Physics Interplay of the LHC and the ILC (2008)
Weiglein, G., Barklow, T., Boos, E., De Roeck, A., Desch, K., Gianotti, F., ...
Physics at the Large Hadron Collider (LHC) and the International e+e- Linear Collider (ILC) will be complementary in many respects, as has been demonstrated at previous generations of hadron and...
Physics Interplay of the LHC and the ILC (2008)
Weiglein, G., Barklow, T., Boos, E., De Roeck, A., Desch, K., Gianotti, F., ...
Physics at the Large Hadron Collider (LHC) and the International e+e- Linear Collider (ILC) will be complementary in many respects, as has been demonstrated at previous generations of hadron and...
Physics Interplay of the LHC and the ILC (2008)
Weiglein, G., Barklow, T., Boos, E., De Roeck, A., Desch, K., Gianotti, F., ...
Physics at the Large Hadron Collider (LHC) and the International e+e- Linear Collider (ILC) will be complementary in many respects, as has been demonstrated at previous generations of hadron and...
Adjoint Messengers and Perturbative Unification at the String Scale (2007)
Han Yanagida And, T. Han, T. Yanagida
We consider states in the adjoint representation of the Standard Model gauge group as messengers for mediation of supersymmetry (SUSY) breaking. These new messengers can shift the gauge coupling...
EXPERIMENTAL STUDIES OF PHOTOCATHODE RF GUN WITH LASER PULSE SHAPING (2007)
J. Yang, F. Sakai, T. Yanagida, M. Yorozu, Y. Okada, T. Nakajyo, ...
A technique of laser pulse shaping was developed for low-emittance electron beam generation in a photocathode RF gun. The emittance growth due to space charge and RF effects in the RF gun was...
Gravitino Dark Matter in R-Parity Breaking Vacua. (2007)
W. Buchmuller, DESY Forschung Hochenergiephysik, L. Covi, K. Hamaguchi, A. Ibarra, T. Yanagida
Journal article
Hard X-ray Detector (HXD) on Board Suzaku (2006)
Takahashi, T., Abe, K., Endo, M., Endo, Y., Ezoe, Y., Fukazawa, Y., ...
The Hard X-ray Detector (HXD) on board Suzaku covers a wide energy range from 10 keV to 600 keV by combination of silicon PIN diodes and GSO scintillators. The HXD is designed to achieve an extremely...
In-Orbit Performance of the Hard X-ray Detector on board Suzaku (2006)
Kokubun, M., Makishima, K., Takahashi, T., Murakami, T., Tashiro, M., Fukazawa, Y., ...
The in-orbit performance and calibration of the Hard X-ray Detector (HXD) on board the X-ray astronomy satellite Suzaku are described. Its basic performances, including a wide energy bandpass of...
Physics interplay of the LHC and the ILC. (2006)
Weiglein, G., Barklow, T., Boos, E., De Roeck, A., Desch, K., Gianotti, F., ...
Physics at the Large Hadron Collider (LHC) and the International e(+)e(-) Linear Collider (ILC) will be complementary in many respects, as has been demonstrated at previous generations of hadron and...
Testing the see-saw mechanism at collider energies (2006)
We propose a low energy extension of the Standard Model consisting of an additional gauged U(1)B-L plus three right-handed neutrinos. Although the lightest right-handed neutrinos have TeV scale...
A Higher-dimensional Origin of the Inverted Mass Hierarchy for Neutrino (2005)
We present successful lepton mass matrices with an inverted mass hierarchy for neutrinos, which follow from a geometrical structure of a (1+5) dimensional space-time where two extra dimensions are...
More on Conformally Sequestered SUSY Breaking (2005)
Ibe, M., Nakayama, Yu, Shinbara, Y., Yanagida, T.
We extend our models for conformal sequestering of dynamical supersymmetry breaking with decoupling vector-like matter in several different ways. These extensions enable us to simplify concrete model...
Physics Interplay of the LHC and the ILC (2005)
Weiglein, G., Barklow, T., Boos, E., De Roeck, A., Desch, K., Gianotti, F., ...
Physics at the Large Hadron Collider (LHC) and the International e+e- Linear Collider (ILC) will be complementary in many respects, as has been demonstrated at previous generations of hadron and...
Conformally Sequestered SUSY Breaking in Vector-like Gauge Theories (2005)
Ibe, M., Nakayama, Yu, Shinbara, Y., Yanagida, T.
We provide, in a framework of vector-like gauge theories, concrete models for conformal sequestering of dynamical supersymmetry (SUSY) breaking in the hidden sector. If the sequestering is...
511 keV Gamma Ray from Moduli Decay in the Galactic Bulge (2005)
We show that the $e^++e^-$ decay of a light scalar boson of mass 1-10 MeV may account for the fluxes of 511 keV gamma ray observed by SPI/INTEGRAL. We argue that candidates of such a light scalar...
On Myosin II dynamics in the presence of external loads (2005)
Buonocore, A., Caputo, L., Ishii, Y., Pirozzi, E., Yanagida, T., Ricciardi, L. M.
We address the controversial hot question concerning the validity of the loose coupling versus the lever-arm theories in the actomyosin dynamics by re-interpreting and extending the phenomenological...
Leptogenesis as the origin of matter (2005)
Buchmuller, W., Peccei, R. D., Yanagida, T.
We explore in some detail the hypothesis that the generation of a primordial lepton-antilepton asymmetry (Leptogenesis) early on in the history of the Universe is the root cause for the origin of...
Dark Matter and Baryon Asymmetry of the Universe in Large-Cutoff Supergravity (2005)
Ibe, M., Moroi, Takeo, Yanagida, T.
We propose a consistent scenario of the evolution of the universe based on the large cutoff supergravity (LCSUGRA) hypothesis of supersymmetry breaking, where the gravitino and sfermion become as...
Strongly Coupled Gauge Mediation (2005)
A model of gauge mediation with the gravitino mass of order 1eV is considered to motivate 100TeV colliders. Massive mediators with standard-model and supersymmetry-breaking gauge quantum numbers let...
A Phenomenological model of Myosin II dynamics in the presence of external loads (2004)
Buonocore, A., Caputo, L., Ishii, Y., Pirozzi, E., Yanagida, T., Ricciardi, L. M.
We address the controversial hot question concerning the validity of the loose coupling versus the lever-arm theories in the actomyosin dynamics by re-interpreting and extending the phenomenological...
Testing the see-saw mechanism at collider energies (2004)
We propose a low energy extension of the Standard Model consisting of an additional gauged $U(1)_{B-L}$ plus three right-handed neutrinos. The lightest right-handed neutrinos have TeV scale masses...
Physics Interplay of the LHC and the ILC (2004)
Barklow, T., Boos, E., De Roeck, A., Desch, K., Gianotti, F., ...
Physics at the Large Hadron Collider (LHC) and the International e+e- Linear Collider (ILC) will be complementary in many respects, as has been demonstrated at previous generations of hadron and...
Realization of Minimal Supergravity (2004)
Minimal supergravity mediation of supersymmetry breaking has attracted much attention due to its simplicity, which leads to its predictive power. We consider how Nature possibly realizes minimal...
