T. Omura

Publication List Details

Period

2004 - 2004

Number

25

Co-Authors

Functions of signal and signal-anchor sequences are determined by the balance between the hydrophobic segment and the N-terminal charge.

Sakaguchi, M, Tomiyoshi, R, Kuroiwa, T, Mihara, K, Omura, T

The signal sequence of secretory proteins and the signal-anchor sequence of type II membrane proteins initiate the translocation of the following polypeptide segments, whereas the signal-anchor...

A different cytochrome P450 form is induced in primary cultures of rat hepatocytes.

Emi, Y, Chijiiwa, C, Omura, T

A 49-kDa protein (P49) was discovered in the primary cultures of rat hepatocytes. P49 cross-reacted with the antibodies against purified P450IIC11 [formerly P-450(M-1)]. P49 was located in microsomes...

The loss of outer capsid protein P2 results in nontransmissibility by the insect vector of rice dwarf phytoreovirus.

Tomaru, M, Maruyama, W, Kikuchi, A, Yan, J, Zhu, Y, Suzuki, N, ...

A transmission-defective (TD) isolate of rice dwarf phytoreovirus lacked the ability to infect cells when derived from the virus-free insect vector Nephotettix cincticeps. Analysis by sodium dodecyl...

Details of the arrangement of the outer capsid of rice dwarf phytoreovirus, as visualized by two-dimensional crystallography.

Zhu, Y, Hemmings, A M, Iwasaki, K, Fujiyoshi, Y, Zhong, B, Yan, J, ...

Two-dimensional crystals were obtained from purified P8, an outer capsid protein of rice dwarf phytoreovirus. A filtered image of the two-dimensional crystal, in combination with the results of...

Molecular cloning and nucleotide sequence of cDNA for mRNA of mitochondrial cytochrome P-450(SCC) of bovine adrenal cortex.

Morohashi, K, Fujii-Kuriyama, Y, Okada, Y, Sogawa, K, Hirose, T, Inayama, S, ...

We have isolated cDNA clones of the mRNA for cytochrome P-450(SCC), which catalyzes the side-chain cleavage reaction of cholesterol in bovine adrenal cortex mitochondria, by using synthetic...

MSF, a novel cytoplasmic chaperone which functions in precursor targeting to mitochondria.

Hachiya, N, Komiya, T, Alam, R, Iwahashi, J, Sakaguchi, M, Omura, T, ...

Mitochondrial import stimulation factor (MSF) unfolds wheat germ lysate synthesized aggregated mitochondrial precursor proteins and stimulates their mitochondrial import in an ATP dependent manner....

Purification and characterization of a processing protease from rat liver mitochondria.

Ou, W J, Ito, A, Okazaki, H, Omura, T

A processing protease has been purified from the matrix fraction of rat liver mitochondria. The purified protease contained two protein subunits of 55 kd (P-55) and 52 kd (P-52) as determined by...

A mitochondrial import factor purified from rat liver cytosol is an ATP-dependent conformational modulator for precursor proteins.

Hachiya, N, Alam, R, Sakasegawa, Y, Sakaguchi, M, Mihara, K, Omura, T

Rat liver cytosol contained an activity that stimulated the import of wheat germ lysate-synthesized precursor proteins into mitochondria. The activity was purified 10,000-fold from the cytosol as a...

Cytosolic and mitochondrial surface factor-independent import of a synthetic peptide into mitochondria.

Furuya, S, Mihara, K, Aimoto, S, Omura, T

We chemically synthesized a peptide, 11 beta-45, which was composed of 45 amino acid residues including the whole extension peptide and some of the mature portion of bovine cytochrome P-450(11 beta)...

The amino-terminal structures that determine topological orientation of cytochrome P-450 in microsomal membrane.

Sato, T, Sakaguchi, M, Mihara, K, Omura, T

We previously showed that the amino-terminal region of P-450 is responsible not only for targeting to endoplasmic reticulum (ER) membrane but also for stable anchoring to the membrane. In the present...

Functions of signal and signal-anchor sequences are determined by the balance between the hydrophobic segment and the N-terminal charge.

Sakaguchi, M, Tomiyoshi, R, Kuroiwa, T, Mihara, K, Omura, T

The signal sequence of secretory proteins and the signal-anchor sequence of type II membrane proteins initiate the translocation of the following polypeptide segments, whereas the signal-anchor...

