T. Ogura

Publication List Details

Period

1991 - 2009

Number

108

Co-Authors

A phase II dose-ranging study of palonosetron in Japanese patients receiving moderately emetogenic chemotherapy, including anthracycline and cyclophosphamide-based chemotherapy (2009)

Segawa, Y., Aogi, K., Inoue, K., Sano, M., Sekine, I., Tokuda, Y., ...

Background: The 5-HT3 receptor antagonists (RAs) help maintain the standard of care, in various combinations with other agents, for prevention of chemotherapy-induced nausea and vomiting (CINV)....

Measurement by load cells of impact force which a human body receives by external force (2008)

Y. Ito, T. Nemoto, T. Ogura, H. Yamasita, S. Yanai, H. Matsuura

Purpose: By development of a robotics technique, the assisted living instruments which have intelligent functions are being developed. As a result, there is a possibility that the accident to which...

Importance of the mixed-phase cloud distribution in the control climate for assessing the response of clouds to carbon dioxide increase: a multi-model study (2006)

Ringer, M. A., Webb, M. J., Williams, K. D., Soden, B. J., Kimoto, M., Tsushima, Yoko, ...

We have conducted a multi-model intercomparison of cloud-water in five state-of-the-art AGCMs run for control and doubled carbon dioxide climates. The most notable feature of the differences between...

On the contribution of local feedback mechanisms to the range of climate sensitivity in two GCM ensembles (2006)

Bony, S., Musat, I., Li, B., Webb, M. J., Senior, C. A., Sexton, D. M. H., ...

Global and local feedback analysis techniques have been applied to two ensembles of mixed layer equilibrium CO 2 doubling climate change experiments, from the CFMIP (Cloud Feedback Model...

IGF-1 phosphorylates AMPK-alpha subunit in ATM-dependent and LKB1-independent manner (2004)

Suzuki, A, Kusakai, G, Kishimoto, A, Shimojo, Y, Ogura, T, Lavin, MF, ...

Serine/threonine protein kinase AMP-activated protein kinase (AMPK) is a key metabolic stress-responsive factor that promotes the adaptation of cells to their microenvironment. Elevated...

IGF-1 phosphorylates AMPK-alpha subunit in ATM-dependent and LKB1-independent manner (2004)

Suzuki, A, Kusakai, G, Kishimoto, A, Shimojo, Y, Ogura, T, Lavin, MF, ...

Serine/threonine protein kinase AMP-activated protein kinase (AMPK) is a key metabolic stress-responsive factor that promotes the adaptation of cells to their microenvironment. Elevated...

Language as Lens: Plurality Marking and Numeral Learning (2004)

In English Japanese, B. W. Sarnecka, V. G. Kamenskaya, T. Ogura, Y. Yamana, J. B. Yudovina

this paper argues that, for one kind of concept (numbers), during one developmental period (ages 2-4), one part of language (plurality marking) plays a lens-like role in conceptual formation....

Identification of a novel protein kinase mediating Akt survival signaling to the ATM protein (2003)

Suzuki, A, Kusakai, G, Kishimoto, A, Lu, J, Ogura, T, Lavin, MF, ...

We identified a novel human AMP-activated protein kinase (AMPK) family member, designated ARK5, encoding 661 amino acids with an estimated molecular mass of 74 kDa. The putative amino acid sequence...

Identification of a novel protein kinase mediating Akt survival signaling to the ATM protein (2003)

Suzuki, A, Kusakai, G, Kishimoto, A, Lu, J, Ogura, T, Lavin, MF, ...

We identified a novel human AMP-activated protein kinase (AMPK) family member, designated ARK5, encoding 661 amino acids with an estimated molecular mass of 74 kDa. The putative amino acid sequence...

The crystal structure of the AAA domain of the ATP-dependent protease FtsH of Escherichia coli at 1.5 Å resolution (2002)

Krzywda, S., Brzozowski, A.M, Verma, C., Karata, K., Ogura, T., Wilkinson, A.J.

Eubacteria and eukaryotic cellular organelles have membrane-bound ATP-dependent proteases, which degrade misassembled membrane protein complexes and play a vital role in membrane quality control. The...

A retinoic acid-triggered cascade of HOXB1 gene activation.

Ogura, T, Evans, R M

Retinoic acid (RA) has been proposed to be a direct regulator of HOX gene complexes. However, the molecular mechanism of the RA signaling pathway during normal development is unclear. We have...

