Lynn, K. J. W., Harris, T. J., Sjarifudin, M.
The development and decay of the southern equatorial anomaly night-time peak in electron density as seen at a number of ionosonde reflection points extending from New Guinea and Indonesia into...
Lynn, K. J. W., Sjarifudin, M., Harris, T. J., Le Huy, M.
Ionospheric storms showing a strong depression in daytime foF2 values were sought which penetrated to low-latitudes, as identified by vertical ionosondes operating at Darwin and Townsville over the...
Lynn, K. J. W., Harris, T. J., Sjarifudin, M.
The development and decay of the southern equatorial anomaly night-time peak in electron density as seen at a number of ionosonde reflection points extending from New Guinea and Indonesia into...
Lynn, K. J. W., Sjarifudin, M., Harris, T. J., Le Huy, M.
Ionospheric storms showing a strong depression in daytime foF2 values were sought which penetrated to low-latitudes, as identified by vertical ionosondes operating at Darwin and Townsville over the...
Lynn, K.J.W., Sjarifudin, M., Harris, T.J., Le Huy, M.
Ionospheric storms showing a strong depression in daytime foF2 values were sought which penetrated to low-latitudes, as identified by vertical ionosondes operating at Darwin and Townsville over the...
A minimal coherence time for the solar tides in the middle atmosphere (1997)
The time scale of the variability in solar tides gives a measure of the time interval over which data will need to be averaged in order to remove local, transient effects. Hence, it gives a measure...
Removal of the genome-linked protein of foot-and-mouth disease virus by rabbit reticulocyte lysate.
Sangar, D V, Bryant, J, Harris, T J, Brown, F, Rowlands, D J
Rabbit reticulocyte lysate cleaves the genome-linked protein VPg from foot-and-mouth disease virus (FMDV) RNA. This activity could be reliably monitored since removal of the protein resulted in a...
Sangar, D V, Black, D N, Rowlands, D J, Harris, T J, Brown, F
An mRNA-dependent reticulocyte lysate has been used to translate foot-and-mouth disease virus RNA in vitro. Polypeptides P16, P20a, and P88, which have been shown to be derived from the 5' end of the...
Heterogeneity of the genome-linked protein of foot-and-mouth disease virus.
King, A M, Sangar, D V, Harris, T J, Brown, F
The genome-linked protein of foot-and-mouth disease virus was examined by electrofocusing in polyacrylamide gels. Two proteins of different charge and amino acid composition were found. The tryptic...
RsrII--a novel restriction endonuclease with a heptanucleotide recognition site.
O'Connor, C D, Metcalf, E, Wrighton, C J, Harris, T J, Saunders, J R
A sequence-specific endonuclease present in extracts of Rhodopseudomonas sphaeroides 630 has been purified and characterized. The enzyme, Rsr II, recognises and cleaves the palindromic...
Molecular cloning and nucleotide sequence of cDNA coding for calf preprochymosin.
Harris, T J, Lowe, P A, Lyons, A, Thomas, P G, Eaton, M A, Millican, T A, ...
DNA complementary to calf stomach mRNA has been synthesised and inserted into the Pst1 site of pAT153 by G-C tailing. Clones containing sequences coding for prochymosin were recognised by colony...
The structure of poliovirus replicative form.
Larsen, G R, Dorner, A J, Harris, T J, Wimmer, E
The structure of polio replicative form (RF) has been investigated by 3' end labeling and the use of polynucleotide phosphorylase to now allow a complete composite of the RF structure. The evidence...
O4-(5'-uridylyl)tyrosine is the bond between the genome-linked protein and the RNA of poliovirus.
Rothberg, P G, Harris, T J, Nomoto, A, Wimmer, E
Virion RNA of poliovirus type 1 has been analyzed for the linkage between genome-protein VPg and the polyribonucleotide chain. Hydrolysis of the linkage with acid or alkali and enzymatic degradation...
Hayward, B E, Hussain, A, Wilson, R H, Lyons, A, Woodcock, V, McIntosh, B, ...
The nucleotide sequence for a glutamine synthetase (GS) mRNA from gene-amplified Chinese hamster (CHO) cells was determined from recombinant cDNA clones obtained from both pBR322 and lambda gt10...
Molecular cloning and nucleotide sequence of rat lingual lipase cDNA.
Docherty, A J, Bodmer, M W, Angal, S, Verger, R, Riviere, C, Lowe, P A, ...
Purified rat lingual lipase (EC3113), a glycoprotein of approximate molecular weight 52,000, was used to generate polyclonal antibodies which were able to recognise the denatured and deglycosylated...
The nucleotide sequence at the 5' end of foot and mouth disease virus RNA.
Foot and mouth disease virus RNA has been treated with RNase H in the presence of oligo (dG) specifically to digest the poly(C) tract which lies near the 5' end of the molecule (10). The short (S)...
