T. S. Theodore

Integration is required for productive infection of monocyte-derived macrophages by human immunodeficiency virus type 1.

Englund, G, Theodore, T S, Freed, E O, Engelman, A, Martin, M A

Certain human immunodeficiency virus type 1 (HIV-1) isolates are able to productively infect nondividing cells of the monocyte/macrophage lineage. We have used a molecular genetic approach to...

Isolation and characterization of a syncytium-inducing, macrophage/T-cell line-tropic human immunodeficiency virus type 1 isolate that readily infects chimpanzee cells in vitro and in vivo.

Shibata, R, Hoggan, M D, Broscius, C, Englund, G, Theodore, T S, Buckler-White, A, ...

Fresh human immunodeficiency virus type 1 (HIV-1) isolates from patients with AIDS were screened for infectivity in chimpanzee peripheral blood mononuclear cells (PBMC) to identify strains...

Amino acid substitutions in the human immunodeficiency virus type 1 gp120 V3 loop that change viral tropism also alter physical and functional properties of the virion envelope.

Willey, R L, Theodore, T S, Martin, M A

The third variable (V3) region within the gp120 envelope glycoprotein of the human immunodeficiency virus type 1 (HIV-1) has been reported to be an important determinant of viral tropism. In this...

Characterization of epitopes defining two major subclasses of polytropic murine leukemia viruses (MuLVs) which are differentially expressed in mice infected with different ecotropic MuLVs.

Lavignon, M, Walker, J L, Perryman, S M, Malik, F G, Khan, A S, Theodore, T S, ...

Polytropic murine leukemia viruses (MuLVs) arise in mice by recombination of ecotropic MuLVs with endogenous retroviral envelope genes and have been implicated in the induction of hematopoietic...

Variable role of the long terminal repeat Sp1-binding sites in human immunodeficiency virus replication in T lymphocytes.

Parrott, C, Seidner, T, Duh, E, Leonard, J, Theodore, T S, Buckler-White, A, ...

The long terminal repeat (LTR) of the human immunodeficiency virus (HIV) contains three binding sites for the transcriptional factor Sp1. In order to investigate the role that the Sp1-binding sites...

Lipoteichoic Acid Localization in Mesosomal Vesicles of Staphylococcus aureus

Huff, E., Cole, R. M., Theodore, T. S.

Mesosomal vesicles and plasma membranes of Staphylococcus aureus ATCC 6538P have been prepared and examined for the presence of lipoteichoic acid. Lipids were first removed by treatment with...

Respiratory Activities Associated with Mesosomal Vesicles and Protoplast Membranes of Staphylococcus aureus

Theodore, T. S., Weinbach, E. C.

Analysis of oxidase and dehydrogenase activities, cytochrome content of mesosomal vesicles, and protoplast membranes showed that the respiratory chain in Staphylococcus aureus is associated...

Cellular Location of Degradative Enzymes in Staphylococcus aureus

Nugent, K. M., Huff, E., Cole, R. M., Theodore, T. S.

Staphylococus aureus, ATCC 6538P, was fractionated into protoplast membranes, mesosomal vesicles, periplasm, and cytoplasm. These fractions and the culture fluid were then assayed for various...

In vitro mutagenesis identifies a region within the envelope gene of the human immunodeficiency virus that is critical for infectivity.

Willey, R L, Smith, D H, Lasky, L A, Theodore, T S, Earl, P L, Moss, B, ...

Site-specific mutagenesis was used to introduce amino acid substitutions at the asparagine codons of four conserved potential N-linked glycosylation sites within the gp120 envelope protein of human...

Functional interaction of constant and variable domains of human immunodeficiency virus type 1 gp120.

Willey, R L, Ross, E K, Buckler-White, A J, Theodore, T S, Martin, M A

A previously reported amino acid substitution within the second conserved domain of the human immunodeficiency virus type 1 (HIV-1) gp120 envelope results in the production of noninfectious...

Biologic and molecular characterization of two newly isolated ras-containing murine leukemia viruses.

Fredrickson, T N, O'Neill, R R, Rutledge, R A, Theodore, T S, Martin, M A, Ruscetti, S K, ...

