Abdelwahab, A., Gardner, M., Parkash, R., Basta, M., Sapp, J., Veltmann, C., ...
Introduction: Scar-related ventricular tachycardia (VT) is often unmappable. Data regarding the outcomes of ablation for mappable vs unmappable VT are lacking. Methods: Catheter ablation of...
Habazaki, H., Ogasawara, T., Fushimi, K., Shimizu, K., Nagata, S., Izumi, T., ...
The present work demonstrates effective inhibition of field crystallization of amorphous anodic niobium oxide by incorporation of silicon species from substrate. The field crystallization,...
Thermal degradation of anodic niobia on niobium and oxygen-containing niobium (2008)
Habazaki, H., Yamasaki, M., Ogasawara, T., Fushimi, K., Konno, H., Shimizu, K., ...
Thermal treatment of anodized niobium and oxygen-containing niobium has been carried out to elucidate the thermal degradation mechanism of niobium capacitors and to clarify the influence of oxygen...
Nagao, K, Nakamura, T, Nishimura, T, Ogama, Y, Kashima, N, Nagaya, S, ...
Radiative and nonradiative recombination processes in GaN-based semiconductors (2001)
Kawakami, Y, Omae, K, Kaneta, A, Okamoto, K, Izumi, T, Saijou, S, ...
Kaneta, A, Izumi, T, Okamoto, K, Kawakami, Y, Fujita, S, Narita, Y, ...
Knowledge and attitudes toward AIDS among female college students in Nagasaki, Japan (2000)
Maswanya, E., Moji, K., Aoyagi, K., Yahata, Y., Kusano, Y., Nagata, K., ...
This study assesses knowledge and attitudes concerning HIV infection and individuals with AIDS among 383 female students attending colleges in Nagasaki, Japan. A structured questionnaire containing...
Izumi, T., Suzuki, K., Saeki, M., Ookura, Y., Hirono, S., Inomata, T., ...
The previously described animal model of autoimmune myocarditis induced by immunization of Lewis rats with cardiac myosin was investigated pathologically, ultrastructurally and immunohistologically....
WATANABE, K., IZUMI, T., NATSUI, M., MATSUBARA, N., MIYAKITA, Y., KOYAMA, S., ...
A 47-year-old woman whose elder son had typical Duchenne's muscular dystrophy (DMD) was diagnosed as the manifesting carrier of the disease. She had developed congestive heart failure but had no...
Gohji, K, Higuchi, A, Maruyama, S, Minayoshi, K, Fujii, A, Itoh, N, ...
Experimental murine myocarditis after immunization with cardiac membranous proteins (1987)
Izumi, T., Maisch, B., Kochsiek, K.
It has been investigated whether or not it is possible to induce experimental murine myocarditis after immunization with cardiac membranous proteins. Cardiac proteins were prepared either from mice...
COHERENCY OF THE TRANSFORMATION STRAIN AT THE GRAIN BOUNDARY AND FRACTURE IN Cu-Zn-Al ALLOY (1982)
Takezawa, K., Izumi, T., Chiba, H., Sato, S.
Two types of Cu-Zn-Al bicrystal specimens having e/a≈1.4, one with the boundary parallel to and the other perpendicular to the tensile direction, were extended at room temperature. The...
COHERENCY OF THE TRANSFORMATION STRAIN AT THE GRAIN BOUNDARY AND FRACTURE IN Cu-Zn-Al ALLOY (1982)
Takezawa, K., Izumi, T., Chiba, H., Sato, S.
Two types of Cu-Zn-Al bicrystal specimens having e/a≈1.4, one with the boundary parallel to and the other perpendicular to the tensile direction, were extended at room temperature. The...
COHERENCY OF THE TRANSFORMATION STRAIN AT THE GRAIN BOUNDARY AND FRACTURE IN Cu-Zn-Al ALLOY (1982)
Takezawa, K., Izumi, T., Chiba, H., Sato, S.
Two types of Cu-Zn-Al bicrystal specimens having e/a≈1.4, one with the boundary parallel to and the other perpendicular to the tensile direction, were extended at room temperature. The...
