Suppressor of cytokine signaling-1 ameliorates dextran sulfate sodium-induced colitis in mice (2008)
Horino, Jiro, Fujimoto, Minoru, Terabe, Fumitaka, Serada, Satoshi, Takahashi, Tsuyoshi, Soma, Yoshihito, ...
Inflammatory bowel disease (IBD) is a chronic disorder of the gastrointestinal tract. Although the etiology and pathogenesis of IBD remain unknown, pro-inflammatory cytokines including IFN-γ play an...
Finotto, Susetta, Eigenbrod, Tatjana, Karwot, Roman, Boross, Ildiko, Doganci, Aysefa, Ito, Hiroaki, ...
We previously reported high levels of the soluble form of the IL-6R (sIL-6R) in the airways of asthmatic subjects. Here, we analyzed the IL-6R effects on Th2 cell survival in the lung by locally...
Interleukin-6: discovery of a pleiotropic cytokine (2006)
Abstract In the late 1960s, the essential role played by T cells in antibody production was reported. This led to our hypothesis that certain molecules would have to be released from T cells to...
Straub, Rainer H., Härle, Peter, Yamana, Seizo, Matsuda, Takemasa, Takasugi, Kiyoshi, Kishimoto, Tadamitsu, ...
OBJECTIVE: Proinflammatory cytokines such as tumor necrosis factor (TNF) were demonstrated to inhibit adrenal steroidogenesis in patients with rheumatoid arthritis (RA), and this was particularly...
Woo, Patricia, Wilkinson, Nicholas, Prieur, Anne-Marie, Southwood, Taunton, Leone, Valentina, Livermore, Polly, ...
Abstract Eighteen Caucasian (white, Middle East and Asian) children diagnosed by paediatric rheumatologists in the UK and France as having systemic juvenile idiopathic arthritis (sJIA) were enrolled...
Oshima, Yuichi, Fujio, Yasushi, Nakanishi, Tsuyoshi, Itoh, Norio, Yamamoto, Yasuhiro, Negoro, Shinji, ...
Objective: Activation of signal transducer and activator of transcription 3 (STAT3) was reported to be correlated with myocardial protection against ischemia/reperfusion (I/R) injury in ischemic...
Komazaki, Toshiaki, Nagai, Hisaki, Emi, Mitsuru, Terada, Yoshie, Yabe, Aya, Jin, Enjing, ...
Background: SOCS-1, a JAK-binding protein (SSI-1/SOCS-1/JAB), regulates the JAK/STAT signal transduction pathway that relays signals from various cytokines in the extracellular matrix into the cell....
SOCS-1 suppresses TNF-{alpha}-induced apoptosis through the regulation of Jak activation (2004)
Kimura, Akihiro, Naka, Tetsuji, Nagata, Shigekazu, Kawase, Ichiro, Kishimoto, Tadamitsu
Suppressor of cytokine signaling‐1 (SOCS‐1) was identified as one of the negative feedback regulators of Janus kinase...
Fujimoto, Minoru, Tsutsui, Hiroko, Xinshou, Ouyang, Tokumoto, Masanori, Watanabe, Dai, Shima, Yoshihito, ...
Suppressor of cytokine signaling (SOCS)‐1 is a cytokine‐inducible, negative regulatory molecule of Janus kinases (JAK) and its deficiency causes hyper‐response to various cytokines....
The paradigm of IL-6: from basic science to medicine (2002)
Naka, Tetsuji, Nishimoto, Norihiro, Kishimoto, Tadamitsu
Chapter summary IL-6 is a pleiotropic cytokine with a wide range of biological activities in immune regulation, hematopoiesis, inflammation, and oncogenesis. Its activities are shared by IL-6-related...
Joint disease caused by defective gp130-mediated STAT signaling (2002)
Naka, Tetsuji, Kishimoto, Tadamitsu
Abstract IL-6 is a multifunctional cytokine produced by lymphoid and nonlymphoid cells; it regulates immune responses, acute-phase reactions, and inflammation. IL-6 signaling is mediated exclusively...
A regulatory role for suppressor of cytokine signaling-1 in Th polarization in vivo (2002)
Fujimoto, Minoru, Tsutsui, Hiroko, Yumikura-Futatsugi, Shizue, Ueda, Haruyasu, Xingshou, Ouyang, Abe, Tatsuo, ...
