Precipitation of Cu in Fe-Cu alloys by high-speed deformation (2003)
Ishizaki, T, Yoshiie, T, Sato, K, Yanagita, S, Xu, Q, Komatsu, M, ...
Kiyotani, K., Yamazaki, H., Fujieda, M., Iwano, S., Matsumura, K., Satarug, S., ...
One of seven poor metabolizers of coumarin found in Thai subjects was previously genotyped as heterozygote for the CYP2A6*4 (whole deletion) and CYP2A6*9. Thus, we aimed to investigate the...
Cefotiam disposition in markedly obese athlete patients, Japanese sumo wrestlers.
Chiba, K, Tsuchiya, M, Kato, J, Ochi, K, Kawa, Z, Ishizaki, T
Markedly obese athletes like Japanese sumo wrestlers may frequently suffer various traumas which result in the prophylaxis or treatment of posttraumatic infection with antibiotics. However,...
Katahira, J, Ishizaki, T, Sakai, H, Adachi, A, Yamamoto, K, Shida, H
The viral transactivator proteins Rex and Rev are necessary for the expression of structural proteins of human T-cell leukemia virus type I and human immunodeficiency virus type 1, respectively....
Nucleotide sequence of the gene for cholesterol oxidase from a Streptomyces sp.
Ishizaki, T, Hirayama, N, Shinkawa, H, Nimi, O, Murooka, Y
The nucleotide sequence of a 2.1-kilobase-pair fragment containing the Streptomyces choA gene, which codes a secreted cholesterol oxidase, was determined. A single open reading frame encodes a mature...
Horii, M, Ishizaki, T, Paik, S Y, Manome, T, Murooka, Y
The nucleotide sequence of the promoter region of the gene for cholesterol oxidase (choA) from Streptomyces sp. strain SA-COO was determined. We found an open reading frame (choP) that is located...
Murooka, Y, Ishizaki, T, Nimi, O, Maekawa, N
The cholesterol oxidase gene (cho) of Streptomyces sp. was cloned into Streptomyces lividans with the vector pIJ702. Deletion analysis of the recombinant plasmid showed that entire coding sequence of...
Goto, M, Sugiyama, M, Ishizaki, T
The pharmacokinetics of dibekacin, a new aminoglycoside antibiotic, was studied in volunteers given the same dose (100 mg) intramuscularly on two separate occasions and intravenously at two different...
Ishizaki, T, Maekawa, M, Fujisawa, K, Okawa, K, Iwamatsu, A, Fujita, A, ...
The small GTP-binding protein Rho functions as a molecular switch in the formation of focal adhesions and stress fibers, cytokinesis and transcriptional activation. The biochemical mechanism...
Watanabe, N, Madaule, P, Reid, T, Ishizaki, T, Watanabe, G, Kakizuka, A, ...
Rho small GTPase regulates cell morphology, adhesion and cytokinesis through the actin cytoskeleton. We have identified a protein, p140mDia, as a downstream effector of Rho. It is a mammalian homolog...
p160ROCK mediates RhoA activation of Na-H exchange.
Tominaga, T, Ishizaki, T, Narumiya, S, Barber, D L
The ubiquitously expressed Na-H exchanger, NHE1, acts downstream of RhoA in a pathway regulating focal adhesion and actin stress fiber formation. p160ROCK, a serine/threonine protein kinase, is a...
Fujita, A, Saito, Y, Ishizaki, T, Maekawa, M, Fujisawa, K, Ushikubi, F, ...
p160(ROCK) is a protein serine/threonine kinase that binds to GTP-Rho and is activated by this binding. We have recently found that the expression of p160(ROCK) induces focal adhesions and stress...
Cefotiam disposition in markedly obese athlete patients, Japanese sumo wrestlers.
Chiba, K, Tsuchiya, M, Kato, J, Ochi, K, Kawa, Z, Ishizaki, T
Markedly obese athletes like Japanese sumo wrestlers may frequently suffer various traumas which result in the prophylaxis or treatment of posttraumatic infection with antibiotics. However,...
Katahira, J, Ishizaki, T, Sakai, H, Adachi, A, Yamamoto, K, Shida, H
The viral transactivator proteins Rex and Rev are necessary for the expression of structural proteins of human T-cell leukemia virus type I and human immunodeficiency virus type 1, respectively....
Nucleotide sequence of the gene for cholesterol oxidase from a Streptomyces sp.
