Chronic lymphocytic leukaemia (2008)
Chronic lymphocytic leukaemia is the commonest form of leukaemia in Europe and North America, and mainly, though not exclusively, affects older individuals. It has a very variable course, with...
Ligandless receptors find a role (2008)
The discovery that patients with chronic lymphocytic leukemia (CLL) who showed somatic hypermutation of their immunoglobulin heavy chain variable region genes (IGHV) lived on average 3 times longer...
Porakishvili, N., Kulikova, N., Jewell, A.P., Youinou, P.Y., Yong, K., Nathwani, A., ...
We have studied the surface expression of the Toll-like receptor family member CD180 on cells from 78 patients with B-chronic lymphocytic leukaemia (B-CLL). B-CLL cells had variable levels of CD180...
Chronic lymphocytic leukaemia: clinical translations of biological features (2005)
The chronic lymphatic leukaemia (CLL) world was surprised to find that the disease split so neatly down the middle into those patients with unmutated immunoglobulin genes who were mainly men, had...
ZAP-70 expression and prognosis in chronic lymphocytic leukaemia (2004)
Orchard, J.A., Ibbotson, R.E., Davis, Z., Wiestner, A., Rosenwald, A., Thomas, P.W., ...
Background: Chronic lymphocytic leukaemia (CLL) is a heterogeneous disease; many patients never need treatment, whereas some have poor outcomes. New treatments, which can induce complete remissions,...
Achieving optimal outcomes in chronic lymphocytic leukaemia (2001)
Chronic lymphocytic leukaemia (CLL) is a disease of late middle age and older. The majority of patients are diagnosed because of a lymphocytosis of at least 5 x 10/L on an incidental blood count. It...
Immunotherapy of disease / edited by T.J. Hamblin (1989)
Incluye bibliografía e índice
Red cell aplasia in myelodysplastic syndrome.
Williamson, P J, Oscier, D G, Bell, A J, Hamblin, T J
Six cases of red cell aplasia occurring in patients with myelodysplastic syndromes (MDS) showed a diversity of clinical course and prognosis. In some patients red cell aplasia may have represented an...
Autoimmunity in chronic lymphocytic leukaemia.
Hamblin, T J, Oscier, D G, Young, B J
The prevalence of autoantibodies in B cell chronic lymphocytic leukaemia (B-CLL) was investigated. A lower prevalence of autoimmune haemolytic anaemia than that found in other series was found: large...
CD3+ CD8+ T cell lymphocytosis masking B cell leukaemia.
Smith, J L, Oscier, D G, Haegert, D G, Jones, D B, Howell, M, Hodges, E, ...
A patient with CD3, CD8 positive lymphocytosis presented with features consistent with T cell chronic lymphocytic leukaemia/proliferations of large granular lymphocytes. The marrow and blood lymphoid...
Immunological reason for chronic ill health after infectious mononucleosis.
Hamblin, T J, Hussain, J, Akbar, A N, Tang, Y C, Smith, J L, Jones, D B
In a group of patients who suffered from chronic ill health after an attack of acute infectious mononucleosis a disorder of T cell regulation was found. By means of cytochemical reactions the...
Anti-keratin antibodies in rheumatoid arthritis.
Young, B J, Mallya, R K, Leslie, R D, Clark, C J, Hamblin, T J
A naturally occurring antibody that reacts with the keratinised tissue of animal oesophagus was found in the serum of 75 out of 129 patients (58%) with classical or definite rheumatoid arthritis (RA)...
Red cell aplasia in myelodysplastic syndrome.
Williamson, P J, Oscier, D G, Bell, A J, Hamblin, T J
Six cases of red cell aplasia occurring in patients with myelodysplastic syndromes (MDS) showed a diversity of clinical course and prognosis. In some patients red cell aplasia may have represented an...
Autoimmunity in chronic lymphocytic leukaemia.
Hamblin, T J, Oscier, D G, Young, B J
The prevalence of autoantibodies in B cell chronic lymphocytic leukaemia (B-CLL) was investigated. A lower prevalence of autoimmune haemolytic anaemia than that found in other series was found: large...
