McElrath, M J, Corey, L, Greenberg, P D, Matthews, T J, Montefiori, D C, Rowen, L, ...
With efforts underway to develop a preventive human immunodeficiency virus type 1 (HIV-1) vaccine, it remains unclear which immune responses are sufficient to protect against infection and whether...
Wild, C T, Shugars, D C, Greenwell, T K, McDanal, C B, Matthews, T J
To define the role of the human immunodeficiency virus type 1 (HIV-1) envelope proteins in virus infection, a series of peptides were synthesized based on various regions of the HIV-1 transmembrane...
Ivey-Hoyle, M, Culp, J S, Chaikin, M A, Hellmig, B D, Matthews, T J, Sweet, R W, ...
The envelope glycoprotein gp120 of primate immunodeficiency viruses initiates viral attachment to CD4+ cells by binding to the CD4 antigen on host cell surfaces. However, among different CD4+ cell...
Gorse, G J, Patel, G B, Newman, F K, Belshe, R B, Berman, P W, Gregory, T J, ...
The ability of antibody induced by MN and IIIB recombinant gp120 (rgp120) human immunodeficiency virus type 1 (HIV-1) vaccines the bind to oligomeric native and monomeric recombinant HIV-1 envelope...
Chen, C H, Matthews, T J, McDanal, C B, Bolognesi, D P, Greenberg, M L
We have previously reported that synthetic peptides representing the leucine zipper domain (DP107) and a second putative helical domain (DP178) of human immunodeficiency virus type 1 (HIV-1) gp41...
Shugars, D C, Wild, C T, Greenwell, T K, Matthews, T J
Envelope oligomerization is thought to serve several crucial functions during the life cycle of human immunodeficiency virus type 1 (HIV-1). We recently reported that virus entry requires coiled-coil...
Robert-Guroff, M, Aldrich, K, Muldoon, R, Stern, T L, Bansal, G P, Matthews, T J, ...
In contrast to infrequent and low-titer cross-neutralization of human immunodeficiency virus type 1 (HIV-1) isolates by HIV-2- and simian immunodeficiency virus (SIV)-positive sera, extensive...
Rovinski, B, Haynes, J R, Cao, S X, James, O, Sia, C, Zolla-Pazner, S, ...
Noninfectious human immunodeficiency virus type 1 (HIV-1) viruslike particles containing chimeric envelope glycoproteins were expressed in mammalian cells by using inducible promoters. We engineered...
Berman, P W, Matthews, T J, Riddle, L, Champe, M, Hobbs, M R, Nakamura, G R, ...
Vaccines prepared from the envelope glycoprotein, gp120, of the common laboratory isolate of human immunodeficiency virus type 1 (HIV-1) (IIIB/LAV-1) elicit antibodies that neutralize the homologous...
Shadduck, P P, Weinberg, J B, Haney, A F, Bartlett, J A, Langlois, A J, Bolognesi, D P, ...
The influence of human anti-human immunodeficiency virus type 1 (HIV-1) antibody on HIV-1 infection of freshly isolated normal human peritoneal macrophages and blood monocytes was examined. Each of...
Neutralizing antibodies to an immunodominant envelope sequence do not prevent gp120 binding to CD4.
Skinner, M A, Langlois, A J, McDanal, C B, McDougal, J S, Bolognesi, D P, Matthews, T J
Animals immunized with the human immunodeficiency virus type 1 gp160 glycoprotein or certain recombinant envelope components develop potent virus-neutralizing activity. This activity is principally...
Palker, T J, Clark, M E, Langlois, A J, Matthews, T J, Weinhold, K J, Randall, R R, ...
A synthetic peptide (SP-10-IIIB) with an amino acid sequence [Cys-Thr-Arg-Pro-Asn-Asn-Asn-Thr-Arg-Lys-Ser-Ile-Arg-Ile-Gln-Arg-Gly-Pro -Pro-Gly-(Tyr); amino acids 303-321] from the human...
Richardson, N E, Brown, N R, Hussey, R E, Vaid, A, Matthews, T J, Bolognesi, D P, ...
The external segment of the T4 (CD4) glycoprotein functions as the T-cell surface receptor for human immunodeficiency virus by binding the major viral coat protein (gp120) with relatively high...
Matthews, T J, Weinhold, K J, Lyerly, H K, Langlois, A J, Wigzell, H, Bolognesi, D P
Interactions between retroviruses associated with acquired immunodeficiency syndrome and their receptors on lymphocytes represent the initial steps in the process of infection and are also involved...
Palker, T J, Matthews, T J, Clark, M E, Cianciolo, G J, Randall, R R, Langlois, A J, ...
A highly immunogenic epitope from a conserved COOH-terminal region of the human immunodeficiency virus (HIV) gp120 envelope protein has been identified with antisera from HIV-seropositive subjects...
Lyerly, H K, Matthews, T J, Langlois, A J, Bolognesi, D P, Weinhold, K J
The lymphocyte differentiation antigen CD4 serves as a receptor for human retroviruses associated with acquired immunodeficiency syndrome (AIDS) through its interaction with the major envelope virion...