A murine sarcoma virus (MSV) was recovered from an (NFS X NS.C58v-1) F1 mouse which developed splenic sarcoma and erythroleukemia 6 months after inoculation with a mink cell focus-inducing murine...

Envelope and long terminal repeat sequences of a cloned infectious NZB xenotropic murine leukemia virus.

O'Neill, R R, Buckler, C E, Theodore, T S, Martin, M A, Repaske, R

An infectious NZB xenotropic murine leukemia virus (MuLV) provirus (NZB was molecularly cloned from the Hirt supernatant of NZB-IU-6-infected mink cells, and the nucleotide sequence of its env gene...

Protein and Fatty Acid Composition of Mesosomal Vesicles and Plasma Membranes of Staphylococcus aureus

Theodore, T. S., Panos, C.

Qualitatively, the protein and fatty acid composition of purified mesosomal vesicles and the plasma membrane isolated from Staphylococcus aureus ATCC 6538P are identical, the major difference between...

Characterization of the lipids of mesosomal vesicles and plasma membranes from Staphylococcus aureus.

Beining, P R, Huff, E, Prescott, B, Theodore, T S

Mesosomal vesicles and plasma membranes were isolated from Staphylococcus aureus ATCC 6538P by protoplasting and differential centrifugation. The lipids of each of the two membrane fractions were...

Streptolysin S activation by lipoteichoic acid.

Theodore, T S, Calandra, G B

Lipoteichoic acid from streptococci and Staphylococcus aureus both activated membrane-bound precursor streptolysin S and induced the formation of extracellular streptolysin S. Lipoteichoic acid could...

Cellular location of alpha-hemolysin in Staphylococcus aureus.

Nugent, K M, Calandra, G B, Theodore, T S

Protoplast fractionation techniques were used to prepare subcellular fractions of three strains of Staphylococcus aureus for the analysis of alpha-hemolysin activity. More than 90% of the cellular...

Cellular location of streptolysin O.

Calandra, G B, Theodore, T S

Streptolysin O was measured in subcellular fractions of group A streptococci obtained after preparation of protoplasts in a hypertonic buffer containing raffinose. Most of the activity was located in...

Integration is required for productive infection of monocyte-derived macrophages by human immunodeficiency virus type 1.

Englund, G, Theodore, T S, Freed, E O, Engelman, A, Martin, M A

Certain human immunodeficiency virus type 1 (HIV-1) isolates are able to productively infect nondividing cells of the monocyte/macrophage lineage. We have used a molecular genetic approach to...

Isolation and characterization of a syncytium-inducing, macrophage/T-cell line-tropic human immunodeficiency virus type 1 isolate that readily infects chimpanzee cells in vitro and in vivo.

Shibata, R, Hoggan, M D, Broscius, C, Englund, G, Theodore, T S, Buckler-White, A, ...

Fresh human immunodeficiency virus type 1 (HIV-1) isolates from patients with AIDS were screened for infectivity in chimpanzee peripheral blood mononuclear cells (PBMC) to identify strains...

Amino acid substitutions in the human immunodeficiency virus type 1 gp120 V3 loop that change viral tropism also alter physical and functional properties of the virion envelope.

Willey, R L, Theodore, T S, Martin, M A

The third variable (V3) region within the gp120 envelope glycoprotein of the human immunodeficiency virus type 1 (HIV-1) has been reported to be an important determinant of viral tropism. In this...

Characterization of epitopes defining two major subclasses of polytropic murine leukemia viruses (MuLVs) which are differentially expressed in mice infected with different ecotropic MuLVs.

Lavignon, M, Walker, J L, Perryman, S M, Malik, F G, Khan, A S, Theodore, T S, ...

Polytropic murine leukemia viruses (MuLVs) arise in mice by recombination of ecotropic MuLVs with endogenous retroviral envelope genes and have been implicated in the induction of hematopoietic...

Variable role of the long terminal repeat Sp1-binding sites in human immunodeficiency virus replication in T lymphocytes.

Parrott, C, Seidner, T, Duh, E, Leonard, J, Theodore, T S, Buckler-White, A, ...

The long terminal repeat (LTR) of the human immunodeficiency virus (HIV) contains three binding sites for the transcriptional factor Sp1. In order to investigate the role that the Sp1-binding sites...

