Dunn, L. A., Andrews, K. T., McCarthy, J. S., Wright, J. M., Skinner-Adams, T. S., Upcroft, P., ...
Antiretroviral protease inhibitors were assessed in vitro for their activity against Giardia duodenalis and Trichomonas vaginalis. Kaletra (a co-formulation of ritonavir and lopinavir) was the most...
Skinner-Adams, T. S., Andrews, K. T., Melville, L., McCarthy, J., Gardiner, D. L.
The antimalarial activity of several antiretroviral protease inhibitor combinations was investigated. Data demonstrate that ritonavir and saquinavir behave synergistically with chloroquine and...
Stack, C. M., Lowther, J., Cunningham, E., Donnelly, S., Gardiner, D. L., Trenholme, K. R., ...
Amino acids generated from the catabolism of hemoglobin by intra-erythrocytic malaria parasites are not only essential for protein synthesis but also function in maintaining an osmotically stable...
Gardiner, D. L., Dixon, M. W. A., Spielmann, T., Skinner-Adams, T. S., Hawthorne, P. L., Ortega, M. R., ...
Gametocytogenesis is fundamental for transmission of the malaria parasite Plasmodium falciparum from the human host to the mosquito vector, yet very little is understood about what triggers the...
Antiretrovirals as antimalarial agents (2004)
Skinner-Adams, T. S., McCarthy, J. S., Gardiner, D. L., Hilton, P. M., Andrews, K. T.
Recent studies have indicated that antiretroviral protease inhibitors may affect outcome in malarial disease. We have investigated the antimalarial activities of 6 commonly used antiretroviral...
A novel Plasmodium falciparum ring stage protein, REX, is located in Maurer's clefts (2004)
Hawthorne, P. L., Trenholme, K. R., Skinner-Adams, T. S., Spielmann, T., Fischer, K., Dixon, M. W. A., ...
The asexual stages of the malaria parasite Plasmodium falciparum develop inside erythrocytes of the human host. Erythrocytes are highly specialized cells lacking organelles and trafficking machinery....
CLAG 9 is located in the rhoptries of Plasmodium falciparum (2004)
Gardiner, D. L., Spielmann, T., Dixon, M. W. A., Hawthorne, P. L., Ortega, M. R., Anderson, K. L., ...
Clag 9, a gene located on chromosome 9 of Plasmodium falciparum has previously been associated with the cytoadherence of parasitized erythrocytes to CD36. This gene is part of a multi-gene family...
Hamzah, J., Skinner-Adams, T. S., Davis, T. M. E.
Retinol (vitamin A alcohol) may have a beneficial role in the host response to malaria in humans and previously published data have suggested that it has a direct inhibitory effect on the growth of...
Comparison of Plasmodium falciparum transfection methods (2003)
Skinner-Adams, T. S., Lawrie, P. M., Hawthorne, P. L., Gardiner, D. L., Trenholme, K. R.
The development of an electroporation based transfection method for Plasmodium falciparum has been very successful for the study of some genes but its efficiency remains very low. While alternative...
Skinner-Adams, T. S., Andrews, K. T., Melville, L., McCarthy, J., Gardiner, D. L.
The antimalarial activity of several antiretroviral protease inhibitor combinations was investigated. Data demonstrate that ritonavir and saquinavir behave synergistically with chloroquine and...
Potent Antimalarial Activity of Histone Deacetylase Inhibitor Analogues▿ †
Andrews, K. T., Tran, T. N., Lucke, A. J., Kahnberg, P., Le, G. T., Boyle, G. M., ...
The malaria parasite Plasmodium falciparum has at least five putative histone deacetylase (HDAC) enzymes, which have been proposed as new antimalarial drug targets and may play roles in regulating...
Lek-Uthai, U., Suwanarusk, R., Ruengweerayut, R., Skinner-Adams, T. S., Nosten, F., Gardiner, D. L., ...
Recent studies using laboratory clones have demonstrated that several antiretroviral protease inhibitors (PIs) inhibit the growth of Plasmodium falciparum at concentrations that may be of clinical...