The metabolism and dechlorination of chlorotyrosine in vivo (2007)
Mani, A.R., Ippolito, S., Moreno, J.C., Visser, T.J., Moore, K.P.
During inflammation, neutrophil- and monocyte-derived myeloperoxidase catalyzes the formation of hypochlorous acid, which can chlorinate tyrosine residues in proteins to form chlorotyrosine. However,...
Rajatapiti, P., Keijzer, R., Blommaart, P.E., Lamers, W.H., Kruger, R.R. De, Visser, T.J., ...
The degree of associated pulmonary hypoplasia and persistent pulmonary hypertension are major determination factors for survival in congenital diaphragmatic hernia (CDH) patients. Glucocorticoids,...
Changes within the thyroid axis during critical illness (2006)
Peeters, R.P., Debaveye, Y., Fliers, E., Visser, T.J.
Pronounced alterations in plasma thyroid stimulating hormone and thyroid hormone levels occur during critical illness without any evidence for thyroid disease. Plasma T3 decreases and plasma rT3...
Regulation of type III iodothyronine deiodinase expression in human cell lines (2006)
Kester, M.H.A., Versteeg, R., Visser, T.J.
Type I iodothyronine deiodinase (D1) and type II iodothyronine deiodinase (D2) catalyze the activation of the prohormone T-4 to the active hormone T-3; type III iodothyronine deiodinase (D3)...
Novel neuroanatomical pathways for thyroid hormone action in the human anterior pituitary (2006)
Alkemade, J.M., Friesema, E.C., Kuiper, G.G., Wiersinga, W.M., Swaab, D.F., Visser, T.J., ...
Neuroanatomical pathways for thyroid hormone feedback in the human hypothalamus (2005)
Alkemade, J.M., Friesema, E.C., Unmehopa, U.A., Fabriek, B.O., Kuiper, G.C., Leonard, J.L., ...
Neuroanatomical pathways for thyroid hormone feedback in the human hypothalamus (2005)
Alkemade, J.M., Friesema, E.C., Unmehopa, U.A., Fabriek, B.O., Kuiper, G.C., Leonard, J.L., ...
Thyroid hormone concentrations, disease, physical function and mortality in elderly men. (2005)
Visser, T.J., Feelders, R.A., Grobbee, D.E., Lamberts, S.W.J.
Marissen, W.E., Kramer, R.A., Rice, A., Weldon, W.C., Niezgoda, M., Faber, M., ...
Anti-rabies virus immunoglobulin combined with rabies vaccine protects humans from lethal rabies infections. For cost and safety reasons, replacement of the human or equine polyclonal immunoglobulin...
Expression of pituitary hormones in the Pax8-/- mouse model of congenital hypothyroidism (2004)
Friedrichsen, S., Christ, S., Heuer, H., Schafer, M. K., Parlow, A. F., Visser, T. J., ...
Signaling mechanisms in pituitary morphogenesis as well as pituitary cell fate determination during early embryonic development are relatively well characterized. In contrast, the cues that determine...
Rabeler, R., Mittag, J., Geffers, L., Ruther, U., Leitges, M., Parlow, A. F., ...
To provide an animal model of central hypothyroidism, mice deficient in the TRH-receptor 1 (TRH-R1) gene were generated by homologous recombination. The pituitaries of TRH-R1-/- mice are devoid of...
Expression of pituitary hormones in the Pax8–/– mouse model of congenital hypothyroidism. (2004)
Friedrichsen, S., Christ, S., Heuer, H., Schaefer, M. K. H., Parlow, A. F., Visser, T. J., ...
Friedrichsen, S., Christ, S., Heuer, H., Schafer, M. K. H., Mansouri, A., Bauer, K., ...
Thyroid hormones are essential for a variety of developmental and metabolic processes. Congenital hypothyroidism (CHT) results in severe defects in the development of different tissues, in particular...
Kuiper, G.G., Klootwijk, W., Visser, T.J.
