Lace, Michael J., Anson, James R., Klingelhutz, Aloysius J., Harada, Hisashi, Taniguchi, Tadatsugu, Bossler, Aaron D., ...
Interferons (IFNs) have been used to treat mucosal lesions caused by human papillomavirus (HPV) infection, such as intraepithelial precursor lesions to cancer of the uterine cervix, genital warts or...
Regulation of the type I IFN induction: a current view (2005)
Honda, Kenya, Yanai, Hideyuki, Takaoka, Akinori, Taniguchi, Tadatsugu
The type I IFN-α/β gene family was identified about a quarter of a century ago as a prototype of many cytokine gene families, which led to the subsequent burst of studies on molecular mechanisms...
Regulation of the type I IFN induction: a current view (2005)
Honda, Kenya, Yanai, Hideyuki, Takaoka, Akinori, Taniguchi, Tadatsugu
The type I IFN-α/β gene family was identified about a quarter of a century ago as a prototype of many cytokine gene families, which led to the subsequent burst of studies on molecular mechanisms...
Kim, Sunhwa, Koga, Takako, Isobe, Miho, Kern, Britt E., Yokochi, Taeko, Chin, Y. Eugene, ...
Bone remodeling is central to maintaining the integrity of the skeletal system, wherein the developed bone is constantly renewed by the balanced action of osteoblastic bone formation and osteoclastic...
Integral role of Noxa in p53-mediated apoptotic response (2003)
Shibue, Tsukasa, Takeda, Kiyoshi, Oda, Eri, Tanaka, Hiroshi, Murasawa, Hideki, Takaoka, Akinori, ...
The tumor suppressor p53 exerts its versatile function to maintain the genomic integrity of a cell, and the life of cancerous cells with DNA damage is often terminated by induction of apoptosis. We...
Integral role of Noxa in p53-mediated apoptotic response (2003)
Shibue, Tsukasa, Takeda, Kiyoshi, Oda, Eri, Tanaka, Hiroshi, Murasawa, Hideki, Takaoka, Akinori, ...
The tumor suppressor p53 exerts its versatile function to maintain the genomic integrity of a cell, and the life of cancerous cells with DNA damage is often terminated by induction of apoptosis. We...
Signaling crosstalk between RANKL and interferons in osteoclast differentiation (2002)
Takayanagi, Hiroshi, Kim, Sunhwa, Taniguchi, Tadatsugu
Chapter summary Regulation of osteoclast differentiation is an aspect central to the understanding of the pathogenesis and the treatment of bone diseases such as autoimmune arthritis and...
Cell cycle regulation of histone H4 gene transcription requires the oncogenic factor IRF-2 (1998)
Vaughan, Patricia S., Aziz, Farah, Harada, Hisashi, Taniguchi, Tadatsugu, Van Wijnen, Andre J., ...
Histone genes display a peak in transcription in early S phase and are ideal models for cell cycle-regulated gene expression. We have previously shown that the transcription factor interferon...
Pyk2 is a downstream mediator of the IL-2 receptor-coupled Jak signaling pathway (1998)
Miyazaki, Tadaaki, Takaoka, Akinori, Nogueira, Leonor, Dikic, Ivan, Fujii, Hodaka, Tsujino, Shiho, ...
Activation of a cell-cycle-regulated histone gene by the oncogenic transcription factor IRF-2 (1995)
Vaughan, Patricia S., Aziz, Farah, Van Wijnen, Andre J., Wu, Shujian, Harada, Hisashi, Taniguchi, Tadatsugu, ...
The human histone H4 gene FO108 is regulated during the cell cycle with a peak in transcription during early S phase. The cell-cycle element (CCE) required for H4 histone activation is a sequence of...
Matsuyama, Toshifumi, Grossman, Alex, Mittrücker, Hans-Willi, Siderovski, David P., Kiefer, Friedemann, Kawakami, Takatoshi, ...
Interferon regulatory factor (IRF) genes encode a family of DNA-blndlng proteins that are involved in the transcriptional regulation of type-l Interferon and/or interferon-inducible genes. We report...
Characterization of the DNA binding domain of the mouse IRF-2 protein (1993)
Uegaki, Koichi, Shirakawa, Masahiro, Fujita, Takashi, Taniguchi, Tadatsugu, Kyogoku, Yoshimasa
The DNA binding domain of the interferon regulatory factor-2 protein (IRF-2) has been produced and characterized, α-chymotrypsin digestion of the purified IRF-2 protein bound to a synthetic binding...
Tanaka, Toshiyuki, Tsudo, Mitsuru, Karasuyama, Hajime, Toyama, Noriko, Hatakeyama, Masanori, Taniguchi, Tadatsugu, ...
Non-covalent association between at least two polypeptides, α (p55) and β (p70), yields a high-affinity interieukln 2 receptor (IL-2R). Recent findings suggest that the β-chain can mediate IL-2...