If a bosonic partner of a right-handed neutrino dominates the early universe sufficiently before its decay, important ingredients in the present universe are related to physics of the right-handed...
Super- and CP-symmetric QCD in Higher Dimensions (2004)
An extremely precise global symmetry is necessary in the Peccei--Quinn solution to the strong CP problem. Such symmetry arises when colored chiral fermions are localized in an internal space. We...
Product-Group Unification in Type IIB String Thoery (2004)
The product-group unification is a model of unified theories, in which masslessness of the two Higgs doublets and absence of dimension-five proton decay are guaranteed by a symmetry. It is based on...
GUT Phase Transition and Hybrid Inflation (2004)
The supersymmetric model of hybrid inflation is interesting not only because of its naturalness but also because of another reason. Its energy scale determined by the COBE normalization is 10^15 -...
Physics Interplay of the LHC and the ILC (2004)
Weiglein, G., Barklow, T., Boos, E., De Roeck, A., Desch, K., Gianotti, F., ...
Physics at the Large Hadron Collider (LHC) and the International e+e- Linear Collider (ILC) will be complementary in many respects, as has been demonstrated at previous generations of hadron and...
Physics Interplay of the LHC and the ILC (2004)
Weiglein, G., Barklow, T., Boos, E., De Roeck, A., Desch, K., Gianotti, F., ...
Physics at the Large Hadron Collider (LHC) and the International e+e- Linear Collider (ILC) will be complementary in many respects, as has been demonstrated at previous generations of hadron and...
Upper Bound On Gluino Mass From Thermal Leptogenesis (2003)
Fujii, M., Ibe, M., Yanagida, T.
Thermal leptogenesis requires the reheating temperature $T_R \gsim 3\times 10^{9}$ GeV, which contradicts a recently obtained constraint on the reheating temperature, $T_R \lsim 10^6$ GeV, for the...
Thermal Leptogenesis and Gauge Mediation (2003)
Fujii, M., Ibe, M., Yanagida, T.
We show that a mini-thermal inflation occurs naturally in a class of gauge mediation models of supersymmetry (SUSY) breaking, provided that the reheating temperature T_R of the primary inflation is...
Ellis, Jonathan Richard, Raidal, Martti, Yanagida, T
We reconsider the possibility that inflation was driven by a sneutrino - the scalar supersymmetric partner of a heavy singlet neutrino - in the minimal seesaw model of neutrino masses. We show that...
Ellis, J., Raidal, M., Yanagida, T.
We reconsider the possibility that inflation was driven by a sneutrino - the scalar supersymmetric partner of a heavy singlet neutrino - in the minimal seesaw model of neutrino masses. We show that...
Predictions from the Fritzsch-Type Lepton Mass Matrices (2003)
Fukugita, M., Tanimoto, M., Yanagida, T.
We revisit the Fritzsch-type lepton mass matrix models confronted with new experiments for neutrino mixings. It is shown that the model is viable and leads to a rather narrow range of free...
Removing Ambiguities in the Neutrino Mass Matrix (2002)
Branco, G. C., Felipe, R. Gonzalez, Joaquim, F. R., Yanagida, T.
We suggest that the weak-basis independent condition det(M_nu)=0 for the effective neutrino mass matrix can be used in order to remove the ambiguities in the reconstruction of the neutrino mass...
Higher-Dimensional Origin of Heavy Sneutrino Domination and Low-Scale Leptogenesis (2002)
Hebecker, A, March-Russell, John David, Yanagida, T
If the expectation value of the right-handed (rhd) sneutrino comes to dominate the universe, its decay naturally leads to successful leptogenesis, as well as significant dilution of dangerous...
Higher-Dimensional Origin of Heavy Sneutrino Domination and Low-Scale Leptogenesis (2002)
Hebecker, A., March-Russell, J., Yanagida, T.
If the expectation value of the right-handed (rhd) sneutrino comes to dominate the universe, its decay naturally leads to successful leptogenesis, as well as significant dilution of dangerous...
We point out that there is no cosmological gravitino problem in a certain class of gauge-mediated supersymmetry-breaking (GMSB) models. The constant term in the superpotential naturally causes small...
We point out that there is no cosmological gravitino problem in a certain class of gauge-mediated supersymmetry-breaking (GMSB) models. The constant term in the superpotential naturally causes small...
Cosmological Sign of Neutrino CP Violation (2002)
Frampton, Paul H, Glashow, Sheldon Lee, Yanagida, T
It is shown how, in a class of models, the sign of the baryon number of the universe can be related to CP violation in neutrino oscillation experiments.
Cosmological Sign of Neutrino CP Violation (2002)
Frampton, P. H., Glashow, S. L., Yanagida, T.
It is shown how, in a class of models, the sign of the baryon number of the universe can be related to CP violation in neutrino oscillation experiments.
A Solution to the Doublet-Triplet Splitting Problem in the Type IIB Supergravity (2002)
The doublet--triplet mass splitting problem is one of the most serious problems in supersymmetric grand unified theories (GUTs). A class of models based on a product gauge group, such as the...
A Solution to the Doublet-Triplet Splitting Problem in the Type IIB Supergravity (2002)
The doublet--triplet mass splitting problem is one of the most serious problems in supersymmetric grand unified theories (GUTs). A class of models based on a product gauge group, such as the...
Baryogenesis and Gravitino Dark Matter in Gauge-Mediated Supersymmetry-Breaking Models (2002)
We discuss two cosmological issues in a generic gauge-mediated supersymmetry (SUSY)-breaking model, namely the Universe's baryon asymmetry and the gravitino dark-matter density. We show that both...
Baryogenesis and Gravitino Dark Matter in Gauge-Mediated Supersymmetry-Breaking Models (2002)
We discuss two cosmological issues in a generic gauge-mediated supersymmetry (SUSY)-breaking model, namely the Universe's baryon asymmetry and the gravitino dark-matter density. We show that both...
Observable consequences of partially degenerate leptogenesis (2002)
Ellis, Jonathan Richard, Raidal, Martti, Yanagida, T
In the context of the seesaw mechanism, it is natural that the large solar and atmospheric neutrino mixing angles originate separately from large 2 by 2 mixings in the neutrino and charged-lepton...
Observable Consequences of Partially Degenerate Leptogenesis (2002)
Ellis, John, Raidal, Martti, Yanagida, T.
In the context of the seesaw mechanism, it is natural that the large solar and atmospheric neutrino mixing angles originate separately from large 2 by 2 mixings in the neutrino and charged-lepton...
A Solution to the Coincidence Puzzle of $\Omega_{B}$ and $\Omega_{DM}$ (2002)
We show that a class of Affleck--Dine baryogenesis directly relates the observed mass density of baryons, \Omega_{B}, to that of dark matter, \Omega_{DM}. In this scenario, the ratio of baryon to...
A Solution to the Coincidence Puzzle of \Omega_{B} and \Omega_{DM} (2002)
We show that a class of Affleck--Dine baryogenesis directly relates the observed mass density of baryons, \Omega_{B}, to that of dark matter, \Omega_{DM}. In this scenario, the ratio of baryon to...
Geometric Origin of Large Lepton Mixing in a Higher Dimensional Spacetime (2002)
The large mixing in the lepton sector observed in the recent neutrino-oscillation experiments strongly suggest that nature of left-handed lepton doublets is very different from that of left-handed...
