Torres, A. M., Bansal, P. S., Sunde, M., Clarke, C. E., Bursill, J. A., Smith, D. J., ...
The HERG K+ channel has very unusual kinetic behavior that includes slow activation but rapid inactivation. These features are critical for normal cardiac repolarization as well as in preventing...
ATEC Digital Adaptation Study. Volume I. FKV Requirements for PA/FI/TA. (2002)
Armstrong,T. R., Campbell,T. J., Doyle,D. T., Dulaney,E. N.
The Frankfurt-Koenigstuhl-Vaihingen (FKV) digital transmission system and its equipments were studied and analyzed for the purpose of identifying points of attachment which can be used to gather...
ATEC Digital Adaptation Study. Volume II. ATEC Applicability and Adaptations. (2002)
Armstrong,T. R., Campbell,T. J., Doyle,D. T., Dulaney,E. N.
The ATEC Digital Adaptation Study sought to answer the questions: (1) What should be monitored for PA/FI/TA of the FKV system; (2) What measurements, data collection, and analysis should a monitor...
ATEC Digital Adaptation Study. Volume III. Summary and Recommendations. (2002)
Armstrong,T. R., Blough Jr.,A. K., Campbell,T. J., Doyle,D. T., Dulaney,E. N.
The automated technical control (ATEC) Digital Adaptation Study sought to answer the questions: (1) What should be monitored for PA/FI/TA of the FKV system; (2) What measurements, data collection,...
Campbell,T. J., Acker,W. F., Christner,C. L., Doyle,D. T., Goldstein,W. M.
Subsequent to the completion of the feasibility phase of the ATEC Digital Adaptation Study, existing ATEC hardware and software was adapted or developed to provide Performance Assessment (PA), Fault...
Campbell,T. J., Acker,W. F., Christner,C. L., Doyle,D. T., Goldstein,W. M.
This section is essentially reproduced from Section III of the test report for the Field Test and Evaluation phase of the ATEC Digital Adaptation program. The data taken from the test scenarios has...
Campbell,T. J., Acker,W. F., Christner,C. L., Doyle,D. T., Goldstein,W. M.
The overall conclusion of this report is that the DATEC system successfully completed all requirements of the Statement of Work (S.O.W.). This conclusion is based on the satisfactory adaptation of...
Baseband Eye Monitor Signal Discrimination and Identification Study Program. (2002)
Campbell,T. J., Kearns,B. M., Doty,L. F., Hurst,S. G.
The Baseband Eye Monitor Signal Discrimination and Identification Study Program sought to determine techniques to characterize interference signal types using the present Baseband Eye Monitor Unit;...
Studies on the mode of action of cardioactive drugs in animals and man. (1982)
Thesis (Ph. D.)--University of Oxford, 1982.
4 p. L., 144 p., 1 L.
Ventral hernia in the treatment of omphalocele and gastroschisis.
Swartz, K R, Harrison, M W, Campbell, J R, Campbell, T J
Twenty-three patients with gastroschisis or omphalocele undergoing delayed ventral herniorrhaphy were reviewed. The ventral defects resulted from elective skin flap coverage in 15 patients,...
Selective management of gastroschisis.
Swartz, K R, Harrison, M W, Campbell, J R, Campbell, T J
Mortality of patients with gastroschisis has decreased from nearly 90% to 13% (14 of 106) during the period from 1967 to 1984. Coincident with advances in perioperative management, including...
Ventral hernia in the treatment of omphalocele and gastroschisis.
Swartz, K R, Harrison, M W, Campbell, J R, Campbell, T J
Twenty-three patients with gastroschisis or omphalocele undergoing delayed ventral herniorrhaphy were reviewed. The ventral defects resulted from elective skin flap coverage in 15 patients,...
Selective management of gastroschisis.
Swartz, K R, Harrison, M W, Campbell, J R, Campbell, T J
Mortality of patients with gastroschisis has decreased from nearly 90% to 13% (14 of 106) during the period from 1967 to 1984. Coincident with advances in perioperative management, including...
Effect of S5P α-helix charge mutants on inactivation of hERG K+ channels
Clarke, C E, Hill, A P, Zhao, J, Kondo, M, Subbiah, R N, Campbell, T J, ...
The ether-à-go-go (EAG) family of voltage-gated K+ channels contains three subfamilies, EAG, ether-à-go-go related (ERG) and ether-à-go-go like (ELK). The human ether-à-go-go related gene (hERG)...
Campbell, T J, Gavaghan, T P, Morgan, J J
The efficacy of sotalol in treating acute atrial fibrillation and flutter after open heart surgery was compared with that of a digoxin/disopyramide combination. Forty adult patients with...
Gavaghan, T P, Koegh, A M, Kelly, R P, Campbell, T J, Thorburn, C, Morgan, J J
Fifty six adult patients were randomised to treatment with flecainide (group 1, n = 29) or a combination of digoxin and disopyramide (group 2, n = 27) for acute atrial fibrillation and flutter after...
A potassium ion channel is involved in cytokine production by activated human macrophages
QIU, M R, CAMPBELL, T J, BREIT, S N
Macrophages play an important role in immune and inflammatory responses, largely through secretion of bioactive molecule such as cytokines. While calcium is known to be an important regulator of this...
