the beta-NMR spectroscopy using a spin-polarized 31Al beam produced in the projectile...

Report on 6th US-Japan Joint Seminar on Nanoscale Transport PhenomenaScience and Engineering (2008)

Borca-Tasciuc, T, Cahill, DG, Chen, G, Cronin, SB, Daiguji, H, Dames, C, ...

Localization of normal and abnormal function in patients with band heterotopia (2007)

M. Ishitobi, N. Nakasato, M. Munakata, T. Inoue, S. Takahashi, K. Iinuma

Cortical dysplasia is caused by the failure of migration and development of cortical neurons, resulting in misplacement of neurons or absence of cortical lamination. Band heterotopia (BH) is one of

Elastic analysis of pavement structure with application of vertical and centripetal surface forces (2006)

Maina, JW, Fujinami, K, Matsui, K, Inoue, T

2006: ICAP: 10th Annual International Conference on Asphalt Pavements

Elastic analysis of pavement structure with application of vertical and centripetal surface forces (2006)

Maina, JW, Fujinami, K, Matsui, K, Inoue, T

2006: ICAP: 10th Annual International Conference on Asphalt Pavements

A novel spleen tyrosine kinase inhibitor blocks c-jun N-terminal kinase-mediated gene expression in synoviocytes (2006)

Cha, H.S., Boyle, D.L., Inoue, T., Schoot, R., Tak, P.P., Pine, P., ...

Spleen tyrosine kinase (Syk) is a key regulator of cell signaling induced by cytokines or Fc receptor engagement. However, the role of Syk in rheumatoid arthritis ( RA) is not known yet. We...

Screening level analysis for monitoring pesticide in river water using a hydrological diffuse pollution model with limited input data (2006)

Matsui, Y., Narita, K., Inoue, T., Matsushita, T.

To predict rice-farming pesticide concentrations in river water with imprecise model inputs for screening-level analysis, a basin-scale runoff model was developed. The Monte Carlo method was applied...

trans-Dichlorobis(10-dodecyl-9-phospha-10-silatriptycene-kappa P)palladium(II) (2006)

Tsuji, H, Inoue, T, Sase, S, Tamao, K

Crystal structure of intein homing endonuclease II encoded in DNA polymerase gene from hyperthermophilic Archaeon Thermococcus kodakaraensis strain KOD1 (2006)

Matsumura, H, Takahashi, H, Inoue, T, Yamamoto, T, Hashimoto, H, Nishioka, M, ...

Nonlinear rheology and retraction of entangled thread-like micelles (2006)

Takagi, A, Sasaki, H, Kuriyama, A, Matsumiya, Y, Inoue, T, Watanabe, H

Fracture toughness of a crystalline silicon carbide fiber (Tyranno-SA3((R))) (2006)

Morishita, K, Ochiai, S, Okuda, H, Inshikawa, T, Sato, M, Inoue, T

Transient conformational change of bead-spring ring chain during creep process (2006)

Watanabe, H, Inoue, T, Matsumiya, Y

Electric field-induced strain of PbZrO3 films (2006)

Kanno, I, Inoue, T, Suzuki, T, Kotera, H, Wasa, K

Rheooptical study on poly(styrene macromonomer) (2006)

Inoue, T, Matsuno, K, Watanabe, H, Nakamura, Y

Orientational anisotropy of bead-spring star chains during creep process (2006)

Matsumiya, Y, Inoue, T, Oishi, Y, Watanabe, H

Synthesis, structure, and properties of 9-phospha-10-silatriptycenes and their derivatives (2006)

Tsuji, H, Inoue, T, Kaneta, Y, Sase, S, Kawachi, A, Tamao, K

Role of chain connectivity in viscoelastic properties of polymeric liquids: A review (2006)

Watanabe, H, Inoue, T

Effect of prophylactic bronchodilator treatment with i.v. carperitide on airway resistance and lung compliance after tracheal intubation (2006)

Wajima, Z., Shiga, T., Imanaga, K., Inoue, T., Ogawa, R.

Background. Lung resistance increases after induction of anaesthesia. We hypothesized that prophylactic bronchodilation with i.v. carperitide before tracheal intubation would decrease airway...

Lifting to the suspension of the real projective plane(Mathematical Sciences) (2005)

Inoue, T, Mukai, J

The elements ε_3 and μ_3 of the homotopy groups of the 3-sphere are lifted to the suspension of the real projective plane.

Chiral dynamics of hadrons in nuclei (2005)

Oset, E., Cabrera, D., Magas, V. K., Roca, L., Vacas, M. J. Vicente, Ramos, A., ...

In this talk I report on selected topics of hadron modification in the nuclear medium using the chiral unitary approach to describe the dynamics of the problems. I shall mention how antikaons,...

Overview of thermal-stimulation production-test results for the JAPEX/JNOC/GSC et al. Mallik 5L-38 gas hydrate production research well (2005)

Hancock, S., Collett, T. S., Dallimore, S. R., Satoh, T., Inoue, T., Huenges, E., ...

Structural mechanism for coordination of proofreading and polymerase activities in archaeal DNA polymerases (2005)

Kuroita, T, Matsumura, H, Yokota, N, Kitabayashi, M, Hashimoto, H, Inoue, T, ...

Conformational dynamics of Rouse chains during creep/recovery processes: a review (2005)

Watanabe, H, Inoue, T

Dielectric and viscoelastic study of entanglement dynamics: A review of recent findings (2005)

Watanabe, H, Matsumiya, Y, Inoue, T

Nonlinear rheology of CTAB/NaSal aqueous solutions: Finite extensibility of a network of wormlike micelles (2005)

Inoue, T, Inoue, Y, Watanabe, H

Chlorination of UO2, PuO2 and rare earth oxides using ZrCl4 in LiCl-KCl eutectic melt (2005)

Sakamura, Y, Inoue, T, Iwai, T, Moriyama, H

Magnetic moments of S-shell pentaquarks in the constituent quark model (2004)

Inoue, T., Lyubovitskij, V. E., Gutsche, Th., Faessler, Amand

We discuss the magnetic moments of the recently discovered exotic baryons Theta(+) and Xi(--) and their multiplet partners in the framework of a naive additive quark model. These baryons are set up...

Mass spectrum of the J^P=1/2^- and 3/2^- pentaquark antidecuplets in the perturbative chiral quark model (2004)

Inoue, T., Lyubovitskij, V. E., Gutsche, Th., Faessler, Amand

We study the recently discovered Theta^+ baryon in the context of the perturbative chiral quark model. The basic configuration of the Theta^+ is set up as a pentaquark bound state, where the single...

Fabrication of zero-speed sensor using weakly Coupled NiFe/CoFe multilayer films (2004)

Takemura, Yasushi, Inoue, T., Nishimoto, A., Yamada, T., 竹村, 泰司, タケムラ, ヤスシ, ...

A magnetic sensor consisting of NiFe/Al2O3/CoFe thin film was fabricated. Magnetization reversal of the NiFe soft layer was asymmetric in switching to parallel and antiparallel alignments to...

Ground-state baryon masses in the perturbative chiral quark model (2004)

Inoue, T., Lyubovitskij, V. E., Gutsche, Th., Faessler, Amand

Mass differences of the flavor octet and decuplet ground-state baryons are studied in the perturbative chiral quark model. We present a way to understand the nontrivial spin- and flavor dependent...

Laboratory Tests of Gravitational Physics Using a Cryogenic Torsion Pendulum (2004)

Berg, E. C., Steffen, J. H., Bantel, M. K., Boynton, P. E., Cross, W. D., Inoue, T., ...

Progress and plans are reported for a program of gravitational physics experiments using cryogenic torsion pendula undergoing large amplitude torsional oscillation. The program includes a UC Irvine...

Test of full and partial tube dilation pictures in entangled blends of linear polyisoprenes (2004)

Watanabe, H, Ishida, S, Matsumiya, Y, Inoue, T

Stress overshoot of entangled polymers in Theta solvent (2004)

Inoue, T, Yamashita, Y, Watanabe, H, Endoh, MK, Hashimoto, T

Viscoelastic and dielectric behavior of entangled blends of linear polyisoprenes having widely separated molecular weights: Test of tube dilation picture (2004)

Watanabe, H, Ishida, S, Matsumiya, Y, Inoue, T

In situ dielectric characterization of poly(ethylene oxide) melts containing lithium perchlorate under steady shear flow (2004)

Matsumiya, Y, Balsara, NP, Kerr, JB, Inoue, T, Watanabe, H

Conformational changes of short, discrete Rouse chain during creep and recovery processes (2004)

Watanabe, H, Inoue, T

Creep behavior for combined rouse-reptation mechanism (2004)

Watanabe, H, Inoue, T

Conformational changes during creep process of binary blends of Rouse chains (2004)

Watanabe, H, Inoue, T

Updated analysis of meson-nucleon sigma terms in the perturbative chiral quark model (2003)

Inoue, T., Lyubovitskij, V. E., Gutsche, Th., Faessler, Amand

We present an updated analysis of meson-baryon sigma terms in the perturbative chiral quark model, which is based on effective chiral Lagrangian. The new feature concerns the inclusion of excited...

The $\Lambda \Lambda \to YN$ Weak Transition in Double-$\Lambda$ Hypernuclei (2003)

Sasaki, K., Inoue, T., Oka, M.

We calculate the $\Lambda \Lambda \to YN$ transition rate of ${^{\phantom{\Lambda}6}_{\Lambda \Lambda}}$He by the hybrid picture, the $\pi$ and $K$ exchanges plus the direct quark processes. It is...