Geometric Origin of Large Lepton Mixing in a Higher Dimensional Spacetime (2002)
The large mixing in the lepton sector observed in the recent neutrino-oscillation experiments strongly suggest that nature of left-handed lepton doublets is very different from that of left-handed...
Resurrection of Grand Unified Theory Baryogenesis (2002)
A `new' scenario is proposed for baryogenesis. We show that delayed decay of coloured Higgs particles in grand unified theories may generate excess baryon number of the empirically desired amount, if...
Fujii, Masaaki, Hamaguchi, K., Yanagida, T.
If the baryon asymmetry in the present universe is generated by decays of the $L H_u$ flat direction, the observed baryon asymmetry requires the mass of the lightest neutrino to be much smaller than...
Leptogenesis with Almost Degenerate Majorana Neutrinos (2002)
Fujii, Masaaki, Hamaguchi, K., Yanagida, T.
We investigate the leptogenesis with almost degenerate neutrinos, in the framework of democratic mass matrix, which naturally explains the large mixing angles for neutrino oscillations as well as...
Higher-Dimensional QCD without the Strong CP Problem (2002)
QCD in a five-dimensional sliced bulk with chiral extra-quarks on the boundaries is generically free from the strong CP problem. Accidental axial symmetry is naturally present except for suppressed...
Higher Dimensional Supersymmetry as an Origin of the Three Families for Quarks and Leptons (2002)
In a (0,1) supersymmetric (SUSY) six-dimensional gauge theory, a gauge fermion gives rise to box anomalies. These anomalies are completely canceled by assuming a vector multiplet of (1,1) SUSY. With...
Leptogenesis via $LH_{u}$ flat direction with a gauged $U(1)_{B-L}$ (2001)
Fujii, Masaaki, Hamaguchi, K., Yanagida, T.
We study the supersymmetric leptogenesis via $LH_{u}$ flat direction with a gauged $U(1)_{B-L}$ symmetry. We find that the resultant baryon asymmetry is enhanced compared with the case without a...
Leptogenesis from $\widetilde{N}$-dominated early universe (2001)
Hamaguchi, K., Murayama, Hitoshi, Yanagida, T.
We investigate in detail the leptogenesis by the decay of coherent right-handed sneutrino $\widetilde{N}$ having dominated the energy density of the early universe, which was originally proposed by...
We construct supersymmetric (SUSY) grand unification (GUT) models in the six dimensional space-time where the GUT symmetry is broken down to the standard-model gauge group by a simple orbifolding...
Semi-Simple Unification on T^6/Z_12 Orientifold in the Type IIB Supergravity (2001)
The semi-simple unification model based on SU(5)_GUT \times U(3)_H gauge group is an interesting extension of the minimal SU(5)_GUT grand unification theory (GUT), since it solves the two serious...
Nonanomalous R-symmetry in supersymmetric unified theories of quarks and leptons (2001)
Kurosawa, Kiichi, Maru, Nobuhito, Yanagida, T.
A discrete R-symmetry often appears as an exact gauge symmetry in the low energy effective theory of superstring theories. We search for such discrete R-symmetries from a phenomenological point of...
Affleck-Dine baryo/leptogenesis with a gauged U(1)(B-L) (2001)
Fujii, Masaaki, Hamaguchi, K., Yanagida, T.
We briefly review the present status of Affleck-Dine baryo/leptogenesis scenarios in the minimal supersymmetric standard model (MSSM) in the context of the gravity-mediated SUSY breaking, and show...
Semi-simple group unification in the supersymmetric brane world (2001)
Imamura, Y., Watari, T., Yanagida, T.
The conventional supersymmetric grand unified theories suffer from two serious problems, the large mass splitting between doublet and triplet Higgs multiplets, and the too long lifetime of the...
Fujii, Masaaki, Hamaguchi, K., Yanagida, T.
In this paper we point out that the cosmological baryon asymmetry in our universe is generated almost independently of the reheating temperature $T_R$ in Affleck-Dine leptogenesis and it is...
Variations on Supersymmetry Breaking and Neutrino Spectra (2000)
Borzumati, F., Hamaguchi, K., Nomura, Y., Yanagida, T.
The problem of generating light neutrinos within supersymmetric models is discussed. It is shown that the hierarchy of scales induced by supersymmetry breaking can give rise to suppression factors of...
N = 2 Supersymmetry in a Hybrid Inflation Model (2000)
The slow roll inflation requires an extremely flat inflaton potential. The supersymmetry (SUSY) is not only motivated from the gauge hierarchy problem, but also from stabilizing that flatness of the...
Supersymmetric seesaw model for the (1+3)-scheme of neutrino masses (2000)
Borzumati, F., Hamaguchi, K., Yanagida, T.
A four-neutrino spectrum with a sterile neutrino without significant involvement in the atmospheric and solar neutrino oscillation experiments has been recently advocated as the correct picture to...
Natural Chaotic Inflation in Supergravity and Leptogenesis (2000)
Kawasaki, M., Yamaguchi, Masahide, Yanagida, T.
We comprehensively investigate a chaotic inflation model proposed recently in the framework of supergravity. In this model, the form of K\"ahler potential is determined by a symmetry, that is, the...
A Constraint on Yukawa-Coupling Unification from Lepton-Flavor Violating Processes (2000)
We present a new constraint on a lepton mixing matrix $V$ from lepton-flavor violating (LFV) processes in supersymmetric standard models with massive neutrinos. Here, we assume Yukawa-coupling...
A Constraint on Yukawa-Coupling Unification from Lepton-Flavor Violating Processes (2000)
Sato, J., Tobe, K., Yanagida, T.
We present a new constraint on a lepton mixing matrix $V$ from lepton-flavor violating (LFV) processes in supersymmetric standard models with massive neutrinos. Here, we assume Yukawa-coupling...
LSND, SN1987A, and CPT Violation (2000)
Murayama, Hitoshi, Yanagida, T.
We point out that neutrino events observed at Kamiokande and IMB from SN1987A disfavor the neutrino oscillation parameters preferred by the LSND experiment. For $\Delta m^2 > 0$ (the light side), the...
LSND, SN1987A, and CPT violation (2000)
Murayama, Hitoshi, Yanagida, T.
We point out that neutrino events observed at Kamiokande and IMB from SN1987A disfavor the neutrino oscillation parameters preferred by the LSND experiment. For Delta m2 > 0 (the light side), the...
Vacuum Instability in Anomaly Mediation Models with Massive Neutrinos (2000)
Kawasaki, Masahiro, Watari, T., Yanagida, T.
We study the vacuum stability in the anomaly mediated supersymmetry (SUSY) breaking models with massive neutrinos. It is shown that, because of the seesaw-induced mass terms for neutrinos, the true...
Low-Energy Predictions of Lopsided Family Charges (2000)
We consider the Froggatt-Nielsen (FN) mechanism reproducing the observed mass hierarchies and mixing angles for quarks and leptons. The large $\nu_\mu $-$ \nu_\tau$ mixing suggested from recent...
