Hanai, J., Chen, L. F., Kanno, T., Ohtani-Fujita, N., Kim, W. Y., Guo, W. H., ...
Smads are signal transducers for members of the transforming growth factor-beta (TGF-beta) superfamily. Upon ligand stimulation, receptor-regulated Smads (R-Smads) are phosphorylated by...
Kanno, T, Franzoso, G, Siebenlist, U
The human T-cell leukemia virus type I Tax protein transforms T cells through induced expression of many cellular genes, including those encoding the growth-related proteins interleukin 2 and the...
Mutual regulation of the transcriptional activator NF-kappa B and its inhibitor, I kappa B-alpha.
Brown, K, Park, S, Kanno, T, Franzoso, G, Siebenlist, U
The NK-kappa B transcription factor complex is sequestered in the cytoplasm by the inhibitory protein I kappa B-alpha (MAD-3). Various cellular stimuli relieve this inhibition by mechanisms largely...
Endogenous viral sequences and their potential contribution to heritable virus resistance in plants
Mette, M.F., Kanno, T., Aufsatz, W., Jakowitsch, J., Matzke, M.A., ...
Tobacco endogenous pararetroviruses (TEPRVs) represent the first virus-derived repetitive sequence family found in plants. The sequence conservation of TEPRVs and the lack of an exogenous form of the...
Zhang, Y W, Bae, S C, Huang, G, Fu, Y X, Lu, J, Ahn, M Y, ...
The gene AML1/PEBP2 alphaB encodes the alpha subunit of transcription factor PEBP2/CBF and is essential for the establishment of fetal liver hematopoiesis. Rearrangements of AML1 are frequently...
Franzoso, G, Bours, V, Azarenko, V, Park, S, Tomita-Yamaguchi, M, Kanno, T, ...
Previously we have proposed a role for Bcl-3 in facilitating transactivation through kappa B sites by counteracting the inhibitory effects of bound, non-transactivating homodimers of the p50 subunit...
Saito, A, Williams, J A, Kanno, T
Using an isolated perfused rat pancreas preparation, the interrelationship between the endocrine and exocrine portions of the pancreas were studied. Addition of exogenous rat insulin (1-20 mU/ml) to...
Properties and activities of aminopeptidases in normal and mitogen-stimulated human lymphocytes.
Human peripheral lymphocytes were found to contain at least two distinct aminopeptidases, designated cytosol aminopeptidase and microsomal aminopeptidase, which differed from one another with respect...
Tributyltin interacts with mitochondria and induces cytochrome c release.
Nishikimi, A, Kira, Y, Kasahara, E, Sato, E F, Kanno, T, Utsumi, K, ...
Although triorganotins are potent inducers of apoptosis in various cell types, the critical targets of these compounds and the mechanisms by which they lead to cell death remain to be elucidated....
Kinetic analysis of human T-cell leukemia virus type I Tax-mediated activation of NF-kappa B.
Kanno, T, Brown, K, Franzoso, G, Siebenlist, U
The human T-cell leukemia virus type I (HTLV-I) Tax protein induces the expression of cellular genes, at least in part, by activating the endogenous NF-kappa B transcription factors. Induced...
Photodynamic triggering of calcium oscillation in the isolated rat pancreatic acini.
1. Photodynamic agents, due to their photon-dependent selective activation, can selectively activate a number of physiological processes and may directly modulate signal transduction in a number of...
Cold acclimation in the secretory responses of the isolated exocrine pancreas of the rat
Habara, Y., Kanno, T., Saito, A.
1. The secretory function of the isolated and perfused exocrine pancreas has been studied in the course of cold acclimation in rats that were fed at an ambient temperature of 1 °C in an artificial...
1. The inhibitory effect of a diminution in [K+]o on the secretory processes of the pancreatic acinar cell was analysed in the isolated and perfused rat pancreas. 2. Partial replacement of KCl with...
1. Differentiation between the secretory effects of pure natural cholecystokinin-pancreozymin (CCK-PZ) and those of synthetic secretin was studied in the isolated pancreas of the rat perfused with a...
1. The secretory function of the exocrine pancreas and the stomach have been studied in the course of cold acclimation of rats that had been fed at an ambient temperature of 1 degree C in a climatic...
1. Insulin (1 mu./ml.) potentiated the release of amylase from isolated pancreas of rats perfused with erythrocyte-containing medium and stimulated by 0-5 m-u. pancreozymin (Pz)/ml., whereas the same...
The role of Ca ions in stimulus-secretion coupling has been analysed in the isolated and perfused rat pancreas. 2. The omission of [Ca2+]O diminished but did not abolish the release of amylase in...
1. Transmembrane potential, effective membrane resistance, and amylase release were recorded simultaneously from acinar cells of isolated rat pancreas perfused with Krebs-Henseleit solution. 2. The...
Calcium-dependent amylase release and electrophysiological measurements in cells of the pancreas
1. Transmembrane potential, effective membrane resistance, and amylase output were recorded from acinar cells of rat pancreas perfused in vitro.
Kanno, T., Saito, A., Sato, Y.