Evidence for two distinct retinoic acid response pathways for HOXB1 gene regulation.

Ogura, T, Evans, R M

We have recently identified a promoter proximal retinoic acid (RA)-responsive site in the 5' region of the HOXB1 gene. In this report, we have identified the second RA-responsive site in the 3'...

Cell growth and lambda phage development controlled by the same essential Escherichia coli gene, ftsH/hflB.

Herman, C, Ogura, T, Tomoyasu, T, Hiraga, S, Akiyama, Y, Ito, K, ...

The lambda phage choice between lysis and lysogeny is influenced by certain host functions in Escherichia coli. We found that the frequency of lambda lysogenization is markedly increased in the ftsH1...

Abnormally high expression of proteasomes in human leukemic cells.

Kumatori, A, Tanaka, K, Inamura, N, Sone, S, Ogura, T, Matsumoto, T, ...

Proteasomes are eukaryotic ring-shaped or cylindrical particles with multicatalytic protease activities. To clarify the involvement of proteasomes in tumorigenesis of human blood cells, we compared...

The tolZ gene of Escherichia coli is identified as the ftsH gene.

Qu, J N, Makino, S I, Adachi, H, Koyama, Y, Akiyama, Y, Ito, K, ...

Escherichia coli tolZ mutants are tolerant to colicins E2, E3, D, Ia, and Ib (Tol-), can grow on glucose but not on succinate or other nonfermentable carbon sources (Nfc-), and show...

SpoVM, a small protein essential to development in Bacillus subtilis, interacts with the ATP-dependent protease FtsH.

Cutting, S, Anderson, M, Lysenko, E, Page, A, Tomoyasu, T, Tatematsu, K, ...

The spoVM gene encodes a 26-amino-acid polypeptide that is essential for spore formation in Bacillus subtilis. A transposon insertion within the spoVM open reading frame has been shown to encode a...

The Escherichia coli FtsH protein is a prokaryotic member of a protein family of putative ATPases involved in membrane functions, cell cycle control, and gene expression.

Tomoyasu, T, Yuki, T, Morimura, S, Mori, H, Yamanaka, K, Niki, H, ...

The ftsH gene is essential for cell viability in Escherichia coli. We cloned and sequenced the wild-type ftsH gene and the temperature-sensitive ftsH1(Ts) gene. It was suggested that FtsH protein was...

Topology and subcellular localization of FtsH protein in Escherichia coli.

Tomoyasu, T, Yamanaka, K, Murata, K, Suzaki, T, Bouloc, P, Kato, A, ...

FtsH protein in Escherichia coli is an essential protein of 70.7 kDa (644 amino acid residues) with a putative ATP-binding sequence. Western blots (immunoblots) of proteins from fractionated cell...

Escherichia coli mutant Y16 is a double mutant carrying thermosensitive ftsH and ftsI mutations.

Begg, K J, Tomoyasu, T, Donachie, W D, Khattar, M, Niki, H, Yamanaka, K, ...

The Escherichia coli mutant Y16, which shows thermosensitive colony formation and filamentation with reduced amounts of penicillin-binding protein 3 (PBP3), has mutations in the ftsI gene encoding...

Identification and characterization of the smbA gene, a suppressor of the mukB null mutant of Escherichia coli.

Yamanaka, K, Ogura, T, Niki, H, Hiraga, S

The mukB gene encodes a protein involved in chromosome partitioning in Escherichia coli. To study the function of this protein, we isolated from the temperature-sensitive mukB null mutant and...

Positioning of replicated chromosomes in Escherichia coli.

Hiraga, S, Ogura, T, Niki, H, Ichinose, C, Mori, H

The positioning of replicated chromosomes at one-fourth and three-fourths of the cell length was inhibited when protein synthesis was inhibited by chloramphenicol or rifampin or by starvation for...

Identification and characterization of gyrB mutants of Escherichia coli that are defective in partitioning of mini-F plasmids.

Ogura, T, Niki, H, Mori, H, Morita, M, Hasegawa, M, Ichinose, C, ...

hopA mutants, which have been suggested to be defective in mini-F plasmid partitioning (H. Niki, C. Ichinose, T. Ogura, H. Mori, M. Morita, M. Hasegawa, N. Kusukawa, and S. Hiraga, J. Bacteriol....