Suppressor of cytokine signaling (SOCS)‐1 is an inhibitory molecule for JAK, and its deficiency in mice leads to lymphocyte‐dependent multi‐organ disease and perinatal death. Crossing...
Negoro, Shinji, Kunisada, Keita, Tone, Eiroh, Funamoto, Masanobu, Oh, Hidemasa, Kishimoto, Tadamitsu, ...
Objectives: We reported that the activation of gp130 transduced hypertrophic and cytoprotective signals via Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway in cardiac...
Matsui, Hideo, Ihara, Yoshiji, Fujio, Yasushi, Kunisada, Keita, Akira, Sizuo, Kishimoto, Tadamitsu, ...
Objectives: We have previously reported that interleukin (IL)-6 is induced by hypoxic stimulation in cardiac myocytes. In the present study, we examined the induction of potent transcription factors...
Murakami-Morl, Kaoru, Taga, Tetsuya, Kishimoto, Tadamitsu, Nakamura, Shuji, Takatsu, K
Kaposi's sarcoma (KS) is most frequently associated with HIV-intected individuals (AIDS-KS). While AIDS-KS-derived spindle cells (AIDS-KS cells) contribute to the development of KS lesions, growth...
The genomic structure and chromosomal localization of the mouse STAT3 gene (1996)
Shi, Wei, Inoue, Masahiro, Minami, Masashi, Takeda, Kiyoshi, Matsumoto, Makoto, Matsuda, Yoichi, ...
A variety of cytokines Induce the tyrosine phosphorylation of signal transducers and activators of transcription (STATs). Activation of the same STAT proteins by distinct cytokines and activation of...
Oka, Yoshiro, Rolink, Antonius G., Andersson, Jan, Kamanaka, Masahito, Uchida, Junji, Yasui, Teruhito, ...
It has been known for some time that single mutant nude or CD40T mice have apparently normal numbers of cells in the precursor compartments of bone marrow and the mature B cell compartments of the...
Kobayashi, Ichiro, Matsuda, Tadashi, Saito, Takashi, Yasukawa, Kiyoshi, Kikutani, Hitoshi, Hirano, Toshio, ...
A mAb against murlne IL-6 receptor (IL-6R), KMH7, was obtained by immunization of hamster with recombinant soluble murlne IL-6R. Flow cytometry analysis of IL-6R distribution on lymphocytes in...
Expression of the CD2 molecule on human B lymphoid progenitors (1992)
Muraguchi, Atsushi, Kawamura, Nobuaki, Hori, Akira, Horii, Yasuhiro, Ichigi, Yasuhisa, Kimoto, Masao, ...
CD2 expression on human B lymphoid progenitor cells was examined. By Immunofluorescence analysis, a small fraction of bone marrow B cells was found to express CD2 on their surface. CD2 expression was...
Age-associated increase in interleukin 6 in MRL/lpr mice (1991)
Tang, Bo, Matsuda, Tadashl, Akira, Shizuo, Nagata, Norikazu, Ikehara, Susumu, Hirano, Toshio, ...
It has been demonstrated that abnormal expression of Interleukin 6 (IL-6) may be Involved In the pathogenesls of a variety of autoimmune diseases and glomerulonephrltls. In this study, we demonstrate...
Naoko Nakano, Hitoshi Kikutani, Tadamitsu Kishimoto
Three distinct T-cell precursors: bone marrow cells that express low levels of the Thy-1 antigen but no lineage markers (Thy-1-lo/BM); CD4-, CD8-, and CD3- thymocytes that express low levels of the...
Purification and Characterization of Soluble Human IL-6 Receptor Expressed in CHO Cells (1990)
Yasukawa, Kiyoshi, Saito, Takashi, Fukunaga, Takeshi, Sekimori, Yasuo, Koishihara, Yasuo, Fukui, Hiroyasu, ...
An immunosorbent assay system to detect genetically engineered IL-6 receptor (IL-6R) was established, whereby soluble IL-6 receptor (sEL-6R) was detected in the culture medium when sIL-6R cDNA was...