1. The roles of Na and Ca ions in stimulus-secretion coupling were analysed in the isolated and perfused rat pancreas.
Douglas, W. W., Kanno, T., Sampson, S. R.
1. Intracellular recordings were made from chromaffin cells isolated from adrenal medullae of gerbils to examine the effects, on membrane potential, of changes in the ionic environment that are...
Douglas, W. W., Kanno, T., Sampson, S. R.
1. A method has been devised for isolating adrenal chromaffin cells (from gerbils) and maintaining them in vitro. Transmembrane potentials of these cells were recorded with intracellular...
Matzke, M, Mette, M F, Jakowitsch, J, Kanno, T, Moscone, E A, ...
To study whether DNA pairing that influences gene expression can take place in somatic plant cells, a system designed to mimic transvection was established in transgenic tobacco. Pairing was...
Safety of Ablation of the Sigmoid and Transverse Sinuses: An Experimental Study
Kanno, T., Kasama, A., Suzuki, H.
If the sigmoid and transverse sinuses could be divided safely, surgeons could broaden their access during skull base surgery without retracting the brain extensively. We undertook this study in...
Immunochemical studies on lactate dehydrogenase A subunit deficiencies.
In lactate dehydrogenase (LDH) A subunit deficiency, is there not only a lack of activity but also a lack of subunit production? We demonstrated three remarkable points to answer this question: There...
Estimation of the gene frequency of lactate dehydrogenase subunit deficiencies.
Maekawa, M, Kanda, S, Sudo, K, Kanno, T
To detect the frequency of lactate dehydrogenase (LDH) subunit deficiency, screening for LDH subunit deficiency was performed on 3,776 blood samples from healthy individuals in Shizuoka Prefecture by...
Kanno, T, Franzoso, G, Siebenlist, U
The human T-cell leukemia virus type I Tax protein transforms T cells through induced expression of many cellular genes, including those encoding the growth-related proteins interleukin 2 and the...
Mutual regulation of the transcriptional activator NF-kappa B and its inhibitor, I kappa B-alpha.
Brown, K, Park, S, Kanno, T, Franzoso, G, Siebenlist, U
The NK-kappa B transcription factor complex is sequestered in the cytoplasm by the inhibitory protein I kappa B-alpha (MAD-3). Various cellular stimuli relieve this inhibition by mechanisms largely...
Endogenous viral sequences and their potential contribution to heritable virus resistance in plants
Mette, M.F., Kanno, T., Aufsatz, W., Jakowitsch, J., Matzke, M.A., ...
Tobacco endogenous pararetroviruses (TEPRVs) represent the first virus-derived repetitive sequence family found in plants. The sequence conservation of TEPRVs and the lack of an exogenous form of the...
Zhang, Y W, Bae, S C, Huang, G, Fu, Y X, Lu, J, Ahn, M Y, ...
The gene AML1/PEBP2 alphaB encodes the alpha subunit of transcription factor PEBP2/CBF and is essential for the establishment of fetal liver hematopoiesis. Rearrangements of AML1 are frequently...
Kinetic analysis of human T-cell leukemia virus type I Tax-mediated activation of NF-kappa B.
Kanno, T, Brown, K, Franzoso, G, Siebenlist, U
The human T-cell leukemia virus type I (HTLV-I) Tax protein induces the expression of cellular genes, at least in part, by activating the endogenous NF-kappa B transcription factors. Induced...
Franzoso, G, Bours, V, Azarenko, V, Park, S, Tomita-Yamaguchi, M, Kanno, T, ...
Previously we have proposed a role for Bcl-3 in facilitating transactivation through kappa B sites by counteracting the inhibitory effects of bound, non-transactivating homodimers of the p50 subunit...
Saito, A, Williams, J A, Kanno, T
Using an isolated perfused rat pancreas preparation, the interrelationship between the endocrine and exocrine portions of the pancreas were studied. Addition of exogenous rat insulin (1-20 mU/ml) to...
Properties and activities of aminopeptidases in normal and mitogen-stimulated human lymphocytes.
Human peripheral lymphocytes were found to contain at least two distinct aminopeptidases, designated cytosol aminopeptidase and microsomal aminopeptidase, which differed from one another with respect...
Photodynamic triggering of calcium oscillation in the isolated rat pancreatic acini.
1. Photodynamic agents, due to their photon-dependent selective activation, can selectively activate a number of physiological processes and may directly modulate signal transduction in a number of...
Tributyltin interacts with mitochondria and induces cytochrome c release.
Nishikimi, A, Kira, Y, Kasahara, E, Sato, E F, Kanno, T, Utsumi, K, ...
Although triorganotins are potent inducers of apoptosis in various cell types, the critical targets of these compounds and the mechanisms by which they lead to cell death remain to be elucidated....
Cold acclimation in the secretory responses of the isolated exocrine pancreas of the rat
Habara, Y., Kanno, T., Saito, A.
1. The secretory function of the isolated and perfused exocrine pancreas has been studied in the course of cold acclimation in rats that were fed at an ambient temperature of 1 °C in an artificial...
