Scientific Commons: T. Reinheckel

Osteoclastic bone degradation and the role of different cysteine proteinases and matrix metalloproteinases: differences between calvaria and long bone (2006)

Everts, V., Korper, W., Hoeben, K.A., Jansen, I.D., Bromme, D., ...

Calvarial osteoclasts express a higher level of tartrate-resistant acid phosphatase than long bone osteoclasts and activation does not depend on cathepsin K or L activity (2006)

Perez Amodio, S.G., Jansen, D.C., Schoenmaker, A.M., Vogels, I.M., Reinheckel, T., Hayman, A.R., ...

Calvarial osteoclasts express a higher level of tartrate-resistant acid phosphatase than long bone osteoclasts and activation does not depend on cathepsin K or L activity (2006)

Perez-Amodio, S., Jansen, D.C., Schoenmaker, T., Vogels, I.M.C., Reinheckel, T., Hayman, A.R., ...

Bone resorption by osteoclasts depends on the activity of various proteolytic enzymes, in particular those belonging to the group of cysteine proteinases. Next to these enzymes, tartrate-resistant...

Osteoclastic bone degradation and the role of different cysteine proteinases and matrix metalloproteinases: Differences between calvaria and long bone (2006)

Everts, V., Korper, W., Hoeben, K.A., Jansen, I.D.C., Bromme, D., ...

Introduction: The osteoclast resorbs bone by lowering the pH in the resorption lacuna, which is followed by secretion of proteolytic enzymes. One of the enzymes taken to be essential in resorption is...

Tumor cell-derived and macrophage-derived cathepsin B promotes progression and lung metastasis of mammary cancer (2006)

Vasiljeva, O., Papazoglou, A., Krueger, A., Brodoefel, H., Korovin, M., Deussing, J., ...

Short-term impairment of energy production in isolated rat liver mitochondria by hypoxia/reoxygenation: involvement of oxidative protein modification.

Schild, L, Reinheckel, T, Wiswedel, I, Augustin, W

The aim of the present study was to elucidate the role of mitochondria in liver impairment after ischaemia/reperfusion. It is commonly assumed that mitochondria are in part responsible for tissue...

Comparative resistance of the 20S and 26S proteasome to oxidative stress.

Reinheckel, T, Sitte, N, Ullrich, O, Kuckelkorn, U, Davies, K J, Grune, T

Oxidatively modified ferritin is selectively recognized and degraded by the 20S proteasome. Concentrations of hydrogen peroxide (H2O2) higher than 10 micromol/mg of protein are able to prevent...