Influence of food on the pharmacokinetics of ketoconazole.
Daneshmend, T K, Warnock, D W, Ene, M D, Johnson, E M, Potten, M R, Richardson, M D, ...
Eight healthy adults were given single oral doses of ketoconazole (200, 400, 600, and 800 mg) in the fasting state and with a standard breakfast at weekly intervals according to a balanced block...
Effect of reactive pharmacy intervention on quality of hospital prescribing.
Hawkey, C J, Hodgson, S, Norman, A, Daneshmend, T K, Garner, S T
OBJECTIVE--To evaluate the medical impact of reactive pharmacy intervention. DESIGN--Analysis of all interventions during 28 days by all 35 pharmacists in hospitals in Nottingham. SETTING--All (six)...
Influence of food on the pharmacokinetics of ketoconazole.
Daneshmend, T K, Warnock, D W, Ene, M D, Johnson, E M, Potten, M R, Richardson, M D, ...
Eight healthy adults were given single oral doses of ketoconazole (200, 400, 600, and 800 mg) in the fasting state and with a standard breakfast at weekly intervals according to a balanced block...
Effect of reactive pharmacy intervention on quality of hospital prescribing.
Hawkey, C J, Hodgson, S, Norman, A, Daneshmend, T K, Garner, S T
OBJECTIVE--To evaluate the medical impact of reactive pharmacy intervention. DESIGN--Analysis of all interventions during 28 days by all 35 pharmacists in hospitals in Nottingham. SETTING--All (six)...
Human gastric mucosal bleeding induced by low dose aspirin, but not warfarin.
Prichard, P. J., Kitchingman, G. K., Walt, R. P., Daneshmend, T. K., Hawkey, C. J.
OBJECTIVE--To investigate the suitability of treatment with low dose aspirin or warfarin, or both, as possible prophylaxis against cardiovascular disease by determining the effect on gastric mucosal...
Abolition by omeprazole of aspirin induced gastric mucosal injury in man.
Daneshmend, T K, Stein, A G, Bhaskar, N K, Hawkey, C J
This study investigates whether aspirin injury to the human gastric mucosa can be prevented by profound acid suppression with omeprazole, in a randomised, double blind, crossover design according to...
Sedation for upper gastrointestinal endoscopy: results of a nationwide survey.
Daneshmend, T K, Bell, G D, Logan, R F
A postal questionnaire inquiring about routine sedation and premedication practice for upper gastrointestinal endoscopy was sent to 1048 doctors. Of 665 appropriate returns, 81% were from consultant...
Hawthorne, A B, Daneshmend, T K, Hawkey, C J, Belluzzi, A, Everitt, S J, Holmes, G K, ...
The effect of fish oil on the course of ulcerative colitis was investigated in a randomised blinded controlled study. Eighty seven patients received supplements of 20 ml HiEPA fish oil as...
Clinical trial value of trimipramine versus placebo in duodenal ulcer healing.
Daneshmend, T K, Homeida, M M, Mountford, R A, Brown, P, Neumann, C S
Thirty-two patients with duodenal ulceration took trimipramine 50 mg or placebo. Fifteen patients on each treatment completed the study. Endoscopy at four weeks showed ulcer healing in seven (46%)...
Effects of cirrhosis and ageing on the elimination and bioavailability of ranitidine.
Young, C J, Daneshmend, T K, Roberts, C J
The plasma concentrations of ranitidine after oral and intravenous administration have been measured in 10 healthy young adults, nine cirrhotic patients, and eight healthy elderly people. In the...
Disposition of oral metronidazole in hepatic cirrhosis and in hepatosplenic schistosomiasis.
Daneshmend, T K, Homeida, M, Kaye, C M, Elamin, A A, Roberts, C J
The pharmacokinetics of metronidazole 500 mg orally were determined in patients with hepatosplenic schistosomiasis and normal controls in the Sudan, and in cirrhotics and normal controls in Bristol....
Daneshmend, T K, Ene, M D, Parker, G, Roberts, C J
Cimetidine 200 mg three times daily and 400 mg at night was given to 10 subjects for four weeks. Apparent liver blood flow was measured by indocyanine green clearance and microsomal enzyme activity...
Assessment of oxidative metabolism in adults with hepatocellular carcinoma in the Sudan.
Homeida, M M, Daneshmend, T K, Ali, E M, Yousif-Elkadaru, A G, Arbab, B M
The hypothesis that an increased rate of oxidative metabolism may be an initiator or promoter of hepatocellular carcinoma was tested in vivo. Elimination of antipyrine (phenazone) was used as an...
Devastating diarrhoea caused by azathioprine: management difficulty in inflammatory bowel disease.
Cox, J, Daneshmend, T K, Hawkey, C J, Logan, R F, Walt, R P
Azathioprine toxicity complicated the management of four patients with inflammatory bowel disease. All patients received the drug as adjunctive therapy to steroids when responses to the latter were...
Daneshmend, T. K., Hawkey, C. J., Langman, M. J., Logan, R. F., Long, R. G., Walt, R. P.
OBJECTIVE--To investigate the possible therapeutic role of omeprazole, a powerful proton pump inhibitor, in unselected patients presenting with upper gastrointestinal bleeding. DESIGN--Double blind...
Ocular findings in a case of haemoglobin H disease.
A case is reported of a patient with known haemoglobin H disease who was found to have angioid streaks and retinal detachment. Angioid streaks have not previously been reported in cases of...
Failure of ethamsylate to reduce aspirin-induced gastric mucosal bleeding in humans.
Daneshmend, T K, Stein, A G, Bhaskar, N K, Hawkey, C J
1. We investigated the effect of the haemostatic agent ethamsylate on aspirin-induced gastric mucosal bleeding. 2. Eighteen healthy subjects were studied three times: at the end of 48 h periods of...
Kitchingman, G K, Prichard, P J, Daneshmend, T K, Walt, R P, Hawkey, C J
1. We evaluated injury to the human gastric mucosa caused by low doses of aspirin and its prophylaxis by ranitidine. On two separate occasions, 30 subjects took aspirin 300 mg daily for 12 days...
Physiological and pharmacological variability in estimated hepatic blood flow in man.
Daneshmend, T K, Jackson, L, Roberts, C J
1 Changes in hepatic blood flow have been estimated by measurement of single-dose indocyanine green kinetics in groups of healthy individuals. 2 The effects of change in posture, exercise and...
1 The effects of three day courses of propranolol 40 mg three times daily, atenolol 100 mg twice daily and labetalol 100 mg three times daily on antipyrine kinetics were examined in 13 normal...
1 The effects of food on the pharmacokinetics of orally and intravenously administered labetalol were assessed in six healthy volunteers. 2 Food caused a 38% increase in the mean systemic...
Systemic absorption of ketoconazole from vaginal pessaries.
Ene, M D, Williamson, P J, Daneshmend, T K, Blatchford, N R
Eight healthy female subjects were each given (a) ketoconazole 400 mg orally, (b) ketoconazole 400 mg as a single vaginal pessary, (c) ketoconazole 800 mg as two vaginal pessaries, and (d)...
The effects of enzyme induction and enzyme inhibition on labetalol pharmacokinetics.
The oral and intravenous pharmacokinetics of labetalol were determined in five subjects before and after a 3 week course of glutethimide 500 mg/day. After glutethimide there was a significant...
Anticonvulsant intoxication precipitated by azapropazone
Roberts, C. J. C., Macfarlane, D., Daneshmend, T. K., Dieppe, P. A.
A patient is reported who developed a hitherto unrecognized drug interaction between azapropazone and anticonvulsants which led to toxicity with the latter. The mechanism of this interaction is...