Structure of E. coli ketopantoate hydroymethyltransferase complexed with ketopantoate and Mg(2+), solved by locating 160 selenomethionine sites (2003)

VonDelft, F, Inoue, T, Saldanha, SA, Ottenhof, HH, Schmitzberger, F, Birch, LM, ...

Rheo-dielectrics in oligomeric and polymeric fluids: a review of recent findings (2003)

Watanabe, H, Matsumiya, Y, Inoue, T

eta nucleus optical potential in a chiral unitary approach (2002)

Inoue, T., Oset, E.

The self-energy of an eta in a nuclear medium is calculated in a chiral unitary model, and applied to eta states in nuclei. Our calculation predicts an attractive eta nucleus optical potential which...

Chiral unitary approach to hadron spectroscopy (2002)

Oset, E., Inoue, T., Vacas, M. J. Vicente, Ramos, A., Bennhold, C.

The s-wave meson-baryon interaction in the $S = -1$, $S= 0$ and $S= -2$ sectors is studied by means of coupled channels, using the lowest-order chiral Lagrangian and the N/D method or equivalently...

$\eta$ bound states in nuclei (2002)

Nieves, J., Inoue, T., Oset, E.

The energies and widths of bound states of the $\eta$ meson in different nuclei are obtained using the results for its selfenergy in a nuclear medium, which is evaluated in a selfconsistent manner...

eta in the nuclear medium within a chiral unitary approach (2002)

Inoue, T., Oset, E.

The self-energy of an eta meson in the nuclear medium is calculated in a chiral unitary approach. A coupled channel Bethe-Salpeter equation is solved to obtain the effective eta-N interaction in the...

Nonmesonic weak decay of light hypernuclei with coherent $\Sigma$ mixing (2002)

Sasaki, K., Inoue, T., Oka, M.

Nonmesonic weak decays of the A=4, and 5 hypernuclei are studied. The short range parts of the hyperon-nucleon weak interactions are described by the direct quark (DQ) weak transition potential,...

複合ラーメン橋結合部の応力分布と構造特性の解析 (2002)

月岡, 雅人, 大島, 俊之, 三上, 修一, 山崎, 智之, 佐藤, 孝英, 井上, 稔康, ...

Dielectric and viscoelastic relaxation of highly entangled star polyisoprene: Quantitative test of tube dilation model (2002)

Watanabe, H, Matsumiya, Y, Inoue, T

Solution structure of an RNA fragment with the P7/P9.0 region and the 3'-terminal guanosine of the tetrahymena group I intron (2002)

Kitamura, A., Muto, Y., Watanabe, S., Kim, I., Ito, T., Nishiya, Y., ...

Chiral dynamics and pion-nucleon scattering around the N*(1535) resonance (2001)

Inoue, T., Nacher, J. C., Vacas, M. J. Vicente, Oset, E.

We study the S-wave interaction of mesons with baryons in the strangeness S=0 sector in a coupled channel unitary approach. The basic dynamics is drawn from the lowest order meson baryon chiral...

Chiral unitary approach to S-wave meson baryon scattering in the strangeness S=0 sector (2001)

Inoue, T., Oset, E., Vacas, M. J. Vicente

We study the S-wave interaction of mesons with baryons in the strangeness S=0 sector in a coupled channel unitary approach. The basic dynamics is drawn from the lowest order meson baryon chiral...

Magnetic Properties of a Pressure-induced Superconductor UGe$_2$ (2001)

Tateiwa, N., Hanazono, K., Kobayashi, T. C., Amaya, K., Inoue, T., Kindo, K., ...

We performed the DC-magnetization and neutron scattering experiments under pressure {\it P} for a pressure-induced superconductor UGe$_2$. We found that the magnetic moment is enhanced at a...

Crystal structure of Escherichia coli ketopantoate reductase at 1.7 Å resolution and insight into the enzyme mechanism (2001)

Matak-Vincovic, D, Vinkovic, M, Saldanha, SA, Ashurst, JL, VonDelft, F, Inoue, T, ...

Polarization of impurity ion emission lines from the GAMMA 10 tandem mirror plasma (2001)

Inoue, T, Nakai, M, Tanaka, A, Kawakami, K, Iwamae, A, Fujimoto, T, ...

Spatial inhomogeneity of photoluminescence in an InGaN-based light-emitting diode structure probed by near-field optical microscopy under illumination-collection mode (2001)

Kaneta, A, Izumi, T, Okamoto, K, Kawakami, Y, Fujita, S, Narita, Y, ...

Crystal structure of DNA polymerase from hyperthermophilic archaeon Pyrococcus kodakaraensis KOD1 (2001)

Hashimoto, H, Nishioka, M, Fujiwara, S, Takagi, M, Imanaka, T, Inoue, T, ...

Orally administered clonidine significantly reduces pain during injection of propofol{{dagger}} (2001)

Yoshikawa, T., Wajima, Z., Ogura, A., Inoue, T., Ogawa, R.

We examined the analgesic effects of orally administered clonidine on pain induced by injection of propofol (Diprivan; 2,6‐diisopropyl phenol). Female patients (n=81) were randomly...

Remote Sensing of Clouds and Precipitation from MSG Data (2000)

Wendling, P., Mannstein, H., Kästner, M., Meerkötter, R., Mayer, B., Büll, R., ...

Nano bubbles on a hydrophobic surface in water observed by tapping-mode atomic force microscopy (2000)

Ishida, N, Inoue, T, Miyahara, M, Higashitani, K

Nano bubbles on a hydrophobic surface in water observed by tapping-mode atomic force microscopy (2000)

Ishida, N, Inoue, T, Miyahara, M, Higashitani, K

Crystallographic study of intein homing endonuclease II encoded in the archaeal DNA polymerase gene (2000)

Hashimoto, H, Takahashi, H, Nishioka, M, Fujiwara, S, Takagi, M, Imanaka, T, ...

Insulin resistance affects endothelium-dependent acetylcholine-induced coronary artery response (2000)

Inoue, T, Matsunaga, R, Sakai, Y, Yaguchi, I, Takayanagi, K, Morooka, S

Aims This study was designed to investigate the relationship between insulin resistance and the acetylcholine-induced endothelium-dependent coronary artery response in patients without...

Epithelial--mesenchymal transformation of renal tubular epithelial cells in vitro and in vivo (2000)

Okada, H., Inoue, T., Suzuki, H., Strutz, F., Neilson, E. G.

Advanced Envelopes - Methodology Evaluation and Design Tools (2000)

Baker, P., Grace, M., Inoue, T.

Weak Decay of $\Lambda$ in Nuclei : Quarks vs Mesons (1999)

Sasaki, K., Inoue, T., Oka, M.

Decays of $\Lambda$ in nuclei, nonmesonic mode, are studied by using the $\Lambda N \to NN$ weak transition potential derived from the meson exchange mechanism and the direct quark mechanism. The...

Intrinsic Resistivity via Quantum Nucleation of Phase Slips in a One-Dimensional Josephson Junction Array (1999)

Inoue, T., Nishida, M., Kurihara, S.

The resistivity of a one-dimensional Josephson junction array at zero temperature is calculated by estimating the nucleation rate of quantum phase slips. We choose a certain collective coordinate...

Degradation Mechanism of SiC/Super Alpha 2 Composite Due to Interfacial Reaction (1999)

Ochiai, S., Inoue, T., Fujita, T., Hojo, M., Dudek, H.J., Leucht, R.

National average for the process of radiation therapy in Japan by Patterns of Care Study (1999)

Tanisada, K, Teshima, T, Inoue, T, Owen, JB, Hanks, GE, Abe, M, ...

Comparison of the concentrations of pentosidine in the synovial fluid, serum and urine of patients with rheumatoid arthritis and osteoarthritis (1999)

Chen, J. R., Takahashi, M., Suzuki, M., Kushida, K., Miyamoto, S., Inoue, T.

Objective.Pentosidine, an advanced glycation end product (AGE), has recently been observed to be elevated in rheumatoid arthritis (RA). The aim was to elucidate which pentosidine levels, i.e. in...

Daytime hypertension, sleep apnea and metabolic alkalosis in a haemodialysis patient - the result of sodium bicarbonate abuse (1999)

Okada, H, Inoue, T, Takahira, S, Sugahara, S, Nakamoto, H, Suzuki, H

Measurement of matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases-1 (TIMP-1) in patients with knee osteoarthritis: comparison with generalized osteoarthritis (1999)

Naito, K, Takahashi, M, Kushida, K, Suzuki, M, Ohishi, T, Miura, M, ...

Trans-activation of the Tetrahymena group I intron ribozyme via a non- native RNA-RNA interaction (1999)

Ikawa, Y, Shiraishi, H, Inoue, T

A conserved motif in group IC3 introns is a new class of GNRA receptor (1999)

Ikawa, Y, Naito, D, Aono, N, Shiraishi, H, Inoue, T

Roles of Quarks in Strong and Weak YN Interactions (1998)

Oka, M., Tani, Y., Inoue, T., Sasaki, K.

The short range parts of the strong and weak hyperon-nucleon interactions are studied with quark substructure of the baryons taken into account. A summary of the quark cluster model calculations of...

Development of High-Strength Hot-Rolled Sheet Steel Containing Retained Austenite With Extra-High Ductility. (1998)

Tsukatani, I., Hashimoto, S., Inoue, T.

By utilizing transformation-induced plasticity of retained austenite in 0.2% carbon steels, an 80 Kgf/mm(2) grade high strength hot rolled sheet has been developed. The maximum volume fraction of...

Reactive compatibilization of A/(B/C) polymer blends - Part 3. Quantitative analysis of the interfacial thickness and the interfacial reaction (1998)

Inoue, T

The interfacial thickness in reactively compatibilized polymer blends is analysed with ellipsometry for the blend system polyamide 12/(polystyrene/poly(styrene-co-maleic anhydride)) PA-12/(PS/SMA2)...

