Takahashi, H, Matsuda, M, Kojima, A, Sata, T, Andoh, T, Kurata, T, ...
A number of studies have suggested that topoisomerase I (topo I) activity may be important in human immunodeficiency virus type 1 (HIV-1) replication. Specifically it has been reported that purified...
Tanaka, S, Morishita, T, Hashimoto, Y, Hattori, S, Nakamura, S, Shibuya, M, ...
CRK protein, together with GRB2/ASH and Nck proteins, belongs to the adaptor-type Src homology (SH)2-containing molecules, which transduce signals from tyrosine kinases. Here another guanine...
Transgenic mice susceptible to poliovirus.
Koike, S, Taya, C, Kurata, T, Abe, S, Ise, I, Yonekawa, H, ...
Poliovirus-sensitive transgenic mice were produced by introducing the human gene encoding cellular receptors for poliovirus into the mouse genome. Expression of the receptor mRNAs in tissues of the...
Ogawa-Goto, K., Irie, S., Omori, A., Miura, Y., Katano, H., Hasegawa, H., ...
We have used a virus overlay assay to detect cellular proteins associated with human cytomegalovirus (HCMV) particles. The radiolabeled HCMV particles specifically bound to two host proteins with...
Microtubule Network Facilitates Nuclear Targeting of Human Cytomegalovirus Capsid
Ogawa-Goto, K., Tanaka, K., Gibson, W., Moriishi, E., Miura, Y., Kurata, T., ...
We assessed the requirement of the host cytoskeleton for the intracytosolic transport of incoming human cytomegalovirus (HCMV) capsids. Treatments with microtubule (MT)-depolymerizing drugs...
Auwanit, W, Ayuthaya, P I, Nakaya, T, Fujiwara, S, Kurata, T, Yamanishi, K, ...
The seroprevalence of Borna disease virus (BDV) in human immunodeficiency virus type 1-infected individuals in Thailand was examined by using recombinant BDV p24. A high (38 to 48%) rate of...
Mechanistic study of inhibition of levofloxacin absorption by aluminum hydroxide.
Tanaka, M, Kurata, T, Fujisawa, C, Ohshima, Y, Aoki, H, Okazaki, O, ...
The mechanisms of reduction in absorption of levofloxacin (LVFX) by coadministration of aluminum hydroxide were studied. The partition coefficient of LVFX (0.1 mM) between chloroform and phosphate...
Hasegawa, H, Kiyokawa, E, Tanaka, S, Nagashima, K, Gotoh, N, Shibuya, M, ...
CRK belongs to a family of adaptor proteins that consist mostly of SH2 and SH3 domains. Far Western blotting with CRK SH3 has demonstrated that it binds to 135- to 145-, 160-, and 180-kDa proteins....
Horie, H, Koike, S, Kurata, T, Sato-Yoshida, Y, Ise, I, Ota, Y, ...
Recombinant viruses between the virulent Mahoney and attenuated Sabin 1 strains of poliovirus type 1 were subjected to neurovirulence tests using a transgenic (Tg) mouse line, ICR-PVRTg1, that...
Yasuda, A, Kimura-Kuroda, J, Ogimoto, M, Miyamoto, M, Sata, T, Sato, T, ...
A cDNA clone representing the genome of structural proteins of Japanese encephalitis virus (JEV) was inserted into the thymidine kinase gene of vaccinia virus strains LC16mO and WR under the control...
Murayama, S Y, Sakai, T, Makino, S, Kurata, T, Sasakawa, C, Yoshikawa, M
We examined the possibility that mice could be used in the Sereny test instead of guinea pigs or rabbits. Although the reactions in mice were more transient and not as pronounced as those in guinea...
Immunofluorescence studies of disseminated Hantaan virus infection of suckling mice.
Kurata, T, Tsai, T F, Bauer, S P, McCormick, J B
Hantaan virus, the etiological agent of Korean hemorrhagic fever, was inoculated intracerebrally or intraperitoneally into suckling mice, and the course of the infection was followed by infectivity...
Tanaka, S, Hattori, S, Kurata, T, Nagashima, K, Fukui, Y, Nakamura, S, ...
Human CRK protein is a homolog of the chicken v-crk oncogene product and consists mostly of src homology region 2 (SH2) and SH3, which are shared by many proteins, in particular those involved in...
Two species of human CRK cDNA encode proteins with distinct biological activities.
Matsuda, M, Tanaka, S, Nagata, S, Kojima, A, Kurata, T, Shibuya, M
Two distinct human CRK cDNAs, designated CRK-I and CRK-II, were isolated from human embryonic lung cells by polymerase chain reaction and by screening of a human placenta cDNA library, respectively....