Uehira, Masahiro, Uno, Masashi, Kürner, Thomas, Kikutani, Hitoshi, Mori, Koh-ichi, Inomoto, Takeaki, ...
Two lines of Eαd-expressing NOD mice were established by continuously backcrosslng [Eαd B6 transgenic mice × NOD] F1 to parental NOD or directly microinjecting the Eαd gene into fertilized NOD...
Tonouchi, Naoto, Oouchi, Naoki, Kashima, Nobukazu, Kawai, Misako, Nagase, Kazuo, Okano, Akira, ...
BSF-2 (B cell stimulatory factor-2/IL-6) is a member of the lymphokine family and responsible for B celldifferentiation. Expression plasmids of human BSF-2 cDNA were constructed using a trp...
Introduction of Human {gamma}1 Immunoglobulin Genes into Fertilized Mouse Eggs (1984)
YAMAMURA, Ken-ichi, KIKUTANI, Hitoshi, TAKAHASHI, Naoki, TAGA, Tetsuya, AKIRA, Shizuo, KAWAI, Kazuhiko, ...
A rearranged human γ1 immunoglobulin gene was introduced into fertilized mouse eggs. The phage Ch4A-VCE-γ1 was constructed by ligating an EcoRI and BglII fragment of pBR322-CESSV(CE-l) containing...
The D-JH complex is an intermediate to the complete immunoglobulin beavy-chain V-region gene (1983)
Yaoita, Yoshio, Matsunami, Norisada, Yong Choi, Cha, Sugiyama, Haruo, Kishimoto, Tadamitsu, Honjo, Tasuku
We have examined the organization of the immunoglobulin JH segments in three clones derived from a single Abelson murine leukemia virus-transformed cell. Cloning and nucleotide sequence analyses of...
Kumanogoh, Atsushi, Marukawa, Satoko, Kumanogoh, Takayuki, Hirota, Hisao, Yoshida, Kenji, Lee, Ihn-Sook, ...
gp130 is a common signal-transducing receptor component for the interleukin 6 family of cytokines functioning in, for example, immune, hematopoietic, and nervous systems. In this study, to...
Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality
Takeda, Kiyoshi, Noguchi, Koichi, Shi, Wei, Tanaka, Takashi, Matsumoto, Makoto, Yoshida, Nobuaki, ...
Signal transducer and activator of transcription (STAT) proteins have been shown to mediate biological actions in response to cytokines. Stat3, a member of the STAT family, is activated by a variety...
Interleukin 6 plays a key role in the development of antigen-induced arthritis
Ohshima, Shiro, Saeki, Yukihiko, Mima, Toru, Sasai, Mitsuko, Nishioka, Katsuhiro, Nomura, Shintaro, ...
To investigate the direct role of interleukin (IL) 6 in the development of rheumatoid arthritis, IL-6-deficient (IL-6 −/−) mice were backcrossed for eight generations into C57BL/6 mice, a strain...
Ma, Qing, Jones, Dan, Borghesani, Paul R., Segal, Rosalind A., Nagasawa, Takashi, Kishimoto, Tadamitsu, ...
The chemokine stromal cell-derived factor 1, SDF-1, is an important regulator of leukocyte and hematopoietic precursor migration and pre-B cell proliferation. The receptor for SDF-1, CXCR4, also...
A cell-autonomous requirement for CXCR4 in long-term lymphoid and myeloid reconstitution
Kawabata, Kenji, Ujikawa, Miho, Egawa, Takeshi, Kawamoto, Hiroshi, Tachibana, Kazunobu, Iizasa, Hisashi, ...
Mice lacking the chemokine stromal cell-derived factor/pre-B cell growth stimulating factor or its primary physiological receptor CXCR4 revealed defects in B lymphopoiesis and bone marrow...
Narazaki, Masashi, Fujimoto, Minoru, Matsumoto, Tomoshige, Morita, Yoshiaki, Saito, Hiroshi, Kajita, Tadahiro, ...
Cytokine-inducible protein SSI-1 [signal transducers and activators of transcription (STAT)-induced STAT inhibitor 1, also referred to as SOCS-1 (suppressor of cytokine signaling 1) or JAB (Janus...
Morita, Yoshiaki, Naka, Tetsuji, Kawazoe, Yoshinori, Fujimoto, Minoru, Narazaki, Masashi, Nakagawa, Reiko, ...