The effects of menopausal status and disease activity on biochemical markers of bone metabolism in female patients with rheumatoid arthritis (1998)

Suzuki, M, Takahashi, M, Miyamoto, S, Hoshino, H, Kushida, K, Miura, M, ...

P5abc of the Tetrahymena ribozyme consists of three functionally independent elements (1998)

Naito, Y., Shiraishi, H., Inoue, T.

Membrane-bound carboxypeptidase-M is expressed on human ovarian follicles and corpora lutea of menstrual cycle and early pregnancy (1998)

Yoshioka, S, Fujiwara, H, Yamada, S, Nakayama, T, Higuchi, T, Inoue, T, ...

Patterns of care study of radiation therapy for esophageal cancer in Japan: influence of the stratification of institution on the process (1998)

Teshima, T, Abe, M, Ikeda, H, Hanks, GE, Owen, JB, Hiraoka, M, ...

Testing for the programming circuit of LUT-based FPGAs (1997)

Michinishi, H., Yokohira, T., Okamoto, T., Inoue, T., Fujiwara, H.

The programming circuit of look-up table based FPGAs consists of two shift registers, a control circuit and a configuration memory (SRAM) cell array. Because the configuration memory cell array can...

Non-mesonic Weak Decays of Light Hypernuclei in the Direct Quark and the One-Pion Exchange Mechanisms (1997)

Inoue, T., Oka, M., Motoba, T., Itonaga, K.

Contributions of the direct quark mechanism are studied in the nonmesonic weak decays of light hypernuclei. The $\Lambda N \to NN$ transition is described by the one pion exchange mechanism and the...

Amelioration of systemic autoimmune disease by the stimulation of apoptosis-promoting receptor Fas with anti-Fas mAb (1997)

Nishimura-Morita, Y, Nose, M, Inoue, T, Yonehara, S

Relationship between pentosidine levels in serum and urine and activity in rheumatoid arthritis (1997)

Takahashi, M, Suzuki, M, Kushida, K, Miyamoto, S, Inoue, T

In vivo analysis of Fas antigen-mediated apoptosis: effects of agonistic anti-mouse Fas mAb on thymus, spleen and liver (1997)

Nishimura, Y, Hirabayashi, Y, Matsuzaki, Y, Musette, P, Ishii, A, Nakauchi, H, ...

Continuous brachial plexus infusion of butorphanol-mepivacaine mixtures for analgesia after upper extremity surgery (1997)

Wajima, Z., Shitara, T., Nakajima, Y., Kim, C., Kobayashi, N., Kadotani, H., ...

Photoreactivation of UV-induced damage to embryos of a planktonic copepod (1997)

Naganuma, T., Inoue, T., Uye, S.

UV irradiation damaged the embryos of the planktonic copepod Calanus sinicus. The hatching rate was reduced, and the hatched larvae were deformed by the UV irradiation at unweighted intensities...

Enhanced gene expression of scavenger receptor in peripheral blood monocytes from patients on cuprophane haemodialysis (1997)

Konishi, Y, Okamura, M, Konishi, M, Negoro, N, Yoshida, T, Inoue, T, ...

Long-range interaction between the P2.1 and P9.1 peripheral domains of the Tetrahymena ribozyme (1997)

Ikawa, Y, Ohta, H, Shiraishi, H, Inoue, T

Influence of multi wafer annealing of LEC GaAs substrates on the quality of epitaxial layers (1996)

Forker, J., Baeumler, M., Weyher, J.L., Jantz, W., Bernklau, D., Riechert, H., ...

The lateral distribution of dislocations and nonradiative recombination centers in buik LEC GaAs is reproduced in the epilayer. Combined ingot/multi wafer annealing reduces the excess As...

Fluorescence detection of specific sequence of nucleic acids by oxazole yellow-linked oligonucleotides. Homogeneous quantitative monitoring of in vitro transcription (1996)

Ishiguro, T, Saitoh, J, Yawata, H, Otsuka, M, Inoue, T, Sugiura, Y

An RNA fragment consisting of the P7 and P9.0 stems and the 3'-terminal guanosine of the Tetrahymena group I intron (1996)

Watanabe, S, Kawai, G, Muto, Y, Watanabe, K, Inoue, T, Yokoyama, S

A unique origin and multistep process for the generation of expanded DRPLA triplet repeats (1996)

Yanagisawa, H, Fujii, K, Nagafuchi, S, Nakahori, Y, Nakagome, Y, Akane, A, ...

$K \to 2 \pi$ Decay in the Nambu-Jona-Lasinio Model (1995)

Takizawa, M., Inoue, T., Oka, M.

We study the $K \to 2 \pi$ decays using the $U_L(3) \times U_R(3)$ version of the Nambu-Jona-Lasinio model with the effective $\Delta S = 1$ nonleptonic weak interaction. The $\Delta I = {3/2}$...

Receiver Operating Characteristic Analysis of Urinary Pyridinium Cross-links in Arthritis (1995)

TAKAHASHI, M., KUSHIDA, K., INOUE, T.

Comparison of continuous brachial plexus infusion of butorphanol, mepivacaine and mepivacaine-butorphanol mixtures for postoperative analgesia (1995)

Wajima, Z., Shitara, T., Nakajima, Y., Kim, C., Kobayashi, N., Kadotani, H., ...

I.v. compared with brachial plexus infusion of butorphanol for postoperative analgesia (1995)

WAJIMA, Z., NAKAJIMA, Y., KIM, C., KOBAYASHI, N., KADOTANI, H., ADACHI, H., ...

In a randomized, double-blind, controlled study, we have compared two groups of patients receiving either continuous systemic i.v. or continuous brachial plexus infusion of butorphanol for an algesia...

Implantation: Tumour necrosis factor {alpha} inhibits in-vitro decidualization of human endometrial stromal cells (1994)

Inoue, T., Kanzaki, H., Iwai, M., Imai, K., Narukawa, S., Higuchi, T., ...

Interleukin-1 (IL-1) has been reported previously to inhibit the in-vitro decidualization of human endometrial stromal cells as assessed by progesterone-induced prolactin production and morphological...

Wide-Wavelength-Tunable Active Filter with a Lambda/4-Shifted Distributed Feedback Structure with Independently Current-Injected Tuning Waveguide, (1992)

Tanaka, K., Inoue, T., Matsuda, M., Yamamoto, T., Kobayashi, H., Wakao, K.

Wavelength division multiplexing of optical signals has attracted increasing interest in fiber communication and photonic switching systems for the large amount of signals that can be processed....

Isolation and characterization of a restriction enzyme BspO41 from an alkalophilic bacterium (1992)

Moriya, S., Yanagawa, S., Aoki, N., Iwabuchi, M., Inoue, T., Ando, T.

Polymerase chain reaction (PCR) for detection of APal polymorphism at the insulin like growth factor II gene (IGF2) (1991)

Tadokoro, K., Fujii, H., Inoue, T., Yamada, M.

Effect of Hot Rolling Condition on Texture of Cold Rolled and Annealed Ultra-Low-Carbon Steel Sheet (1991)

S. Hashimoto, T. Kashima, T. Inoue

A novel technique for the rapid preparation of mutant RNAs (1989)

Joyce, GF, Inoue, T

DIRECT SUPPORT BY SPOT WELDING AND CHEMICAL ETCHING OF COMPOUND SEMICONDUCTOR WHISKER (1987)

Inoue, T., Nakada, M.

When electron and ion beams of angstrom order using fine emitter tips with small radius can be obtained easily, we have some merits in the field of the electron microscope with high resolution, the...

DIRECT SUPPORT BY SPOT WELDING AND CHEMICAL ETCHING OF COMPOUND SEMICONDUCTOR WHISKER (1987)

Inoue, T., Nakada, M.

When electron and ion beams of angstrom order using fine emitter tips with small radius can be obtained easily, we have some merits in the field of the electron microscope with high resolution, the...

DIRECT SUPPORT BY SPOT WELDING AND CHEMICAL ETCHING OF COMPOUND SEMICONDUCTOR WHISKER (1987)

Inoue, T., Nakada, M.

When electron and ion beams of angstrom order using fine emitter tips with small radius can be obtained easily, we have some merits in the field of the electron microscope with high resolution, the...

LATTICE MODES IN 1,3,5-TRICHLOROBENZENE. (1969)

Muller, D. E., Inoue, T., Larkin, Robert H., Stidham, Howard D.

Author Institution: Department of Chemistry, University of Massachusetts

Surface climate information from GMS-5 data

Okada, I., Kawamoto, Kazuaki, 井上, 豊志郎, Inoue, T., 高村, 民雄, Takamura, T., ...

Surface climate information from GMS-5 data

Okada, I., Kawamoto, Kazuaki, 井上, 豊志郎, Inoue, T., 高村, 民雄, Takamura, T., ...

Cloning, expression, and characterization of cDNAs encoding Arabidopsis thaliana squalene synthase.

Nakashima, T, Inoue, T, Oka, A, Nishino, T, Osumi, T, Hata, S

We have isolated and characterized two overlapping cDNA clones for Arabidopsis thaliana squalene synthase. Their nucleotide sequences contained an open reading frame for a 410-amino acid polypeptide...

Hemopoietic stem-cell compartment of the SCID mouse: double-exponential survival curve after gamma irradiation.

Taniguchi, S, Hirabayashi, Y, Inoue, T, Kanisawa, M, Sasaki, H, Komatsu, K, ...

It has been reported that SCID (severe combined immunodeficiency, scid/scid) mice are more radiosensitive than normal mice. In the present studies, graded doses of radiation were given to bone marrow...