A different cytochrome P450 form is induced in primary cultures of rat hepatocytes.

Emi, Y, Chijiiwa, C, Omura, T

A 49-kDa protein (P49) was discovered in the primary cultures of rat hepatocytes. P49 cross-reacted with the antibodies against purified P450IIC11 [formerly P-450(M-1)]. P49 was located in microsomes...

The loss of outer capsid protein P2 results in nontransmissibility by the insect vector of rice dwarf phytoreovirus.

Tomaru, M, Maruyama, W, Kikuchi, A, Yan, J, Zhu, Y, Suzuki, N, ...

A transmission-defective (TD) isolate of rice dwarf phytoreovirus lacked the ability to infect cells when derived from the virus-free insect vector Nephotettix cincticeps. Analysis by sodium dodecyl...

Details of the arrangement of the outer capsid of rice dwarf phytoreovirus, as visualized by two-dimensional crystallography.

Zhu, Y, Hemmings, A M, Iwasaki, K, Fujiyoshi, Y, Zhong, B, Yan, J, ...

Two-dimensional crystals were obtained from purified P8, an outer capsid protein of rice dwarf phytoreovirus. A filtered image of the two-dimensional crystal, in combination with the results of...

Molecular cloning and nucleotide sequence of cDNA for mRNA of mitochondrial cytochrome P-450(SCC) of bovine adrenal cortex.

Morohashi, K, Fujii-Kuriyama, Y, Okada, Y, Sogawa, K, Hirose, T, Inayama, S, ...

We have isolated cDNA clones of the mRNA for cytochrome P-450(SCC), which catalyzes the side-chain cleavage reaction of cholesterol in bovine adrenal cortex mitochondria, by using synthetic...

MSF, a novel cytoplasmic chaperone which functions in precursor targeting to mitochondria.

Hachiya, N, Komiya, T, Alam, R, Iwahashi, J, Sakaguchi, M, Omura, T, ...

Mitochondrial import stimulation factor (MSF) unfolds wheat germ lysate synthesized aggregated mitochondrial precursor proteins and stimulates their mitochondrial import in an ATP dependent manner....

Purification and characterization of a processing protease from rat liver mitochondria.

Ou, W J, Ito, A, Okazaki, H, Omura, T

A processing protease has been purified from the matrix fraction of rat liver mitochondria. The purified protease contained two protein subunits of 55 kd (P-55) and 52 kd (P-52) as determined by...

A mitochondrial import factor purified from rat liver cytosol is an ATP-dependent conformational modulator for precursor proteins.

Hachiya, N, Alam, R, Sakasegawa, Y, Sakaguchi, M, Mihara, K, Omura, T

Rat liver cytosol contained an activity that stimulated the import of wheat germ lysate-synthesized precursor proteins into mitochondria. The activity was purified 10,000-fold from the cytosol as a...

Cytosolic and mitochondrial surface factor-independent import of a synthetic peptide into mitochondria.

Furuya, S, Mihara, K, Aimoto, S, Omura, T

We chemically synthesized a peptide, 11 beta-45, which was composed of 45 amino acid residues including the whole extension peptide and some of the mature portion of bovine cytochrome P-450(11 beta)...

The amino-terminal structures that determine topological orientation of cytochrome P-450 in microsomal membrane.

Sato, T, Sakaguchi, M, Mihara, K, Omura, T

We previously showed that the amino-terminal region of P-450 is responsible not only for targeting to endoplasmic reticulum (ER) membrane but also for stable anchoring to the membrane. In the present...

AT1 receptor-mediated stimulation by angiotensin II of rat aortic fibronectin gene expression in vivo.

Kim, S, Ohta, K, Hamaguchi, A, Omura, T, Tominaga, K, Yukimura, T, ...

Fibronectin plays an important role in various vascular diseases. A subpressor (200 ng kg-1 min-1) or pressor (1000 ng kg-1 min-1) dose of angiotensin II was continuously infused into rats by osmotic...

Angiotensin converting enzyme inhibitor prevents left ventricular remodelling after myocardial infarction in angiotensin II type 1 receptor knockout mice

Yoshiyama, M, Nakamura, Y, Omura, T, Izumi, Y, Matsumoto, R, Oda, S, ...

Background: It is well known that angiotensin converting enzyme (ACE) inhibitors and angiotensin II type 1 (AT1) receptor blockers (ARBs) prevent left ventricular (LV) remodelling after myocardial...