Signal transducers and activators of transcription (STAT)-induced STAT inhibitor-1 [SSI-1; also known as suppressor of cytokine signaling-1 (SOCS-1)] was identified as a negative feedback regulator...
Nagasawa, Takashi, Nakajima, Toshihiro, Tachibana, Kazunobu, Iizasa, Hisashi, Bleul, Conrad C., Yoshie, Osamu, ...
Pre-B-cell growth-stimulating factor/stromal cell-derived factor 1 (PBSF/SDF-1) is a member of the CXC group of chemokines that is initially identified as a bone marrow stromal cell-derived factor...
Kunisada, Keita, Negoro, Shinji, Tone, Eiroh, Funamoto, Masanobu, Osugi, Tomoaki, Yamada, Shuichi, ...
The signal transducer and activator of transcription (STAT) 3, a transcriptional factor downstream of several cytokines, is activated by Janus kinase families and plays a pivotal role in cardiac...
Bruton’s tyrosine kinase activity is negatively regulated by Sab, the Btk-SH3 domain-binding protein
Yamadori, Tomoki, Baba, Yoshihiro, Matsushita, Masato, Hashimoto, Shoji, Kurosaki, Mari, Kurosaki, Tomohiro, ...
Bruton’s tyrosine kinase (Btk) is a cytoplasmic tyrosine kinase that is crucial for human and murine B cell development, and its deficiency causes human X-linked agammaglobulinemia and murine...
Naka, Tetsuji, Matsumoto, Tomoshige, Narazaki, Masashi, Fujimoto, Minoru, Morita, Yoshiaki, Ohsawa, Yoshiyuki, ...
Growth, differentiation, and programmed cell death (apoptosis) are mainly controlled by cytokines. The Janus kinase–signal transducers and activators of transcription (JAK-STAT) signal pathway is...
BLNK mediates Syk-dependent Btk activation
Baba, Yoshihiro, Hashimoto, Shoji, Matsushita, Masato, Watanabe, Dai, Kishimoto, Tadamitsu, Kurosaki, Tomohiro, ...
Btk is a critical molecule in B cell antigen receptor (BCR)-coupled signaling, and its activity is regulated by Lyn and Syk. Although the molecular mechanism of Lyn-dependent Btk activation has been...
Nakashima, Kinichi, Takizawa, Takumi, Ochiai, Wataru, Yanagisawa, Makoto, Hisatsune, Tatsuhiro, Nakafuku, Masato, ...
We show that when telencephalic neural progenitors are briefly exposed to bone morphogenetic protein 2 (BMP2) in culture, their developmental fate is changed from neuronal cells to astrocytic cells....
IL-6 transgenic mouse model for extraosseous plasmacytoma
Kovalchuk, Alexander L., Kim, Joong Su, Park, Sung Sup, Coleman, Allen E., Ward, Jerrold M., Morse, Herbert C., ...
Plasma cell neoplasms in humans comprise plasma cell myeloma, otherwise known as multiple myeloma, Ig deposition and heavy chain diseases, and plasmacytoma (PCT). A subset of PCT, designated...
Joint disease caused by defective gp130-mediated STAT signaling
Naka, Tetsuji, Kishimoto, Tadamitsu
IL-6 is a multifunctional cytokine produced by lymphoid and nonlymphoid cells; it regulates immune responses, acute-phase reactions, and inflammation. IL-6 signaling is mediated exclusively by the...
Seki, Yoh-ichi, Hayashi, Katsuhiko, Matsumoto, Akira, Seki, Noriyasu, Tsukada, Jun, Ransom, John, ...
The development of helper T (Th) cell subsets, which secrete distinct cytokines, plays an important role in determining the type of immune response. The IL-4-mediated Janus kinase–signal transducer...
Ara, Toshiaki, Nakamura, Yuri, Egawa, Takeshi, Sugiyama, Tatsuki, Abe, Kuniya, Kishimoto, Tadamitsu, ...
Primordial germ cells (PGCs) are the founders of sperm or oocytes. PGCs migrate through the tissues of the embryos and colonize the gonads during development. However, the cytokines essential for...
