T. P. Shanley

Streptococcal cysteine protease augments lung injury induced by products of group A streptococci.

Shanley, T P, Schrier, D, Kapur, V, Kehoe, M, Musser, J M, Ward, P A

Streptococcus pyogenes infections in humans may be associated with severe clinical manifestations, including adult respiratory distress syndrome and a toxic shock-like syndrome. These observations...

Regulatory effects of endogenous interleukin-1 receptor antagonist protein in immunoglobulin G immune complex-induced lung injury.

Shanley, T P, Peters, J L, Jones, M L, Chensue, S W, Kunkel, S L, Ward, P A

IL-1 receptor antagonist (IL-1Ra) has regulatory effects on IL-1 activity both in vitro and in vivo. In the IgG immune complex model of lung injury in rats, exogenously administered human IL-1Ra...

Glomerular inflammation induces resistance to tubular injury in the rat. A novel form of acquired, heme oxygenase-dependent resistance to renal injury.

Vogt, B A, Shanley, T P, Croatt, A, Alam, J, Johnson, K J, Nath, K A

Considerable attention is directed to a surprising biologic phenomenon wherein tissues exposed to one insult acquire resistance to another. We identify a novel example of acquired resistance to acute...

In vivo suppression of NF-kappa B and preservation of I kappa B alpha by interleukin-10 and interleukin-13.

Lentsch, A B, Shanley, T P, Sarma, V, Ward, P A

IL-10 and IL-13 have powerful antiinflammatory activities in vitro and in vivo. In the IgG immune complex model of lung injury in rats, exogenously administered IL-10 or IL-13 have recently been...

Streptococcal cysteine protease augments lung injury induced by products of group A streptococci.

Shanley, T P, Schrier, D, Kapur, V, Kehoe, M, Musser, J M, Ward, P A

Streptococcus pyogenes infections in humans may be associated with severe clinical manifestations, including adult respiratory distress syndrome and a toxic shock-like syndrome. These observations...

Regulatory effects of endogenous interleukin-1 receptor antagonist protein in immunoglobulin G immune complex-induced lung injury.

Shanley, T P, Peters, J L, Jones, M L, Chensue, S W, Kunkel, S L, Ward, P A

IL-1 receptor antagonist (IL-1Ra) has regulatory effects on IL-1 activity both in vitro and in vivo. In the IgG immune complex model of lung injury in rats, exogenously administered human IL-1Ra...

Glomerular inflammation induces resistance to tubular injury in the rat. A novel form of acquired, heme oxygenase-dependent resistance to renal injury.

Vogt, B A, Shanley, T P, Croatt, A, Alam, J, Johnson, K J, Nath, K A

Considerable attention is directed to a surprising biologic phenomenon wherein tissues exposed to one insult acquire resistance to another. We identify a novel example of acquired resistance to acute...

In vivo suppression of NF-kappa B and preservation of I kappa B alpha by interleukin-10 and interleukin-13.

Lentsch, A B, Shanley, T P, Sarma, V, Ward, P A

IL-10 and IL-13 have powerful antiinflammatory activities in vitro and in vivo. In the IgG immune complex model of lung injury in rats, exogenously administered IL-10 or IL-13 have recently been...

Regulatory effects of interleukin-6 in immunoglobulin G immune-complex-induced lung injury.

Shanley, T. P., Foreback, J. L., Remick, D. G., Ulich, T. R., Kunkel, S. L., Ward, P. A.

Interleukin-6 (IL-6) is a cytokine produced in response to a variety of inflammatory stimuli. Although IL-6 is often observed in increased amounts in acute respiratory distress syndrome, its role in...

Sublytic concentrations of the membrane attack complex of complement induce endothelial interleukin-8 and monocyte chemoattractant protein-1 through nuclear factor-kappa B activation.

Kilgore, K. S., Schmid, E., Shanley, T. P., Flory, C. M., Maheswari, V., Tramontini, N. L., ...

Activation of the complement cascade and subsequent assembly of the membrane attack complex (MAC) occur in a number of pathophysiological settings. When formed on the surface of endothelial cells in...