McLean, C, Matthews, T J, Rueckert, R R
Pulse-chase kinetics and extensive pactamycin mapping studies show that the translation of rhinovirus 1A proceeds in the order: initiate-P1-S-P2-terminate, where P1 is the precursor to the capsid...
Robey, W G, Arthur, L O, Matthews, T J, Langlois, A, Copeland, T D, Lerche, N W, ...
This study initiates an effort to develop a safe vaccine against the acquired immunodeficiency syndrome (AIDS) that is caused by infection with a retrovirus designated human immunodeficiency virus...
Matthews, T J, Langlois, A J, Robey, W G, Chang, N T, Gallo, R C, Fischinger, P J, ...
By analogy to other retroviruses, the major envelope glycoprotein, gp120, of human T-lymphotropic virus type III (HTLV-III) is a probable target for neutralizing antibody. This antigen has been...
Matthews, T J, Hornall, D, Sheppard, M N
To establish if antibodies to alpha smooth muscle actin (ASMA) are better than desmin as a tumour marker in pulmonary lymphangioleiomyomatosis both antisera were applied to five cases. ASMA strongly...
Leiomyosarcoma of soft tissue and pulmonary metastasis, both with osteoclast-like giant cells.
A case is described of leiomyosarcoma with osteoclast-like giant cells in soft tissues which metastasised to the lung. The secondary tumour also contained abundant osteoclast-like giant cells, which...
Sexual reinforcement in the female rat.
Matthews, T J, Grigore, M, Tang, L, Doat, M, Kow, L M, Pfaff, D W
Sexual reinforcement in the female rat was studied in a preparation that allowed continuous operant responding for access to a male rat leading to intromission. Experiment 1 used a high operant level...
Selective sensitivity of schedule-induced activity to an operant suppression contingency.
The sensitivity of pigeons' schedule-induced activity to operant consequences was studied in two experiments. During a 30-s interval between food presentations, a keylight stimulus brightened...
Pigeons were trained on a variant of the autoshaping procedure devised by Matthews and Lerer (1987) in which a keylight stimulus ramp of increasing brightness signaled the passing of a 30-s interfood...
"Turning back the clock" on serial-stimulus sign tracking.
Two experiments examined the effects of a negative (setback) response contingency on key pecking engendered by a changing light-intensity stimulus clock (ramp stimulus) signaling fixed-time 30-s food...
McElrath, M J, Corey, L, Greenberg, P D, Matthews, T J, Montefiori, D C, Rowen, L, ...
With efforts underway to develop a preventive human immunodeficiency virus type 1 (HIV-1) vaccine, it remains unclear which immune responses are sufficient to protect against infection and whether...
Wild, C T, Shugars, D C, Greenwell, T K, McDanal, C B, Matthews, T J
To define the role of the human immunodeficiency virus type 1 (HIV-1) envelope proteins in virus infection, a series of peptides were synthesized based on various regions of the HIV-1 transmembrane...
Ivey-Hoyle, M, Culp, J S, Chaikin, M A, Hellmig, B D, Matthews, T J, Sweet, R W, ...
The envelope glycoprotein gp120 of primate immunodeficiency viruses initiates viral attachment to CD4+ cells by binding to the CD4 antigen on host cell surfaces. However, among different CD4+ cell...
Gorse, G J, Patel, G B, Newman, F K, Belshe, R B, Berman, P W, Gregory, T J, ...
The ability of antibody induced by MN and IIIB recombinant gp120 (rgp120) human immunodeficiency virus type 1 (HIV-1) vaccines the bind to oligomeric native and monomeric recombinant HIV-1 envelope...
Chen, C H, Matthews, T J, McDanal, C B, Bolognesi, D P, Greenberg, M L
We have previously reported that synthetic peptides representing the leucine zipper domain (DP107) and a second putative helical domain (DP178) of human immunodeficiency virus type 1 (HIV-1) gp41...
Shugars, D C, Wild, C T, Greenwell, T K, Matthews, T J
Envelope oligomerization is thought to serve several crucial functions during the life cycle of human immunodeficiency virus type 1 (HIV-1). We recently reported that virus entry requires coiled-coil...
Robert-Guroff, M, Aldrich, K, Muldoon, R, Stern, T L, Bansal, G P, Matthews, T J, ...
In contrast to infrequent and low-titer cross-neutralization of human immunodeficiency virus type 1 (HIV-1) isolates by HIV-2- and simian immunodeficiency virus (SIV)-positive sera, extensive...
Rovinski, B, Haynes, J R, Cao, S X, James, O, Sia, C, Zolla-Pazner, S, ...
Noninfectious human immunodeficiency virus type 1 (HIV-1) viruslike particles containing chimeric envelope glycoproteins were expressed in mammalian cells by using inducible promoters. We engineered...
Berman, P W, Matthews, T J, Riddle, L, Champe, M, Hobbs, M R, Nakamura, G R, ...
Vaccines prepared from the envelope glycoprotein, gp120, of the common laboratory isolate of human immunodeficiency virus type 1 (HIV-1) (IIIB/LAV-1) elicit antibodies that neutralize the homologous...