Walker, B D, Valenzuela, S M, Singleton, C B, Tie, H, Bursill, J A, Wyse, K R, ...
Perhexiline has been used as an anti-anginal agent for over 25 years, and is known to cause QT prolongation and torsades de pointes. We hypothesized that the cellular basis for these effects was...
Singleton, C B, Valenzuela, S M, Walker, B D, Tie, H, Wyse, K R, Bursill, J A, ...
The Kv4.3 gene is believed to encode a large proportion of the transient outward current (Ito), responsible for the early phase of repolarization of the human cardiac action potential. There is...
Walker, B D, Singleton, C B, Bursill, J A, Wyse, K R, Valenzuela, S M, Qiu, M R, ...
Cisapride is a prokinetic agent which has been associated with QT prolongation, torsades de pointes and cardiac arrest. The cellular mechanism for these observations is high affinity blockade of IKr...
Inhibition of HERG potassium channels by the antimalarial agent halofantrine
Tie, H, Walker, B D, Singleton, C B, Valenzuela, S M, Bursill, J A, Wyse, K R, ...
Halofantrine is a widely used antimalarial agent which has been associated with prolongation of the ‘QT interval' of the electrocardiogram (ECG), torsades de pointes and sudden death. Whilst QT...
Pallandi, R. T., Campbell, T. J.
1 The cellular electrophysiological effects of amiodarone and its metabolite desethylamiodarone (DEA) were studied in guinea-pig ventricular myocardium by use of standard microelectrode techniques. 2...
Hemsworth, P. D., Campbell, T. J.
1. Standard microelectrode methods have been used to record action potentials from guinea-pig ventricular myocardium and dog Purkinje fibres, and to study the effects of the two major metabolites of...
Cardiac electrophysiological actions of captopril: lack of direct antiarrhythmic effects.
Hemsworth, P. D., Pallandi, R. T., Campbell, T. J.
1. Standard microelectrode techniques were used to study the effects of captopril (1, 10 and 100 microM) on action potentials recorded from guinea-pig ventricular cells and sinoatrial node cells. 2....
Therapeutic drug monitoring: antiarrhythmic drugs
Antiarrhythmic agents are traditionally classified according to Vaughan Williams into four classes of action. Class I antiarrhythmic agents include most of the drugs traditionally thought of as...
Wyse, K. R., Ye, V., Campbell, T. J.
1 Standard microelectrode methods were used to record intracellular action potentials from strips of guinea-pig right ventricular myocardium superfused with either standard physiological saline ([K+]...
Martin, D. K., Nakaya, Y., Wyse, K. R., Campbell, T. J.
1. Standard patch-clamp techniques were used to study the interaction of therapeutic concentrations of flecainide and disopyramide with single inwardly-rectifying potassium channels in cell-attached...
The effects of racemic DL-sotalol and D-sotalol on guinea-pig sino-atrial node, atrium and ventricle and on human atrium were studied using standard microelectrode techniques. Both compounds...
Therapeutic drug monitoring: antiarrhythmic drugs
Antiarrhythmic agents are traditionally classified according to Vaughan Williams into four classes of action. Class I antiarrhythmic agents include most of the drugs traditionally thought of as...
1 The voltage- and time-dependence of the depression of the maximum rate of depolarization (Vmax) by two steroidal anti-arrhythmic drugs, CCI22277 and Org 6001 were studied in guinea-pig ventricle. 2...
The effects of Class I antiarrhythmic drugs on the maximum rate of depolarization (Vmax) of guinea-pig ventricular action potentials were studied by standard microelectrode techniques. The ability of...
Campbell, T. J., Vaughan Williams, E. M.
1 CCI22277 (methyl 2 beta-ethoxy-2 alpha-hydroxy-11 alpha-(3-methylbutylamino)-5 alpha-androstane-17 beta-carboxylate hydrochloride) is an aminosteroid with antiarrhythmic properties in animal...
The Nature and Rates of Excretion of Radioactive Breakdown Products of I131-Albumin in the Rabbit
Zizza, F., Campbell, T. J., Reeve, E. B.
When I131-albumin is given intravenously to rabbits, the radioactive breakdown products that are released into the plasma and urine can be extracted into acetone. Paper chromatography and paper...
Mechanism of Block of the hERG K+ Channel by the Scorpion Toxin CnErg1
Hill, Adam P., Sunde, M., Campbell, T. J., Vandenberg, J. I.
The scorpion toxin CnErg1 binds to human ether-a-go-go related gene (hERG) K+ channels with a 1:1 stoichiometry and high affinity. However, in contrast to other scorpion toxin-ion channel...
The S631A Mutation Causes a Mechanistic Switch in the Block of hERG Channels by CnErg1
Hill, Adam P., Campbell, T. J., Bansal, P. S., Kuchel, P. W., Vandenberg, J. I.
We have studied the interaction of CnErg1, a member of the γ-KTX subfamily of scorpion toxins with the inactivation-deficient S631A hERG channel. In the background of this mutation, we observed a...