Doganci, Aysefa, Eigenbrod, Tatjana, Krug, Norbert, De Sanctis, George T., Hausding, Michael, Erpenbeck, Veit J., ...
The cytokine IL-6 acts via a specific receptor complex that consists of the membrane-bound IL-6 receptor (mIL-6R) or the soluble IL-6 receptor (sIL-6R) and glycoprotein 130 (gp130). In this study, we...
Doganci, Aysefa, Eigenbrod, Tatjana, Krug, Norbert, De Sanctis, George T., Hausding, Michael, Erpenbeck, Veit J., ...
Woo, Patricia, Wilkinson, Nicholas, Prieur, Anne-Marie, Southwood, Taunton, Leone, Valentina, Livermore, Polly, ...
Eighteen Caucasian (white, Middle East and Asian) children diagnosed by paediatric rheumatologists in the UK and France as having systemic juvenile idiopathic arthritis (sJIA) were enrolled in this...
Kimura, Akihiro, Naka, Tetsuji, Muta, Tatsushi, Takeuchi, Osamu, Akira, Shizuo, Kawase, Ichiro, ...
Suppressor of cytokine signaling-1 (SOCS-1) is one of the negative-feedback regulators of Janus kinase (JAK)–signal transducer and activator of transcription (STAT) signaling. We previously showed...
Kumanogoh, Atsushi, Marukawa, Satoko, Kumanogoh, Takayuki, Hirota, Hisao, Yoshida, Kenji, Lee, Ihn-Sook, ...
gp130 is a common signal-transducing receptor component for the interleukin 6 family of cytokines functioning in, for example, immune, hematopoietic, and nervous systems. In this study, to...
Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality
Takeda, Kiyoshi, Noguchi, Koichi, Shi, Wei, Tanaka, Takashi, Matsumoto, Makoto, Yoshida, Nobuaki, ...
Signal transducer and activator of transcription (STAT) proteins have been shown to mediate biological actions in response to cytokines. Stat3, a member of the STAT family, is activated by a variety...
Interleukin 6 plays a key role in the development of antigen-induced arthritis
Ohshima, Shiro, Saeki, Yukihiko, Mima, Toru, Sasai, Mitsuko, Nishioka, Katsuhiro, Nomura, Shintaro, ...
To investigate the direct role of interleukin (IL) 6 in the development of rheumatoid arthritis, IL-6-deficient (IL-6 −/−) mice were backcrossed for eight generations into C57BL/6 mice, a strain...
Ma, Qing, Jones, Dan, Borghesani, Paul R., Segal, Rosalind A., Nagasawa, Takashi, Kishimoto, Tadamitsu, ...
The chemokine stromal cell-derived factor 1, SDF-1, is an important regulator of leukocyte and hematopoietic precursor migration and pre-B cell proliferation. The receptor for SDF-1, CXCR4, also...
A cell-autonomous requirement for CXCR4 in long-term lymphoid and myeloid reconstitution
Kawabata, Kenji, Ujikawa, Miho, Egawa, Takeshi, Kawamoto, Hiroshi, Tachibana, Kazunobu, Iizasa, Hisashi, ...
Mice lacking the chemokine stromal cell-derived factor/pre-B cell growth stimulating factor or its primary physiological receptor CXCR4 revealed defects in B lymphopoiesis and bone marrow...
Narazaki, Masashi, Fujimoto, Minoru, Matsumoto, Tomoshige, Morita, Yoshiaki, Saito, Hiroshi, Kajita, Tadahiro, ...
Cytokine-inducible protein SSI-1 [signal transducers and activators of transcription (STAT)-induced STAT inhibitor 1, also referred to as SOCS-1 (suppressor of cytokine signaling 1) or JAB (Janus...
Morita, Yoshiaki, Naka, Tetsuji, Kawazoe, Yoshinori, Fujimoto, Minoru, Narazaki, Masashi, Nakagawa, Reiko, ...
Signal transducers and activators of transcription (STAT)-induced STAT inhibitor-1 [SSI-1; also known as suppressor of cytokine signaling-1 (SOCS-1)] was identified as a negative feedback regulator...
Nagasawa, Takashi, Nakajima, Toshihiro, Tachibana, Kazunobu, Iizasa, Hisashi, Bleul, Conrad C., Yoshie, Osamu, ...
