The effects of cigarette smoke inhalation on lung function. (1980)
Thesis (Ph. D.)--University of London, 1980.
Mushroom compost worker's lung.
Phillips, M S, Robinson, A A, Higenbottam, T W, Calder, I M
This study draws attention to difficulties in the diagnosis and the understanding of the mechanism of action of mushroom compost worker's lung. Descriptions are given of 4 workers in one factory who...
Mohammed, S P, Higenbottam, T W, Adcock, J J
1. Capsaicin, prostaglandin E2 (PGE2) and histamine are potent stimuli for reflex coughing and bronchoconstriction in many species including man. We have studied the effects of solutions of...
Serious interaction between cyclosporin A and sulphadimidine.
Jones, D K, Hakim, M, Wallwork, J, Higenbottam, T W, White, D J
Motor neurone disease presenting as respiratory failure.
Al-Shaikh, B, Kinnear, W, Higenbottam, T W, Smith, H S, Shneerson, J M, Wilkinson, I
Chlormethiazole in treatment of status epilepticus.
Harvey, P K, Higenbottam, T W, Loh, L
Chlormethiazole (Heminevrin) was successful in controlling fits in seven out of nine episodes of intractable status epilepticus. It was administered as a constant intravenous injection at rates of up...
Mohammed, S P, Higenbottam, T W, Adcock, J J
1. Capsaicin, prostaglandin E2 (PGE2) and histamine are potent stimuli for reflex coughing and bronchoconstriction in many species including man. We have studied the effects of solutions of...
Mushroom compost worker's lung.
Phillips, M S, Robinson, A A, Higenbottam, T W, Calder, I M
This study draws attention to difficulties in the diagnosis and the understanding of the mechanism of action of mushroom compost worker's lung. Descriptions are given of 4 workers in one factory who...
Serious interaction between cyclosporin A and sulphadimidine.
Jones, D K, Hakim, M, Wallwork, J, Higenbottam, T W, White, D J
Motor neurone disease presenting as respiratory failure.
Al-Shaikh, B, Kinnear, W, Higenbottam, T W, Smith, H S, Shneerson, J M, Wilkinson, I
Chlormethiazole in treatment of status epilepticus.
Harvey, P K, Higenbottam, T W, Loh, L
Chlormethiazole (Heminevrin) was successful in controlling fits in seven out of nine episodes of intractable status epilepticus. It was administered as a constant intravenous injection at rates of up...
Appetite suppressants and primary pulmonary hypertension in the United Kingdom.
Thomas, S. H., Butt, A. Y., Corris, P. A., Egan, J. J., Higenbottam, T. W., Madden, B. P., ...
OBJECTIVE--Amphetamine-like appetite suppressants, particularly fenfluramines, have been implicated in the aetiology of primary pulmonary hypertension. At one specialist centre in France 20% of...
Higenbottam, T W, Spiegelhalter, D, Scott, J P, Fuster, V, Dinh-Xuan, A T, Caine, N, ...
OBJECTIVE--To determine whether epoprostenol (prostacyclin, PGI2) or heart-lung transplantation (HLT), or both improves survival of patients with severe pulmonary hypertension. DESIGN--This was a...
Treatment of primary pulmonary hypertension intravenous epoprostenol (prostacyclin).
Jones, D K, Higenbottam, T W, Wallwork, J
Ten patients with severe primary pulmonary hypertension and pronounced disability who were unresponsive to oral vasodilators were treated with intravenous epoprostenol (prostacyclin). All had been...
Impairment of pulmonary endothelium-dependent relaxation in patients with Eisenmenger's syndrome.
Dinh Xuan, A. T., Higenbottam, T. W., Clelland, C., Pepke-Zaba, J., Cremona, G., Wallwork, J.
A comparison has been made between the endothelium-dependent relaxation of pulmonary arteries (PA) obtained at heart-lung transplantation from 4 patients with Eisenmenger's syndrome and secondary...
Dinh-Xuan, A. T., Pepke-Zaba, J., Butt, A. Y., Cremona, G., Higenbottam, T. W.
1. Endothelium-dependent relaxation mediated by endothelium-derived relaxing factor (EDRF) or nitric oxide (NO), is impaired in pulmonary arteries (PA) of hypoxic patients with chronic obstructive...
Penketh, A R, Higenbottam, T W, Hutter, J, Coutts, C, Stewart, S, Wallwork, J
The main clinical problems that follow heart-lung transplantation are opportunist infections of the lungs and pulmonary rejection. Of 23 patients undergoing heart-lung transplantation, eight had...
Opportunistic pulmonary strongyloidiasis complicating asthma treated with steroids.
A man aged 57 years who had lived most of his life in London, suffered from asthma which had begun during army service in Burma 37 years previously. Latterly he was treated with increasing doses of...
Use of a single pair of magnetometer coils to monitor breathing patterns in an intensive care unit
Rees, P J, Higenbottam, T W, Clark, T J H
The use of a single pair of magnetometer coils placed centrally on the trunk to record tidal volumes and breath times has been evaluated in five normal subjects in five positions. Breath times were...
Katayama, Y., Higenbottam, T. W., D Diaz,, Cremona, G., Akamine, S., Barbera, J. A., ...
BACKGROUND: Inhaled nitric oxide (NO) is a selective pulmonary vasodilator which can improve gas exchange in acute lung injury. However, it is uncertain that this effect on arterial oxygenation can...
Tar, nicotine, and carbon monoxide yields of some Nigerian cigarettes.
Awotedu, A A, Higenbottam, T W, Onadeko, B O
Fourteen cigarette brands manufactured in Nigeria in 1981 were analysed to determine the tar, nicotine, and carbon monoxide yields. Five of the brands belonged to the high and middle to high tar...
Sustained release theophylline in nocturnal asthma.
Elias-Jones, A C, Higenbottam, T W, Barnes, N D, Godden, D J
Twice daily sustained release theophylline gave satisfactory steady serum theophylline concentrations in asthmatic children aged 7 to 14 years. The children showed improvement in symptoms, less...
Early experience of heart-lung transplantation.
Smyth, R L, Higenbottam, T W, Scott, J P, McGoldrick, J P, Whitehead, B, Helms, P, ...
We report our experience of heart-lung transplantation for the treatment of children with terminal respiratory disease. Between May 1987 and October 1988 we performed heart-lung transplantation in...
Heart-lung transplantation for cystic fibrosis. 1: Assessment.
Whitehead, B, Helms, P, Goodwin, M, Martin, I, Lask, B, Serrano, E, ...
Forty five patients with cystic fibrosis (age 5-15 years) were assessed for heart-lung transplantation between September 1987 and March 1990. The two main conditions for acceptance were (i) life...
Heart-lung transplantation for cystic fibrosis. 2: Outcome.
Whitehead, B, Helms, P, Goodwin, M, Martin, I, Scott, J P, Smyth, R L, ...
From March 1988 to March 1990, 11 children with cystic fibrosis (age 5-15 years) underwent combined heart-lung transplantation at our institutes. Maintenance immunosuppression consisted of...