Patchen, M. L., Fischer, R., MacVittie, T. J., Seiler, F. R., Williams, D. E.
In the presence of hemopoietic cytokines such as granulocyte- macrophage colony-stimulating factor (GM-CSF) and interleukin-3 (IL-3), mast cell growth factor (MGF; also known as steel factor, stem...
Patchen, M. L., Fischer, R., Macvittie, T. J., Seiler, F., Williams, D. E.
One of the most recent cytokines implicated in hematopoietic regulation is c-kit ligand, also known as mast cell growth factor (MGF), steel factor (SLF), and stem cell factor (SCF) (1-3). The c-kit...
MacVittie, T. J., O'Brien, A. D., Walker, R. I., Weinberg, S. R.
Pub. in Macrophages and Natural Killer Cells, p325-334, 1982.
Canine Hematopoiesis in a Model of Combined Injury, (2005)
MacVittie,T. J., Monroy,R. L., Fink,M., Gruber,D. F., Patchen,M. L.
The development of a large animal model for CI within the context of a nuclear disaster required that we describe, experimentally, the essential features of the radiobiology of acute effects in the...
Jemionek, John F., Monroy, R. L., MacVittie, T. J., Contreras, T. J., Espy, S. B.
Pub. in British Jnl. of Haematology, v51 p585-594 1982.
Inhibition of Granulopoiesis in Diffusion Chambers by a Granulocyte Chalone, (2002)
MacVittie,T. J., McCarthy,K. F.
Granulocyte chalone obtained from media conditioned by rat granulocytes was tested on normal and vinblastine treated regenerating mouse marrow placed in an in vivo diffusion chamber culture system....
McCarthy,K. F., MacVittie,T. J.
The ability of a single injection of Bordetella pertussis vaccine to cause an increase in the number of circulating transplantable colony forming units (CFU) in mice of genotype S1/S1d and their...
Regulation of Hemopoietic Stem Cell Turnover and Population Size in Neonatal Mice. (2002)
McCarthy,K. F., MacVittie,T. J., Kirchgessner,P. J.
Following birth the hematopoietic stem cell population of the liver as measured by the in vivo spleen nodule assay (CFU) declines with a halving time of about 48 hours. The stem cell population of...
MacVittie,T. J., McCarthy,K. F., McCarthy,E. G.
The in vivo diffusion chamber (DC) technique for mouse marrow culture was used to determine the effect of a granulocyte inhibitor (chalone) on the proliferation of the pluripotent stem cell (CFU-S)...
Gambrill,M. R., Ledney,G. D., MacVittie,T. J.
Murine spleen cells were separated on the basis of adherence to glass beads into distinct subpopulations that differ in their ability to produce acute graft versus host disease (GVHD). Nonadherent...
Colony Forming Capacity of Mouse Thymus Cells 'in vitro'. (2002)
MacVittie,T. J., McCarthy,K. F., Crawford,R. M.
A small number of cells within the mouse thymus were induced to form colonies of mononuclear cells in an in vitro agar system. The specific factor necessary to induce colony formation was present in...
Ledney,G. D., Moniot,J. V., Gambrill,M. R., MacVittie,T. J., Levin,S. G.
An integrated study of the host's hematocytopoietic responses to malignancy was undertaken with the aid of an animal model. The Lewis lung (3LL) transplantable carcinoma produces splenic enlargement...
MacVittie,T. J., Weatherly,T. L.
The enigmatic presence of in vitro colony-forming cells (CFC) within the thymus (T) and lymph node (LN) organs prompted us to determine additional characteristics of this cell population in an effort...
Separation of Spleen Cells in Iso-Osmotic Ficoll Density Gradients. (1998)
McCarthy,K. F., Nutter,J. E., MacVittie,T. J.
Osmotic pressures of polymer solutions were examined as a function of density by equilibrium dialysis, and it was reaffirmed that the van't Hoff equation cannot be used to calculate the osmotic...
Pathophysiology of Combined Injury and Trauma: An Overview, (1983)
Conklin,J. J., MacVittie,T. J., Walker,R. I.
It has been 15 years since the problem of combined injuries has been reviewed. Since then a great deal has been learned about the pathophysiology of combined injuries. This proceedings will review...
Recovery of aerobic and anaerobic bacteria from irradiated mice.
Brook, I, MacVittie, T J, Walker, R I
Anaerobic and aerobic bacteria were often found as mixed infections in 225 lethally irradiated mice. Of a total of 57 mice that were sacrificed, aerobic bacteria were recovered exclusively in 9 (27%)...
Natanson, C, Danner, R L, Elin, R J, Hosseini, J M, Peart, K W, Banks, S M, ...
Using different types of bacteria and a canine model simulating human septic shock, we investigated the role of endotoxin in cardiovascular dysfunction and mortality. Either Escherichia coli (a...
Natanson, C, Fink, M P, Ballantyne, H K, MacVittie, T J, Conklin, J J, Parrillo, J E
A canine sepsis model that simulates the human cardiovascular response to septic shock was produced in 10 conscious unsedated dogs by implanting an Escherichia coli-infected clot into the peritoneum,...
Farese, A M, Hunt, P, Grab, L B, MacVittie, T J
This study compared the therapeutic potential of recombinant, native versus pegylated megakaryocyte growth and development factor (rMGDF and PEG-rMGDF, respectively), as well as that of the combined...
Inhibition of prostaglandin synthesis restores normal hemodynamics in canine hyperdynamic sepsis.
Fink, M P, MacVittie, T J, Casey, L C
This study investigates the role of prostaglandins (PG) in hyperdynamic sepsis. Thirteen chronically instrumented dogs were rendered septic by implanting in the peritoneal cavity a fibrin clot...
Recovery of aerobic and anaerobic bacteria from irradiated mice.
Brook, I, MacVittie, T J, Walker, R I
Anaerobic and aerobic bacteria were often found as mixed infections in 225 lethally irradiated mice. Of a total of 57 mice that were sacrificed, aerobic bacteria were recovered exclusively in 9 (27%)...
Natanson, C, Danner, R L, Elin, R J, Hosseini, J M, Peart, K W, Banks, S M, ...
Using different types of bacteria and a canine model simulating human septic shock, we investigated the role of endotoxin in cardiovascular dysfunction and mortality. Either Escherichia coli (a...
Natanson, C, Fink, M P, Ballantyne, H K, MacVittie, T J, Conklin, J J, Parrillo, J E
A canine sepsis model that simulates the human cardiovascular response to septic shock was produced in 10 conscious unsedated dogs by implanting an Escherichia coli-infected clot into the peritoneum,...
Farese, A M, Hunt, P, Grab, L B, MacVittie, T J
This study compared the therapeutic potential of recombinant, native versus pegylated megakaryocyte growth and development factor (rMGDF and PEG-rMGDF, respectively), as well as that of the combined...
Inhibition of prostaglandin synthesis restores normal hemodynamics in canine hyperdynamic sepsis.
Fink, M P, MacVittie, T J, Casey, L C
This study investigates the role of prostaglandins (PG) in hyperdynamic sepsis. Thirteen chronically instrumented dogs were rendered septic by implanting in the peritoneal cavity a fibrin clot...
Davis, T A, Monroy, R L, Skelly, R R, Donahue, R E, MacVittie, T J
The effect of recombinant human interleukin-1 (IL-1) alpha, granulocyte-macrophage colony-stimulating factor (GM-CSF), and combined factor therapy (CFT) on Rhesus monkey peripheral blood natural...