Pre-B-cell growth-stimulating factor/stromal cell-derived factor 1 (PBSF/SDF-1) is a member of the CXC group of chemokines that is initially identified as a bone marrow stromal cell-derived factor...
Kunisada, Keita, Negoro, Shinji, Tone, Eiroh, Funamoto, Masanobu, Osugi, Tomoaki, Yamada, Shuichi, ...
The signal transducer and activator of transcription (STAT) 3, a transcriptional factor downstream of several cytokines, is activated by Janus kinase families and plays a pivotal role in cardiac...
Bruton’s tyrosine kinase activity is negatively regulated by Sab, the Btk-SH3 domain-binding protein
Yamadori, Tomoki, Baba, Yoshihiro, Matsushita, Masato, Hashimoto, Shoji, Kurosaki, Mari, Kurosaki, Tomohiro, ...
Bruton’s tyrosine kinase (Btk) is a cytoplasmic tyrosine kinase that is crucial for human and murine B cell development, and its deficiency causes human X-linked agammaglobulinemia and murine...
Naka, Tetsuji, Matsumoto, Tomoshige, Narazaki, Masashi, Fujimoto, Minoru, Morita, Yoshiaki, Ohsawa, Yoshiyuki, ...
Growth, differentiation, and programmed cell death (apoptosis) are mainly controlled by cytokines. The Janus kinase–signal transducers and activators of transcription (JAK-STAT) signal pathway is...
BLNK mediates Syk-dependent Btk activation
Baba, Yoshihiro, Hashimoto, Shoji, Matsushita, Masato, Watanabe, Dai, Kishimoto, Tadamitsu, Kurosaki, Tomohiro, ...
Btk is a critical molecule in B cell antigen receptor (BCR)-coupled signaling, and its activity is regulated by Lyn and Syk. Although the molecular mechanism of Lyn-dependent Btk activation has been...
Nakashima, Kinichi, Takizawa, Takumi, Ochiai, Wataru, Yanagisawa, Makoto, Hisatsune, Tatsuhiro, Nakafuku, Masato, ...
We show that when telencephalic neural progenitors are briefly exposed to bone morphogenetic protein 2 (BMP2) in culture, their developmental fate is changed from neuronal cells to astrocytic cells....
IL-6 transgenic mouse model for extraosseous plasmacytoma
Kovalchuk, Alexander L., Kim, Joong Su, Park, Sung Sup, Coleman, Allen E., Ward, Jerrold M., Morse, Herbert C., ...
Plasma cell neoplasms in humans comprise plasma cell myeloma, otherwise known as multiple myeloma, Ig deposition and heavy chain diseases, and plasmacytoma (PCT). A subset of PCT, designated...
Joint disease caused by defective gp130-mediated STAT signaling
Naka, Tetsuji, Kishimoto, Tadamitsu
IL-6 is a multifunctional cytokine produced by lymphoid and nonlymphoid cells; it regulates immune responses, acute-phase reactions, and inflammation. IL-6 signaling is mediated exclusively by the...
Seki, Yoh-ichi, Hayashi, Katsuhiko, Matsumoto, Akira, Seki, Noriyasu, Tsukada, Jun, Ransom, John, ...
The development of helper T (Th) cell subsets, which secrete distinct cytokines, plays an important role in determining the type of immune response. The IL-4-mediated Janus kinase–signal transducer...
Ara, Toshiaki, Nakamura, Yuri, Egawa, Takeshi, Sugiyama, Tatsuki, Abe, Kuniya, Kishimoto, Tadamitsu, ...
Primordial germ cells (PGCs) are the founders of sperm or oocytes. PGCs migrate through the tissues of the embryos and colonize the gonads during development. However, the cytokines essential for...
Doganci, Aysefa, Eigenbrod, Tatjana, Krug, Norbert, De Sanctis, George T., Hausding, Michael, Erpenbeck, Veit J., ...
The cytokine IL-6 acts via a specific receptor complex that consists of the membrane-bound IL-6 receptor (mIL-6R) or the soluble IL-6 receptor (sIL-6R) and glycoprotein 130 (gp130). In this study, we...
Doganci, Aysefa, Eigenbrod, Tatjana, Krug, Norbert, De Sanctis, George T., Hausding, Michael, Erpenbeck, Veit J., ...