Ishizaki, T, Hirayama, N, Shinkawa, H, Nimi, O, Murooka, Y
The nucleotide sequence of a 2.1-kilobase-pair fragment containing the Streptomyces choA gene, which codes a secreted cholesterol oxidase, was determined. A single open reading frame encodes a mature...
Horii, M, Ishizaki, T, Paik, S Y, Manome, T, Murooka, Y
The nucleotide sequence of the promoter region of the gene for cholesterol oxidase (choA) from Streptomyces sp. strain SA-COO was determined. We found an open reading frame (choP) that is located...
Murooka, Y, Ishizaki, T, Nimi, O, Maekawa, N
The cholesterol oxidase gene (cho) of Streptomyces sp. was cloned into Streptomyces lividans with the vector pIJ702. Deletion analysis of the recombinant plasmid showed that entire coding sequence of...
Goto, M, Sugiyama, M, Ishizaki, T
The pharmacokinetics of dibekacin, a new aminoglycoside antibiotic, was studied in volunteers given the same dose (100 mg) intramuscularly on two separate occasions and intravenously at two different...
Ishizaki, T, Maekawa, M, Fujisawa, K, Okawa, K, Iwamatsu, A, Fujita, A, ...
The small GTP-binding protein Rho functions as a molecular switch in the formation of focal adhesions and stress fibers, cytokinesis and transcriptional activation. The biochemical mechanism...
Watanabe, N, Madaule, P, Reid, T, Ishizaki, T, Watanabe, G, Kakizuka, A, ...
Rho small GTPase regulates cell morphology, adhesion and cytokinesis through the actin cytoskeleton. We have identified a protein, p140mDia, as a downstream effector of Rho. It is a mammalian homolog...
p160ROCK mediates RhoA activation of Na-H exchange.
Tominaga, T, Ishizaki, T, Narumiya, S, Barber, D L
The ubiquitously expressed Na-H exchanger, NHE1, acts downstream of RhoA in a pathway regulating focal adhesion and actin stress fiber formation. p160ROCK, a serine/threonine protein kinase, is a...
Fujita, A, Saito, Y, Ishizaki, T, Maekawa, M, Fujisawa, K, Ushikubi, F, ...
p160(ROCK) is a protein serine/threonine kinase that binds to GTP-Rho and is activated by this binding. We have recently found that the expression of p160(ROCK) induces focal adhesions and stress...
Echizen, H, Minegishi, A, Hayashi, S, Umeda, N, Oda, T, Ishizaki, T
We measured the plasma concentration of a centrally derived noradrenaline (NA) metabolite, 3-methoxy-4-hydroxyphenylethyleneglycol (MHPG), in 20 cirrhotic patients (eight with (group A) and 12...
Chiba, K, Saitoh, A, Koyama, E, Tani, M, Hayashi, M, Ishizaki, T
1. The metabolism of imipramine (N-demethylation and 2-hydroxylation) was studied in relation to the activity of S-mephenytoin 4'-hydroxylase in human liver microsomes. 2. Eadie-Hofstee plots for the...
Setiabudy, R, Kusaka, M, Chiba, K, Darmansjah, I, Ishizaki, T
1. The metabolism of proguanil (PG) was studied by measuring PG, cycloguanil (CG) and 4-chlorophenylbiguanide (CPB) in plasma and urine samples after an oral 200 mg dose of PG hydrochloride...
Yoshimoto, K, Echizen, H, Chiba, K, Tani, M, Ishizaki, T
1. Studies using human liver microsomes and six recombinant human CYP isoforms (i.e. CYP1A2, 2A6, 2B6, 2D6, 2E1 and 3A4) were performed to identify the cytochrome P450 (CYP) isoform(s) involved in...
Kobayashi, K, Yamamoto, T, Chiba, K, Tani, M, Ishizaki, T, Kuroiwa, Y
The inhibitory effects of four selective serotonin reuptake inhibitors (SSRIs), fluoxetine, sertraline, paroxetine and citalopram, and three metabolites (norfluoxetine, demethylcitalopram and...
Sohn, D R, Shin, S G, Park, C W, Kusaka, M, Chiba, K, Ishizaki, T
We examined metoprolol oxidation capacity in 218 unrelated, healthy Korean subjects using the 8 h urinary metabolic ratio (MR) of metoprolol to alpha-hydroxymetoprolol after an oral dose of 100 mg...
