T. J. Spira

Mechanisms of human immunodeficiency virus Type 1 (HIV-1) neutralization: irreversible inactivation of infectivity by anti-HIV-1 antibody.

McDougal, J S, Kennedy, M S, Orloff, S L, Nicholson, J K, Spira, T J

An assay for the neutralization of human immunodeficiency virus type 1 (HIV-1) is described in which the reduction in infectious titer of HIV-1 after preincubation at 37 degrees C with...

Micromethod for assaying reverse transcriptase of human T-cell lymphotropic virus type III/lymphadenopathy-associated virus.

Spira, T J, Bozeman, L H, Holman, R C, Warfield, D T, Phillips, S K, Feorino, P M

A micromethod for assaying the reverse transcriptase enzyme of human T-cell lymphotropic virus type III/lymphadenopathy-associated virus in cocultures of clinical specimens for viral isolation was...

Nonrandom development of immunologic abnormalities after infection with human immunodeficiency virus: implications for immunologic classification of the disease.

Zolla-Pazner, S, Des Jarlais, D C, Friedman, S R, Spira, T J, Marmor, M, Holzman, R, ...

Blood specimens from 165 intravenous drug users who were seropositive for the human immunodeficiency virus (HIV), from 158 seropositive homosexual men with lymphadenopathy, and from 77 patients with...

Genetic polymorphism in C8 beta-chains. Evidence for two unlinked genetic loci for the eighth component of human complement (C8).

Alper, C A, Marcus, D, Raum, D, Petersen, B H, Spira, T J

Genetic polymorphism in the beta-subunit of the eighth component of human complement, C8, was defined by isoelectric focusing of serum in polyacrylamide gel in the presence of urea and development of...

Genomic diversity of the acquired immunodeficiency syndrome retroviruses is reflected in alteration of its translational products.

Devare, S G, Srinivasan, A, Bohan, C A, Spira, T J, Curran, J W, Kalyanaraman, V S

We have isolated retroviruses from six acquired immunodeficiency syndrome (AIDS) and three lymphadenopathy syndrome (LAS) patients by cocultivation of patients' lymphocytes with...

Immunoregulatory subsets of the T helper and T suppressor cell populations in homosexual men with chronic unexplained lymphadenopathy.

Nicholson, J K, McDougal, J S, Spira, T J, Cross, G D, Jones, B M, Reinherz, E L

Unexplained, generalized lymphadenopathy in homosexual men, which can be a prodrome to the acquired immunodeficiency syndrome, is associated with impaired cell-mediated immunity, a low ratio of T...

Antibody response to human immunodeficiency virus in homosexual men. Relation of antibody specificity, titer, and isotype to clinical status, severity of immunodeficiency, and disease progression.

McDougal, J S, Kennedy, M S, Nicholson, J K, Spira, T J, Jaffe, H W, Kaplan, J E, ...

The titers and isotypes of antibodies to specific proteins of the human immunodeficiency virus were determined by Western blot analysis of sera from 107 homosexual men. Antibody titers were generally...

Mechanisms of human immunodeficiency virus Type 1 (HIV-1) neutralization: irreversible inactivation of infectivity by anti-HIV-1 antibody.

McDougal, J S, Kennedy, M S, Orloff, S L, Nicholson, J K, Spira, T J

An assay for the neutralization of human immunodeficiency virus type 1 (HIV-1) is described in which the reduction in infectious titer of HIV-1 after preincubation at 37 degrees C with...

Micromethod for assaying reverse transcriptase of human T-cell lymphotropic virus type III/lymphadenopathy-associated virus.

Spira, T J, Bozeman, L H, Holman, R C, Warfield, D T, Phillips, S K, Feorino, P M

A micromethod for assaying the reverse transcriptase enzyme of human T-cell lymphotropic virus type III/lymphadenopathy-associated virus in cocultures of clinical specimens for viral isolation was...

Nonrandom development of immunologic abnormalities after infection with human immunodeficiency virus: implications for immunologic classification of the disease.

Zolla-Pazner, S, Des Jarlais, D C, Friedman, S R, Spira, T J, Marmor, M, Holzman, R, ...

Blood specimens from 165 intravenous drug users who were seropositive for the human immunodeficiency virus (HIV), from 158 seropositive homosexual men with lymphadenopathy, and from 77 patients with...

Genetic polymorphism in C8 beta-chains. Evidence for two unlinked genetic loci for the eighth component of human complement (C8).

Alper, C A, Marcus, D, Raum, D, Petersen, B H, Spira, T J

Genetic polymorphism in the beta-subunit of the eighth component of human complement, C8, was defined by isoelectric focusing of serum in polyacrylamide gel in the presence of urea and development of...

Genomic diversity of the acquired immunodeficiency syndrome retroviruses is reflected in alteration of its translational products.

Devare, S G, Srinivasan, A, Bohan, C A, Spira, T J, Curran, J W, Kalyanaraman, V S

We have isolated retroviruses from six acquired immunodeficiency syndrome (AIDS) and three lymphadenopathy syndrome (LAS) patients by cocultivation of patients' lymphocytes with...

Immunoregulatory subsets of the T helper and T suppressor cell populations in homosexual men with chronic unexplained lymphadenopathy.

Nicholson, J K, McDougal, J S, Spira, T J, Cross, G D, Jones, B M, Reinherz, E L

Unexplained, generalized lymphadenopathy in homosexual men, which can be a prodrome to the acquired immunodeficiency syndrome, is associated with impaired cell-mediated immunity, a low ratio of T...

Antibody response to human immunodeficiency virus in homosexual men. Relation of antibody specificity, titer, and isotype to clinical status, severity of immunodeficiency, and disease progression.

McDougal, J S, Kennedy, M S, Nicholson, J K, Spira, T J, Jaffe, H W, Kaplan, J E, ...

The titers and isotypes of antibodies to specific proteins of the human immunodeficiency virus were determined by Western blot analysis of sera from 107 homosexual men. Antibody titers were generally...