Nieda, M, Okai, M, Tazbirkova, A, Lin, H, Yamaura, A, Ide, K, ...
Human Valpha24(+)Vbeta11(+) natural killer T (NKT) cells are a distinct CD1d-restricted lymphoid subset specifically and potently activated by alpha-galactosylceramide (alpha-GalCer) (KRN7000)...
Kashiwase, K, Kikuchi, A, Ando, Y, Nicol, A, Porcelli, SA, Tokunaga, K, ...
Natural killer T (NKT) cells play an important role in controlling cancers, infectious diseases and autoimmune diseases. Although the rhesus macaque is a useful primate model for many human diseases...
Okai, M, Nieda, M, Tazbirkova, A, Horley, D, Kikuchi, A, Durrant, S, ...
Background and Objectives We have undertaken the first clinical trial involving the administration of alpha-GalactosylCeramine (alpha-GalCer)-pulsed dendritic cells (DCs) to human subjects, to...
Kikuchi, A, Nieda, M, Schmidt, C, Koezuka, Y, Ishihara, S, Ishikawa, Y, ...
alpha -galactosylceramide (KRN 7000, alpha -GalCer) has shown potent in vivo anti-tumour activity in mice, including against melanoma and the highly specific effect of inducing proliferation and...
Nieda, M, Kikuchi, A, Nicol, A, Koezuka, Y, Ando, Y, Ishihara, S, ...
Human V alpha 24 natural killer T (V alpha 24NKT) cells are activated by -glycosylceramide-pulsed dendritic cells (DCs) in a CDld-dependent and T-cell receptor-mediated manner. There are two major...
Nieda, M, Nicol, A, Koezuka, Y, Kikuchi, A, Lapteva, N, Tanaka, Y, ...
Human V alpha 24NKT cells are activated by alpha -galactosylceramide (alpha -GalCer)-pulsed dendritic cells in a CD1d-dependent and a T-cell receptor-mediated manner. Here, we demonstrate that...
Lapteva, N, Nieda, M, Ando, Y, Nicol, A, Ide, K, Yamaura, A, ...
In vitro proliferation and functional activation of V alpha 24NKT cells following stimulation with alpha -galactosylceramide (alpha -GalCer)-pulsed dendritic cells (DCs) have been observed. Because...
Nieda, M., Nicol, A. J., Koezuka, Y., Kikuchi, A., Takahashi, T., Nakamura, H., ...
Vα14NK(natural killer) T cells play an important role in controlling tumors or in preventing autoimmunity in the murine system. Vα24NKT cells, the human counterpart of Vα14NKT cells, may...
HLA antigens in Japanese patients with myasthenia gravis.
Matsuki, K, Juji, T, Tokunaga, K, Takamizawa, M, Maeda, H, Soda, M, ...
HLA antigens in 104 Japanese patients and 41 families with myasthenia gravis (MG) were investigated. The frequencies of DR9 and DRw13 were significantly increased in the patients who developed MG...
A simple method for detecting single base substitutions and its application to HLA-DPB1 typing.
Oka, T, Matsunaga, H, Tokunaga, K, Mitsunaga, S, Juji, T, Yamane, A
We have developed a simple and reliable method, PCR-PHFA (polymerase chain reaction dependent preferential homoduplex formation assay), for detection of single base substitutions within PCR...
The purified human monocytes of a responding donor preincubated with heat-inactivated serum T1264 or T1295 derived from pregnant women for 30 min at 37 degrees C expressed allogeneic suppressive...
Matsuki, K, Juji, T, Tokunaga, K, Naohara, T, Satake, M, Honda, Y
In order to deduce the predominant haplotypes in Japanese narcoleptics, we have studied a total of 111 Japanese patients with narcolepsy and six multiple-case families for HLA class I and class II...
Tokunaga, K, Dewald, G, Omoto, K, Juji, T
Genetic polymorphisms of the sixth and seventh complement components (C6 and C7) have been studied in Japanese family material using polyacrylamide gel isoelectric focusing followed by...