Natural Mass Generation for the Sterile Neutrino (2000)
We point out that there is a serious cosmological problem in the supersymmetric standard model if a sterile neutrino is responsible for the solar neutrino oscillation, and propose a possible solution...
Affleck-Dine Leptogenesis with an Ultralight Neutrino (2000)
Asaka, T., Fujii, Masaaki, Hamaguchi, K., Yanagida, T.
We perform a detailed analysis on Affleck-Dine leptogenesis taking into account the thermal effects on the dynamics of the flat direction field $\phi$. We find that an extremely small mass for the...
Double Inflation in Supergravity and the Boomerang Observations (2000)
Kanazawa, Toshiyuki, Kawasaki, Masahiro, Sugiyama, Naoshi, Yanagida, T.
One of the biggest mystery of the recent observation of cosmic microwave background anisotropies by the boomerang team is insignificance of the second acoustic peak in the angular power spectrum. It...
Solving the Gravitino Problem by Axino (2000)
In a large class of supersymmetric (SUSY) axion model the mass of axino $\axino$ (a fermionic superpartner of the axion) is predicted as $m_{\axino} \lesssim {\cal O}(1)$ keV. Thus, the axino is the...
Nomura, Yasunori, Yanagida, T.
We propose a new U(1) gauge interaction in the bulk in higher dimensional spacetime, which transmits supersymmetry-breaking effects on the hidden brane to the observable our brane. We find that...
Topological Inflation in Supergravity (2000)
Kawasaki, M., Sakai, Nobuyuki, Yamaguchi, Masahide, Yanagida, T.
We investigate a topological inflation model in supergravity. By means of numerical simulations, it is confirmed that topological inflation can take place in supergravity. We also show that the...
Natural Chaotic Inflation in Supergravity (2000)
Kawasaki, M., Yamaguchi, Masahide, Yanagida, T.
We propose a chaotic inflation model in supergravity. In the model the K\"ahler potential has a Nambu-Goldstone-like shift symmetry of the inflaton chiral multiplet which ensures the flatness of the...
Quintessence Axion Potential Induced by Electroweak Instanton Effects (2000)
Nomura, Yasunori, Watari, T., Yanagida, T.
Recent cosmological observations suggest the presence of small but nonzero cosmological constant $\Lambda_{cos}^4 \simeq (2 \times 10^{-3} eV)^4$. It is an intriguing possibility that such a small...
Double inflation in supergravity and the primordial black hole formation (2000)
Kanazawa, Toshiyuki, Kawasaki, M., Yanagida, T.
We study a double inflation model (a hybrid inflation + a new inflation) in supergravity and discuss the formation of primordial black holes (PBHs) with mass \sim 10^{-20}-10^{5}M_{\odot}. We find...
Variations on Supersymmetry Breaking and Neutrino Spectra (2000)
Borzumati, Francesca, Hamaguchi, K., Nomura, Y., Yanagida, T.
Broad-Band Magnetic Brain Activity (2000)
Holroyd Nielsen Miyauchi, T. Holroyd, M. Nielsen, S. Miyauchi, T. Yanagida
this paper, we investigate the magnetic brain activity of subjects performing two rhythmic tapping and synchronization tasks. We use an adaptive linearfiltering technique known as differential...
Mass Generation for an Ultralight Axion (1999)
Nomura, Yasunori, Watari, T., Yanagida, T.
If a global chiral symmetry is explicitly broken by anomalies in nonabelian gauge theories, a pseudo Nambu-Goldstone boson (axion) associated with a spontaneous breakdown of such a global symmetry...
Double Inflation in Supergravity and the Large Scale Structure (1999)
Kanazawa, Toshiyuki, Kawasaki, M., Sugiyama, Naoshi, Yanagida, T.
The cosmological implication of a double inflation model with hybrid + new inflations in supergravity is studied. The hybrid inflation drives an inflaton for new inflation close to the origin through...
Cosmological Constants as Messenger between Branes (1999)
Nomura, Yasunori, Yanagida, T.
We present a supersymmetry-breaking scenario in which both the breaking in the hidden sector with no-scale type supergravity and that in the observable sector with gauge mediation are taken into...
Leptogenesis in Inflationary Universe (1999)
Asaka, T., Hamaguchi, K., Kawasaki, M., Yanagida, T.
We investigate the leptogenesis via decays of heavy Majorana neutrinos which are produced non-thermally in inflaton decays. We make a comprehensive study on the leptogenesis assuming various...
Leptogenesis in Inflaton Decay (1999)
Asaka, T., Hamaguchi, K., Kawasaki, M., Yanagida, T.
We study a leptogenesis via decays of heavy Majorana neutrinos produced non-thermally in inflaton decays. We find that this scenario is fully consistent with existing supersymmetric inflation models...
Superheavy Dark Matter and Thermal Inflation (1999)
Asaka, T., Kawasaki, M., Yanagida, T.
The thermal inflation is the most plausible mechanism that solves the cosmological moduli problem naturally. We discuss relic abundance of superheavy particle $X$ in the presence of the thermal...
Dynamical Inflation and Vacuum Selection (1999)
We consider an inflationary scenario where the energy scale of inflation stems from gauge theory dynamics. We point out its generic implications on vacuum selection of our universe, in particular, on...
Democratic Mass Matrices from Broken $O(3)_L\times O(3)_R$ Flavor Symmetry (1999)
Tanimoto, M., Watari, T., Yanagida, T.
We impose $O(3)_L\times O(3)_R$ flavor symmetry in the supersymmetric standard model. Three lepton doublets $\ell_i$ transform as an $O(3)_L$ triplet and three charged leptons $\bar e_i$ as an...
Grand-Unification Scale Generation through the Anomalous U(1) Breaking (1999)
Kurosawa, Kiichi, Nomura, Yasunori, Yanagida, T.
We discuss the anomalous U(1) gauge symmetry as a mechanism of generating the grand-unification scale. We conclude that unification to a simple group cannot be realized unless some parameters are...
Prediction of the CP violation in the Phenomenological Quark-Lepton Mass Matrix Approach (1999)
Fukugita, M., Tanimoto, M., Yanagida, T.
We explore the phenomenological quark-lepton mass matrices, which are devised following the S$_3$ flavour symmetry principle, yet fully consistent with SU(5) gauge models with the Higgs particles of...
Long-Lived Superheavy Particles in Dynamical Supersymmetry-Breaking Models in Supergravity (1999)
Hamaguchi, K., Nomura, Yasunori, Yanagida, T.
Superheavy particles of masses $\simeq 10^{13}-10^{14} GeV$ with lifetimes $\simeq 10^{10}-10^{22} years$ are very interesting, since their decays may account for the ultra-high energy (UHE) cosmic...
A Gauge-Mediation Model of Dynamical SUSY Breaking with a Wide Range of the Gravitino Mass (1999)
Nomura, Yasunori, Yanagida, T.
We provide a gauge-mediation model of dynamical supersymmetry breaking where the gravitino mass takes a value in a wide range from 0.1 eV to 10 GeV. The lower mass region of order 100 keV or less...
Anorexia nervosa: an important cause of chronic tubulointerstitial nephropathy (1999)
Arimura, Y, Tanaka, H, Yoshida, T, Shinozaki, M, Yanagida, T, Ando, T, ...