Partitioning of a mini-F plasmid into anucleate cells of the mukB null mutant.

Ezaki, B, Ogura, T, Niki, H, Hiraga, S

The partition-proficient mini-F plasmid pXX325 was stably maintained in the mukB null mutant, which is defective in chromosome partitioning into the two daughter cells. In the null mutant, the...

Chromosome partitioning in Escherichia coli: novel mutants producing anucleate cells.

Hiraga, S, Niki, H, Ogura, T, Ichinose, C, Mori, H, Ezaki, B, ...

To study the chromosomal partitioning mechanism in cell division, we have isolated a novel type of Escherichia coli mutants which formed anucleate cells, by using newly developed techniques. One of...

Penicillin-binding protein 2 is essential in wild-type Escherichia coli but not in lov or cya mutants.

Ogura, T, Bouloc, P, Niki, H, D'Ari, R, Hiraga, S, Jaffé, A

Penicillin-binding protein 2 (PBP2), target of the beta-lactam mecillinam, is required for rod morphology and cell wall elongation in Escherichia coli. A new temperature-sensitive PBP2 allele and an...

Chromosomal genes essential for stable maintenance of the mini-F plasmid in Escherichia coli.

Niki, H, Ichinose, C, Ogura, T, Mori, H, Morita, M, Hasegawa, M, ...

We have isolated mutants of Escherichia coli which do not support stable maintenance of mini-F plasmids (delta ccd rep+ sop+). These host mutations, named hop, were classified into five linkage...

F plasmid ccd mechanism in Escherichia coli.

Hiraga, S, Jaffé, A, Ogura, T, Mori, H, Takahashi, H

The ccd mechanism specified by the ccdA and ccdB genes of the mini-F plasmid determines fate of plasmid-free segregants in Escherichia coli (Jaffé et al., J. Bacteriol. 163:841-849, 1985). The...

Effects of the ccd function of the F plasmid on bacterial growth.

Jaffé, A, Ogura, T, Hiraga, S

The ccd segment of the mini F plasmid containing the ccdA and ccdB genes controls the coordination between plasmid proliferation and cell physiology and fate. When the DNA replication of a...

The orphan receptor hepatic nuclear factor 4 functions as a transcriptional activator for tissue-specific and hypoxia-specific erythropoietin gene expression and is antagonized by EAR3/COUP-TF1.

Galson, D L, Tsuchiya, T, Tendler, D S, Huang, L E, Ren, Y, Ogura, T, ...

The erythropoietin (Epo) gene is regulated by hypoxia-inducible cis-acting elements in the promoter and in a 3' enhancer, both of which contain consensus hexanucleotide hormone receptor response...

RNase E polypeptides lacking a carboxyl-terminal half suppress a mukB mutation in Escherichia coli.

Kido, M, Yamanaka, K, Mitani, T, Niki, H, Ogura, T, Hiraga, S

We have isolated suppressor mutants that suppress temperature-sensitive colony formation and anucleate cell production of a mukB mutation. A linkage group (smbB) of the suppressor mutations is...

Augmented production of colony-stimulating factor in C3H/HeN mice immunized with Nocardia rubra cell wall skeleton.

Hayashi, S, Masuno, T, Hosoe, S, Kawase, I, Sakatani, M, Ogura, T, ...

C3H/HeN mice subcutaneously injected repeatedly with Nocardia rubra cell wall skeleton (N-CWS) acquired cellular immunity against N-CWS. In these N-CWS-immunized mice, the serum colony-stimulating...

A joining-diversity-joining complex generated by inversion mechanism and a variable-diversity complex in the beta-chain gene of the human T-cell receptor.

Ikuta, K, Ogura, T, Shimizu, A, Honjo, T

We have analysed an inactive allele of the beta-chain gene of the T-cell receptor in a human T-cell line HPB-ALL. Comparison with germline sequences showed that HPB-ALL has a joining (J)-diversity...

Introns and their flanking sequences of Bombyx mori rDNA.

Fujiwara, H, Ogura, T, Takada, N, Miyajima, N, Ishikawa, H, Maekawa, H

We obtained two different clones (16 kb and 13 kb) of B. mori rDNA with intron sequence within the 28S-rRNA coding region. The sequence surrounding the intron was found to be highly conserved as...

Copy-number mutants of the plasmid carrying the replication origin of the Escherichia coli chromosome: evidence for a control region of replication.