Harris, T J, Dunn, J J, Wimmer, E
The small protein (VPg) covalently linked to the 5' end of poliovirus Type 1 (PV-1) RNA has been labeled in vitro with 125I using the Bolton and Hunter reagent. The RNA is not degraded under the...
More precise location of the polycytidylic acid tract in foot and mouth disease virus RNA.
Rowlands, D J, Harris, T J, Brown, F
The polycytidylic acid [poly(C)] tract in foot and mouth disease virus RNA has been located about 400 nucleotides from the 5' end of the RNA by analysis of the products from the digestion of the RNA...
Paterson, R G, Harris, T J, Lamb, R A
The nucleotide sequence of the mRNA coding for the fusion glycoprotein (F) of the paramyxovirus, simian virus 5, has been obtained. There is a single large open reading frame on the mRNA that encodes...
Synthesis of calf prochymosin (prorennin) in Escherichia coli.
Emtage, J S, Angal, S, Doel, M T, Harris, T J, Jenkins, B, Lilley, G, ...
A gene for calf prochymosin (prorennin) has been reconstructed from chemically synthesized oligodeoxyribonucleotides and cloned DNA copies of preprochymosin mRNA. This gene has been inserted into a...
Harris, T J, Underwood, B O, Knowles, N J, Crowther, J R, Brown, F
Variation has been observed in the structural polypeptides of swine vesicular disease viruses isolated from the United Kingdom and Hong Kong. Despite the limited number of isolates examined, several...
Disulphide bond assignment in human tissue inhibitor of metalloproteinases (TIMP).
Williamson, R A, Marston, F A, Angal, S, Koklitis, P, Panico, M, Morris, H R, ...
Disulphide bonds in human recombinant tissue inhibitor of metalloproteinases (TIMP) were assigned by resolving proteolytic digests of TIMP on reverse-phase h.p.l.c. and sequencing those peaks judged...
Comparison of human stromelysin and collagenase by cloning and sequence analysis.
Whitham, S E, Murphy, G, Angel, P, Rahmsdorf, H J, Smith, B J, Lyons, A, ...
A comparison of the cDNA-derived amino acid sequences of human stromelysin and collagenase with the N-terminal sequences of purified enzymes reveals that these metalloproteinases are highly conserved...
Catterall, C F, Lyons, A, Sim, R B, Day, A J, Harris, T J
A cDNA clone of the mRNA coding for the human complement system control protein Factor I has been isolated. The predicted amino acid sequence obtained from the DNA sequence demonstrates a protein...
The complete amino acid sequence of human complement factor H.
Ripoche, J, Day, A J, Harris, T J, Sim, R B
The complete amino acid sequence of the human complement system regulatory protein, factor H, has been derived from sequencing three overlapping cDNA clones. The sequence consists of 1213 amino acids...
Hampe, J, Schreiber, S, Shaw, S H, Lau, K F, Bridger, S, Macpherson, A J, ...
Inflammatory bowel disease (IBD) is characterized by a chronic relapsing intestinal inflammation, typically starting in early adulthood. IBD is subdivided into two subtypes, on the basis of clinical...
Shah, S, Harris, T J, Rink, E, DeWilde, S, Victor, C R, Cook, D G
Traditional measures of socioeconomic status may not be reliable for older people and income may be a useful measure for research into inequalities in health. At the same time, researchers...
Removal of the genome-linked protein of foot-and-mouth disease virus by rabbit reticulocyte lysate.
Sangar, D V, Bryant, J, Harris, T J, Brown, F, Rowlands, D J
Rabbit reticulocyte lysate cleaves the genome-linked protein VPg from foot-and-mouth disease virus (FMDV) RNA. This activity could be reliably monitored since removal of the protein resulted in a...
Sangar, D V, Black, D N, Rowlands, D J, Harris, T J, Brown, F
An mRNA-dependent reticulocyte lysate has been used to translate foot-and-mouth disease virus RNA in vitro. Polypeptides P16, P20a, and P88, which have been shown to be derived from the 5' end of the...
Heterogeneity of the genome-linked protein of foot-and-mouth disease virus.
King, A M, Sangar, D V, Harris, T J, Brown, F
The genome-linked protein of foot-and-mouth disease virus was examined by electrofocusing in polyacrylamide gels. Two proteins of different charge and amino acid composition were found. The tryptic...
RsrII--a novel restriction endonuclease with a heptanucleotide recognition site.
O'Connor, C D, Metcalf, E, Wrighton, C J, Harris, T J, Saunders, J R
A sequence-specific endonuclease present in extracts of Rhodopseudomonas sphaeroides 630 has been purified and characterized. The enzyme, Rsr II, recognises and cleaves the palindromic...
Molecular cloning and nucleotide sequence of cDNA coding for calf preprochymosin.
Harris, T J, Lowe, P A, Lyons, A, Thomas, P G, Eaton, M A, Millican, T A, ...
DNA complementary to calf stomach mRNA has been synthesised and inserted into the Pst1 site of pAT153 by G-C tailing. Clones containing sequences coding for prochymosin were recognised by colony...