We propose a new mechanism called "real CP violation" to originate spontaneous CP violation. Starting with a CP conserving theory with scalar fields in the adjoint representation of a global or local...
R-Invariant Topological Inflation (1998)
We propose a topological inflation model in the framework of supergravity with $R$ invariance. This topological inflation model is not only free from the initial value problem of the inflaton field...
Quark Lepton Mass Hierarchies and the Baryon Asymmetry (1998)
The mass hierarchies of quarks and charged leptons as well as a large $\n_\m$-$\n_\t$ mixing angle are naturally explained by the Frogatt-Nielsen mechanism with a nonparallel family structure of...
Embedding Phenomenological Quark-Lepton Mass Matrices into SU(5) Gauge Models (1998)
Fukugita, M., Tanimoto, M., Yanagida, T.
We construct phenomenological quark-lepton mass matrices based on S$_3$ permutation symmetry in a manner fully compatible with SU(5) grand unification. The Higgs particles we need are {\bf 5}, {\bf...
Long Lived Superheavy Dark Matter with Discrete Gauge Symmetries (1998)
Hamaguchi, K., Nomura, Yasunori, Yanagida, T.
The recently observed ultra-high energy (UHE) cosmic rays beyond the Greisen-Zatsepin-Kuzmin bound can be explained by the decays of some superheavy $X$ particles forming a part of dark matter in our...
R-Invariant Dilaton Fixing (1998)
We consider dilaton stabilization with R invariance, which insures a vanishing cosmological constant at the scale of stabilization. We construct a few models which accommodate weak gauge couplings...
Large Lepton Mixing in Seesaw Models - Coset-space Family Unification - (1998)
We show that the large mixing between $\nu_\mu$ and $\nu_\tau$ observed by the SuperKamiokande collaboration is a quite natural prediction in a large class of seesaw models. This large mixing is...
Primordial Black Hole Formation in Supergravity (1998)
We study a double inflation model (a preinflation + a new inflation) in supergravity and discuss the formation of primordial black holes which may be identified with massive compact halo objects...
Bi-Maximal Neutrino Mixing in SO(10)_{GUT} (1998)
Nomura, Yasunori, Yanagida, T.
We find a grand unified SO(10) model which accommodates the bi-maximal neutrino mixing for vacuum-oscillation solutions to the atmospheric and the solar neutrino problems. This model maintains the...
Superheavy Dark Matter with Discrete Gauge Symmetries (1998)
Hamaguchi, K., Nomura, Yasunori, Yanagida, T.
We show that there are discrete gauge symmetries protect naturally heavy X particles from decaying into the ordinary light particles in the supersymmetric standard model. This makes the proposal very...
Observational Implications of Axionic Isocurvature Fluctuations (1998)
Kanazawa, Toshiyuki, Kawasaki, M., Sugiyama, Naoshi, Yanagida, T.
The axion is the most attractive candidate to solve the strong CP problem in QCD. If it exists, the inflationary universe produces axion fluctuations which are mixtures of isocurvature and adiabatic...
Gravitino Overproduction through Moduli Decay (1998)
Hashimoto, M., Yamaguchi, M., Yanagida, T.
We derive cosmological constraints on the masses of generic scalar fields which decay only through gravitationally suppressed interactions into unstable gravitinos and ordinary particles in the...
Adjoint Messengers and Perturbative Unification at the String Scale (1998)
We consider states in the adjoint representation of the Standard Model gauge group as messengers for mediation of supersymmetry (SUSY) breaking. These new messengers can shift the gauge coupling...
Isocurvature Fluctuations of the M-theory Axion in a Hybrid Inflation Model (1998)
Kanazawa, Toshiyuki, Kawasaki, M., Sugiyama, Naoshi, Yanagida, T.
The M-theory, the strong-coupling heterotic string theory, presents various interesting new phenomenologies. The M-theory bulk axion is one of these. The decay constant in this context is estimated...
Axion Cosmology with its Scalar Superpartner (1998)
Hashimoto, M., Yamaguchi, M., Yanagida, T.
In supersymmetric theories, the Peccei-Quinn symmetry has a complex extension as a symmetry of the superpotential, so that the scalar potential always has an almost flat direction, the dilaton. We...
Spectrum of Background X-rays from Moduli Dark Matter (1998)
Asaka, T., Hashiba, J., Kawasaki, M., Yanagida, T.
We examine the $X$-ray spectrum from the decay of the dark-matter moduli with mass $\sim {\cal O}(100)$keV, in particular, paying attention to the line spectrum from the moduli trapped in the halo of...
Yokota, H., Saito, K., Yanagida, T.
We report the first real time imaging of single fluorophores attached to protein molecules on metal surfaces in aqueous solution using surface plasmon resonance fluorescence microscopy. The...
Cosmological Moduli Problem in Gauge-mediated Supersymmetry Breaking Theories (1997)
Asaka, T., Hashiba, J., Kawasaki, M., Yanagida, T.
A generic class of string theories predicts the existence of light moduli fields, and they are expected to have masses $m_\phi$ comparable to the gravitino mass $m_{3/2}$ which is in a range of...
Atmospheric Neutrino Oscillation and Large Lepton-Flavour Violation in the SUSY SU(5) GUT (1997)
Hisano, J., Nomura, Daisuke, Yanagida, T.
The atmospheric neutrino anomaly reported by the super-Kamiokande collaboration suggests existence of a large flavour violating Yukawa coupling in the lepton sector. We discuss lepton-flavour...
A Gauge Mediation Model of Dynamical Supersymmetry Breaking without Color Instability (1997)
Nomura, Yasunori, Tobe, K., Yanagida, T.
We construct a gauge mediation model of dynamical supersymmetry breaking (DSB) based on a vector-like gauge theory, in which there is a unique color-preserving true vacuum. The DSB scale...
Large Lepton Mixing in a Coset-space Family Unification on $E_7/SU(5) \times U(1)^3$ (1997)
We study a coset-space unification model for families based on $E_7/SU(5) \times U(1)^3$. We find that qualitative structure of quark and lepton mass matrices in this model describes very well the...
Dimension-six Proton Decays in the Modified Missing Doublet SU(5) Model (1997)
Hisano, J., Nomura, Yasunori, Yanagida, T.
Dimension-five operators for nucleon decays are suppressed in the modified missing doublet (MMD) model in the supersymmetric SU(5) grand unification. We show that nonrenormalizable interactions...
Primordial Black Hole Formation in a Double Inflation Model in Supergravity (1997)
Kawasaki, M., Sugiyama, N., Yanagida, T.
It has been recently pointed out that the initial value problem in new inflation models is naturally solved by supergravity effects if there exists a pre-inflation before the new inflation. We study...
R-Invariant Unification with Dynamical Higgs Multiplets (1997)
We construct R-invariant grand unification models with composite Higgs multiplets. Higgs doublets are massless due to the R symmetry, which is not spontaneously broken at the unification scale, while...
Atmospheric Neutrino Oscillation and a Phenomenological Lepton Mass Matrix (1997)
Fukugita, M., Tanimoto, M., Yanagida, T.
We propose simple phenomenological lepton mass matrices which describe the three neutrinos almost degenerate in mass, leading to a very large mixing angle between $\nu_\mu$ and $\nu_\tau$, as...