Cloning of the cDNA for human 12-lipoxygenase.
Izumi, T, Hoshiko, S, Rådmark, O, Samuelsson, B
A full-length cDNA clone encoding 12-lipoxygenase (arachidonate:oxygen 12-oxidoreductase, EC 1.13.11.31) was isolated from a human platelet cDNA library by using a cDNA for human reticulocyte...
Hazra, T K, Izumi, T, Maidt, L, Floyd, R A, Mitra, S
8-Oxoguanine (8-oxoG), induced by reactive oxygen species (ROS) and ionizing radiation, is arguably the most important mutagenic lesion in DNA. This oxidized base, because of its mispairing with A,...
Izumi, T, Ishizaki, K, Ikenaga, M, Yonei, S
A mutant allele of the Escherichia coli nfo gene encoding endonuclease IV, nfo-186, was cloned into plasmid pUC18. When introduced into an E. coli xthA nfo mutant, the gene product of nfo-186...
Periodic changes in phosphorylation of the Xenopus cdc25 phosphatase regulate its activity.
Izumi, T, Walker, D H, Maller, J L
The cdc25 tyrosine phosphatase is known to activate cdc2 kinase in the G2/M transition by dephosphorylation of tyrosine 15. To determine how entry into M-phase in eukaryotic cells is controlled, we...
Elimination of cdc2 phosphorylation sites in the cdc25 phosphatase blocks initiation of M-phase.
The cdc25 phosphatase is a mitotic inducer that activates p34cdc2 at the G2/M transition by dephosphorylation of Tyr15 in p34cdc2. cdc25 itself is also regulated through periodic changes in its...
The M-phase inducer, Cdc25C, is a dual-specificity phosphatase that directly phosphorylates and activates the cyclin B/Cdc2 kinase complex, leading to initiation of mitosis. Cdc25 itself is activated...
Native and mutant 5-lipoxygenase expression in a baculovirus/insect cell system.
Funk, C D, Gunne, H, Steiner, H, Izumi, T, Samuelsson, B
Human 5-lipoxygenase (EC 1.13.11.34), the key enzyme involved in the transformation of arachidonic acid to the potent biologically active leukotrienes, has been overexpressed in insect cells using a...
Shimizu, T, Izumi, T, Seyama, Y, Tadokoro, K, Rådmark, O, Samuelsson, B
Leukotriene A4 synthase was purified from the cytosolic fraction of murine mast cells. The enzyme converted 5-hydroperoxy-6-trans-8,11,14-cis-icosatetraenoic acid (5-HPETE) to leukotriene A4. This...
Phosphorylation of Xenopus cyclins B1 and B2 is not required for cell cycle transitions.
The cdc2 kinase and B-type cyclins are known to be components of maturation- or M-phase-promoting factor (MPF). Phosphorylation of cyclin B has been reported previously and may regulate entry into...
Izumi, T, Kishimoto, S, Takano, T, Nakamura, M, Miyabe, Y, Nakata, M, ...
Platelet-activating factor (PAF) is a potent lipid mediator of allergic inflammation through its interaction with eosinophils. Expression of the PAF receptor is modulated by many agents, including...
Ishii, S, Matsuda, Y, Nakamura, M, Waga, I, Kume, K, Izumi, T, ...
A murine gene encoding a platelet-activating factor receptor (PAFR) was cloned. The gene was mapped to a region of the D2.2 band of chromosome 4 both by fluorescence in situ hybridization and by...
Fukasawa, K M, Fukasawa, K, Harada, M, Hirose, J, Izumi, T, Shimizu, T
Aminopeptidase B (Ap B; EC 3.4.11.6) is a zinc-binding protein that contains the consensus sequence HEXXHX18E (324-347), conserved among the M1 family of metallopeptidases. To determine if these...
cDNA cloning and characterization of guinea-pig leukotriene B4 receptor.
Masuda, K, Yokomizo, T, Izumi, T, Shimizu, T
The cDNA for leukotriene B(4) (LTB(4)) receptor (BLT) was cloned from a guinea-pig leucocyte cDNA library. The cloned receptor cDNA encodes 348 amino acid residues and shares 73% identity with the...