Horai, Y, Taga, J, Ishizaki, T, Ishikawa, K
The study was aimed at defining the relationships among the oxidative capacities for three prototype drugs, metoprolol, debrisoquine and sparteine, used for assessing genetically determined...
Echizen, H, Nakura, M, Saotome, T, Minoura, S, Ishizaki, T
1. The protein binding of disopyramide was measured in plasma obtained from nonpregnant women, pregnant women in the first, second, and third trimesters, matched pairs of mothers and neonates (cord...
Evidence for polymorphic oxidation of sparteine in Japanese subjects.
Ishizaki, T, Eichelbaum, M, Horai, Y, Hashimoto, K, Chiba, K, Dengler, H J
The metabolism of sparteine which exhibits a genetic polymorphism in Caucasians was studied in 84 unrelated Japanese subjects. In contrast to a recent study where debrisoquine was used as a probe and...
Ohnishi, A, Minegishi, A, Sasaki, T, Suganuma, T, Ishizaki, T
The time-course of plasma noradrenaline (NA) and adrenaline (A) concentrations and their dissipation profiles were examined concomitantly with heart rate changes after strenuous exercise in eight...
N-acetylation phenotyping with dapsone in a mainland Chinese population.
Horai, Y, Zhou, H H, Zhang, L M, Ishizaki, T
1 The N-acetylation of dapsone (DDS) was studied in 108 unrelated Chinese subjects residing in the mainland of China. 2 The frequency of slow acetylators determined using the plasma monoacetyldapsone...
Echizen, H, Saima, S, Ishizaki, T
1 Plasma protein binding of disopyramide was determined twice in plasma from seven patients with severe nephrotic syndrome when the disease activity was markedly different for each patient (mean +/-...
N-acetylation polymorphism of dapsone in a Japanese population.
1. The N-acetylation of dapsone (DDS) was studied in 182 unrelated healthy Japanese subjects. The frequency of slow acetylators determined using the plasma monoacetyldapsone (MADDS) to DDS ratio...
Antipyrine clearance and metabolism in patients with psoriasis.
Kubota, K, Ishizaki, T, Chiba, K, Takagi, A, Nakagawa, A, Nakamura, K
The kinetic parameters of antipyrine obtained from saliva samples and the appearance of major antipyrine metabolites (4-hydroxyantipyrine, norantipyrine and 3-hydroxymethylantipyrine) in urine...
Tsujimoto, G, Sasaki, T, Ishizaki, T, Suganuma, T, Hirayama, H
1 Comparison of measured trough serum digoxin concentrations (SDC) with those predicted at steady-state by forty sets of previously described pharmacokinetic equations in conjunction with either...
Horai, Y, Ishizaki, T, Sasaki, T, Koya, G, Matsuyama, K, Iguchi, S
1 Plasma levels of isoniazid (INH) and acetyl INH in plasma were measured with a spectrofluorometric method, and INH and its metabolites (acetyl INH, mono-acetylhydrazine, diacetylhydrazine and free...
Ishizaki, T, Oyama, Y, Suganuma, T, Sasaki, T, Nakaya, H, Shibuya, T, ...
The relationship between the oral dosage and plasma concentration of the long-acting cardioselective beta-adrenoceptor blocker atenolol and the antihypertensive response to the the degree of...
The effect of assay methods on plasma levels and pharmacokinetics of theophylline: HPLC and EIA.
Ishizaki, T, Watanabe, M, Morishita, N
1 The effects of two assay methods, HPLC and EIA, on theophylline plasma levels (n = 254) and pharmacokinetics (n = 6) were examined on blood samples obtained from asthmatic patients and normal adult...
Inhibitory effects of antiarrhythmic drugs on phenacetin O-deethylation catalysed by human CYP1A2
Kobayashi, K, Nakajima, M, Chiba, K, Yamamoto, T, Tani, M, Ishizaki, T, ...
Iwasa, T, Sano, H, Sugiura, A, Uchiyama, N, Hara, K, Okochi, H, ...
The disposition of oral amodiaquine in Papua New Guinean children with falciparum malaria
Hombhanje, FW, Hwaihwanje, I, Tsukahara, T, Saruwatari, J, Nakagawa, M, Osawa, H, ...
Absence of changes in drug disposition and catecholamine sensitivity in the hyperthyroid dog.
1 In order to study the relative contribution of hepatic drug metabolizing enzymes and hepatic blood flow to the clearance of drugs in the hyperthyroid state, the disposition kinetics of two model...