To, M D, Perez-Losada, J, Mao, J H, Hsu, J, Jacks, T, Balmain, A
Pulmonary adenoma susceptibility 1 (Pas1) is the major mouse lung cancer susceptibility locus on chromosome 6 (ref. 1). Kras2 is a common target of somatic mutation in chemically induced mouse lung...
MacPherson, D., Sage, J., Crowley, D., Trumpp, A., Bronson, R. T., Jacks, T.
Targeted disruption of the retinoblastoma gene in mice leads to embryonic lethality in midgestation accompanied by defective erythropoiesis. Rb(-/-) embryos also exhibit inappropriate cell cycle...
Mutations in the p53 and SCID genes cooperate in tumorigenesis (1996)
Nacht, M, Strasser, A, Chan, YR, Harris, AW, Schlissel, M, Bronson, RT, ...
Targeted disruption of p107: functional overlap between p107 and Rb (1996)
Lee, MH, Williams, BO, Mulligan, G, Mukai, S, Bronson, RT, Dyson, N, ...
Shared role of the pRB-related p130 and p107 proteins in limb development (1996)
Cobrinik, D, Lee, MH, Hannon, G, Mulligan, G, Bronson, RT, Dyson, N, ...
Macleod, KF, Sherry, N, Hannon, G, Beach, D, Tokino, T, Kinzler, K, ...
Towards an animal model for retinoblastoma (1989)
Bernards, R.A., O'Brien, J.M., Marcus, D.M., Albert, D.M., Jacks, T., Weinberg, R.A.
Mombaerts, P, Terhorst, C, Jacks, T, Tonegawa, S, Sancho, J
The T-cell receptor (TCR) beta chain is instrumental in the progression of thymocyte differentiation from the CD4-CD8- to the CD4+CD8+ stage. This differentiation step may involve cell surface...
Abrogation of oncogene-associated apoptosis allows transformation of p53-deficient cells.
Lowe, S W, Jacks, T, Housman, D E, Ruley, H E
p53-deficient mouse embryonic fibroblasts were used to establish a direct mechanism of tumor suppression by p53 involving the destruction of oncogene-expressing cells by apoptosis. The absence of p53...
Slebos, R J, Lee, M H, Plunkett, B S, Kessis, T D, Williams, B O, Jacks, T, ...
The cell cycle regulatory tumor suppressor proteins p53 and pRB are targeted for inactivation by several tumor viruses, including the high-risk types of human papillomaviruses (HPVs) via interactions...
Berges, R R, Furuya, Y, Remington, L, English, H F, Jacks, T, Isaacs, J T
Androgen ablation induces programmed death of androgen-dependent prostatic glandular cells, resulting in fragmentation of their genomic DNA and the cells themselves into apoptotic bodies. Twenty...
Conditional Mutation of Rb Causes Cell Cycle Defects without Apoptosis in the Central Nervous System
MacPherson, D., Sage, J., Crowley, D., Trumpp, A., Bronson, R. T., Jacks, T.
Targeted disruption of the retinoblastoma gene in mice leads to embryonic lethality in midgestation accompanied by defective erythropoiesis. Rb−/− embryos also exhibit inappropriate cell cycle...
Herrera, R E, Sah, V P, Williams, B O, Mäkelä, T P, Weinberg, R A, Jacks, T
Fibroblasts prepared from retinoblastoma (Rb) gene-negative mouse embryos exhibit a shorter G1 phase of the growth cycle and smaller size than wild-type cells. In addition, the mutant cells are no...
Aberrant Ras regulation and reduced p190 tyrosine phosphorylation in cells lacking p120-Gap.
Henkemeyer, M, Jacks, T, Pawson, T
The Ras guanine nucleotide-binding protein functions as a molecular switch in signalling downstream of protein-tyrosine kinases. Ras is activated by exchange of GDP for GTP and is turned off by...
Jacks, T, Townsley, K, Varmus, H E, Majors, J
The primary translation products of retroviral pol genes are polyproteins initiated in an upstream gene (gag). To investigate the manner in which the gag-initiated polyproteins of the mouse mammary...