HLA antigens in Japanese patients with myasthenia gravis.
Matsuki, K, Juji, T, Tokunaga, K, Takamizawa, M, Maeda, H, Soda, M, ...
HLA antigens in 104 Japanese patients and 41 families with myasthenia gravis (MG) were investigated. The frequencies of DR9 and DRw13 were significantly increased in the patients who developed MG...
A simple method for detecting single base substitutions and its application to HLA-DPB1 typing.
Oka, T, Matsunaga, H, Tokunaga, K, Mitsunaga, S, Juji, T, Yamane, A
We have developed a simple and reliable method, PCR-PHFA (polymerase chain reaction dependent preferential homoduplex formation assay), for detection of single base substitutions within PCR...
The purified human monocytes of a responding donor preincubated with heat-inactivated serum T1264 or T1295 derived from pregnant women for 30 min at 37 degrees C expressed allogeneic suppressive...
Matsuki, K, Juji, T, Tokunaga, K, Naohara, T, Satake, M, Honda, Y
In order to deduce the predominant haplotypes in Japanese narcoleptics, we have studied a total of 111 Japanese patients with narcolepsy and six multiple-case families for HLA class I and class II...
Tokunaga, K, Dewald, G, Omoto, K, Juji, T
Genetic polymorphisms of the sixth and seventh complement components (C6 and C7) have been studied in Japanese family material using polyacrylamide gel isoelectric focusing followed by...
Nishimura, M, Mitsunaga, S, Akaza, T, Mitomi, Y, Tadokoro, K, Juji, T
Prior study has revealed that the expression of certain major histocompatibility complex (MHC) class I molecules on the membranes of normal or transformed cells can prevent natural killer...
Nieda, M, Kikuchi, A, Nicol, A, Koezuka, Y, Ando, Y, Ishihara, S, ...
Human Vα24 natural killer T (Vα24NKT) cells are activated by α-glycosylceramide-pulsed dendritic cells (DCs) in a CD1d-dependent and T-cell receptor-mediated manner. There are two major...
HLA DR4 and rheumatoid arthritis in Japanese people.
Maeda, H, Juji, T, Mitsui, H, Sonozaki, H, Okitsu, K
Eighty-eight Japanese patients with rheumatoid arthritis and 104 normal Japanese persons were typed for HLA A, B, C, and DR antigens. The frequency of HLA DR4 was 70.5% in patients compared with...
Distribution of HLA-B27 in patients with juvenile rheumatoid arthritis.
Mitsui, H, Juji, T, Sonozaki, H, Seki, H, Watanabe, N
HLA antigens were examined in 27 patients with juvenile rheumatoid arthritis. HLA-B27 was found in none. The result was different from most other previously reported studies. The most likely...
Noiri, E., Kuwata, S., Nosaka, K., Tokunaga, K., Juji, T., Shibata, Y., ...
To study the time course of lipopolysaccharide-induced production of tumor necrosis factor-alpha (TNF-alpha) in the kidney, we utilized a highly sensitive non-radioisotopic in situ hybridization with...
S-antigen specific T cell clones from a patient with Behçet's disease.
Yamamoto, J H, Fujino, Y, Lin, C, Nieda, M, Juji, T, Masuda, K
The isolation and characterisation of T cell clones or lines specific to retinal antigens are valuable tools to clarify the underlying mechanisms of autoimmunity to retinal antigens as a contributing...
Kitayama, J, Atomi, Y, Nagawa, H, Kuroda, A, Mutoh, T, Minami, M, ...
In six patients with advanced pancreatic carcinoma, TIL and tumour-draining lymphocytes (TDL) were isolated from primary pancreatic tumour and regional lymph nodes. In comparison with TDL and...
Nicol, A, Nieda, M, Koezuka, Y, Porcelli, S, Suzuki, K, Tadokoro, K, ...
Human Vα24+ NKT cells, a subpopulation of natural killer cell receptor (NKR-P1A) expressing T cells with an invariant T-cell receptor (TCR; Vα24JαQ) are stimulated by the glycolipid,...