Tachibana, Y, Yasuda, A, Kurata, T, Oka, S, Shimada, K, Kojima, A
The gene encoding the integrase (IN) protein of human immunodeficiency virus type 1 (HIV-1) was expressed in vaccinia virus and Escherichia coli, and sera from 55 HIV-1-infected individuals were...
Human herpesvirus 6 latently infects mononuclear cells but not liver tissue.
Yoshikawa, T, Suzuki, K, Ihira, M, Furukawa, H, Suga, S, Iwasaki, T, ...
AIM: To investigate whether human herpesvirus 6 (HHV-6) can cause latent infection of liver tissue. METHODS: Peripheral blood and liver tissue were collected from 25 living related liver transplant...
Analysis of the inhibitory effect of peritoneal macrophages on the spread of herpes simplex virus.
Hayashi, K, Kurata, T, Morishima, T, Nassery, T
Peritoneal macrophages obtained from mice after an intraperitoneal injection of tryptose peptone inhibited the development of herpes simplex virus type 2 plaques in syngeneic mouse embryonic...
Matsuda, M, Hashimoto, Y, Muroya, K, Hasegawa, H, Kurata, T, Tanaka, S, ...
It has been reported that growth factors activate Ras through a complex of an adaptor type SH2-containing molecule, Grb2, and a Ras guanine nucleotide-releasing protein (GNRP), mSos. We report on the...
Ueno, T., Eizuru, Y., Katano, H., Kurata, T., Sata, T., Irie, S., ...
Promyelocytic leukemia (PML) bodies are discrete nuclear foci that are intimately associated with many DNA viruses. In human cytomegalovirus (HCMV) infection, the IE1 (for “immediate-early 1”)...
Takahashi, H, Matsuda, M, Kojima, A, Sata, T, Andoh, T, Kurata, T, ...
A number of studies have suggested that topoisomerase I (topo I) activity may be important in human immunodeficiency virus type 1 (HIV-1) replication. Specifically it has been reported that purified...
Tanaka, S, Morishita, T, Hashimoto, Y, Hattori, S, Nakamura, S, Shibuya, M, ...
CRK protein, together with GRB2/ASH and Nck proteins, belongs to the adaptor-type Src homology (SH)2-containing molecules, which transduce signals from tyrosine kinases. Here another guanine...
Transgenic mice susceptible to poliovirus.
Koike, S, Taya, C, Kurata, T, Abe, S, Ise, I, Yonekawa, H, ...
Poliovirus-sensitive transgenic mice were produced by introducing the human gene encoding cellular receptors for poliovirus into the mouse genome. Expression of the receptor mRNAs in tissues of the...
Ogawa-Goto, K., Irie, S., Omori, A., Miura, Y., Katano, H., Hasegawa, H., ...
We have used a virus overlay assay to detect cellular proteins associated with human cytomegalovirus (HCMV) particles. The radiolabeled HCMV particles specifically bound to two host proteins with...
Microtubule Network Facilitates Nuclear Targeting of Human Cytomegalovirus Capsid
Ogawa-Goto, K., Tanaka, K., Gibson, W., Moriishi, E., Miura, Y., Kurata, T., ...
We assessed the requirement of the host cytoskeleton for the intracytosolic transport of incoming human cytomegalovirus (HCMV) capsids. Treatments with microtubule (MT)-depolymerizing drugs...
Auwanit, W, Ayuthaya, P I, Nakaya, T, Fujiwara, S, Kurata, T, Yamanishi, K, ...
The seroprevalence of Borna disease virus (BDV) in human immunodeficiency virus type 1-infected individuals in Thailand was examined by using recombinant BDV p24. A high (38 to 48%) rate of...
Mechanistic study of inhibition of levofloxacin absorption by aluminum hydroxide.
Tanaka, M, Kurata, T, Fujisawa, C, Ohshima, Y, Aoki, H, Okazaki, O, ...
The mechanisms of reduction in absorption of levofloxacin (LVFX) by coadministration of aluminum hydroxide were studied. The partition coefficient of LVFX (0.1 mM) between chloroform and phosphate...
Hasegawa, H, Kiyokawa, E, Tanaka, S, Nagashima, K, Gotoh, N, Shibuya, M, ...
CRK belongs to a family of adaptor proteins that consist mostly of SH2 and SH3 domains. Far Western blotting with CRK SH3 has demonstrated that it binds to 135- to 145-, 160-, and 180-kDa proteins....
Horie, H, Koike, S, Kurata, T, Sato-Yoshida, Y, Ise, I, Ota, Y, ...
Recombinant viruses between the virulent Mahoney and attenuated Sabin 1 strains of poliovirus type 1 were subjected to neurovirulence tests using a transgenic (Tg) mouse line, ICR-PVRTg1, that...