Shadduck, P P, Weinberg, J B, Haney, A F, Bartlett, J A, Langlois, A J, Bolognesi, D P, ...
The influence of human anti-human immunodeficiency virus type 1 (HIV-1) antibody on HIV-1 infection of freshly isolated normal human peritoneal macrophages and blood monocytes was examined. Each of...
Neutralizing antibodies to an immunodominant envelope sequence do not prevent gp120 binding to CD4.
Skinner, M A, Langlois, A J, McDanal, C B, McDougal, J S, Bolognesi, D P, Matthews, T J
Animals immunized with the human immunodeficiency virus type 1 gp160 glycoprotein or certain recombinant envelope components develop potent virus-neutralizing activity. This activity is principally...
Palker, T J, Clark, M E, Langlois, A J, Matthews, T J, Weinhold, K J, Randall, R R, ...
A synthetic peptide (SP-10-IIIB) with an amino acid sequence [Cys-Thr-Arg-Pro-Asn-Asn-Asn-Thr-Arg-Lys-Ser-Ile-Arg-Ile-Gln-Arg-Gly-Pro -Pro-Gly-(Tyr); amino acids 303-321] from the human...
Richardson, N E, Brown, N R, Hussey, R E, Vaid, A, Matthews, T J, Bolognesi, D P, ...
The external segment of the T4 (CD4) glycoprotein functions as the T-cell surface receptor for human immunodeficiency virus by binding the major viral coat protein (gp120) with relatively high...
Matthews, T J, Weinhold, K J, Lyerly, H K, Langlois, A J, Wigzell, H, Bolognesi, D P
Interactions between retroviruses associated with acquired immunodeficiency syndrome and their receptors on lymphocytes represent the initial steps in the process of infection and are also involved...
Palker, T J, Matthews, T J, Clark, M E, Cianciolo, G J, Randall, R R, Langlois, A J, ...
A highly immunogenic epitope from a conserved COOH-terminal region of the human immunodeficiency virus (HIV) gp120 envelope protein has been identified with antisera from HIV-seropositive subjects...
Lyerly, H K, Matthews, T J, Langlois, A J, Bolognesi, D P, Weinhold, K J
The lymphocyte differentiation antigen CD4 serves as a receptor for human retroviruses associated with acquired immunodeficiency syndrome (AIDS) through its interaction with the major envelope virion...
McLean, C, Matthews, T J, Rueckert, R R
Pulse-chase kinetics and extensive pactamycin mapping studies show that the translation of rhinovirus 1A proceeds in the order: initiate-P1-S-P2-terminate, where P1 is the precursor to the capsid...
Robey, W G, Arthur, L O, Matthews, T J, Langlois, A, Copeland, T D, Lerche, N W, ...
This study initiates an effort to develop a safe vaccine against the acquired immunodeficiency syndrome (AIDS) that is caused by infection with a retrovirus designated human immunodeficiency virus...
Matthews, T J, Langlois, A J, Robey, W G, Chang, N T, Gallo, R C, Fischinger, P J, ...
By analogy to other retroviruses, the major envelope glycoprotein, gp120, of human T-lymphotropic virus type III (HTLV-III) is a probable target for neutralizing antibody. This antigen has been...
Matthews, T J, Hornall, D, Sheppard, M N
To establish if antibodies to alpha smooth muscle actin (ASMA) are better than desmin as a tumour marker in pulmonary lymphangioleiomyomatosis both antisera were applied to five cases. ASMA strongly...
Leiomyosarcoma of soft tissue and pulmonary metastasis, both with osteoclast-like giant cells.
A case is described of leiomyosarcoma with osteoclast-like giant cells in soft tissues which metastasised to the lung. The secondary tumour also contained abundant osteoclast-like giant cells, which...
Sexual reinforcement in the female rat.
Matthews, T J, Grigore, M, Tang, L, Doat, M, Kow, L M, Pfaff, D W
Sexual reinforcement in the female rat was studied in a preparation that allowed continuous operant responding for access to a male rat leading to intromission. Experiment 1 used a high operant level...
Selective sensitivity of schedule-induced activity to an operant suppression contingency.
The sensitivity of pigeons' schedule-induced activity to operant consequences was studied in two experiments. During a 30-s interval between food presentations, a keylight stimulus brightened...
Pigeons were trained on a variant of the autoshaping procedure devised by Matthews and Lerer (1987) in which a keylight stimulus ramp of increasing brightness signaled the passing of a 30-s interfood...
"Turning back the clock" on serial-stimulus sign tracking.
Two experiments examined the effects of a negative (setback) response contingency on key pecking engendered by a changing light-intensity stimulus clock (ramp stimulus) signaling fixed-time 30-s food...
HIV-1 recombinant gp160 vaccine given in accelerated dose schedules
Gorse, G. J., Schwartz, D. H., Graham, B. S., Matthews, T. J., Stablein, D. M., Frey, S. E., ...
The purpose of this randomized, double-blind study was to test the safety and immunogenicity of an HIV-1LAI recombinant gp160 (rgp160) vaccine in healthy, uninfected volunteers using accelerated...