1. The inhibitory effect of a diminution in [K+]o on the secretory processes of the pancreatic acinar cell was analysed in the isolated and perfused rat pancreas. 2. Partial replacement of KCl with...
1. Differentiation between the secretory effects of pure natural cholecystokinin-pancreozymin (CCK-PZ) and those of synthetic secretin was studied in the isolated pancreas of the rat perfused with a...
1. The secretory function of the exocrine pancreas and the stomach have been studied in the course of cold acclimation of rats that had been fed at an ambient temperature of 1 degree C in a climatic...
1. Insulin (1 mu./ml.) potentiated the release of amylase from isolated pancreas of rats perfused with erythrocyte-containing medium and stimulated by 0-5 m-u. pancreozymin (Pz)/ml., whereas the same...
The role of Ca ions in stimulus-secretion coupling has been analysed in the isolated and perfused rat pancreas. 2. The omission of [Ca2+]O diminished but did not abolish the release of amylase in...
1. Transmembrane potential, effective membrane resistance, and amylase release were recorded simultaneously from acinar cells of isolated rat pancreas perfused with Krebs-Henseleit solution. 2. The...
Calcium-dependent amylase release and electrophysiological measurements in cells of the pancreas
1. Transmembrane potential, effective membrane resistance, and amylase output were recorded from acinar cells of rat pancreas perfused in vitro.
Kanno, T., Saito, A., Sato, Y.
1. The roles of Na and Ca ions in stimulus-secretion coupling were analysed in the isolated and perfused rat pancreas.
Douglas, W. W., Kanno, T., Sampson, S. R.
1. Intracellular recordings were made from chromaffin cells isolated from adrenal medullae of gerbils to examine the effects, on membrane potential, of changes in the ionic environment that are...
Douglas, W. W., Kanno, T., Sampson, S. R.
1. A method has been devised for isolating adrenal chromaffin cells (from gerbils) and maintaining them in vitro. Transmembrane potentials of these cells were recorded with intracellular...
Matzke, M, Mette, M F, Jakowitsch, J, Kanno, T, Moscone, E A, ...
To study whether DNA pairing that influences gene expression can take place in somatic plant cells, a system designed to mimic transvection was established in transgenic tobacco. Pairing was...
Safety of Ablation of the Sigmoid and Transverse Sinuses: An Experimental Study
Kanno, T., Kasama, A., Suzuki, H.
If the sigmoid and transverse sinuses could be divided safely, surgeons could broaden their access during skull base surgery without retracting the brain extensively. We undertook this study in...
Immunochemical studies on lactate dehydrogenase A subunit deficiencies.
In lactate dehydrogenase (LDH) A subunit deficiency, is there not only a lack of activity but also a lack of subunit production? We demonstrated three remarkable points to answer this question: There...
Estimation of the gene frequency of lactate dehydrogenase subunit deficiencies.
Maekawa, M, Kanda, S, Sudo, K, Kanno, T
To detect the frequency of lactate dehydrogenase (LDH) subunit deficiency, screening for LDH subunit deficiency was performed on 3,776 blood samples from healthy individuals in Shizuoka Prefecture by...
Ito, K., Kanno, T., Suzuki, K., Masuzawa-Ito, K., Takewaki, T., Ohashi, H., ...
1. The effects of cromakalim on mechanical and electrical activities of the circular smooth muscles of guinea-pig stomach antrum were observed. 2. Cromakalim (greater than 1 x 10(-7) M) decreased the...
1. The effects of chlorobutanol, a widely used drug preservative, on exocrine response and intracellular Ca2+ dynamics were examined in isolated pancreatic acini of the rat. 2. Chlorobutanol (1 mg...
Ikei, N., Busik, J., Habara, Y., Kanno, T.
1. Procaine (0.03-10 mM) inhibited carbachol (CCh)-induced amylase release from rat isolated pancreatic acini in a competitive manner. Kinetic analysis of the relation between CCh concentrations and...
Voltage-gated and resting membrane currents recorded from B-cells in intact mouse pancreatic islets
Göpel, S, Kanno, T, Barg, S, Galvanovskis, J, Rorsman, P
The perforated patch whole-cell configuration of the patch-clamp technique was applied to superficial cells in intact pancreatic islets. Immunostaining in combination with confocal microscopy...
Göpel, S O, Kanno, T, Barg, S, Weng, X-G, Gromada, J, Rorsman, P
The perforated patch whole-cell configuration of the patch-clamp technique was applied to superficial glucagon-secreting α-cells in intact mouse pancreatic islets.α-cells were distinguished from...
Patch-clamp characterisation of somatostatin-secreting δ-cells in intact mouse pancreatic islets
Göpel, S O, Kanno, T, Barg, S, Rorsman, P
The perforated patch whole-cell configuration of the patch-clamp technique was applied to superficial cells in intact mouse pancreatic islets.Three types of electrical activity were observed...
Kanno, T, Rorsman, P, Göpel, S O
The regulation of a K+ current activating during oscillatory electrical activity (IK,slow) in an insulin-releasing β-cell was studied by applying the perforated patch whole-cell technique to intact...