CD3+ CD8+ T cell lymphocytosis masking B cell leukaemia.
Smith, J L, Oscier, D G, Haegert, D G, Jones, D B, Howell, M, Hodges, E, ...
A patient with CD3, CD8 positive lymphocytosis presented with features consistent with T cell chronic lymphocytic leukaemia/proliferations of large granular lymphocytes. The marrow and blood lymphoid...
Immunological reason for chronic ill health after infectious mononucleosis.
Hamblin, T J, Hussain, J, Akbar, A N, Tang, Y C, Smith, J L, Jones, D B
In a group of patients who suffered from chronic ill health after an attack of acute infectious mononucleosis a disorder of T cell regulation was found. By means of cytochemical reactions the...
Anti-keratin antibodies in rheumatoid arthritis.
Young, B J, Mallya, R K, Leslie, R D, Clark, C J, Hamblin, T J
A naturally occurring antibody that reacts with the keratinised tissue of animal oesophagus was found in the serum of 75 out of 129 patients (58%) with classical or definite rheumatoid arthritis (RA)...
Polymyalgia rheumatica and antimitochondrial antibodies.
Sattar, M A, Cawley, M I, Hamblin, T J, Robertson, J C
Antimitochondrial antibodies (AMA) were detected in the sera of 11 of 36 patients with a clinical diagnosis of polymyalgia rheumatica (PMR) in whom comprehensive autoantibody screening had been...
Pyogenic abscesses in the myelodysplastic syndrome.
Williamson, P. J., Oscier, D. G., Mufti, G. J., Hamblin, T. J.
Mallya, R K, Young, B J, Pepys, M B, Hamblin, T J, Mace, B E, Hamilton, E B
Anti-keratin antibodies (AKA) were detected in 68 out of 98 patients (69%) with classical or definite rheumatoid arthritis (RA). The intensity of the AKA reaction correlated significantly with...
Steven, M M, Tanner, A R, Holdstock, G E, Cockerell, R, Smith, J, Smith, D S, ...
In vitro function tests were performed on peripheral blood monocytes isolated from patients with putative immune complex diseases undergoing therapeutic plasma exchange. Bacterial killing by...
Hamblin, T J, Jones, J V, Peacock, D B
Ten patients with chronic lymphatic leukaemia (CLL) were injected with the antigen phichi174 intravenously on two occasions to test their capacity for antibody production. Nine out of ten patients...
CHAPMAN, C J, MOCKRIDGE, C I, HAMBLIN, T J, STEVENSON, F K
The V4–34 (VH4–21) gene has been found to encode certain IgM autoantibodies, and is mandatory for pathological IgM anti-erythrocyte antibodies of I/i specificity. The gene is also commonly used...
Acute transformation of a myeloproliferative state in sideroblastic anaemia with abnormal karyotype.
Reciprocal translocation between chromosomes 8 and 9 in atypical chronic myeloid leukaemia.
Oscier, D G, Mufti, G J, Gardiner, A, Hamblin, T J
A balanced translocation t(8;9) (p11;q34) was present in the peripheral blood, bone marrow, and spleen cells of a patient with Ph negative chronic myeloid leukaemia. Subsequent transformation into...
Abidi, S M, Griffiths, M, Oscier, D G, Mufti, G J, Hamblin, T J
A patient with Klinefelter's syndrome and diabetes mellitus was diagnosed as having myelodysplasia. Cytogenetic analysis of the peripheral blood and the bone marrow cells confirmed the presence of a...
Exercise-induced urticaria and angio-oedema with relief from cromoglycate insufflation.
Hatty, S., Mufti, G. J., Hamblin, T. J.
The pathogenesis of physical urticarias is unknown and the treatment is often difficult and unsatisfactory. A patient with severe exercise-induced angio-oedema and urticaria is reported who responded...
Relapse of lymphoma in the heart after a 10-year remission.
Bell, A. J., Mufti, G. J., Hamblin, T. J.
A 71-year-old woman presented with intractable cardiac failure 10 years after receiving treatment for lymphoma. Extensive investigations failed to demonstrate a recurrence of her disease, but...