A region of group I introns that contains universally conserved residues but is not essential for self-splicing.

Williams, K P, Fujimoto, D N, Inoue, T

The catalytic core of the self-splicing group I intron RNAs is composed of six paired regions together with their connecting sequences; these are thought to form two elongated domains, with paired...

Reconstitution of a group I intron self-splicing reaction with an activator RNA.

Christian, A, Inoue, T

The self-splicing rRNA intron of Tetrahymena thermophila belongs to a subgroup of group I introns that contain a conserved extra stem-loop structure termed P5abc. A Tetrahymena mutant precursor RNA...

An RNA fragment consisting of the P7 and P9.0 stems and the 3'-terminal guanosine of the Tetrahymena group I intron.

Watanabe, S, Kawai, G, Muto, Y, Watanabe, K, Inoue, T, Yokoyama, S

On the basis of the nucleotide sequence of Tetrahymena group I intron, we constructed a 31 residue RNA that has the P7 stem and the 3'-terminal guanosine residue (3'-G) with a putative stem-loop...

Fluorescence detection of specific sequence of nucleic acids by oxazole yellow-linked oligonucleotides. Homogeneous quantitative monitoring of in vitro transcription.

Ishiguro, T, Saitoh, J, Yawata, H, Otsuka, M, Inoue, T, Sugiura, Y

We have developed a fluorescent DNA probe, oxazole yellow (YO)-linked oligonucleotide complementary to a target DNA/RNA, which can enhance the fluorescence on hybridizing with a target nucleotide. We...

Long-range interaction between the P2.1 and P9.1 peripheral domains of the Tetrahymena ribozyme.

Ikawa, Y, Ohta, H, Shiraishi, H, Inoue, T

The Tetrahymena ribozyme possesses peripheral domains, termed P9.1 and P9.2. They are nonessential in the mechanism of the catalytic reaction but contribute to enhance the catalytic activity of the...

Trans-activation of the Tetrahymena group I intron ribozyme via a non-native RNA-RNA interaction.

Ikawa, Y, Shiraishi, H, Inoue, T

The peripheral P2.1 domain of the Tetrahymena group I intron ribozyme has been shown to be non-essential for splicing. We found, however, that separately prepared P2.1 RNA efficiently accelerates the...

A conserved motif in group IC3 introns is a new class of GNRA receptor.

Ikawa, Y, Naito, D, Aono, N, Shiraishi, H, Inoue, T

Terminal tetraloops consisting of GNRA sequences are often found in biologically active large RNAs. The loops appear to contribute towards the organization of higher order RNA structures by forming...

In vitro bone marrow toxicity of nucleoside analogs against human immunodeficiency virus.

Inoue, T, Tsushita, K, Itoh, T, Ogura, M, Hotta, T, Saneyoshi, M, ...

3'-Azido-2',3'-dideoxythymidine is known to cause severe anemia and neutropenia. Although these are rare for 2',3'-dideoxycytidine, it frequently impairs thrombocytogenesis. These differential...

Application of a ribosomal DNA integration vector in the construction of a brewer's yeast having alpha-acetolactate decarboxylase activity.

Fujii, T, Kondo, K, Shimizu, F, Sone, H, Tanaka, J, Inoue, T

An integration plasmid, pIARL28, containing the ribosomal DNA gene as a homologous recombination sequence was constructed for introduction of the alpha-acetolactate decarboxylase gene into brewer's...

Nucleotide sequence and expression of the Enterobacter aerogenes alpha-acetolactate decarboxylase gene in brewer's yeast.

Sone, H, Fujii, T, Kondo, K, Shimizu, F, Tanaka, J, Inoue, T

The nucleotide sequence of a 1.4-kilobase DNA fragment containing the alpha-acetolactate decarboxylase gene of Enterobacter aerogenes was determined. The sequence contains an entire protein-coding...

Cloning and sequencing of the gene encoding the 72-kilodalton dehydrogenase subunit of alcohol dehydrogenase from Acetobacter aceti.

Inoue, T, Sunagawa, M, Mori, A, Imai, C, Fukuda, M, Takagi, M, ...

A genomic library of Acetobacter aceti DNA was constructed by using a broad-host-range cosmid vector. Complementation of a spontaneous alcohol dehydrogenase-deficient mutant resulted in the isolation...

Involvement of human papillomavirus type 20 in epidermodysplasia verruciformis skin carcinogenesis.

Yutsudo, M, Tanigaki, T, Kanda, R, Sasagawa, T, Inoue, T, Jing, P, ...

The involvement of human papillomavirus (HPV) in skin carcinogenesis in a patient with epidermodysplasia verruciformis was studied. This patient had disseminated pityriasis versicolor-like lesions,...

Potent aquaretic agent. A novel nonpeptide selective vasopressin 2 antagonist (OPC-31260) in men.

Ohnishi, A, Orita, Y, Okahara, R, Fujihara, H, Inoue, T, Yamamura, Y, ...

Solute-free water diuretics (aquaretics) by antagonizing hydrosmotic vasopressin receptors (V2) may be useful in treating water-retaining diseases. The effects of intravenous administration of a...

Expression and localization of human oxytocin receptor mRNA and its protein in chorion and decidua during parturition.

Takemura, M, Kimura, T, Nomura, S, Makino, Y, Inoue, T, Kikuchi, T, ...

Oxytocin (OT) is widely used to induce labor in the clinical setting. However, its physiological role in normal human parturition remains unclear. We demonstrated the enhanced expression of OT...

Nitric oxide mediates cytotoxicity and basic fibroblast growth factor release in cultured vascular smooth muscle cells. A possible mechanism of neovascularization in atherosclerotic plaques.

Fukuo, K, Inoue, T, Morimoto, S, Nakahashi, T, Yasuda, O, Kitano, S, ...

To define the pathophysiological role of nitric oxide (NO) released from vascular smooth muscle cells (VSMC), we examined whether NO released from VSMC induces cytotoxicity in VSMC themselves and...

A human GM-CSF receptor expressed in transgenic mice stimulates proliferation and differentiation of hemopoietic progenitors to all lineages in response to human GM-CSF.

Nishijima, I, Nakahata, T, Hirabayashi, Y, Inoue, T, Kurata, H, Miyajima, A, ...

Granulocyte-macrophage colony-stimulating factor (GM-CSF) mainly stimulates proliferation and maturation of myeloid progenitor cells. Although the signal transduction pathways triggered by GM-CSF...

Structure of the catalytic core of the Tetrahymena ribozyme as indicated by reactive abbreviated forms of the molecule.

Joyce, G F, Inoue, T

The precursor rRNA of Tetrahymena thermophila contains a group I intervening sequence (IVS) that catalyzes its own excision to yield mature rRNA. The excised IVS catalyzes a number of...

Selection of novel forms of a functional domain within the Tetrahymena ribozyme.

Williams, K P, Imahori, H, Fujimoto, D N, Inoue, T

P5abc is an RNA structure within the self-splicing Tetrahymena group I intron that provides an activation function to the remainder of the ribozyme, either when present in cis or when added in trans....

The complete nucleotide sequence of a pathogenic swine vesicular disease virus isolated in Japan (J1'73) and phylogenetic analysis.

Inoue, T, Yamaguchi, S, Kanno, T, Sugita, S, Saeki, T

Six-year survival of unoperated ventricular septal rupture following myocardial infarction.

Kamishirado, H, Inoue, T, Sakai, Y, Matsunaga, R, Morooka, S

We present the case of a patient who survived for 6 years without surgical repair of a ventricular septal rupture that followed an acute myocardial infarction. To the best of our knowledge, only 3...

Polymerase chain reaction (PCR) for detection of ApaI polymorphism at the insulin like growth factor II gene (IGF2)

Tadokoro, K., Fujii, H., Inoue, T., Yamada, M.

A novel technique for the rapid preparation of mutant RNAs.

Joyce, G F, Inoue, T

We have developed a novel in vitro mutagenesis technique that allows us to introduce mutations at the level of double-stranded DNA and then transcribe the mutant DNA directly. The technique is useful...

Isolation and characterization of a restriction enzyme BspO4I from an alkalophilic bacterium.

Moriya, S, Yanagawa, S, Aoki, N, Iwabuchi, M, Inoue, T, Ando, T

A restriction enzyme, BpuI is an isoschizomer of BanII.

Iwabuchi, M, Tajima, S, Inoue, T, Shibata, T, Ando, T

Catalytic activity is retained in the Tetrahymena group I intron despite removal of the large extension of element P5.

Joyce, G F, Inoue, T

We have made sizeable internal deletions within the self-splicing group I intron of Tetrahymena thermophila. Deletions were made in a piecewise manner in order to remove secondary structural elements...

Reactivity of modified ribose moieties of guanosine: new cleavage reactions mediated by the IVS of Tetrahymena precursor rRNA.

Kay, P S, Inoue, T

An RNA molecule consisting of the 5' exon and intervening sequence (IVS) of Tetrahymena precursor rRNA was oxidized with sodium periodate to convert the ribose moiety of the 3' terminal guanosine...

Further purification and characterization of heat-stable enterotoxin produced by Yersinia enterocolitica.

Okamoto, K, Inoue, T, Shimizu, K, Hara, S, Miyama, A

Heat-stable enterotoxin (ST) of Yersinia enterocolitica was produced under defined conditions. It was first detected in the culture supernatant of the late-logarithmic phase of growth and increased...

Partial purification and characterization of heat-stable enterotoxin produced by Yersinia enterocolitica.