Domain Wall Problem of Axion and Isocurvature Fluctuations in Chaotic Inflation Models (1997)
Kasuya, S., Kawasaki, M., Yanagida, T.
We study the domain wall problem of an axion in chaotic inflation models. We show that the production of domain walls does not occurs if the Peccei-Quinn scalar has a flat potential and its breaking...
Hashiba, J., Kawasaki, M., Yanagida, T.
The dilaton field in string theories (if exists) is expected to have a mass of the order of the gravitino mass $m_{3/2}$ which is in a range of $10^{-2}$keV--1GeV in gauge-mediated supersymmetry...
Dynamical Tuning of the Initial Condition for New Inflation in Supergravity (1997)
We point out that for a class of `new inflation' models in supergravity the required initial value of the inflaton field is dynamically set if there is another inflation (`pre-inflation') before the...
Direct-Transmission Models of Dynamical Supersymmetry Breaking (1997)
Nomura, Y., Tobe, K., Yanagida, T.
We systematically construct gauge-mediated supersymmetry(SUSY)-breaking models with direct transmission of SUSY-breaking effects to the standard-model sector. We obtain a natural model with the...
R-invariant Natural Unification (1997)
We construct R-invariant unification models where a pair of massless Higgs doublets is naturally obtained. The masslessness of the Higgs doublets is guaranteed by the unbroken R symmetry. Mass...
Are Isocurvature Fluctuations of the M-theory Axion Observable? (1997)
Banks and Dine have recently shown that the M theory naturally accommodates the Peccei-Quinn axion. Since the decay constant $F_a$ of the axion is large as $F_a \simeq 10^{15}-10^{16}$GeV, the halo...
A Solution to the $\mu$ Problem in Gauge-mediated Supersymmetry-breaking Models (1997)
We point out that a sector required to set the cosmological constant to zero in gauge-mediated supersymmetry-breaking models naturally produces a supersymmetry-invariant mass ($\mu$ term) for Higgs...
We derive a constraint on the cosmic density of string moduli fields in gauge-mediated supersymmetry-breaking theories by requiring that photons emitted from the unstable moduli fields should not...
Cosmological Axion Problem in Chaotic Inflationary Universe (1996)
Kasuya, S., Kawasaki, M., Yanagida, T.
We investigate two cosmological axion problems (isocurvature fluctuations and domain-wall formation) in chaotic inflationary universe. It is believed that these problems are solved if potential for...
Natural New Inflation in Broken Supergravity (1996)
We consider a natural new inflationary model in broken supergravity based on an R symmetry. The model predicts a concrete relation between the amplitude of primordial density fluctuations and the...
Gravitino Warm Dark Matter Motivated by the CDF $ee\gamma\gamma $ Event (1996)
Kawasaki, M., Sugiyama, N., Yanagida, T.
The $ee\gamma\gamma +\rlap/E_T$ event observed by the CDF at Fermilab is naturally explained by dynamically supersymmetry breaking models and suggests the presence of the light gravitino which can be...
Is the ee gamma gamma+ Missing E(T) Event an Evidence of the Light Axino? (1996)
Hisano, J., Tobe, K., Yanagida, T.
We point out that if the Peccei-Quinn symmetry breaking scale $F_a$ is in a range of the hadronic axion window ($F_a\sim 10^6$GeV), the ee$\gamma\gamma+/\!\!\!\! E_T$ event in the CDF experiment can...
Dynamical Supersymmetry Breaking without Messenger Gauge Interactions (1996)
We investigate low-energy models of supersymmetry (SUSY) breaking by means of vector-like gauge theories for dynamical SUSY breaking. It is not necessary to introduce messenger gauge interactions...
Affleck-Dine Baryogenesis after Thermal Inflation (1996)
Stewart, E. D., Kawasaki, M., Yanagida, T.
We argue that an extension of the Minimal Supersymmetric Standard Model that gives rise to viable thermal inflation, and so does not suffer from a Polonyi/moduli problem, should contain right-handed...
Natural Unification with a Supersymmetric SO(10)$_{GUT} \:\times$ SO(6)$_H$ Gauge Theory (1996)
We propose a unified model of elementary particles based on a supersymmetric SO(10)$_{GUT} \:\times$ SO(6)$_H$ gauge theory. This model completely achieves natural unification of the strong and...
Dynamical Supersymmetry Breaking in Vector-like Gauge Theories (1996)
We provide vector-like gauge theories which break supersymmetry dynamically.
Nonabelian Duality and Higgs Multiplets in Supersymmetric Grand Unified Theories (1996)
We consider strongly interacting supersymmetric gauge theories which break dynamically the GUT symmetry and produce the light Higgs doublets naturally. Two models we proposed in the previous articles...
Kawasaki, M., Sugiyama, Naoshi, Yanagida, T.
In the chaotic inflation models, quantum fluctuations for axion fields lead to the overproduction of domain walls and too large isocurvature fluctuations which is inconsistent with the observations...
Quantum Restoration of the U(1)_Y Symmetry in Dynamically Broken SUSY-GUT's (1995)
We propose a supersymmetric hypercolor SU(3)_H gauge theory interacting strongly at the grand unification scale, in which the hyperquark condensation breaks SU(5)_GUT down to SU(3)_C x SU(2)_L...
Possible explanation of Zbb vertex anomaly in one-family technicolor models (1995)
In technicolor theories a large radiative correction to the Zbb vertex generally emerges, because of the large top quark mass and SU(2)_L gauge symmetry. The correction can give us an explanation for...
Can Decaying Particles Raise the Upperbound on the Peccei-Quinn Scale? (1995)
Kawasaki, M., Moroi, T., Yanagida, T.
We have reexamine the effect of entropy production on the cosmic axion density and find that the Peccei-Quinn scale $F_a$ larger than about $10^{15}$~GeV is not allowed even if large entropy is...
Natural gauge-coupling unification at the string scale (1995)
Bachas, C., Fabre, C., Yanagida, T.
We argue that moduli in the adjoint representation of the standard- model gauge group are a natural feature of superstring models, and that they can account for the apparent discrepancy between the...
An N=2 SUSY Gauge Model for Dynamical Breaking of the Grand Unified SU(5) Symmetry (1995)
We construct an extension of the recently proposed dynamical model for the breaking of SU(5)$_{\rm GUT}$ gauge symmetry, in which a pair of massless chiral supermultiplets for Higgs doublets are...
A viable one-family technicolor model (1995)
We construct a one-family technicolor model which is consistent with the precision experiments on the electroweak interaction. The Majorana mass of the right-handed techni-neutrino is introduced and...
Constraint on the Reheating Temperature from the Decay of the Polonyi Field (1995)
Kawasaki, M., Moroi, T., Yanagida, T.
We study the Polonyi problem in the framework of no-scale type supergravity models. We show that the lightest superparticle (LSP) produced in the decay of the Polonyi field may contribute too much to...
Dynamical Models for Light Higgs Doublets in Supersymmetric Grand Unified Theories (1995)
We consider a supersymmetric hypercolor gauge theory with six flavors of quarks interacting strongly at the grand unification scale. This model solves the most serious problem -- doublet-triplet...
