Munemasa, Mitsuru, Yoshino, Tadashi, Kobayashi, Keita, Miyake, Takayoshi, Sakugawa, Sumie Takase, Mannami, Tomohiko, ...
Reportedly, thyroid mucosa-associated lymphoid tissue (MALT) lymphoma is closely associated with Hashimoto's thyroiditis. However, it remains unknown which antigen is closely associated with thyroid...
Three cell lines, spontaneously transformed in vitro, MWE-l and MWE-2 originating from C3Hf/Bi mouse whole embryos and NHLu-l originating from newborn syrian hamster lungs were obtained. These...
Human cell line (HGC-27) derived from the metastatic lymph node of gastric cancer (2007)
Akagi, Tadaatsu, Kimoto, Tetsuo
A cell line (HGC-27) was established by culture of the metastatic lymph node from a gastric cancer patient diagnosed histologically as undifferentiated carcinoma. HGC-27 cells were polygonal or short...
Akagi, Tadaatsu, Sonobe, Hiroshi, Miyoshi, Isao, Yoshimoto, Shizuo
Antiserum was produced in white rabbit by intravenously injecting living cells of a B cell acute lymphoblastic leukemia (ALL) line (BALL-1). The reactivity of the antiserum against various lymphoid...
Teramoto, Norihiro, Tonoyama, Yuji, Akagi, Tadaatsu, Sarker, Ashit Baran, Yoshino, Tadashi, Yamadori, Ichiro, ...
The sensitivity and specificity of single cell polymerase chain reaction (PCR) were studied. Its high sensitivity enabled detection of a single-copy gene, such as human T-lymphotropic virus type I...
Partial Purification and Chraracterization of Dendritic Cell Differentiation Factor (2007)
Miyatani, Katsuya, Takahashi, Kiyoshi, Yanai, Hiroyuki, Yoshino, Tadashi, Akagi, Tadaatsu
Previously, we reported that interleukin-2 (IL-2)-stimulated helper T cells produced an unknown soluble factor which induced dendritic cell-like differentiation in primary cultures of monocytic...
Chen, Hong Li, Hayashi, Kazuhiko, Koirala, Tirtha Raj, Ino, Hideo, Fuimoto, Koji, Yoshikawa, Yasuhiro, ...
Malignant lymphoma was induced in Japanese (JWY), New Zealand (NZY) and Dutch (DUY) white rabbits by oral spray of cell-free pellets of culture fluid (crude virus fraction) of Ts-B6 cells (cynomolgus...
Teramoto, Norihito, Cao, Liu, Kawasaki, Nobuhiro, Tonoyama, Yuji, Sarker, Ashit Baran, Yoshino, Tadashi, ...
Reed-Sternberg cells (RS cells) of Hodgkin's disease (HD) are frequently infected with Epstein-Barr virus (EBV) and express EBV-encoded nonpolyadenylated RNA transcripts (EBER)-1. EBV latency has...
Yanai, Hiroyuki, Yoshino, Tadashi, Takahashi, Kiyoshi, Ninomiya, Yoshifumi, Akagi, Tadaatsu
Circulating hepatitis C virus (HCV) particles can be fractionated by means of differential flotation centrifugation. It is reported that in the bottom fraction HCV is in the form immune complexes,...
Detection of Epstein-Barr virus RNA and related antigens in non-neoplastic lymphoid lesions. (2007)
Tonoyama, Yuji, Teramoto, Norihiro, Sarker, Ashit Baran, Yoshino, Tadashi, Hayashi, Kazuhiko, Takahashi, Kiyoshi, ...
To elucidate the latent state and reactivation of Epstein-Barr virus (EBV) in non-neoplastic lymphoid lesions, we investigated 144 non-neoplastic lymphoid lesions by in situ hybridization (ISH) to...
Fujiwara, Kotaro, Yoshino, Tadashi, Miyake, Kenji, Ohara, Nobuya, Akagi, Tadaatsu
Lymphocyte adhesion molecules defined by anti-CD44 antibody (Hermes-3) may be involved in lymphocyte binding to high endothelial venules at sites where lymphocytes exist the blood. CD44 expression...