Okamoto, K, Inoue, T, Ichikawa, H, Kawamoto, Y, Miyama, A

By using a suckling mouse assay, heat-stable enterotoxin (ST) was purified from the culture filtrate of Yersinia enterocolitica isolated from a diarrheal patient. The purification procedures involve...

Tissue-specific in vitro transcription from the mouse myelin basic protein promoter.

Tamura, T, Aoyama, A, Inoue, T, Miura, M, Okano, H, Mikoshiba, K

The mouse myelin basic protein promoter was transcribed in brain nuclear extracts. The distal promoter region from -253 to -54 directed preferential transcription in brain extracts, whereas the same...

Relationship between number of spleen colonies and 125IdUrd incorporation into spleen and femur.

Inoue, T, Bullis, J E, Cronkite, E P, Hübner, G E

Graded numbers of bone marrow (BM) cells were injected into fatally irradiated mice. Eight days later the mice were given 3.0 microCi (1 Ci = 3.7 X 10(10) Bq) of 125IdUrd to label proliferating cells...

Secondary structure of the circular form of the Tetrahymena rRNA intervening sequence: a technique for RNA structure analysis using chemical probes and reverse transcriptase.

Inoue, T, Cech, T R

The structure of the intervening sequence (IVS) of the Tetrahymena rRNA precursor mediates cleavage-ligation reactions that result in pre-rRNA splicing and IVS cyclization. We have developed a method...

Blood pressure regulates platelet-derived growth factor A-chain gene expression in vascular smooth muscle cells in vivo. An autocrine mechanism promoting hypertensive vascular hypertrophy.

Negoro, N, Kanayama, Y, Haraguchi, M, Umetani, N, Nishimura, M, Konishi, Y, ...

To clarify the role of PDGF A-chain in hypertensive vascular hypertrophy of spontaneously hypertensive rats (SHRs), we studied levels of PDGF A-chain gene expression and transcription factors related...

Two guanosine binding sites exist in group I self-splicing IVS RNAs.

Kay, P S, Menzel, P, Inoue, T

A shortened form of the self-splicing rRNA intervening sequence (IVS) of Tetrahymena thermophila can catalyze a transesterification reaction, termed G-exchange, between a monomeric guanosine...

Driven by the same Ig enhancer and SV40 T promoter ras induced lung adenomatous tumors, myc induced pre-B cell lymphomas and SV40 large T gene a variety of tumors in transgenic mice.

Suda, Y, Aizawa, S, Hirai, S, Inoue, T, Furuta, Y, Suzuki, M, ...

Different types of tumors developed in transgenic mice following the introduction of the entire coding region of ras, myc or SV40 large T gene (T) linked to the same regulatory unit, consisting of a...

1,2-alpha-D-mannosidase from Penicillium citrinum: molecular and enzymic properties of two isoenzymes.

Yoshida, T, Inoue, T, Ichishima, E

Two isoforms of acidic 1,2-alpha-D-mannosidases have been isolated from culture filtrate of Penicillium citrinum. The pI values of the two forms, designated 1,2-alpha-mannosidase Ia and Ib, were 4.6...

Ca2+-induced accumulation of pyrophosphate in mitochondria during acetate metabolism.

Inoue, T, Yamada, T, Furuya, E, Tagawa, K

The mechanism of pyrophosphate (PPi) accumulation in rat liver during acetate metabolism was investigated. Perfusion of the liver with acetate in the presence of noradrenaline and glucagon induced...

Expression of complement regulating factors in gastric cancer cells

Inoue, T, Yamakawa, M, Takahashi, T

Aims: To investigate the deposition of complement components, C3d and C5b–9, and the expression of complement regulating factors (S protein, membrane cofactor protein (MCP; CD46), protectin (CD59),...

Molecular and enzymic properties of recombinant 1, 2-alpha-mannosidase from Aspergillus saitoi overexpressed in Aspergillus oryzae cells.

Ichishima, E, Taya, N, Ikeguchi, M, Chiba, Y, Nakamura, M, Kawabata, C, ...

For the construction of an overexpression system of the intracellular 1,2-alpha-mannosidase (EC 3.2.1.113) gene (msdS) from Aspergillus saitoi (now designated Aspergillus phoenicis), the N-terminal...

Morphological behavior of acidic and neutral liposomes induced by basic amphiphilic alpha-helical peptides with systematically varied hydrophobic-hydrophilic balance.

Kitamura, A, Kiyota, T, Tomohiro, M, Umeda, A, Lee, S, Inoue, T, ...

Lipid-peptide interaction has been investigated using cationic amphiphilic alpha-helical peptides and systematically varying their hydrophobic-hydrophilic balance (HHB). The influence of the peptides...

Does pressure antagonize anesthesia? High-pressure stopped-flow study of firefly luciferase and anatomy of initial flash.

Ueda, I, Minami, H, Matsuki, H, Inoue, T

The antagonizing effect of high pressure against anesthesia is well known. With purified firefly luciferase, however,. Biophys. J. 60:1309-1314) reported that high pressure did not affect the initial...

P5abc of the Tetrahymena ribozyme consists of three functionally independent elements.

Naito, Y, Shiraishi, H, Inoue, T

P5abc domain of Tetrahymena LSU intron functions as an activator that is not essential for but enhances the activity of the ribozyme either when present in cis or when added in trans. This domain...

Route of nutritional supply influences local, systemic, and remote organ responses to intraperitoneal bacterial challenge.

Lin, M T, Saito, H, Fukushima, R, Inaba, T, Fukatsu, K, Inoue, T, ...

OBJECTIVE: The authors' aim was to investigate whether antecedent nutritional routes influence immune responses after surgical insult. SUMMARY BACKGROUND DATA: Total parenteral nutrition (TPN) may...

Is preoperative hepatic arterial chemoembolization safe and effective for hepatocellular carcinoma?

Harada, T, Matsuo, K, Inoue, T, Tamesue, S, Inoue, T, Nakamura, H

OBJECTIVE. The value of preoperative transcatheter arterial chemoembolization (TACE) for hepatocellular carcinoma (HCC) has not been duly appreciated. The authors assessed the advantages and...

Characteristics of neuro-effector transmission in the smooth muscle layer of dog bronchiole and modifications by autacoids.

Inoue, T, Ito, Y

Electrical and mechanical properties of smooth muscle cells and of neuro-effector transmission in the smooth muscle layer of the dog bronchiole (about 1 mm in diameter) were studied with...

Prostaglandin-induced inhibition of acetylcholine release from neuronal elements of dog tracheal tissue.

Inoue, T, Ito, Y, Takeda, K

In an attempt to elucidate the possible roles of endogenous prostaglandins on the neuro-effector transmission in the dog trachea, effects of a prostaglandin antagonist (1-acetyl-2-[8-chloro-10, 11-...

A review of toxicology studies on cyanurate and its chlorinated derivatives.

Hammond, B G, Barbee, S J, Inoue, T, Ishida, N, Levinskas, G J, Stevens, M W, ...

Chlorinated cyanurates are added to swimming pools as disinfectants. In the presence of water, these materials hydrolyze to yield cyanurate and hypochlorous acid. To evaluate the safety of exposure...

Genetic Analysis of the Roles of Daf-28 and Age-1 in Regulating Caenorhabditis Elegans Dauer Formation

Malone, E. A., Inoue, T., Thomas, J. H.

Based on environmental cues, the nervous system of Caenorhabditis elegans regulates formation of the dauer larva, an alternative larval form specialized for long-term survival under harsh conditions....

Suppressors of transforming growth factor-beta pathway mutants in the Caenorhabditis elegans dauer formation pathway.

Inoue, T, Thomas, J H

The dauer is a developmentally arrested alternative third larval stage of Caenorhabditis elegans. Entry into this state is regulated by environmental cues, including temperature, food, and the...

Hematotoxicity and carcinogenicity of inhaled benzene.

Cronkite, E P, Drew, R T, Inoue, T, Hirabayashi, Y, Bullis, J E

CBA/Ca male mice have been exposed to benzene in air at 10, 25, 100, 300, 400, and 3000 ppm for variable intervals 6 hr/day, 5 days/week for up to 16 weeks. Two weeks of inhaling 10 ppm produced no...

Factors necessary for successful replantation of upper extremities.

Inoue, T, Toyoshima, Y, Fukusumi, H, Uemichi, A, Inui, K, Harada, S, ...

Cloning, expression, and characterization of cDNAs encoding Arabidopsis thaliana squalene synthase.

Nakashima, T, Inoue, T, Oka, A, Nishino, T, Osumi, T, Hata, S

We have isolated and characterized two overlapping cDNA clones for Arabidopsis thaliana squalene synthase. Their nucleotide sequences contained an open reading frame for a 410-amino acid polypeptide...

Hemopoietic stem-cell compartment of the SCID mouse: double-exponential survival curve after gamma irradiation.

Taniguchi, S, Hirabayashi, Y, Inoue, T, Kanisawa, M, Sasaki, H, Komatsu, K, ...

It has been reported that SCID (severe combined immunodeficiency, scid/scid) mice are more radiosensitive than normal mice. In the present studies, graded doses of radiation were given to bone marrow...

A region of group I introns that contains universally conserved residues but is not essential for self-splicing.

Williams, K P, Fujimoto, D N, Inoue, T

The catalytic core of the self-splicing group I intron RNAs is composed of six paired regions together with their connecting sequences; these are thought to form two elongated domains, with paired...

Reconstitution of a group I intron self-splicing reaction with an activator RNA.

Christian, A, Inoue, T

The self-splicing rRNA intron of Tetrahymena thermophila belongs to a subgroup of group I introns that contain a conserved extra stem-loop structure termed P5abc. A Tetrahymena mutant precursor RNA...

An RNA fragment consisting of the P7 and P9.0 stems and the 3'-terminal guanosine of the Tetrahymena group I intron.