Cloning of the cDNA for human 12-lipoxygenase.
Izumi, T, Hoshiko, S, Rådmark, O, Samuelsson, B
A full-length cDNA clone encoding 12-lipoxygenase (arachidonate:oxygen 12-oxidoreductase, EC 1.13.11.31) was isolated from a human platelet cDNA library by using a cDNA for human reticulocyte...
Hazra, T K, Izumi, T, Maidt, L, Floyd, R A, Mitra, S
8-Oxoguanine (8-oxoG), induced by reactive oxygen species (ROS) and ionizing radiation, is arguably the most important mutagenic lesion in DNA. This oxidized base, because of its mispairing with A,...
Izumi, T, Ishizaki, K, Ikenaga, M, Yonei, S
A mutant allele of the Escherichia coli nfo gene encoding endonuclease IV, nfo-186, was cloned into plasmid pUC18. When introduced into an E. coli xthA nfo mutant, the gene product of nfo-186...
Periodic changes in phosphorylation of the Xenopus cdc25 phosphatase regulate its activity.
Izumi, T, Walker, D H, Maller, J L
The cdc25 tyrosine phosphatase is known to activate cdc2 kinase in the G2/M transition by dephosphorylation of tyrosine 15. To determine how entry into M-phase in eukaryotic cells is controlled, we...
Elimination of cdc2 phosphorylation sites in the cdc25 phosphatase blocks initiation of M-phase.
The cdc25 phosphatase is a mitotic inducer that activates p34cdc2 at the G2/M transition by dephosphorylation of Tyr15 in p34cdc2. cdc25 itself is also regulated through periodic changes in its...
The M-phase inducer, Cdc25C, is a dual-specificity phosphatase that directly phosphorylates and activates the cyclin B/Cdc2 kinase complex, leading to initiation of mitosis. Cdc25 itself is activated...
Native and mutant 5-lipoxygenase expression in a baculovirus/insect cell system.
Funk, C D, Gunne, H, Steiner, H, Izumi, T, Samuelsson, B
Human 5-lipoxygenase (EC 1.13.11.34), the key enzyme involved in the transformation of arachidonic acid to the potent biologically active leukotrienes, has been overexpressed in insect cells using a...
Shimizu, T, Izumi, T, Seyama, Y, Tadokoro, K, Rådmark, O, Samuelsson, B
Leukotriene A4 synthase was purified from the cytosolic fraction of murine mast cells. The enzyme converted 5-hydroperoxy-6-trans-8,11,14-cis-icosatetraenoic acid (5-HPETE) to leukotriene A4. This...
Phosphorylation of Xenopus cyclins B1 and B2 is not required for cell cycle transitions.
The cdc2 kinase and B-type cyclins are known to be components of maturation- or M-phase-promoting factor (MPF). Phosphorylation of cyclin B has been reported previously and may regulate entry into...
Izumi, T, Kishimoto, S, Takano, T, Nakamura, M, Miyabe, Y, Nakata, M, ...
Platelet-activating factor (PAF) is a potent lipid mediator of allergic inflammation through its interaction with eosinophils. Expression of the PAF receptor is modulated by many agents, including...
Ishii, S, Matsuda, Y, Nakamura, M, Waga, I, Kume, K, Izumi, T, ...
A murine gene encoding a platelet-activating factor receptor (PAFR) was cloned. The gene was mapped to a region of the D2.2 band of chromosome 4 both by fluorescence in situ hybridization and by...
Fukasawa, K M, Fukasawa, K, Harada, M, Hirose, J, Izumi, T, Shimizu, T
Aminopeptidase B (Ap B; EC 3.4.11.6) is a zinc-binding protein that contains the consensus sequence HEXXHX18E (324-347), conserved among the M1 family of metallopeptidases. To determine if these...
cDNA cloning and characterization of guinea-pig leukotriene B4 receptor.
