T. J. Grattan

The effect of inhaled and oral dextromethorphan on citric acid induced cough in man.

Grattan, T J, Marshall, A E, Higgins, K S, Morice, A H

1. Dextromethorphan is a widely used antitussive agent which is a non-narcotic codeine analogue. We have investigated whether inhaled administration of dextromethorphan provides antitussive activity...

Capsaicin and neurokinin A-induced bronchoconstriction in the anaesthetised guinea-pig: evidence for a direct action of menthol on isolated bronchial smooth muscle

Wright, C E, Laude, E A, Grattan, T J, Morice, A H

For many years menthol has been used in the treatment of respiratory disorders although, a bronchodilator effect of menthol has yet to be described. Using the bronchoconstrictors capsaicin (acting...

Identification of the L-menthol binding site in guinea-pig lung membranes

Wright, C E, Bowen, W P, Grattan, T J, Morice, A H

L-Menthol inhibits both neurokinin A and capsaicin-induced bronchoconstriction in the guinea-pig and relaxes pre-constricted guinea-pig isolated bronchi. Structure-activity relationships have been...

A new laser pain threshold model detects a faster onset of action from a liquid formulation of 1 g paracetamol than an equivalent tablet formulation

Sutton, J A, Gillin, W P, Grattan, T J, Clarke, G D, Kilminster, S G

Effect of inhaled menthol on citric acid induced cough in normal subjects.

Morice, A H, Marshall, A E, Higgins, K S, Grattan, T J

BACKGROUND--Menthol is a commonly used ingredient in many over the counter cough remedies, but there is little objective evidence as to its efficacy. METHODS--Twenty healthy subjects received a cough...