Watanabe, S, Kawai, G, Muto, Y, Watanabe, K, Inoue, T, Yokoyama, S

On the basis of the nucleotide sequence of Tetrahymena group I intron, we constructed a 31 residue RNA that has the P7 stem and the 3'-terminal guanosine residue (3'-G) with a putative stem-loop...

Fluorescence detection of specific sequence of nucleic acids by oxazole yellow-linked oligonucleotides. Homogeneous quantitative monitoring of in vitro transcription.

Ishiguro, T, Saitoh, J, Yawata, H, Otsuka, M, Inoue, T, Sugiura, Y

We have developed a fluorescent DNA probe, oxazole yellow (YO)-linked oligonucleotide complementary to a target DNA/RNA, which can enhance the fluorescence on hybridizing with a target nucleotide. We...

Long-range interaction between the P2.1 and P9.1 peripheral domains of the Tetrahymena ribozyme.

Ikawa, Y, Ohta, H, Shiraishi, H, Inoue, T

The Tetrahymena ribozyme possesses peripheral domains, termed P9.1 and P9.2. They are nonessential in the mechanism of the catalytic reaction but contribute to enhance the catalytic activity of the...

Trans-activation of the Tetrahymena group I intron ribozyme via a non-native RNA-RNA interaction.

Ikawa, Y, Shiraishi, H, Inoue, T

The peripheral P2.1 domain of the Tetrahymena group I intron ribozyme has been shown to be non-essential for splicing. We found, however, that separately prepared P2.1 RNA efficiently accelerates the...

A conserved motif in group IC3 introns is a new class of GNRA receptor.

Ikawa, Y, Naito, D, Aono, N, Shiraishi, H, Inoue, T

Terminal tetraloops consisting of GNRA sequences are often found in biologically active large RNAs. The loops appear to contribute towards the organization of higher order RNA structures by forming...

In vitro bone marrow toxicity of nucleoside analogs against human immunodeficiency virus.

Inoue, T, Tsushita, K, Itoh, T, Ogura, M, Hotta, T, Saneyoshi, M, ...

3'-Azido-2',3'-dideoxythymidine is known to cause severe anemia and neutropenia. Although these are rare for 2',3'-dideoxycytidine, it frequently impairs thrombocytogenesis. These differential...

Application of a ribosomal DNA integration vector in the construction of a brewer's yeast having alpha-acetolactate decarboxylase activity.

Fujii, T, Kondo, K, Shimizu, F, Sone, H, Tanaka, J, Inoue, T

An integration plasmid, pIARL28, containing the ribosomal DNA gene as a homologous recombination sequence was constructed for introduction of the alpha-acetolactate decarboxylase gene into brewer's...

Nucleotide sequence and expression of the Enterobacter aerogenes alpha-acetolactate decarboxylase gene in brewer's yeast.

Sone, H, Fujii, T, Kondo, K, Shimizu, F, Tanaka, J, Inoue, T

The nucleotide sequence of a 1.4-kilobase DNA fragment containing the alpha-acetolactate decarboxylase gene of Enterobacter aerogenes was determined. The sequence contains an entire protein-coding...

Cloning and sequencing of the gene encoding the 72-kilodalton dehydrogenase subunit of alcohol dehydrogenase from Acetobacter aceti.

Inoue, T, Sunagawa, M, Mori, A, Imai, C, Fukuda, M, Takagi, M, ...

A genomic library of Acetobacter aceti DNA was constructed by using a broad-host-range cosmid vector. Complementation of a spontaneous alcohol dehydrogenase-deficient mutant resulted in the isolation...

Involvement of human papillomavirus type 20 in epidermodysplasia verruciformis skin carcinogenesis.

Yutsudo, M, Tanigaki, T, Kanda, R, Sasagawa, T, Inoue, T, Jing, P, ...

The involvement of human papillomavirus (HPV) in skin carcinogenesis in a patient with epidermodysplasia verruciformis was studied. This patient had disseminated pityriasis versicolor-like lesions,...

Potent aquaretic agent. A novel nonpeptide selective vasopressin 2 antagonist (OPC-31260) in men.

Ohnishi, A, Orita, Y, Okahara, R, Fujihara, H, Inoue, T, Yamamura, Y, ...

Solute-free water diuretics (aquaretics) by antagonizing hydrosmotic vasopressin receptors (V2) may be useful in treating water-retaining diseases. The effects of intravenous administration of a...

Expression and localization of human oxytocin receptor mRNA and its protein in chorion and decidua during parturition.

Takemura, M, Kimura, T, Nomura, S, Makino, Y, Inoue, T, Kikuchi, T, ...

Oxytocin (OT) is widely used to induce labor in the clinical setting. However, its physiological role in normal human parturition remains unclear. We demonstrated the enhanced expression of OT...

Nitric oxide mediates cytotoxicity and basic fibroblast growth factor release in cultured vascular smooth muscle cells. A possible mechanism of neovascularization in atherosclerotic plaques.

Fukuo, K, Inoue, T, Morimoto, S, Nakahashi, T, Yasuda, O, Kitano, S, ...

To define the pathophysiological role of nitric oxide (NO) released from vascular smooth muscle cells (VSMC), we examined whether NO released from VSMC induces cytotoxicity in VSMC themselves and...

A human GM-CSF receptor expressed in transgenic mice stimulates proliferation and differentiation of hemopoietic progenitors to all lineages in response to human GM-CSF.

Nishijima, I, Nakahata, T, Hirabayashi, Y, Inoue, T, Kurata, H, Miyajima, A, ...

Granulocyte-macrophage colony-stimulating factor (GM-CSF) mainly stimulates proliferation and maturation of myeloid progenitor cells. Although the signal transduction pathways triggered by GM-CSF...

Structure of the catalytic core of the Tetrahymena ribozyme as indicated by reactive abbreviated forms of the molecule.

Joyce, G F, Inoue, T

The precursor rRNA of Tetrahymena thermophila contains a group I intervening sequence (IVS) that catalyzes its own excision to yield mature rRNA. The excised IVS catalyzes a number of...

Selection of novel forms of a functional domain within the Tetrahymena ribozyme.

Williams, K P, Imahori, H, Fujimoto, D N, Inoue, T

P5abc is an RNA structure within the self-splicing Tetrahymena group I intron that provides an activation function to the remainder of the ribozyme, either when present in cis or when added in trans....

The complete nucleotide sequence of a pathogenic swine vesicular disease virus isolated in Japan (J1'73) and phylogenetic analysis.

Inoue, T, Yamaguchi, S, Kanno, T, Sugita, S, Saeki, T

Six-year survival of unoperated ventricular septal rupture following myocardial infarction.

Kamishirado, H, Inoue, T, Sakai, Y, Matsunaga, R, Morooka, S

We present the case of a patient who survived for 6 years without surgical repair of a ventricular septal rupture that followed an acute myocardial infarction. To the best of our knowledge, only 3...

Polymerase chain reaction (PCR) for detection of ApaI polymorphism at the insulin like growth factor II gene (IGF2)

Tadokoro, K., Fujii, H., Inoue, T., Yamada, M.

A novel technique for the rapid preparation of mutant RNAs.

Joyce, G F, Inoue, T

We have developed a novel in vitro mutagenesis technique that allows us to introduce mutations at the level of double-stranded DNA and then transcribe the mutant DNA directly. The technique is useful...

Isolation and characterization of a restriction enzyme BspO4I from an alkalophilic bacterium.

Moriya, S, Yanagawa, S, Aoki, N, Iwabuchi, M, Inoue, T, Ando, T

A restriction enzyme, BpuI is an isoschizomer of BanII.

Iwabuchi, M, Tajima, S, Inoue, T, Shibata, T, Ando, T

Catalytic activity is retained in the Tetrahymena group I intron despite removal of the large extension of element P5.

Joyce, G F, Inoue, T

We have made sizeable internal deletions within the self-splicing group I intron of Tetrahymena thermophila. Deletions were made in a piecewise manner in order to remove secondary structural elements...

Reactivity of modified ribose moieties of guanosine: new cleavage reactions mediated by the IVS of Tetrahymena precursor rRNA.

Kay, P S, Inoue, T

An RNA molecule consisting of the 5' exon and intervening sequence (IVS) of Tetrahymena precursor rRNA was oxidized with sodium periodate to convert the ribose moiety of the 3' terminal guanosine...

Further purification and characterization of heat-stable enterotoxin produced by Yersinia enterocolitica.

Okamoto, K, Inoue, T, Shimizu, K, Hara, S, Miyama, A

Heat-stable enterotoxin (ST) of Yersinia enterocolitica was produced under defined conditions. It was first detected in the culture supernatant of the late-logarithmic phase of growth and increased...

Partial purification and characterization of heat-stable enterotoxin produced by Yersinia enterocolitica.

Okamoto, K, Inoue, T, Ichikawa, H, Kawamoto, Y, Miyama, A

By using a suckling mouse assay, heat-stable enterotoxin (ST) was purified from the culture filtrate of Yersinia enterocolitica isolated from a diarrheal patient. The purification procedures involve...

Tissue-specific in vitro transcription from the mouse myelin basic protein promoter.

Tamura, T, Aoyama, A, Inoue, T, Miura, M, Okano, H, Mikoshiba, K

The mouse myelin basic protein promoter was transcribed in brain nuclear extracts. The distal promoter region from -253 to -54 directed preferential transcription in brain extracts, whereas the same...

Relationship between number of spleen colonies and 125IdUrd incorporation into spleen and femur.