Ogura, T, Miki, T, Hiraga, S

A composite plasmid (pXX11) was constructed by joining of an oriC plasmid (pMCR115) carrying the replication origin (oriC) of the Escherichia coli chromosome and a mini-F plasmid (pSC138) carrying...

Mini-F plasmid genes that couple host cell division to plasmid proliferation.

Ogura, T, Hiraga, S

A mechanism for stable maintenance of plasmids, besides the replication and partition mechanisms, has been found to be specified by genes of a mini-F plasmid. An oriC plasmid carrying both a mini-F...

Low frequency of somatic mutation in beta-chain variable region genes of human T-cell receptors.

Ikuta, K, Ogura, T, Shimizu, A, Honjo, T

We have cloned three pairs of rearranged and germ-line variable region (V beta) genes of the beta chain of the human T-cell receptor from the cell lines ATL2, ATL12, and MT-1 of patients with adult...

The new gene mukB codes for a 177 kd protein with coiled-coil domains involved in chromosome partitioning of E. coli.

Niki, H, Jaffé, A, Imamura, R, Ogura, T, Hiraga, S

An Escherichia coli temperature sensitive mutant which produces spontaneously normal size anucleate cells at low temperature was isolated. The mutant is defective in a previously undescribed gene,...

E.coli MukB protein involved in chromosome partition forms a homodimer with a rod-and-hinge structure having DNA binding and ATP/GTP binding activities.

Niki, H, Imamura, R, Kitaoka, M, Yamanaka, K, Ogura, T, Hiraga, S

mukB mutants of Escherichia coli are defective in the correct partitioning of replicated chromosomes. This results in the appearance of normal-sized anucleate (chromosome-less) cells during cell...

Kinetic evidence distinguishing volume-sensitive chloride current from other types in guinea-pig ventricular myocytes.

Shuba, L M, Ogura, T, McDonald, T F

1. Kinase-mediated chloride currents (ICl) in guinea-pig ventricular myocytes were activated by application of phorbol ester or forskolin, and compared with currents induced by hyposmotic swelling....

Membrane currents underlying the modified electrical activity of guinea-pig ventricular myocytes exposed to hyperosmotic solution.

Ogura, T, You, Y, McDonald, T F

1. Guinea-pig ventricular myocytes were superfused with hyperosmotic (sucrose) Tyrode solution (1.2-2.8 times (T) normal osmolality) for up to 40 min. Action potentials were recorded with...

A retinoic acid-triggered cascade of HOXB1 gene activation.

Ogura, T, Evans, R M

Retinoic acid (RA) has been proposed to be a direct regulator of HOX gene complexes. However, the molecular mechanism of the RA signaling pathway during normal development is unclear. We have...

Evidence for two distinct retinoic acid response pathways for HOXB1 gene regulation.

Ogura, T, Evans, R M

We have recently identified a promoter proximal retinoic acid (RA)-responsive site in the 5' region of the HOXB1 gene. In this report, we have identified the second RA-responsive site in the 3'...

Cell growth and lambda phage development controlled by the same essential Escherichia coli gene, ftsH/hflB.

Herman, C, Ogura, T, Tomoyasu, T, Hiraga, S, Akiyama, Y, Ito, K, ...

The lambda phage choice between lysis and lysogeny is influenced by certain host functions in Escherichia coli. We found that the frequency of lambda lysogenization is markedly increased in the ftsH1...

Abnormally high expression of proteasomes in human leukemic cells.

Kumatori, A, Tanaka, K, Inamura, N, Sone, S, Ogura, T, Matsumoto, T, ...

Proteasomes are eukaryotic ring-shaped or cylindrical particles with multicatalytic protease activities. To clarify the involvement of proteasomes in tumorigenesis of human blood cells, we compared...

The tolZ gene of Escherichia coli is identified as the ftsH gene.

Qu, J N, Makino, S I, Adachi, H, Koyama, Y, Akiyama, Y, Ito, K, ...

Escherichia coli tolZ mutants are tolerant to colicins E2, E3, D, Ia, and Ib (Tol-), can grow on glucose but not on succinate or other nonfermentable carbon sources (Nfc-), and show...

SpoVM, a small protein essential to development in Bacillus subtilis, interacts with the ATP-dependent protease FtsH.

Cutting, S, Anderson, M, Lysenko, E, Page, A, Tomoyasu, T, Tatematsu, K, ...