Sarker, Ashit Baran, Akagi, Tadaatsu, Yoshino, Tadashi, Fujiwara, Kotaro, Nose, Soichiro
The distribution of lectin receptors in the human tonsil was studied using 16 biotinylated lectins. The avidin-biotin-peroxidase complex (ABC) method was used on frozen and paraffin-embedded tissue...
Kimura's disease: clinical, histological and immunohistochemical studies. (2007)
Motoi, Makoto, Wahid, Syariffudin, Horie, Yasushi, Akagi, Tadaatsu
In the present study, 14 cases of Kimura's disease were clinicopathologically studied. The disease occurred at ages ranging from 5 to 75 years. The average age was 37.8 years. Sexes were about...
Detection of oncogene rearrangements in human non-Hodgkin's lymphomas. (2007)
Kondo, Eisaku, Yoshino, Tadashi, Akagi, Tadaatsu, Hayashi, Kazuhiko, Takahashi, Kiyoshi
Southern blot hybridization was used to detect the rearrangement and amplification of five proto-oncogenes (bcl-2, bcl-1, c-myc, c-myb and c-Ha-ras) and one tumor suppressor gene (RB-1) in 55...
Takata, Hiroshi, Yoshino, Tadashi, Hoshida, Yoshihiko, Takata, Ikuko, Akagi, Tadaatsu
A cell line of human lung large cell carcinoma (LCC) was established directly from the metastatic skin tumor tissue. The clinical course of the patient who carried this carcinoma was peculiar;...
A monoclonal antibody (OPT1) to T cells which is available for paraffin-embedded materials. (2007)
Mukuzono, Hiroshi, Yoshino, Tadashi, Akagi, Tadaatsu
A monoclonal antibody (MAb), OPT1, reactive with T cells in formalin-fixed, paraffin-embedded tissue sections, has been identified through immunization with activated T cells from peripheral blood...
Hirasawa, Ryoto, Hashimoto, Hozo, Makino, Shinya, Suemaru, Shuso, Takao, Toshihiro, Ota, Zensuke, ...
A 46-year-old woman with acromegaly and hyperthyroidism due to a pituitary adenoma. She had high serum thyroid-stimulating hormone (TSH) levels and very high serum growth hormone (GH) levels....
Pre-elastofibroma-like colonic polyp: another cause of colonic polyp. (2007)
Hayashi, Kazuhiko, Ohtsuki, Yuji, Sonobe, Hiroshi, Iwata, Jun, Furihata, Matsuo, Hikita, Tomonori, ...
We present a case of pre-elastofibroma-like lesion, a kind of elastic-producing fibrous tumor. The small colonic polyp, which was found in a 49-year-old asymptomatic man in association with a large...
Yoshino, Tadashi, Hoshida, Yoshihiko, Murakami, Ichiro, Takahashi, Kiyoshi, Akagi, Tadaatsu
We have attempted to clarify the characteristics of monoclonal antibodies (MAbs) detecting lymphocyte subsets in fixed materials. We examined by means of flow cytometric technique influences of...
Akagi, Tadaatsu, Nose, Soichiro, Takahashi, Kiyoshi, Yoshino, Tadashi, Horie, Yasushi, Motoi, Makoto, ...
In the human lymphoreticular system, the alpha and beta subunits of S-100 protein are found in ordinary monocyte-macrophages and non-phagocytic histiocytes such as Langerhans cells and...
Immortalization of rat spleen and thymus T cells by human T-cell leukemia virus type I. (2007)
Akagi, Tadaatsu, Takata, Hiroshi, Yoshino, Tadashi, Teramoto, Norihiro, Yano, Shoki, Oka, Takashi
Co-cultivation of thymus and spleen cells of Fisher and Lewis rats with lethally irradiated MT-2 cells harboring human T-cell leukemia virus type I (HTLV-I) resulted in the establishment of lymphoid...
Metaplastic bone formation in a hyperplastic polyp of the stomach: a case report. (2007)
Ohtsuki, Yuji, Danbara, Yoshifumi, Takeda, Isao, Takahashi, Kiyoshi, Hayashi, Kazuhiko, Sonobe, Hiroshi, ...
Metaplastic bony tissue along with hyperplastic mucosal epithelium showing no atypism was detected in biopsy materials from a Yamada type I gastric polyp. The tissue was metaplastic woven bone...