Williams, B O, Schmitt, E M, Remington, L, Bronson, R T, Albert, D M, Weinberg, R A, ...
Homozygosity for a mutation in the Rb tumor suppressor gene causes mid-gestation embryonic lethality in the mouse. Using a two-step targeting protocol, we have constructed Rb homozygous mutant mouse...
Attardi, L D, Lowe, S W, Brugarolas, J, Jacks, T
The p53 tumor suppressor limits cellular proliferation by inducing either G1 arrest or apoptosis, depending on the cellular context. To determine if these pathways are mechanistically distinct, we...
Extensive apoptosis occurs in the nervous system of mouse embryos homozygous mutant for a targeted disruption of the retinoblastoma (Rb) gene. This cell death is present in both the central (CNS) and...
Mombaerts, P, Terhorst, C, Jacks, T, Tonegawa, S, Sancho, J
The T-cell receptor (TCR) beta chain is instrumental in the progression of thymocyte differentiation from the CD4-CD8- to the CD4+CD8+ stage. This differentiation step may involve cell surface...
Abrogation of oncogene-associated apoptosis allows transformation of p53-deficient cells.
Lowe, S W, Jacks, T, Housman, D E, Ruley, H E
p53-deficient mouse embryonic fibroblasts were used to establish a direct mechanism of tumor suppression by p53 involving the destruction of oncogene-expressing cells by apoptosis. The absence of p53...
Slebos, R J, Lee, M H, Plunkett, B S, Kessis, T D, Williams, B O, Jacks, T, ...
The cell cycle regulatory tumor suppressor proteins p53 and pRB are targeted for inactivation by several tumor viruses, including the high-risk types of human papillomaviruses (HPVs) via interactions...
Berges, R R, Furuya, Y, Remington, L, English, H F, Jacks, T, Isaacs, J T
Androgen ablation induces programmed death of androgen-dependent prostatic glandular cells, resulting in fragmentation of their genomic DNA and the cells themselves into apoptotic bodies. Twenty...
Conditional Mutation of Rb Causes Cell Cycle Defects without Apoptosis in the Central Nervous System
MacPherson, D., Sage, J., Crowley, D., Trumpp, A., Bronson, R. T., Jacks, T.
Targeted disruption of the retinoblastoma gene in mice leads to embryonic lethality in midgestation accompanied by defective erythropoiesis. Rb−/− embryos also exhibit inappropriate cell cycle...
Herrera, R E, Sah, V P, Williams, B O, Mäkelä, T P, Weinberg, R A, Jacks, T
Fibroblasts prepared from retinoblastoma (Rb) gene-negative mouse embryos exhibit a shorter G1 phase of the growth cycle and smaller size than wild-type cells. In addition, the mutant cells are no...
Aberrant Ras regulation and reduced p190 tyrosine phosphorylation in cells lacking p120-Gap.
Henkemeyer, M, Jacks, T, Pawson, T
The Ras guanine nucleotide-binding protein functions as a molecular switch in signalling downstream of protein-tyrosine kinases. Ras is activated by exchange of GDP for GTP and is turned off by...
Jacks, T, Townsley, K, Varmus, H E, Majors, J
The primary translation products of retroviral pol genes are polyproteins initiated in an upstream gene (gag). To investigate the manner in which the gag-initiated polyproteins of the mouse mammary...
Williams, B O, Schmitt, E M, Remington, L, Bronson, R T, Albert, D M, Weinberg, R A, ...
Homozygosity for a mutation in the Rb tumor suppressor gene causes mid-gestation embryonic lethality in the mouse. Using a two-step targeting protocol, we have constructed Rb homozygous mutant mouse...
Attardi, L D, Lowe, S W, Brugarolas, J, Jacks, T
The p53 tumor suppressor limits cellular proliferation by inducing either G1 arrest or apoptosis, depending on the cellular context. To determine if these pathways are mechanistically distinct, we...
Extensive apoptosis occurs in the nervous system of mouse embryos homozygous mutant for a targeted disruption of the retinoblastoma (Rb) gene. This cell death is present in both the central (CNS) and...