T. R. Burke

Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B.

Natarajan, K, Singh, S, Burke, T R, Grunberger, D, Aggarwal, B B

Caffeic acid phenethyl ester (CAPE), an active component of propolis from honeybee hives, is known to have antimitogenic, anticarcinogenic, antiinflammatory, and immunomodulatory properties. The...

Diarylsulfones, a novel class of human immunodeficiency virus type 1 integrase inhibitors.

Neamati, N, Mazumder, A, Zhao, H, Sunder, S, Burke, T R, Schultz, R J, ...

A majority of reported human immunodeficiency virus type 1 integrase (HIV-1 IN) inhibitors are polyhydroxylated aromatic compounds containing two phenyl rings separated by aliphatic or aromatic...

Cellular effects of phosphotyrosine-binding domain inhibitors on insulin receptor signaling and trafficking.

Giorgetti-Peraldi, S, Ottinger, E, Wolf, G, Ye, B, Burke, T R, Shoelson, S E

Shc and insulin receptor substrate 1 (IRS-1) are cytoplasmic substrates of tyrosine kinase receptors that engage, localize, and activate downstream SH2 enzymes. Each contains a...

Purification of the opiate receptor of NG108-15 neuroblastoma-glioma hybrid cells.

Simonds, W F, Burke, T R, Rice, K C, Jacobson, A E, Klee, W A

Opiate receptors from NG108-15 neuroblastoma-glioma hybrid cell membranes were purified to apparent homogeneity in a form covalently labeled with the opiate affinity ligand...

Phosphonate inhibitors of protein-tyrosine and serine/threonine phosphatases.

Kole, H K, Smyth, M S, Russ, P L, Burke, T R

In all, 15 aryl-containing phosphonates have been synthesized and tested for their effect on protein-tyrosine phosphatase (PTPase) activity. Two compounds, (naphth-2-yl) difluoromethylphosphonic acid...

The economic impact of alcohol abuse and alcoholism.

Burke, T R

The economic effects of alcohol abuse are as damaging to the nation as the health effects, affecting the family, the community, and persons of all ages. Underaged drinking is interfering with...

Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B.

Natarajan, K, Singh, S, Burke, T R, Grunberger, D, Aggarwal, B B

Caffeic acid phenethyl ester (CAPE), an active component of propolis from honeybee hives, is known to have antimitogenic, anticarcinogenic, antiinflammatory, and immunomodulatory properties. The...

Diarylsulfones, a novel class of human immunodeficiency virus type 1 integrase inhibitors.

Neamati, N, Mazumder, A, Zhao, H, Sunder, S, Burke, T R, Schultz, R J, ...

A majority of reported human immunodeficiency virus type 1 integrase (HIV-1 IN) inhibitors are polyhydroxylated aromatic compounds containing two phenyl rings separated by aliphatic or aromatic...

Cellular effects of phosphotyrosine-binding domain inhibitors on insulin receptor signaling and trafficking.

Giorgetti-Peraldi, S, Ottinger, E, Wolf, G, Ye, B, Burke, T R, Shoelson, S E

Shc and insulin receptor substrate 1 (IRS-1) are cytoplasmic substrates of tyrosine kinase receptors that engage, localize, and activate downstream SH2 enzymes. Each contains a...

Purification of the opiate receptor of NG108-15 neuroblastoma-glioma hybrid cells.

Simonds, W F, Burke, T R, Rice, K C, Jacobson, A E, Klee, W A

Opiate receptors from NG108-15 neuroblastoma-glioma hybrid cell membranes were purified to apparent homogeneity in a form covalently labeled with the opiate affinity ligand...

Phosphonate inhibitors of protein-tyrosine and serine/threonine phosphatases.

Kole, H K, Smyth, M S, Russ, P L, Burke, T R

In all, 15 aryl-containing phosphonates have been synthesized and tested for their effect on protein-tyrosine phosphatase (PTPase) activity. Two compounds, (naphth-2-yl) difluoromethylphosphonic acid...

The economic impact of alcohol abuse and alcoholism.

Burke, T R

The economic effects of alcohol abuse are as damaging to the nation as the health effects, affecting the family, the community, and persons of all ages. Underaged drinking is interfering with...