Kimura, Akihiro, Naka, Tetsuji, Muta, Tatsushi, Takeuchi, Osamu, Akira, Shizuo, Kawase, Ichiro, ...
Suppressor of cytokine signaling-1 (SOCS-1) is one of the negative-feedback regulators of Janus kinase (JAK)–signal transducer and activator of transcription (STAT) signaling. We previously showed...
Woo, Patricia, Wilkinson, Nicholas, Prieur, Anne-Marie, Southwood, Taunton, Leone, Valentina, Livermore, Polly, ...
Eighteen Caucasian (white, Middle East and Asian) children diagnosed by paediatric rheumatologists in the UK and France as having systemic juvenile idiopathic arthritis (sJIA) were enrolled in this...
Kimura, Akihiro, Naka, Tetsuji, Kishimoto, Tadamitsu
CD4+ T cells producing IL-17 [T helper (Th)17], as distinct from Th1 or Th2 cells, have recently been shown to be associated with autoimmunity, but it is not entirely clear how Th17 cells are...
Nakano, Naoko, Kikutani, Hitoshi, Kishimoto, Tadamitsu
Three distinct T-cell precursors: bone marrow cells that express low levels of the Thy-1 antigen but no lineage markers (Thy-1-lo/BM); CD4-, CD8-, and CD3- thymocytes that express low levels of the...
Kawazoe, Yoshinori, Naka, Tetsuji, Fujimoto, Minoru, Kohzaki, Hidetsugu, Morita, Yoshiaki, Narazaki, Masashi, ...
Signal transducer and activator of transcription (STAT)-induced STAT inhibitor 1 (SSI-1) is known to function as a negative feedback regulator of cytokine signaling, but it is unclear whether it is...
CXCR4/fusin Is Not a Species-specific Barrier in Murine Cells for HIV-1 Entry
Tachibana, Kazunobu, Nakajima, Toshihiro, Sato, Akihiko, Igarashi, Kenji, Shida, Hisatoshi, Iizasa, Hisashi, ...
Since some murine cells expressing human CD4 fail to internalize HIV-1, another block was thought to be located at the level of viral entry in addition to CD4. Recently, CXCR4 was shown to function...
A Small Molecule CXCR4 Inhibitor that Blocks T Cell Line–tropic HIV-1 Infection
Murakami, Tsutomu, Nakajima, Toshihiro, Koyanagi, Yoshio, Tachibana, Kazunobu, Fujii, Nobutaka, Tamamura, Hirokazu, ...
Several members of the chemokine receptor family have been shown to function in association with CD4 to permit human immunodeficiency virus type 1 (HIV-1) entry and infection. The CXC chemokine...
Betz, Ulrich A.K., Bloch, Wilhelm, Van Den Broek, Maries, Yoshida, Kanji, Taga, Tetsuya, Kishimoto, Tadamitsu, ...
The pleiotrophic but overlapping functions of the cytokine family that includes interleukin (IL)-6, IL-11, leukemia inhibitory factor, oncostatin M, ciliary neurotrophic factor, and cardiotrophin 1...
Serada, Satoshi, Fujimoto, Minoru, Mihara, Masahiko, Koike, Nobuo, Ohsugi, Yoshiyuki, Nomura, Shintaro, ...
The development of Th17 cells is a key event in the pathogenesis of experimental autoimmune encephalomyelitis (EAE), a murine model of human multiple sclerosis (MS). Previous studies have...
Kimura, Akihiro, Naka, Tetsuji, Nohara, Keiko, Fujii-Kuriyama, Yoshiaki, Kishimoto, Tadamitsu
IL-17-producing T helper cells (Th17) have been recently identified as a previously undescribed subset of helper T cells. Here, we demonstrate that aryl hydrocarbon receptor (Ahr) has an important...
Nishimoto, Norihiro, Miyasaka, Nobuyuki, Yamamoto, Kazuhiko, Kawai, Shinichi, Takeuchi, Tsutomu, Azuma, Junichi, ...
We investigated the clinical efficacy and safety of tocilizumab (a humanized anti-IL-6 receptor antibody) monotherapy in active rheumatoid arthritis (RA) patients with an inadequate response to low...