Human type III iodothyronine deiodinase (D3) catalyzes the conversion of T(4) to rT(3) and of T(3) to 3, 3'-diiodothyronine (T2) by inner-ring deiodination. Like types I and II iodothyronine...
Peeters, R.P., Toor, H. Van, Klootwijk, W., Rijke, Y.B. De, Kuiper, G.G., Uitterlinden, A.G., ...
Single nucleotide polymorphisms (SNPs) in genes involved in thyroid hormone metabolism may affect thyroid hormone bioactivity. We investigated the occurrence and possible effects of SNPs in the...
Peeters, R.P., Wouters, P.J., Kaptein, E., Toor, H. Van, Visser, T.J., Berghe, G. Van Den
Critical illness is often associated with reduced TSH and thyroid hormone secretion as well as marked changes in peripheral thyroid hormone metabolism, resulting in low serum T(3) and high rT(3)...
Characterization of iodothyronine sulfatase activities in human and rat liver and placenta (2002)
Kester, M.H., Kaptein, E., Dijk, C.H. Van, Roest, T.J., Tibboel, D., Coughtrie, M.W., ...
In conditions associated with high serum iodothyronine sulfate concentrations, e.g. during fetal development, desulfation of these conjugates may be important in the regulation of thyroid hormone...
Kester, M.H., Visser, T.J., Bulduk, S., Toor, H. Van, Tibboel, D., Meinl, W., ...
Polyhalogenated aromatic hydrocarbons (PHAHs), such as polychlorinated dibenzo-p-dioxins and dibenzofurans, polybrominated diphenylethers, and bisphenol A derivatives are persistent environmental...
Kuiper, G.G., Klootwijk, W., Visser, T.J.
Human type II iodothyronine deiodinase (D2) catalyzes the activation of T(4) to T(3). The D2 enzyme, like the type I (D1) and type III (D3) deiodinases, contains a selenocysteine (SeC) residue...
Verhoeven, F.A., Hennemann, G., Lamers, J.M., Visser, T.J., Everts, M.E.
Cellular and nuclear uptake of [125I]tri-iodothyronine (T3) and [125I]triiodothyroacetic acid (Triac) were compared in cardiomyocytes of 2-3 day old rats, and the effect of thyroid hormone analogs on...
Induction of thyroid hormone-degrading deiodinase in cardiac hypertrophy and failure (2002)
Wassen, F.W., Schiel, A.E., Kuiper, G.G., Kaptein, E., Bakker, O., Visser, T.J., ...
The similarities between the changes in cardiac gene expression in pathological ventricular hypertrophy and hypothyroidism suggest a role of impaired cardiac thyroid hormone (TH) action in the...
Hypothyroidism induces type I iodothyronine deiodinase expression in tilapia liver (2001)
Toguyeni, A, Baroiller, J F, Fauconneau, B, Fostier, A, Sanders, J P, ...
In the current study, the authors examined the effects of experimentally induced hypothyroidism on peripheral thyroid hormone metabolism and growth in two closely related tilapia species: the Nile...
Hennemann, G., Docter, R., Friesema, E.C., Jong, M. De, Krenning, E.P., Visser, T.J.
Although it was originally believed that thyroid hormones enter target cells by passive diffusion, it is now clear that cellular uptake is effected by carrier-mediated processes. Two stereospecific...
Thyroid hormone transport by the heterodimeric human system L amino acid transporter (2001)
Friesema, E.C., Docter, R., Moerings, E.P., Verrey, F., Krenning, E.P., Hennemann, G., ...
Transport of thyroid hormone across the cell membrane is required for thyroid hormone action and metabolism. We have investigated the possible transport of iodothyronines by the human system L amino...
Verhoeven, F.A., Moerings, E.P., Lamers, J.M., Hennemann, G., Visser, T.J., Everts, M.E.
The effects of the Ca2+ channel blockers verapamil, nifedipine, and diltiazem on triiodothyronine (T3) and thyroxine (T4) uptake were tested in cultured cardiomyocytes from 2-day-old rats....