The structure of poliovirus replicative form.
Larsen, G R, Dorner, A J, Harris, T J, Wimmer, E
The structure of polio replicative form (RF) has been investigated by 3' end labeling and the use of polynucleotide phosphorylase to now allow a complete composite of the RF structure. The evidence...
O4-(5'-uridylyl)tyrosine is the bond between the genome-linked protein and the RNA of poliovirus.
Rothberg, P G, Harris, T J, Nomoto, A, Wimmer, E
Virion RNA of poliovirus type 1 has been analyzed for the linkage between genome-protein VPg and the polyribonucleotide chain. Hydrolysis of the linkage with acid or alkali and enzymatic degradation...
Hayward, B E, Hussain, A, Wilson, R H, Lyons, A, Woodcock, V, McIntosh, B, ...
The nucleotide sequence for a glutamine synthetase (GS) mRNA from gene-amplified Chinese hamster (CHO) cells was determined from recombinant cDNA clones obtained from both pBR322 and lambda gt10...
Molecular cloning and nucleotide sequence of rat lingual lipase cDNA.
Docherty, A J, Bodmer, M W, Angal, S, Verger, R, Riviere, C, Lowe, P A, ...
Purified rat lingual lipase (EC3113), a glycoprotein of approximate molecular weight 52,000, was used to generate polyclonal antibodies which were able to recognise the denatured and deglycosylated...
The nucleotide sequence at the 5' end of foot and mouth disease virus RNA.
Foot and mouth disease virus RNA has been treated with RNase H in the presence of oligo (dG) specifically to digest the poly(C) tract which lies near the 5' end of the molecule (10). The short (S)...
Harris, T J, Dunn, J J, Wimmer, E
The small protein (VPg) covalently linked to the 5' end of poliovirus Type 1 (PV-1) RNA has been labeled in vitro with 125I using the Bolton and Hunter reagent. The RNA is not degraded under the...
More precise location of the polycytidylic acid tract in foot and mouth disease virus RNA.
Rowlands, D J, Harris, T J, Brown, F
The polycytidylic acid [poly(C)] tract in foot and mouth disease virus RNA has been located about 400 nucleotides from the 5' end of the RNA by analysis of the products from the digestion of the RNA...
Paterson, R G, Harris, T J, Lamb, R A
The nucleotide sequence of the mRNA coding for the fusion glycoprotein (F) of the paramyxovirus, simian virus 5, has been obtained. There is a single large open reading frame on the mRNA that encodes...
Synthesis of calf prochymosin (prorennin) in Escherichia coli.
Emtage, J S, Angal, S, Doel, M T, Harris, T J, Jenkins, B, Lilley, G, ...
A gene for calf prochymosin (prorennin) has been reconstructed from chemically synthesized oligodeoxyribonucleotides and cloned DNA copies of preprochymosin mRNA. This gene has been inserted into a...
Harris, T J, Underwood, B O, Knowles, N J, Crowther, J R, Brown, F
Variation has been observed in the structural polypeptides of swine vesicular disease viruses isolated from the United Kingdom and Hong Kong. Despite the limited number of isolates examined, several...
Disulphide bond assignment in human tissue inhibitor of metalloproteinases (TIMP).
Williamson, R A, Marston, F A, Angal, S, Koklitis, P, Panico, M, Morris, H R, ...
Disulphide bonds in human recombinant tissue inhibitor of metalloproteinases (TIMP) were assigned by resolving proteolytic digests of TIMP on reverse-phase h.p.l.c. and sequencing those peaks judged...
Comparison of human stromelysin and collagenase by cloning and sequence analysis.
Whitham, S E, Murphy, G, Angel, P, Rahmsdorf, H J, Smith, B J, Lyons, A, ...
A comparison of the cDNA-derived amino acid sequences of human stromelysin and collagenase with the N-terminal sequences of purified enzymes reveals that these metalloproteinases are highly conserved...
Catterall, C F, Lyons, A, Sim, R B, Day, A J, Harris, T J
A cDNA clone of the mRNA coding for the human complement system control protein Factor I has been isolated. The predicted amino acid sequence obtained from the DNA sequence demonstrates a protein...
The complete amino acid sequence of human complement factor H.
Ripoche, J, Day, A J, Harris, T J, Sim, R B
The complete amino acid sequence of the human complement system regulatory protein, factor H, has been derived from sequencing three overlapping cDNA clones. The sequence consists of 1213 amino acids...
Shah, S, Harris, T J, Rink, E, DeWilde, S, Victor, C R, Cook, D G
Traditional measures of socioeconomic status may not be reliable for older people and income may be a useful measure for research into inequalities in health. At the same time, researchers...
Hampe, J, Schreiber, S, Shaw, S H, Lau, K F, Bridger, S, Macpherson, A J, ...
Inflammatory bowel disease (IBD) is characterized by a chronic relapsing intestinal inflammation, typically starting in early adulthood. IBD is subdivided into two subtypes, on the basis of clinical...