Masuda, K, Yokomizo, T, Izumi, T, Shimizu, T
The cDNA for leukotriene B(4) (LTB(4)) receptor (BLT) was cloned from a guinea-pig leucocyte cDNA library. The cloned receptor cDNA encodes 348 amino acid residues and shares 73% identity with the...
Anti-DNP antibody response after the topical application of DNFB in mice.
Takahashi, C, Nishikawa, S, Katsura, Y, Izumi, T
A single painting or daily paintings for 5 days with dinitrofluorobenzene (DNFB) on the abdominal skin of mice induced both contact sensitivity, detectable by ear swelling, and, hapten-reactive...
Niwano, S, Kitano, Y, Moriguchi, M, Izumi, T
A 55 year old man with intermittent Wolff-Parkinson-White (WPW) syndrome had an episode of atrial fibrillation (AF) that lasted for 117 days. After interruption of the AF a Δwave appeared that...
Hanawa, H, Kodama, M, Inomata, T, Izumi, T, Shibata, A, Tuchida, M, ...
We investigated the effects of anti-alpha beta T cell receptor antibody in rat experimental autoimmune myocarditis (EAM), using a new animal model of autoimmune myocarditis characterized by the...
Emura, M, Nagai, S, Takeuchi, M, Kitaichi, M, Izumi, T
The activation of B lymphocytes and formation of immune complexes have been suggested to play an important role in the pathogenesis of idiopathic pulmonary fibrosis (IPF). To investigate the...
Takeuchi, M, Nagai, S, Nakada, H, Aung, H, Satake, N, Kaneshima, H, ...
IL-1 possesses pleiotropic properties on various cells and its activity may be stringently regulated in several ways. We have previously reported that both IL-1 and its inhibitory factor are...
Alim, M A, Yamaki, S, Hossain, Mst S, Takeda, K, Kozima, M, Izumi, T, ...
Two amyloidogenic Bence Jones proteins (Am37 VκIV and NIG1 VκI) and one non-amyloidogenic protein (NIG26 VκIII) were characterized. The protein Am37 had four deletions when compared with the...
1. A single i.p. injection of bacterial endotoxin in rats (3.5 mg kg-1) caused lung injury assessed as changes in lung dry:wet weight ratio and leukopaenia over the subsequent 28 h. 2. This treatment...
Stanton, A. W., Izumi, T., Antoniw, J. W., Piper, P. J.
1. The actions of intravenously administered platelet-activating factor (Paf) (0.1-3.33 nmol kg-1) and the effect of a recently described Paf antagonist, WEB 2086, were investigated in the...
T cell receptor (TCR) V gene segment use in HLA-typed Japanese healthy subjects
SHIGEMATSU, M, NAGAI, S, MIKUNIYA, T, IZUMI, T, WIGZELL, H, EKLUND, A G, ...
The expression of 13 different α and β V gene segments of the T cell receptor for antigen (TCR) was examined, using V gene-specific MoAbs, on human peripheral blood T lymphocytes from 32 healthy...
Ikeda, A., Nishimura, K., Koyama, H., Tsukino, M., Mishima, M., Izumi, T.
BACKGROUND: Although the bronchodilating effect of inhaled anticholinergics has been established in patients with chronic obstructive pulmonary disease (COPD), their effects on exercise capacity are...
Ikeda, A, Nishimura, K, Koyama, H, Izumi, T
BACKGROUND--Inhaled anticholinergics and beta agonists are widely used in the treatment of patients with chronic obstructive pulmonary disease (COPD). However, dosage requirements have not been...
Koyama, H, Nishimura, K, Mio, T, Ikeda, A, Sugiura, N, Izumi, T
BACKGROUND--Diffuse panbronchiolitis (DPB) is characterised clinically by chronic airflow limitation and respiratory tract infection, and pathologically by chronic bronchiolar inflammation. To...
Tsukino, M., Nishimura, K., Ikeda, A., Hajiro, T., Koyama, H., Izumi, T.
BACKGROUND—The effects of theophylline or anticholinergic agents on exercise capacity in patients with chronic obstructive pulmonary disease (COPD) remain controversial. The aim of the present...