Kester, M.H.A., Bulduk, S., Tibboel, D., Meinl, W., Glatt, H., Falany, C.N., ...
Polychlorinated biphenyls (PCBs) are persistent environmental pollutants which exert a variety of toxic effects in animals, including disturbances of sexual development and reproductive function. The...
Hak, A.E., Pols, H.A., Visser, T.J., Drexhage, H.A., Hofman, A., Witteman, J.C.
BACKGROUND: Overt hypothyroidism has been found to be associated with cardiovascular disease. Whether subclinical hypothyroidism and thyroid autoimmunity are also risk factors for cardiovascular...
Kester, M.H., Bergman, A., Safe, S.H., Visser, T.J., Kuiper, G.G., Brouwer, A., ...
Polychlorinated biphenyls (PCBs) are persistent environmental pollutants which exert a variety of toxic effects in animals, including disturbances of sexual development and reproductive function. The...
Regulation of thyroid hormone metabolism during fasting and refeeding in chicken (1999)
Van Rompaey, E, Sanders, J P, Visser, T J
Fasting and refeeding have considerable effects on thyroid hormone metabolism. In the present study, 8-day-old meat-type cockerels were subjected to a 2-day starvation period followed by 3 days'...
Kaptein, E, Leonard, J L, ...
Type III iodothyronine deiodinase (D3) catalyzes the inner ring deiodination (IRD) of T4 and T3 to the inactive metabolites rT3 and 3,3'-diiodothyronine (3,3'-T2), respectively. Here we describe the...
Characterization of human iodothyronine sulfotransferases (1999)
Kester, M.H., Kaptein, E., Roest, T.J., Dijk, C.H. Van, Tibboel, D., Meinl, W., ...
Sulfation is an important pathway of thyroid hormone metabolism that facilitates the degradation of the hormone by the type I iodothyronine deiodinase, but little is known about which human...
Sulfation of thyroid hormone by estrogen sulfotransferase (1999)
Kester, M.H., Visser, T.J., Dijk, C.H. Van, Tibboel, D., Hood, A.M., Rose, N.J., ...
Sulfation is one of the pathways by which thyroid hormone is inactivated. Iodothyronine sulfate concentrations are very high in human fetal blood and amniotic fluid, suggesting important production...
Sanders, J.P., Geyten, S. Van Der, Kaptein, E., Darras, V.M., Kuhn, E.R., Leonard, J.L., ...
Type III iodothyronine deiodinase (D3) catalyzes the inner ring deiodination (IRD) of T4 and T3 to the inactive metabolites rT3 and 3,3'-diiodothyronine (3,3'-T2), respectively. Here we describe the...
Schuur, A.G., Tacken, P.J., Visser, T.J., Brouwer, A.
In this study we investigated to what extent the induction of detoxification enzymes by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is modulated by concomitant TCDD-induced changes in thyroid state....
Rapid sulfation of 3,3',5'-triiodothyronine in native Xenopus laevis oocytes (1998)
Friesema, E.C., Docter, R., Krenning, E.P., Everts, M.E., Hennemann, G., Visser, T.J.
Sulfation is an important metabolic pathway facilitating the degradation of thyroid hormone by the type I iodothyronine deiodinase. Different human and rat tissues contain cytoplasmic...
Ontogeny of iodothyronine deiodinases in human liver (1998)
Richard, K., Hume, R., Kaptein, E., Sanders, J.P., Toor, H. Van, Herder, W.W. De, ...
The role of the deiodinases D1, D2, and D3 in the tissue-specific and time-dependent regulation of thyroid hormone bioactivity during fetal development has been investigated in animals but little is...
Characterization of a propylthiouracil-insensitive type I iodothyronine deiodinase (1997)
Kaptein, E, Leonard, J L, ...
Mammalian type I iodothyronine deiodinase (D1) activates and inactivates thyroid hormone by outer ring deiodination (ORD) and inner ring deiodination (IRD), respectively, and is potently inhibited by...