Inoue, T, Bullis, J E, Cronkite, E P, Hübner, G E

Graded numbers of bone marrow (BM) cells were injected into fatally irradiated mice. Eight days later the mice were given 3.0 microCi (1 Ci = 3.7 X 10(10) Bq) of 125IdUrd to label proliferating cells...

Secondary structure of the circular form of the Tetrahymena rRNA intervening sequence: a technique for RNA structure analysis using chemical probes and reverse transcriptase.

Inoue, T, Cech, T R

The structure of the intervening sequence (IVS) of the Tetrahymena rRNA precursor mediates cleavage-ligation reactions that result in pre-rRNA splicing and IVS cyclization. We have developed a method...

Blood pressure regulates platelet-derived growth factor A-chain gene expression in vascular smooth muscle cells in vivo. An autocrine mechanism promoting hypertensive vascular hypertrophy.

Negoro, N, Kanayama, Y, Haraguchi, M, Umetani, N, Nishimura, M, Konishi, Y, ...

To clarify the role of PDGF A-chain in hypertensive vascular hypertrophy of spontaneously hypertensive rats (SHRs), we studied levels of PDGF A-chain gene expression and transcription factors related...

Two guanosine binding sites exist in group I self-splicing IVS RNAs.

Kay, P S, Menzel, P, Inoue, T

A shortened form of the self-splicing rRNA intervening sequence (IVS) of Tetrahymena thermophila can catalyze a transesterification reaction, termed G-exchange, between a monomeric guanosine...

Driven by the same Ig enhancer and SV40 T promoter ras induced lung adenomatous tumors, myc induced pre-B cell lymphomas and SV40 large T gene a variety of tumors in transgenic mice.

Suda, Y, Aizawa, S, Hirai, S, Inoue, T, Furuta, Y, Suzuki, M, ...

Different types of tumors developed in transgenic mice following the introduction of the entire coding region of ras, myc or SV40 large T gene (T) linked to the same regulatory unit, consisting of a...

1,2-alpha-D-mannosidase from Penicillium citrinum: molecular and enzymic properties of two isoenzymes.

Yoshida, T, Inoue, T, Ichishima, E

Two isoforms of acidic 1,2-alpha-D-mannosidases have been isolated from culture filtrate of Penicillium citrinum. The pI values of the two forms, designated 1,2-alpha-mannosidase Ia and Ib, were 4.6...

Ca2+-induced accumulation of pyrophosphate in mitochondria during acetate metabolism.

Inoue, T, Yamada, T, Furuya, E, Tagawa, K

The mechanism of pyrophosphate (PPi) accumulation in rat liver during acetate metabolism was investigated. Perfusion of the liver with acetate in the presence of noradrenaline and glucagon induced...

Expression of complement regulating factors in gastric cancer cells

Inoue, T, Yamakawa, M, Takahashi, T

Aims: To investigate the deposition of complement components, C3d and C5b–9, and the expression of complement regulating factors (S protein, membrane cofactor protein (MCP; CD46), protectin (CD59),...

Characteristics of neuro-effector transmission in the smooth muscle layer of dog bronchiole and modifications by autacoids.

Inoue, T, Ito, Y

Electrical and mechanical properties of smooth muscle cells and of neuro-effector transmission in the smooth muscle layer of the dog bronchiole (about 1 mm in diameter) were studied with...

Prostaglandin-induced inhibition of acetylcholine release from neuronal elements of dog tracheal tissue.

Inoue, T, Ito, Y, Takeda, K

In an attempt to elucidate the possible roles of endogenous prostaglandins on the neuro-effector transmission in the dog trachea, effects of a prostaglandin antagonist (1-acetyl-2-[8-chloro-10, 11-...

Genetic Analysis of the Roles of Daf-28 and Age-1 in Regulating Caenorhabditis Elegans Dauer Formation

Malone, E. A., Inoue, T., Thomas, J. H.

Based on environmental cues, the nervous system of Caenorhabditis elegans regulates formation of the dauer larva, an alternative larval form specialized for long-term survival under harsh conditions....

Molecular and enzymic properties of recombinant 1, 2-alpha-mannosidase from Aspergillus saitoi overexpressed in Aspergillus oryzae cells.

Ichishima, E, Taya, N, Ikeguchi, M, Chiba, Y, Nakamura, M, Kawabata, C, ...

For the construction of an overexpression system of the intracellular 1,2-alpha-mannosidase (EC 3.2.1.113) gene (msdS) from Aspergillus saitoi (now designated Aspergillus phoenicis), the N-terminal...

Route of nutritional supply influences local, systemic, and remote organ responses to intraperitoneal bacterial challenge.

Lin, M T, Saito, H, Fukushima, R, Inaba, T, Fukatsu, K, Inoue, T, ...

OBJECTIVE: The authors' aim was to investigate whether antecedent nutritional routes influence immune responses after surgical insult. SUMMARY BACKGROUND DATA: Total parenteral nutrition (TPN) may...

Is preoperative hepatic arterial chemoembolization safe and effective for hepatocellular carcinoma?

Harada, T, Matsuo, K, Inoue, T, Tamesue, S, Inoue, T, Nakamura, H

OBJECTIVE. The value of preoperative transcatheter arterial chemoembolization (TACE) for hepatocellular carcinoma (HCC) has not been duly appreciated. The authors assessed the advantages and...

Morphological behavior of acidic and neutral liposomes induced by basic amphiphilic alpha-helical peptides with systematically varied hydrophobic-hydrophilic balance.

Kitamura, A, Kiyota, T, Tomohiro, M, Umeda, A, Lee, S, Inoue, T, ...

Lipid-peptide interaction has been investigated using cationic amphiphilic alpha-helical peptides and systematically varying their hydrophobic-hydrophilic balance (HHB). The influence of the peptides...

Does pressure antagonize anesthesia? High-pressure stopped-flow study of firefly luciferase and anatomy of initial flash.

Ueda, I, Minami, H, Matsuki, H, Inoue, T

The antagonizing effect of high pressure against anesthesia is well known. With purified firefly luciferase, however,. Biophys. J. 60:1309-1314) reported that high pressure did not affect the initial...

P5abc of the Tetrahymena ribozyme consists of three functionally independent elements.

Naito, Y, Shiraishi, H, Inoue, T

P5abc domain of Tetrahymena LSU intron functions as an activator that is not essential for but enhances the activity of the ribozyme either when present in cis or when added in trans. This domain...

Suppressors of transforming growth factor-beta pathway mutants in the Caenorhabditis elegans dauer formation pathway.

Inoue, T, Thomas, J H

The dauer is a developmentally arrested alternative third larval stage of Caenorhabditis elegans. Entry into this state is regulated by environmental cues, including temperature, food, and the...

A review of toxicology studies on cyanurate and its chlorinated derivatives.

Hammond, B G, Barbee, S J, Inoue, T, Ishida, N, Levinskas, G J, Stevens, M W, ...

Chlorinated cyanurates are added to swimming pools as disinfectants. In the presence of water, these materials hydrolyze to yield cyanurate and hypochlorous acid. To evaluate the safety of exposure...

Hematotoxicity and carcinogenicity of inhaled benzene.

Cronkite, E P, Drew, R T, Inoue, T, Hirabayashi, Y, Bullis, J E

CBA/Ca male mice have been exposed to benzene in air at 10, 25, 100, 300, 400, and 3000 ppm for variable intervals 6 hr/day, 5 days/week for up to 16 weeks. Two weeks of inhaling 10 ppm produced no...

Factors necessary for successful replantation of upper extremities.

Inoue, T, Toyoshima, Y, Fukusumi, H, Uemichi, A, Inui, K, Harada, S, ...

Surface climate information from GMS-5 data

Okada, I., Kawamoto, Kazuaki, 井上, 豊志郎, Inoue, T., 高村, 民雄, Takamura, T., ...

An increase in number of T-cell receptor gamma/delta-bearing T cells in athymic nude mice treated with complete Freund's adjuvants.

Yoshikai, Y, Matsuzaki, G, Inoue, T, Nomoto, K

It has been reported previously that environmental antigens such as intestinal microflora play an important role in an age-associated increase in number of T-cell receptor gamma/delta-bearing T...

Purification and characterization of decay-accelerating factor (DAF) from Raji cells.

Fujita, T, Shinkai, Y, Inoue, T, Tamura, N

Decay-accelerating factor (DAF), a membrane protein that regulates the complement system, was purified to homogeneity from lymphoblastoid (Raji) cells (DAF-R). It exhibited almost the same molecular...

Suppurative coxitis due to Salmonella typhimurium in systemic lupus erythematosus.

Shiota, K, Miki, F, Kanayama, Y, Kohno, M, Ohe, A, Takamatsu, K, ...

A 36-year-old woman with systemic lupus erythematosus (SLE) developed septicaemia and subsequently suppurative coxitis due to Salmonella typhimurium. Although systemic treatment with antibiotics...

Possible involvement of interferon alfa in the pathogenesis of fever in systemic lupus erythematosus.

Kanayama, Y, Kim, T, Inariba, H, Negoro, N, Okamura, M, Takeda, T, ...

Serum concentrations of interferon alfa, interleukin 1, and tumour necrosis factor alpha were measured in 25 untreated patients with systemic lupus erythematosus (SLE). A close correlation was found...

Significance of enzyme linked immunosorbent assay (ELISA) for antibodies to double stranded and single stranded DNA in patients with lupus nephritis: correlation with severity of renal histology.

Okamura, M, Kanayama, Y, Amastu, K, Negoro, N, Kohda, S, Takeda, T, ...

The correlation between renal histology and class specific (IgG and IgM) antibodies to double stranded DNA (dsDNA) and single stranded DNA (ssDNA) was studied by enzyme linked immunosorbent assay...