QCD-like Hidden Sector Models without the Polonyi Problem (1995)
QCD-like hidden sector models of supersymmetry breaking are considered which do not suffer from a cosmological problem due to the Polonyi field. Avoidance of a light gluino leads to introduction of...
Hisano, J., Moroi, T., Tobe, K., Yamaguchi, M., Yanagida, T.
We examine the lepton-flavor violation caused by a Yukawa coupling matrix $y_{\nu,ij}$ for right-handed neutrinos in the supersymmetric standard model. We stress that decay rates for...
Limit on the Color-Triplet Higgs Mass in the Minimum Supersymmetric SU(5) Model (1994)
Hisano, J., Moroi, T., Tobe, K., Yanagida, T.
In the minimum supersymmetric SU(5) GUT, we derive the upper limit on the mass of the color-triplet Higgs multiplets as $\mhc\leq 2.4\times 10^{16}~\GEV$ (90 \% C.L.) taking all possible corrections...
On the Solution to the Polonyi Problem with $O$(10~TeV) Gravitino Mass in Supergravity (1994)
Moroi, T., Yamaguchi, M., Yanagida, T.
We study the solution to the Polonyi problem where the Polonyi field weighs as $O(10{\rm TeV})$ and decays just before the primordial nucleosynthesis. It is shown that in spite of a large entropy...
We construct a supersymmetric grand unified model in which a dynamical symmetry breaking of SU(5)$_{GUT}$ generates large masses for color-triplet Higgs multiplets while keeping SU(2)$_L$-doublet...
Suppression of Proton Decay in the Missing-Partner Model for Supersymmetric SU(5) GUT (1994)
Hisano, J., Moroi, T., Tobe, K., Yanagida, T.
We construct a missing-partner model for supersymmetric SU(5) GUT assuming the Peccei-Quinn symmetry, in which the SU(5) gauge coupling constant remains in the perturbative regime below the...
Flat Potential for Inflaton with a Discrete $R$-invariance in Supergravity (1994)
Kumekawa, K., Moroi, T., Yanagida, T.
We show that a very flat potential of inflaton required for a sufficient inflation is naturally obtained in $N=1$ supergravity by imposing a discrete $R$-invariance $Z_{n}$. Several cosmological...
A Solution to the Polonyi Problem in the Minimum SUSY-GUT (1994)
We show that the Polonyi problem is solved in the minimum SUSY-GUT model in which a self-coupling strength for a heavy Higgs $\Sigma$, $\lambda\Sigma^{3}$, is very small $\lambda\sim 10^{-6}$. It is...
Chaotic Inflation and Baryogenesis in Supergravity (1993)
Murayama, Hitoshi, Suzuki, Hiroshi, Yanagida, T., Yokoyama, Jun'ichi
We propose a K\"ahler potential in supergravity which successfully accommodates chaotic inflation. This model can have a large gravitino mass without giving a large mass to squarks and sleptons, and...
Leptogenesis in Supersymmetric Standard Model with Right-handed Neutrino (1993)
Murayama, Hitoshi, Yanagida, T.
We show that the leptogenesis is automatic within the supersymmetric standard model if there exist right-handed neutrinos with mass less than $H_{\it inf}$, the expansion rate during the inflation....
The Weinberg Angle Without Grand Unification (1993)
Moroi, T., Murayama, Hitoshi, Yanagida, T.
We assume that strong and electroweak interactions become strong at very high energies. With this assumption, we compute the low-energy gauge coupling constants $\alpha_i (m_Z)$ as a function of the...
Nucleon Decay in the Minimal Supersymmetric $SU(5)$ Grand Unification (1992)
Hisano, J., Murayama, H., Yanagida, T.
We make a detailed analysis on the nucleon decay in the minimal supersymmetric $SU(5)$ grand unified model. We find that a requirement of the unification of three gauge coupling constants leads to a...
Fermion mass hierarchy and global horizontal symmetries (1990)
Gelmini, Graciela B, Gérard, J M, Yanagida, T, Zoupanos, George
Naturally massless Higgs doublets in supersymmetric SU(5) (1990)
Masiero, A, Nanopoulos, Dimitri V, Tamvakis, Kyriakos, Yanagida, T
Super B production, matter stability and gauge hierarchy in SUSY GUTs (1990)
Masiero, A, Nanopoulos, Dimitri V, Tamvakis, Kyriakos, Yanagida, T
The magnetic moment of the neutrino and its implications for neutrino signal from SN1987A (1988)
Barbieri, R., Mohapatra, R. N., Yanagida, T.
If the magnetic moment of the neutrino is to provide a resolution of the solar neutrino puzzle without violating the constraints implied by SN1987A observations, there must exist non-standard...
Kojima, H, Ishijima, A, Yanagida, T
In order to explain the molecular mechanism of muscle contraction, it is crucial to know the distribution of the sarcomere compliance of active muscle. Here, we directly measure the stiffness of...
Johara, M, Toyoshima, Y Y, Ishijima, A, Kojima, H, Yanagida, T, Sutoh, K
Amino acid residues D24/D25, E99/E100, E360/E361, and D363/E364 in subdomain 1 of Dictyostelium actin were replaced with histidine residues by site-directed mutagenesis. Mutant actins were expressed...
Mechanics of single kinesin molecules measured by optical trapping nanometry.
Kojima, H, Muto, E, Higuchi, H, Yanagida, T
We have analyzed the mechanics of individual kinesin molecules by optical trapping nanometry. A kinesin molecule was adsorbed onto a latex bead, which was captured by an optical trap and brought into...
Coupling of protein surface hydrophobicity change to ATP hydrolysis by myosin motor domain.
Suzuki, M, Shigematsu, J, Fukunishi, Y, Harada, Y, Yanagida, T, Kodama, T
Dielectric spectroscopy with microwaves in the frequency range between 0.2 and 20 GHz was used to study the hydration of myosin subfragment 1 (S1). The data were analyzed by a method recently...
Ishijima, A, Kojima, H, Higuchi, H, Harada, Y, Funatsu, T, Yanagida, T
We have developed a new technique for measurements of piconewton forces and nanometer displacements in the millisecond time range caused by actin-myosin interaction in vitro by manipulating single...
Prochniewicz, E, Katayama, E, Yanagida, T, Thomas, D D
We have chemically modified a fraction of the monomers in actin filaments, and then measured the effects on the functional interaction of myosin with unmodified monomers within the same filament. Two...
Direct inhibition of the actomyosin motility by local anesthetics in vitro.
Tsuda, Y, Mashimo, T, Yoshiya, I, Kaseda, K, Harada, Y, Yanagida, T
Using a recently developed in vitro motility assay, we have demonstrated that local anesthetics directly inhibit myosin-based movement of single actin filaments in a reversible dose-dependent manner....
Compliance of thin filaments in skinned fibers of rabbit skeletal muscle.
Higuchi, H, Yanagida, T, Goldman, Y E
The mechanical compliance (reciprocal of stiffness) of thin filaments was estimated from the relative compliance of single, skinned muscle fibers in rigor at sarcomere lengths between 1.8 and 2.4...
Orientational distribution of spin-labeled actin oriented by flow.