Akagi, Tadaatsu, Ohtsuki, Yuji, Shiraishi, Yukimasa, Miyoshi, Isao
Co-cultivation of human thymus and spleen lymphocytes, which were obtained from 26-week and 27-week fetuses, with a lethally-irradiated human cord T-cell line harboring human T-cell leukemia virus...
Ohtsuki, Yuji, Akagi, Tadaatsu, Takeda, Isao, Miyoshi, Isao
To search for lymphocyte marker antigens on the surface of human T-cell leukemia virus (HTLV), an immunoelectron microscopic study was performed on a HTLV-producing human T-cell line, MT-2, using...
Antibody and Cytokine Responses in Helicobacter pylori-Infected Various Mouse Strains (2007)
Dey, Ashoka, Yokota, Kenji, Kobayashi, Keita, Oguma, Keiji, Hirai, Yoshikazu, Akagi, Tadaatsu
Helicobacter pylori (H. pylori) infection in the stomach is etiologically closely associated with chronic active gastritis, peptic ulcer, gastric cancer and gastric mucosa-associated lymphoid tissue...
Expression and intracellular localization of FKHRL1 in mammary gland neoplasms. (2006)
Jin, Gui-Shan, Kondo, Eisaku, Miyake, Takayoshi, Shibata, Masao, Takashima, Takako, Liu, Yi-Xuan, ...
FKHRL1 (FOXO3a), a member of the Forkhead family of genes, has been considered to be involved in the development of breast tumors; however, the in vivo expression and activation status of FKHRL1 in...
Recent advances in DNA microarrays. (2006)
Nakanishi, Tohru, Oka, Takashi, Akagi, Tadaatsu
The structure of the human genome is almost completely elucidated and the life sciences will now aim for a general and integrated study of gene expressions and the functional elucidation of proteins....
Characterization of epstein-barr virus-infected mantle cell lymphoma lines. (2006)
Jin, Zaishun, Teramoto, Norihiro, Yoshino, Tadashi, Takada, Kenzo, Oka, Takashi, Hayashi, Kazuhiko, ...
It has been reported that Epstein-Barr virus (EBV) resides in resting B cells in vivo. However, an ideal in vitro system for studying EBV latent infection in vivo has not yet been established. In...
Kuroda, Masahiro, Inamura, Keiji, Tahara, Seiji, Kurabayashi, Yuzuru, Akagi, Tadaatsu, Asaumi, Junichi, ...
We developed a reliable system for the irradiation of xenografted tumors in mice which allows for accurate local irradiation under specific pathogen-free conditions. The system presented here...
Takahashi, Kiyoshi, Asagoe, Kenji, Zaishun, Jin, Yanai, Hiroyuki, Yoshino, Tadashi, Hayashi, Kazuhiko, ...
A two-color immunofluorescent analysis indicated that dendritic cells (DCs) in the human axillar lymph nodes (ie, lymph nodal DCs (LnDCs)) can be classified into three subsets. The first subset...
Oka, Takashi, Yoshino, Tadashi, Hayashi, Kazuhiko, Ohara, Nobuya, Nakanishi, Tohru, Yamaai, Yuichiro, ...
To investigate the lymphomagenesis of NK/T lymphoma, we comprehensively and systematically analyzed the expression pattern of the human NK/T cell line (NK-YS) genome by cDNA expression array and...
Hayashi, Kazuhiko, Jin, Zaishun, Onoda, Sachiyo, Joko, Hiromasa, Teramoto, Norihiro, Ohara, Nobuya, ...
Epstein-Barr virus-associated hemophagocytic syndrome (EBV-AHS) is often associated with fatal infectious mononucleosis or T-cell lymphoproliferative diseases (LPD). To elucidate the true nature of...
Hayashi, Kazuhiko, Ohara, Nobuya, Teramoto, Norihiro, Onoda, Sachiyo, Chen, Hong-Li, Oka, Takashi, ...
Epstein-Barr virus-associated hemophagocytic syndrome (EBV-AHS) is often associated with fatal infectious mononucleosis. However, the animal model for EBV-AHS has not been developed. We reported the...