Concentrations of pyridinoline and deoxypyridinoline in joint tissues from patients with osteoarthritis or rheumatoid arthritis.

Takahashi, M, Kushida, K, Hoshino, H, Suzuki, M, Sano, M, Miyamoto, S, ...

OBJECTIVE: To assess the usefulness of pyridinoline (Pyr) and deoxypyridinoline (Dpyr), intermolecular crosslinks of collagen, as markers in the evaluation of arthritis, by studying their...

Plant reproductive intervals and pollinators in the aseasonal tropics: a new model

Momose, K., Ishii, R., Sakai, S., Inoue, T.

What factors determine reproductive intervals and modes of pollination in plants of the aseasonal tropics? To answer this general question, we present a new explanation for some community patterns of...

Testing Between Competing Models of Business Cycles: The Efficient Long-Term Contract Hypothesis Versus the Intertemporal Substitution Hypothesis

H. Osano, T. Inoue

Postoperative thallium-201 myocardial images. Evidence of regression of right ventricular hypertrophy in man.

Yamazaki, H, Tsugu, T, Handa, S, Takagi, Y, Ohsuzu, F, Kondo, M, ...

Thallium-201 myocardial scintigraphic studies were performed on 24 patients with chronic right ventricular overload before and after surgical correction of haemodynamic overload. The ages of the...

Utility of Fungiflora Y stain in rapid diagnosis of Acanthamoeba keratitis

INOUE, T., ASARI, S., TAHARA, K., KIRITOSHI, A., INOUE, Y., SHIMOMURA, Y.

Immune responsiveness to inhaled antigens: local antibody production in the respiratory tract in health and lung diseases.

Yoshizawa, Y, Ohtani, Y, Inoue, T, Miyake, S, Ikeda, A, Tanba, M, ...

The pulmonary defence mechanism in summer type hypersensitivity pneumonitis induced by Trichosporon cutaneum was investigated. We have studied the antibody response to fungal antigens in sera and...

Autologous rosette forming cells in patients with renal diseases.

Kuramochi, T, Ohnuki, T, Inoue, T, Ishida, M

We studied the distribution of autologous rosette forming cells (ARFC) in the peripheral blood of 30 healthy adult donors, 30 patients with IgA nephropathy, 20 patients with primary glomerular...

Serum levels of interferons in patients with systemic lupus erythematosus.

Kim, T, Kanayama, Y, Negoro, N, Okamura, M, Takeda, T, Inoue, T

Serum levels of alpha (alpha) and gamma (gamma)-interferons (IFN) were measured in 30 patients with untreated systemic lupus erythematosus (SLE) with a solid-phase, sandwich immunoradiometric assay...

Delayed type hypersensitivity (DTH) skin reaction to hepatitis B surface antigen (HBsAg) in patients with type B acute and chronic hepatitis.

Nagafuchi, S, Kashiwagi, S, Hayashi, S, Inoue, T, Imayama, S, Takeshita, M, ...

Skin reactivity to HBsAg was studied in patients with type B acute and chronic hepatitis and in healthy controls. HBsAg preparations containing 50 micrograms/ml of antigen both with and without alum...

In vivo demonstration of T lymphocyte migration and amelioration of ileitis in intestinal mucosa of SAMP1/Yit mice by the inhibition of MAdCAM-1

Matsuzaki, K, Tsuzuki, Y, Matsunaga, H, Inoue, T, Miyazaki, J, Hokari, R, ...

The aetiology of Crohn's disease (CD) remains unknown. Since SAMP1/Yit mice have been reported to develop CD-like spontaneous enteric inflammation, such mice have been studied as an animal model of...

Sodium butyrate blocks interferon-gamma (IFN-γ)-induced biosynthesis of MHC class III gene products (complement C4 and factor B) in human fetal intestinal epithelial cells

Kitamura, K, Andoh, A, Inoue, T, Amakata, Y, Hodohara, K, Fujiyama, Y, ...

Human intestinal epithelial cells have been established as local sites for complement biosynthesis. In this study, we investigated the effects of IFN-γ and sodium butyrate on biosynthesis of MHC...

Black oesophagus—cause?

Sako, A, Kitayama, J, Inoue, T, Kaizaki, S, Nagawa, H, Suzuki, H

Pre- and post-junctional actions of prostaglandin I2, carbocyclic thromboxane A2 and leukotriene C4 in dog tracheal tissue.

Inoue, T., Ito, Y.

Effects of carbocyclic thromboxane A2 (cTxA2), prostacyclin (PGI2) or leukotriene C4 (LTC4) on the membrane and contractile properties of the smooth muscle cells and on the excitatory neuro-effector...

The effects of 2-nicotinamidoethyl nitrate on smooth muscle cells of the dog mesenteric artery and trachea.

Inoue, T., Ito, Y., Takeda, K.

The effects of 2-nicotinamidoethyl nitrate (nicorandil; 2-NN), a synthesized coronary vasodilator, on smooth muscle cells of dog mesenteric artery or trachea were investigated using microelectrode,...

Bilateral internal carotid artery agenesis.

Sunada, I, Inoue, T

Developmental pattern of 3-oxo-Δ4 bile acids in neonatal bile acid metabolism

Inoue, T., Kimura, A., Aoki, K., Tohma, M., Kato, H.

AIMS—To investigate whether a fetal pathway of bile acid synthesis persists in neonates and infants.
METHODS—3-oxo-Δ4 bile acids were determined qualitatively and quantitatively in the urine,...

Protein crystallization in a 100 nl solution with new stirring equipment

Maki, S., Murai, R., Yoshikawa, H. Y., Kitatani, T., Nakata, S., Kawahara, H., ...

To investigate quantitatively the effects of stirring on protein crystallization, a new stirring system which can agitate a protein solution, ∼100 nl, by providing Hagen–Poiseuille flow has...

Citrullinated fibrinogen detected as a soluble citrullinated autoantigen in rheumatoid arthritis synovial fluids

Takizawa, Y, Suzuki, A, Sawada, T, Ohsaka, M, Inoue, T, Yamada, R, ...

Urinary pyridinoline and deoxypyridinoline in prostate carcinoma patients with bone metastasis.

Sano, M., Kushida, K., Takahashi, M., Ohishi, T., Kawana, K., Okada, M., ...

Bone metastases from prostate carcinoma are predominantly osteoblastic. Recently, urinary pyridinoline (Pyr) and deoxypyridinoline (Dpyr) have been employed as indicators of bone resorption. In this...

Establishment of two new scirrhous gastric cancer cell lines: analysis of factors associated with disseminated metastasis.

Yashiro, M., Chung, Y. S., Nishimura, S., Inoue, T., Sowa, M.

Determination of the differences between cell lines which are derived from a primary tumour and a disseminated metastatic lesion from the same patient may aid in elucidating the factors associated...

Serum hepatocyte growth factor as an index of disease status of patients with colorectal carcinoma.

Fukuura, T., Miki, C., Inoue, T., Matsumoto, K., Suzuki, H.

To evaluate the clinical significance of serum levels of hepatocyte growth factor (HGF) in colorectal cancer patients, we measured the venous and portal concentrations of HGF in 60 patients. The...

Role of alpha 2 beta 1- and alpha 3 beta 1-integrin in the peritoneal implantation of scirrhous gastric carcinoma.

Nishimura, S., Chung, Y. S., Yashiro, M., Inoue, T., Sowa, M.

We established a highly peritoneal-seeding cell line, OCUM-2MD3, from a poorly peritoneal-seeding cell line, OCUM-2M, of human scirrhous gastric carcinoma. The intraperitoneal inoculation of...

Comparison of radiobiological effective depths in 65-MeV modulated proton beams.

Tang, J. T., Inoue, T., Inoue, T., Yamazaki, H., Fukushima, S., Fournier-Bidoz, N., ...

To assess the achievement of uniformity of radiobiological effectiveness at different depths in the proton spread-out Bragg peak (SOBP), Chinese hamster ovary (CHO) cells were exposed to 65-MeV...

Glutathione-doxorubicin conjugate expresses potent cytotoxicity by suppression of glutathione S-transferase activity: comparison between doxorubicin-sensitive and -resistant rat hepatoma cells.

Asakura, T., Ohkawa, K., Takahashi, N., Takada, K., Inoue, T., Yokoyama, S.

The cytotoxic mechanism of a conjugate of doxorubicin (DXR) and glutathione (GSH) via glutaraldehyde (GSH-DXR) was investigated using DXR-sensitive (AH66P) and -resistant (AH66DR) rat hepatoma cells....

The role of p16-cyclin D/CDK-pRb pathway in the tumorigenesis of endometrioid-type endometrial carcinoma

Tsuda, H, Yamamoto, K, Inoue, T, Uchiyama, I, Umesaki, N

We analysed p16 gene alteration and p16, cyclin-dependent kinase 4 (CDK4), CDK6, cyclin D1, cyclin D2, cyclin D3 and retinoblastoma protein (pRb) expression in ten normal endometriums (PE), 18...

Progesterone receptor isoforms A and B in human epithelial ovarian carcinoma: immunohistochemical and RT-PCR studies

Akahira, J, Inoue, T, Suzuki, T, Ito, K, Konno, R, Sato, S, ...

Human epithelial ovarian carcinoma is well-known as a sex steroid-dependent neoplasm, but the possible biological significance of progesterone receptor (PR) in this cancer remains controversial....

Down-regulation of Lsm1 is involved in human prostate cancer progression

Takahashi, S, Suzuki, S, Inaguma, S, Cho, Y-M, Ikeda, Y, Hayashi, N, ...

Elucidation of genetic alterations is an approach to understanding the underlying molecular mechanisms of progression of human prostate cancers. We have searched for genes differentially expressed in...