The spoVM gene encodes a 26-amino-acid polypeptide that is essential for spore formation in Bacillus subtilis. A transposon insertion within the spoVM open reading frame has been shown to encode a...

The Escherichia coli FtsH protein is a prokaryotic member of a protein family of putative ATPases involved in membrane functions, cell cycle control, and gene expression.

Tomoyasu, T, Yuki, T, Morimura, S, Mori, H, Yamanaka, K, Niki, H, ...

The ftsH gene is essential for cell viability in Escherichia coli. We cloned and sequenced the wild-type ftsH gene and the temperature-sensitive ftsH1(Ts) gene. It was suggested that FtsH protein was...

Topology and subcellular localization of FtsH protein in Escherichia coli.

Tomoyasu, T, Yamanaka, K, Murata, K, Suzaki, T, Bouloc, P, Kato, A, ...

FtsH protein in Escherichia coli is an essential protein of 70.7 kDa (644 amino acid residues) with a putative ATP-binding sequence. Western blots (immunoblots) of proteins from fractionated cell...

Escherichia coli mutant Y16 is a double mutant carrying thermosensitive ftsH and ftsI mutations.

Begg, K J, Tomoyasu, T, Donachie, W D, Khattar, M, Niki, H, Yamanaka, K, ...

The Escherichia coli mutant Y16, which shows thermosensitive colony formation and filamentation with reduced amounts of penicillin-binding protein 3 (PBP3), has mutations in the ftsI gene encoding...

Identification and characterization of the smbA gene, a suppressor of the mukB null mutant of Escherichia coli.

Yamanaka, K, Ogura, T, Niki, H, Hiraga, S

The mukB gene encodes a protein involved in chromosome partitioning in Escherichia coli. To study the function of this protein, we isolated from the temperature-sensitive mukB null mutant and...

Positioning of replicated chromosomes in Escherichia coli.

Hiraga, S, Ogura, T, Niki, H, Ichinose, C, Mori, H

The positioning of replicated chromosomes at one-fourth and three-fourths of the cell length was inhibited when protein synthesis was inhibited by chloramphenicol or rifampin or by starvation for...

Identification and characterization of gyrB mutants of Escherichia coli that are defective in partitioning of mini-F plasmids.

Ogura, T, Niki, H, Mori, H, Morita, M, Hasegawa, M, Ichinose, C, ...

hopA mutants, which have been suggested to be defective in mini-F plasmid partitioning (H. Niki, C. Ichinose, T. Ogura, H. Mori, M. Morita, M. Hasegawa, N. Kusukawa, and S. Hiraga, J. Bacteriol....

Partitioning of a mini-F plasmid into anucleate cells of the mukB null mutant.

Ezaki, B, Ogura, T, Niki, H, Hiraga, S

The partition-proficient mini-F plasmid pXX325 was stably maintained in the mukB null mutant, which is defective in chromosome partitioning into the two daughter cells. In the null mutant, the...

Chromosome partitioning in Escherichia coli: novel mutants producing anucleate cells.

Hiraga, S, Niki, H, Ogura, T, Ichinose, C, Mori, H, Ezaki, B, ...

To study the chromosomal partitioning mechanism in cell division, we have isolated a novel type of Escherichia coli mutants which formed anucleate cells, by using newly developed techniques. One of...

Penicillin-binding protein 2 is essential in wild-type Escherichia coli but not in lov or cya mutants.

Ogura, T, Bouloc, P, Niki, H, D'Ari, R, Hiraga, S, Jaffé, A

Penicillin-binding protein 2 (PBP2), target of the beta-lactam mecillinam, is required for rod morphology and cell wall elongation in Escherichia coli. A new temperature-sensitive PBP2 allele and an...

Chromosomal genes essential for stable maintenance of the mini-F plasmid in Escherichia coli.

Niki, H, Ichinose, C, Ogura, T, Mori, H, Morita, M, Hasegawa, M, ...

We have isolated mutants of Escherichia coli which do not support stable maintenance of mini-F plasmids (delta ccd rep+ sop+). These host mutations, named hop, were classified into five linkage...

F plasmid ccd mechanism in Escherichia coli.

Hiraga, S, Jaffé, A, Ogura, T, Mori, H, Takahashi, H

The ccd mechanism specified by the ccdA and ccdB genes of the mini-F plasmid determines fate of plasmid-free segregants in Escherichia coli (Jaffé et al., J. Bacteriol. 163:841-849, 1985). The...