Lipoteichoic Acid Localization in Mesosomal Vesicles of Staphylococcus aureus

Huff, E., Cole, R. M., Theodore, T. S.

Mesosomal vesicles and plasma membranes of Staphylococcus aureus ATCC 6538P have been prepared and examined for the presence of lipoteichoic acid. Lipids were first removed by treatment with...

Respiratory Activities Associated with Mesosomal Vesicles and Protoplast Membranes of Staphylococcus aureus

Theodore, T. S., Weinbach, E. C.

Analysis of oxidase and dehydrogenase activities, cytochrome content of mesosomal vesicles, and protoplast membranes showed that the respiratory chain in Staphylococcus aureus is associated...

Cellular Location of Degradative Enzymes in Staphylococcus aureus

Nugent, K. M., Huff, E., Cole, R. M., Theodore, T. S.

Staphylococus aureus, ATCC 6538P, was fractionated into protoplast membranes, mesosomal vesicles, periplasm, and cytoplasm. These fractions and the culture fluid were then assayed for various...

In vitro mutagenesis identifies a region within the envelope gene of the human immunodeficiency virus that is critical for infectivity.

Willey, R L, Smith, D H, Lasky, L A, Theodore, T S, Earl, P L, Moss, B, ...

Site-specific mutagenesis was used to introduce amino acid substitutions at the asparagine codons of four conserved potential N-linked glycosylation sites within the gp120 envelope protein of human...

Functional interaction of constant and variable domains of human immunodeficiency virus type 1 gp120.

Willey, R L, Ross, E K, Buckler-White, A J, Theodore, T S, Martin, M A

A previously reported amino acid substitution within the second conserved domain of the human immunodeficiency virus type 1 (HIV-1) gp120 envelope results in the production of noninfectious...

Biologic and molecular characterization of two newly isolated ras-containing murine leukemia viruses.

Fredrickson, T N, O'Neill, R R, Rutledge, R A, Theodore, T S, Martin, M A, Ruscetti, S K, ...

A murine sarcoma virus (MSV) was recovered from an (NFS X NS.C58v-1) F1 mouse which developed splenic sarcoma and erythroleukemia 6 months after inoculation with a mink cell focus-inducing murine...

Envelope and long terminal repeat sequences of a cloned infectious NZB xenotropic murine leukemia virus.

O'Neill, R R, Buckler, C E, Theodore, T S, Martin, M A, Repaske, R

An infectious NZB xenotropic murine leukemia virus (MuLV) provirus (NZB was molecularly cloned from the Hirt supernatant of NZB-IU-6-infected mink cells, and the nucleotide sequence of its env gene...

Protein and Fatty Acid Composition of Mesosomal Vesicles and Plasma Membranes of Staphylococcus aureus

Theodore, T. S., Panos, C.

Qualitatively, the protein and fatty acid composition of purified mesosomal vesicles and the plasma membrane isolated from Staphylococcus aureus ATCC 6538P are identical, the major difference between...

Characterization of the lipids of mesosomal vesicles and plasma membranes from Staphylococcus aureus.

Beining, P R, Huff, E, Prescott, B, Theodore, T S

Mesosomal vesicles and plasma membranes were isolated from Staphylococcus aureus ATCC 6538P by protoplasting and differential centrifugation. The lipids of each of the two membrane fractions were...

Streptolysin S activation by lipoteichoic acid.

Theodore, T S, Calandra, G B

Lipoteichoic acid from streptococci and Staphylococcus aureus both activated membrane-bound precursor streptolysin S and induced the formation of extracellular streptolysin S. Lipoteichoic acid could...

Cellular location of alpha-hemolysin in Staphylococcus aureus.

Nugent, K M, Calandra, G B, Theodore, T S

Protoplast fractionation techniques were used to prepare subcellular fractions of three strains of Staphylococcus aureus for the analysis of alpha-hemolysin activity. More than 90% of the cellular...

Cellular location of streptolysin O.

Calandra, G B, Theodore, T S

Streptolysin O was measured in subcellular fractions of group A streptococci obtained after preparation of protoplasts in a hypertonic buffer containing raffinose. Most of the activity was located in...