Ostap, E M, Yanagida, T, Thomas, D D
Previous studies on spin-labeled F-actin (MSL-actin), using saturation transfer electron paramagnetic resonance (ST-EPR), have demonstrated that actin has submillisecond rotational flexibility and...
Saito, K, Aoki, T, Aoki, T, Yanagida, T
Movement of single myosin filaments, synthesized by copolymerization of intact myosin and fluorescently labeled light meromyosin, were observed along a single actin filament suspended in solution by...
Tanaka, H, Ishijima, A, Honda, M, Saito, K, Yanagida, T
Displacements of single one-headed myosin molecules in a sparse myosin-rod cofilament were measured from bead displacements at various angles relative to an actin filament by dual optical trapping...
Single-molecule imaging of RNA polymerase-DNA interactions in real time.
Harada, Y, Funatsu, T, Murakami, K, Nonoyama, Y, Ishihama, A, Yanagida, T
Using total internal reflection fluorescence microscopy, we have directly observed individual interactions of single RNA polymerase molecules with a single molecule of lambda-phage DNA suspended in...
Direct inhibition of microtubule-based kinesin motility by local anesthetics.
Miyamoto, Y, Muto, E, Mashimo, T, Iwane, A H, Yoshiya, I, Yanagida, T
Local anesthetics are known to inhibit neuronal fast anterograde axoplasmic transport (FAAT) in a reversible and dose-dependent manner, but the precise mechanism has not been determined. FAAT is...
Spectral fluctuation of a single fluorophore conjugated to a protein molecule.
Wazawa, T, Ishii, Y, Funatsu, T, Yanagida, T
We have measured the fluorescence spectra of a single fluorophore attached to a single protein molecule in aqueous solution using a total internal reflection fluorescence microscope. The most...
Motility of single one-headed kinesin molecules along microtubules.
Inoue, Y, Iwane, A H, Miyai, T, Muto, E, Yanagida, T
The motility of single one-headed kinesin molecules (K351 and K340), which were truncated fragments of Drosophila two-headed kinesin, has been tested using total internal reflection fluorescence...
Kojima, H, Ishijima, A, Yanagida, T
In order to explain the molecular mechanism of muscle contraction, it is crucial to know the distribution of the sarcomere compliance of active muscle. Here, we directly measure the stiffness of...
Johara, M, Toyoshima, Y Y, Ishijima, A, Kojima, H, Yanagida, T, Sutoh, K
Amino acid residues D24/D25, E99/E100, E360/E361, and D363/E364 in subdomain 1 of Dictyostelium actin were replaced with histidine residues by site-directed mutagenesis. Mutant actins were expressed...
Mechanics of single kinesin molecules measured by optical trapping nanometry.
Kojima, H, Muto, E, Higuchi, H, Yanagida, T
We have analyzed the mechanics of individual kinesin molecules by optical trapping nanometry. A kinesin molecule was adsorbed onto a latex bead, which was captured by an optical trap and brought into...
Coupling of protein surface hydrophobicity change to ATP hydrolysis by myosin motor domain.
Suzuki, M, Shigematsu, J, Fukunishi, Y, Harada, Y, Yanagida, T, Kodama, T
Dielectric spectroscopy with microwaves in the frequency range between 0.2 and 20 GHz was used to study the hydration of myosin subfragment 1 (S1). The data were analyzed by a method recently...
Ishijima, A, Kojima, H, Higuchi, H, Harada, Y, Funatsu, T, Yanagida, T
We have developed a new technique for measurements of piconewton forces and nanometer displacements in the millisecond time range caused by actin-myosin interaction in vitro by manipulating single...
Prochniewicz, E, Katayama, E, Yanagida, T, Thomas, D D
We have chemically modified a fraction of the monomers in actin filaments, and then measured the effects on the functional interaction of myosin with unmodified monomers within the same filament. Two...
Direct inhibition of the actomyosin motility by local anesthetics in vitro.
Tsuda, Y, Mashimo, T, Yoshiya, I, Kaseda, K, Harada, Y, Yanagida, T
Using a recently developed in vitro motility assay, we have demonstrated that local anesthetics directly inhibit myosin-based movement of single actin filaments in a reversible dose-dependent manner....
Compliance of thin filaments in skinned fibers of rabbit skeletal muscle.
Higuchi, H, Yanagida, T, Goldman, Y E
The mechanical compliance (reciprocal of stiffness) of thin filaments was estimated from the relative compliance of single, skinned muscle fibers in rigor at sarcomere lengths between 1.8 and 2.4...
Orientational distribution of spin-labeled actin oriented by flow.
Ostap, E M, Yanagida, T, Thomas, D D
Previous studies on spin-labeled F-actin (MSL-actin), using saturation transfer electron paramagnetic resonance (ST-EPR), have demonstrated that actin has submillisecond rotational flexibility and...
Saito, K, Aoki, T, Aoki, T, Yanagida, T
Movement of single myosin filaments, synthesized by copolymerization of intact myosin and fluorescently labeled light meromyosin, were observed along a single actin filament suspended in solution by...
Tanaka, H, Ishijima, A, Honda, M, Saito, K, Yanagida, T
Displacements of single one-headed myosin molecules in a sparse myosin-rod cofilament were measured from bead displacements at various angles relative to an actin filament by dual optical trapping...
Single-molecule imaging of RNA polymerase-DNA interactions in real time.
Harada, Y, Funatsu, T, Murakami, K, Nonoyama, Y, Ishihama, A, Yanagida, T
Using total internal reflection fluorescence microscopy, we have directly observed individual interactions of single RNA polymerase molecules with a single molecule of lambda-phage DNA suspended in...
Direct inhibition of microtubule-based kinesin motility by local anesthetics.
Miyamoto, Y, Muto, E, Mashimo, T, Iwane, A H, Yoshiya, I, Yanagida, T
Local anesthetics are known to inhibit neuronal fast anterograde axoplasmic transport (FAAT) in a reversible and dose-dependent manner, but the precise mechanism has not been determined. FAAT is...
Spectral fluctuation of a single fluorophore conjugated to a protein molecule.
Wazawa, T, Ishii, Y, Funatsu, T, Yanagida, T
We have measured the fluorescence spectra of a single fluorophore attached to a single protein molecule in aqueous solution using a total internal reflection fluorescence microscope. The most...
Motility of single one-headed kinesin molecules along microtubules.
Inoue, Y, Iwane, A H, Miyai, T, Muto, E, Yanagida, T
The motility of single one-headed kinesin molecules (K351 and K340), which were truncated fragments of Drosophila two-headed kinesin, has been tested using total internal reflection fluorescence...
Single-motor mechanics and models of the myosin motor.
Yanagida, T, Esaki, S, Iwane, A H, Inoue, Y, Ishijima, A, Kitamura, K, ...
Recent progress in single-molecule detection techniques is remarkable. These techniques have allowed the accurate determination of myosin-head-induced displacements and how mechanical cycles are...
Inhibition of cyclin A gene expression in human B cells by an immunosuppressant mizoribine
Hirohata, S, Nakanishi, K, Yanagida, T
Mizoribine has been shown to have beneficial effects in the treatment of rheumatoid arthritis and lupus nephritis, in which abnormal B cell functions are involved. Previous studies demonstrated that...