Effects of the ccd function of the F plasmid on bacterial growth.

Jaffé, A, Ogura, T, Hiraga, S

The ccd segment of the mini F plasmid containing the ccdA and ccdB genes controls the coordination between plasmid proliferation and cell physiology and fate. When the DNA replication of a...

The orphan receptor hepatic nuclear factor 4 functions as a transcriptional activator for tissue-specific and hypoxia-specific erythropoietin gene expression and is antagonized by EAR3/COUP-TF1.

Galson, D L, Tsuchiya, T, Tendler, D S, Huang, L E, Ren, Y, Ogura, T, ...

The erythropoietin (Epo) gene is regulated by hypoxia-inducible cis-acting elements in the promoter and in a 3' enhancer, both of which contain consensus hexanucleotide hormone receptor response...

RNase E polypeptides lacking a carboxyl-terminal half suppress a mukB mutation in Escherichia coli.

Kido, M, Yamanaka, K, Mitani, T, Niki, H, Ogura, T, Hiraga, S

We have isolated suppressor mutants that suppress temperature-sensitive colony formation and anucleate cell production of a mukB mutation. A linkage group (smbB) of the suppressor mutations is...

Augmented production of colony-stimulating factor in C3H/HeN mice immunized with Nocardia rubra cell wall skeleton.

Hayashi, S, Masuno, T, Hosoe, S, Kawase, I, Sakatani, M, Ogura, T, ...

C3H/HeN mice subcutaneously injected repeatedly with Nocardia rubra cell wall skeleton (N-CWS) acquired cellular immunity against N-CWS. In these N-CWS-immunized mice, the serum colony-stimulating...

A joining-diversity-joining complex generated by inversion mechanism and a variable-diversity complex in the beta-chain gene of the human T-cell receptor.

Ikuta, K, Ogura, T, Shimizu, A, Honjo, T

We have analysed an inactive allele of the beta-chain gene of the T-cell receptor in a human T-cell line HPB-ALL. Comparison with germline sequences showed that HPB-ALL has a joining (J)-diversity...

Introns and their flanking sequences of Bombyx mori rDNA.

Fujiwara, H, Ogura, T, Takada, N, Miyajima, N, Ishikawa, H, Maekawa, H

We obtained two different clones (16 kb and 13 kb) of B. mori rDNA with intron sequence within the 28S-rRNA coding region. The sequence surrounding the intron was found to be highly conserved as...

Copy-number mutants of the plasmid carrying the replication origin of the Escherichia coli chromosome: evidence for a control region of replication.

Ogura, T, Miki, T, Hiraga, S

A composite plasmid (pXX11) was constructed by joining of an oriC plasmid (pMCR115) carrying the replication origin (oriC) of the Escherichia coli chromosome and a mini-F plasmid (pSC138) carrying...

Mini-F plasmid genes that couple host cell division to plasmid proliferation.

Ogura, T, Hiraga, S

A mechanism for stable maintenance of plasmids, besides the replication and partition mechanisms, has been found to be specified by genes of a mini-F plasmid. An oriC plasmid carrying both a mini-F...

Low frequency of somatic mutation in beta-chain variable region genes of human T-cell receptors.

Ikuta, K, Ogura, T, Shimizu, A, Honjo, T

We have cloned three pairs of rearranged and germ-line variable region (V beta) genes of the beta chain of the human T-cell receptor from the cell lines ATL2, ATL12, and MT-1 of patients with adult...

The new gene mukB codes for a 177 kd protein with coiled-coil domains involved in chromosome partitioning of E. coli.

Niki, H, Jaffé, A, Imamura, R, Ogura, T, Hiraga, S

An Escherichia coli temperature sensitive mutant which produces spontaneously normal size anucleate cells at low temperature was isolated. The mutant is defective in a previously undescribed gene,...

E.coli MukB protein involved in chromosome partition forms a homodimer with a rod-and-hinge structure having DNA binding and ATP/GTP binding activities.

Niki, H, Imamura, R, Kitaoka, M, Yamanaka, K, Ogura, T, Hiraga, S

mukB mutants of Escherichia coli are defective in the correct partitioning of replicated chromosomes. This results in the appearance of normal-sized anucleate (chromosome-less) cells during cell...