Sanders, J P, Kaptein, E, Leonard, J L, ...
In embryonic chicken liver (ECL) two types of iodothyronine deiodinases are expressed: D1 and D3. D1 catalyzes the activation as well as the inactivation of thyroid hormone by outer and inner ring...
The presence of iodothyronine deiodinases was investigated in the different tissues of blue tilapia (Oreochromis aureus), and their biochemical properties were compared with those of mammalian...
Docter, R., Friesema, E.C., Stralen, P.G. Van, Krenning, E.P., Everts, M.E., Visser, T.J., ...
The present study was conducted to explore the possible use of Xenopus laevis oocytes for the expression cloning of cell membrane transporters for iodothyronines. Injection of stage V-VI X. laevis...
Klootwijk, W., Sleddens-Linkels, E., Boer, R. De, Jansen, C.A., Autar, R., Herder, W.W. De, ...
TRH-like peptides have been identified that differ from TRH (pGlu-His-ProNH2) in the middle amino acid. We have estimated TRH-like immunoreactivity (TRH-LI) in human serum and urine by RIA with...
Characterization of iodothyronine sulfotransferase activity in rat liver (1997)
Kaptein, E., Haasteren, G.A. Van, Linkels, E., Greef, W.J. De, Visser, T.J.
Sulfation is an important pathway in the metabolism of thyroid hormone because it strongly facilitates the degradation of the hormone by the type I iodothyronine deiodinase. However, little is known...
Geyten, S. Van Der, Sanders, J.P., Kaptein, E., Darras, V.M., Kuhn, E.R., Leonard, J.L., ...
In embryonic chicken liver (ECL) two types of iodothyronine deiodinases are expressed: D1 and D3. D1 catalyzes the activation as well as the inactivation of thyroid hormone by outer and inner ring...
Characterization of a propylthiouracil-insensitive type I iodothyronine deiodinase (1997)
Sanders, J.P., Geyten, S. Van Der, Kaptein, E., Darras, V.M., Kuhn, E.R., Leonard, J.L., ...
Mammalian type I iodothyronine deiodinase (D1) activates and inactivates thyroid hormone by outer ring deiodination (ORD) and inner ring deiodination (IRD), respectively, and is potently inhibited by...
Greef, W.J. De, Herder, W.W. De, Lambalk, C.B., Klootwijk, W., Sleddens-Linkels, E., Jong, F.H. De, ...
Recent studies have revealed that TRH-like immunoreactivity (TRH-LI) in human serum is predominantly pGlu-Glu-ProNH2 (< EEP-NH2), a peptide previously found in, among others tissues, the pituitary...
Everts, M.E., Visser, T.J., Moerings, E.P., Tempelaars, A.M., Toor, H. Van, Docter, R., ...
We compared the uptake, metabolism, and biological effects of tetraiodothyroacetic acid (Tetrac) and rT3 in anterior pituitary cells with those of T4 and T3. Cells were isolated from adult male...
Haasteren, G.A. Van, Hermus, A.R., Linkels, E., Klootwijk, W., Kaptein, E., ...
The cytokines interleukin-1 (IL-1) and IL-6 are thought to be important mediators in the suppression of thyroid function during nonthyroidal illness. In this study we compared the effects of IL-1 and...
Everts, M.E., Visser, T.J., Moerings, E.P., Docter, R., Toor, H. Van, Tempelaars, A.M., ...
The uptake of [125I]triiodothyroacetic acid ([125I]Triac) in anterior pituitary cells was investigated and compared with that of [125I]T3. Furthermore, the effects of Triac, T3, and T4 on TSH release...
Uptake of thyroxine in cultured anterior pituitary cells of euthyroid rats (1994)
Everts, M.E., Docter, R., Moerings, E.P., Koetsveld, P.M. Van, Visser, T.J., Jong, M. De, ...
The uptake of [125I]T4 was investigated in cultured anterior pituitary cells isolated from adult fed Wistar rats and cultured for 3 days in medium containing 10% fetal calf serum. Experiments were...