Yasuda, A, Kimura-Kuroda, J, Ogimoto, M, Miyamoto, M, Sata, T, Sato, T, ...
A cDNA clone representing the genome of structural proteins of Japanese encephalitis virus (JEV) was inserted into the thymidine kinase gene of vaccinia virus strains LC16mO and WR under the control...
Murayama, S Y, Sakai, T, Makino, S, Kurata, T, Sasakawa, C, Yoshikawa, M
We examined the possibility that mice could be used in the Sereny test instead of guinea pigs or rabbits. Although the reactions in mice were more transient and not as pronounced as those in guinea...
Immunofluorescence studies of disseminated Hantaan virus infection of suckling mice.
Kurata, T, Tsai, T F, Bauer, S P, McCormick, J B
Hantaan virus, the etiological agent of Korean hemorrhagic fever, was inoculated intracerebrally or intraperitoneally into suckling mice, and the course of the infection was followed by infectivity...
Matsuda, M, Hashimoto, Y, Muroya, K, Hasegawa, H, Kurata, T, Tanaka, S, ...
It has been reported that growth factors activate Ras through a complex of an adaptor type SH2-containing molecule, Grb2, and a Ras guanine nucleotide-releasing protein (GNRP), mSos. We report on the...
Tanaka, S, Hattori, S, Kurata, T, Nagashima, K, Fukui, Y, Nakamura, S, ...
Human CRK protein is a homolog of the chicken v-crk oncogene product and consists mostly of src homology region 2 (SH2) and SH3, which are shared by many proteins, in particular those involved in...
Two species of human CRK cDNA encode proteins with distinct biological activities.
Matsuda, M, Tanaka, S, Nagata, S, Kojima, A, Kurata, T, Shibuya, M
Two distinct human CRK cDNAs, designated CRK-I and CRK-II, were isolated from human embryonic lung cells by polymerase chain reaction and by screening of a human placenta cDNA library, respectively....
Tachibana, Y, Yasuda, A, Kurata, T, Oka, S, Shimada, K, Kojima, A
The gene encoding the integrase (IN) protein of human immunodeficiency virus type 1 (HIV-1) was expressed in vaccinia virus and Escherichia coli, and sera from 55 HIV-1-infected individuals were...
Human herpesvirus 6 latently infects mononuclear cells but not liver tissue.
Yoshikawa, T, Suzuki, K, Ihira, M, Furukawa, H, Suga, S, Iwasaki, T, ...
AIM: To investigate whether human herpesvirus 6 (HHV-6) can cause latent infection of liver tissue. METHODS: Peripheral blood and liver tissue were collected from 25 living related liver transplant...
Analysis of the inhibitory effect of peritoneal macrophages on the spread of herpes simplex virus.
Hayashi, K, Kurata, T, Morishima, T, Nassery, T
Peritoneal macrophages obtained from mice after an intraperitoneal injection of tryptose peptone inhibited the development of herpes simplex virus type 2 plaques in syngeneic mouse embryonic...
Ueno, T., Eizuru, Y., Katano, H., Kurata, T., Sata, T., Irie, S., ...
Promyelocytic leukemia (PML) bodies are discrete nuclear foci that are intimately associated with many DNA viruses. In human cytomegalovirus (HCMV) infection, the IE1 (for “immediate-early 1”)...
Hirabayashi, Y, Tamura, S I, Suzuki, Y, Nagamine, T, Aizawa, C, Shimada, K, ...
Cholera toxin B subunit (CTB) has been shown to augment the antibody responses to influenza virus haemagglutinin (HA) in BALB/c mice immunized with HA vaccine together with CTB. In this study, mouse...
Hirabayashi, Y, Tamura, S I, Shimada, K, Kurata, T
The enhancing effect of cholera toxin B subunit (CTB) on primary antibody responses to keyhole limpet haemocyanin (KLH) and the cellular basis of the effect were investigated, using in vitro cultures...
Fatal acute myocarditis in an infant with human herpesvirus 6 infection
Yoshikawa, T, Ihira, M, Suzuki, K, Suga, S, Kito, H, Iwasaki, T, ...
A 5 month old girl had typical clinical features of acute myocarditis just after the febrile period of exanthem subitum and died immediately. She had been healthy, with normal development, and there...
Fatal encephalitis/encephalopathy in primary human herpesvirus-6 infection.
Asano, Y, Yoshikawa, T, Kajita, Y, Ogura, R, Suga, S, Yazaki, T, ...
An encephalitic illness with a fatal outcome occurred in a 9 month old girl with virologically confirmed exanthem subitum. Human herpes-virus-6 (HHV-6) DNA was found in the cerebrospinal fluid at the...