Kinetic evidence distinguishing volume-sensitive chloride current from other types in guinea-pig ventricular myocytes.

Shuba, L M, Ogura, T, McDonald, T F

1. Kinase-mediated chloride currents (ICl) in guinea-pig ventricular myocytes were activated by application of phorbol ester or forskolin, and compared with currents induced by hyposmotic swelling....

Membrane currents underlying the modified electrical activity of guinea-pig ventricular myocytes exposed to hyperosmotic solution.

Ogura, T, You, Y, McDonald, T F

1. Guinea-pig ventricular myocytes were superfused with hyperosmotic (sucrose) Tyrode solution (1.2-2.8 times (T) normal osmolality) for up to 40 min. Action potentials were recorded with...

Regulation of circulating immune complexes by complement receptor type 1 on erythrocytes in chronic viral liver diseases

Miyaike, J, Iwasaki, Y, Takahashi, A, Shimomura, H, Taniguchi, H, Koide, N, ...

Background and aim: Complement receptor type 1 (CR1) is a transmembrane protein, and human erythrocyte CR1 (E-CR1) is involved in the transport of circulating immune complexes (IC) from the...

IL-6 in malignant pleural effusions and its augmentation by intrapleural instillation of IL-2.

Yanagawa, H, Sone, S, Munekata, M, Atagi, S, Nii, A, Ogura, T

The levels and activities of endogenous IL-6 in malignant pleural effusions due to lung cancer before and during daily intrapleural instillations of recombinant IL-2 were examined by enzyme...

Augmentation by transferrin of IL-2-inducible killer activity and perforin production of human CD8+ T cells.

Nakamura, A, Sone, S, Nabioullin, R, Sugihara, K, Munekata, M, Nishioka, Y, ...

The effects of human transferrin (Tf) on lymphokine (IL-2)-activated killer (LAK) induction from blood lymphocytes of healthy donors was examined. LAK cells were induced by 6-day incubation in medium...

High concentration of L-arginine suppresses nitric oxide synthase activity and produces reactive oxygen species in NB9 human neuroblastoma cells.

Todoroki, S., Goto, S., Urata, Y., Komatsu, K., Sumikawa, K., Ogura, T., ...

Hereditary argininemia manifests as neurological disturbance and mental retardation, features not observed in other amino acidemias. The cytotoxic effect of a high concentration of L-arginine (L-Arg)...

Electrophysiological course of uraemic neuropathy in haemodialysis patients

Ogura, T, Makinodan, A, Kubo, T, Hayashida, T, Hirasawa, Y

The objective of this study was to confirm electrophysiologically both the presence and course of uraemic neuropathy in haemodialysis patients. Nerve conduction studies of the lower extremities were...

Effect of alternating combination chemotherapy consisting of cyclophosphamide, doxorubicin, vincristine, cisplatin, and etoposide for small cell lung cancer on hematopoietic progenitors in the peripheral blood.

Shimizu, E., Yamamoto, A., Takahashi, Y., Maniwa, K., Yoshida, S., Mukai, J., ...

The effects of a combination chemotherapy (CAV-PVP) consisting of cyclophosphamide, doxorubicin, hydrochloride (dox) and vincristine (CAV) alternating with cisplatin and etoposide (PVP) on peripheral...

Serum levels of interleukin 6 in patients with lung cancer.

Yanagawa, H., Sone, S., Takahashi, Y., Haku, T., Yano, S., Shinohara, T., ...

Serum interleukin 6 (IL-6) levels were measured in 75 patients with lung cancer and in 20 patients with benign lung diseases. IL-6 was detectable in 29 patients with lung cancer (39%), but was not...

Microsatellite instability in female non-small-cell lung cancer patients with familial clustering of malignancy.

Suzuki, K., Ogura, T., Yokose, T., Sekine, I., Nagai, K., Kodama, T., ...

There is accumulating evidence of an increased risk of familial clustering of cancer in the first-degree relatives of lung cancer probands. However, no explanation has been proposed for these...

Antitumour potential of pleural cavity macrophages in lung cancer patients without malignant effusion.

Kimura, S., Sone, S., Takahashi, K., Uyama, T., Ogura, T., Monden, Y.

The present study was undertaken to examine whether the presence of primary lung cancer could affect the antitumour activities of pleural cavity macrophages (PCM) and peripheral blood monocytes...