Visser, T.J., Kaptein, E., ...
Beetstra, J.B., Karels, P., Docter, R., ...
Kinetic evidence suggesting two mechanisms for iodothyronine 5'-deiodination in rat cerebral cortex.
Visser, T J, Leonard, J L, Kaplan, M M, Larsen, P R
Enzymatic 5'-deiodination of 3,3',5'-triiodothyronine (rT3) and 3,3',5,5'-tetraiodothyronine (thyroxine, T4) was studied in microsomal preparations of rat cerebral cortex. Evidence was obtained for...
Metabolism of reverse triiodothyronine by isolated rat hepatocytes.
Rooda, S J, Van Loon, M A, Visser, T J
Reverse triiodothyronine (rT3) is metabolized predominantly by outer ring deiodination to 3,3'-diiodothyronine (3,3'-T2) in the liver. Metabolism of rT3 and 3,3'-T2 by isolated rat hepatocytes was...
Accumulation of plasma triiodothyronine sulfate in rats treated with propylthiouracil.
Rutgers, M, Bonthuis, F, De Herder, W W, Visser, T J
Triiodothyronine sulfate (T3S) is rapidly deiodinated by the propylthiouracil (PTU)-sensitive type I deiodinase. Here we examined the effects of PTU on plasma T3S levels in rats after intravenous...
Visser, T J, Van Overmeeren, E
Previous studies have shown that 2-thiouracil derivatives are uncompetitive inhibitors of iodothyronine 5'-deiodinase activity of rat liver microsomal fraction. Therefore the interaction of...
Fekkes, D, Hennemann, G, Visser, T J
The enzymic 5'-deiodination of 3',5'-di-iodothyronine and 5-deiodination of 3,3',5-tri-iodothyronine by rat liver microsomal fractions were found to be characterized by apparent Km values of 0.77 and...
Visser, T J, Does-Tobé, I, Docter, R, Hennemann, G
Experiments with rat liver homogenates showed that on subcellular fractionation the ability to catalyse the conversion of thyroxine into tri-iodothyronine was lost. The activity could in part be...
Sequential deiodination of thyroxine in rat liver homogenate.
Visser, T J, Fekkes, D, Docter, R, Hennemann, G
Rat liver homogenate was incubated at 37 degrees C with thyroxine, 3,3',5-tri-iodothyronine, 3,3',5'-tri-iodothyronine or 3,3'-di-iodothyronine. The degradation or accumulation of these compounds was...
Kinetics of enzymic reductive deiodination of iodothyronines. Effect of pH.
Visser, T J, Fekkes, D, Docter, R, Hennemann, G
5'-Deiodination of thyroxine (yielding 3,3',5-tri-iodothyronine; reaction I) and of 3,3',5'-tri-iodothyronine (yielding 3,3'-di-iodothyronine; reaction II) and 5-deiodination of thyroxine (yielding...
Seasonal fluctuations in serum concentrations of vitamin D metabolites in normal subjects.
Juttmann, J R, Visser, T J, Buurman, C, De Kam, E, Birkenhäger, J C
Serum concentrations of 25-hydroxycholecalciferol (25-OHD), 24,25-dihydroxycholecalciferol (24,25-(OH)2D), and 1,25-dihydroxycholecalciferol (1,25-(OH)2D) were measured at monthly intervals...
Hennemann, G, Van Welsum, M, Bernard, B, Docter, R, Visser, T J
Three groups of patients who had undergone subtotal thyroidectomy for Graves's disease, toxic multinodular goitre, or euthyroid multinodular goitre 12 to 15 years before and in whom a normal serum...
Maranduba, C M C, Friesema, E C H, Kok, F, Kester, M H A, Jansen, J, Sertié, A L, ...
We report a novel 1 bp deletion (c.1834delC) in the MCT8 gene in a large Brazilian family with Allan‐Herndon‐Dudley syndrome (AHDS), an X linked condition characterised by severe mental...