Watanabe, Nobumasa, Sakakibara, Jun, Hovanessian, Ara G., Taniguchi, Tadatsugu, Fujita, Takashi
Expression of the Type I IFN (i.e., IFN-αs and IFN-β) genes is efficiently induced by viruses at the transcriptional level. This induction is mediated by at least two types of positive regulatory...
Mori, Hisashi, Barsoumlan, Edward L., Hatakeyama, Masanori, Taniguchi, Tadatsugu
The functional Interleukin 2 receptor (IL-2R) consists of at least two IL-2 binding cell surface molecules, IL-2Rα and IL-2Rβ, the latter component being responsible for the Intracellular growth...
Shibuya, Hiroshi, Yoneyama, Mitsutoshi, Nakamura, Yusuke, Harada, Hisashi, Hatakeyama, Masanori, Minamoto, Seijiro, ...
The chromosomal gene for the human interleukin-2 receptor β-chain (IL-2Rβ) was isolated and characterized. The entire IL-2Rβ3 gene is composed of ten exons spanning about 24.3 kilobases, in which...
Shibuya, Hiroshi, Taniguchi, Tadatsugu
Regulated expression of interleukin-2 (IL-2) gene constitutes an essential part in the clonal proliferation of activated T lymphocytes (T-cells). In order to gain insight on the mechanism(s) of the...
Sequence of a cDNA coding for human IRF-2 (1989)
Itoh, Susumu, Harada, Hisashi, Fujita, Takashi, Mimura, Tsutomu, Taniguchi, Tadatsugu
Yamaguchi, Akira, Ide, Takashi, Hatakeyama, Masanori, Doi, Takeshi, Kono, Takeshi, Uchiyama, Takashi, ...
The structural basis of the high affinity interleukin-2 receptor which was previously reconstituted in a cultured murine T cell line, EL4 by expressing either wild-type Tac antigen complementary DNA...
New Approaches for the High-Level Expression of Human Interleukin-2 cDNA in Escherichia coli (1987)
SATO, Takaaki, MATSUI, Hiroshi, SHIBAHARA, Susumu, KOBAYASHI, Tsuyoshi, MORINAGA, Yasushi, KASHIMA, Nobukazu, ...
We constructed several expression plasmids of human IL-2 gene, some of which directed high-level synthesis of mature IL-2 protein in E. coil. In all the plasmids reported here, we installed the E....
Cloning and Expression of a Novel Variant of Human Interferon-{gamma} cDNA (1985)
NISHI, Tatsunari, FUJITA, Takashi, NISHI-TAKAOKA, Chikako, SAITO, Akiko, MATSUMOTO, Tadashi, SATO, Moriyuki, ...
A cDNA library was prepared from the poly(A) mRNA isolated from human peripheral blood lymphocytes which were induced by combined treatment with phytohemagglutinin and a phorbol ester. Recombinant...
Organization and structure of the mouse interleukin-2 gene (1984)
Fuse, Akira, Fujita, Takashi, Yasumitsu, Hidetaro, Kashima, Nobukazu, Hasegawa, Katsushige, Taniguchi, Tadatsugu
We have cloned a chromosomal DNA segment which covers the entire sequence for the murine interleukin-2 gene and analysed the structure of the gene. The coding regions are separated into four blocks...
Ohno, Shigeo, Taniguchi, Tadatsugu
The structural gene for Herpes simplex virus (HSV) thymidine kinase (Tk) was fused downstream of the 5'-flanking sequence (from −284 to +20;numbering relative to the putative transcription...
Ohno, Shigeo, Taniguchi, Tadatsugu
A hybrid plasmid was constructed from pSV2-Ecogpt (Mulligan and Berg, 1981) and the cloned 1.8 kilobase chromosomal DNA segment which contains the human interferon (HIFN- β1 ) gene and its flanking...
FUJII-KURIYAMA, Yoshiaki, TANIGUCHI, Tadatsugu, MIZUKAMI, Yuzuru, SAKAI, Masaharu, TASHIRO, Yutaka, MURAMATSU, Masami
Cytochrome P-450 mRNA has been partially purified from membrane-bound poly-somes of the livers of phenobarbital-treated rats by SDS-phenol-chloroform extraction, followed by poly(U)-Sepharose...
An official site of the Department of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo. The department conducts research on cytokine genes, mainly the genes...
Chen, Min, Cheng, Alan, Chen, Yi-Qing, Hymel, Anka, Hanson, Eric P., Kimmel, Lida, ...
JAK3 is a protein tyrosine kinase that specifically associates with the common γ chain (γc), a shared subunit of receptors for interleukin (IL) 2, 4, 7, 9, and 15. Patients deficient in either JAK3...
Tsujino, Shiho, Di Santo, James P., Takaoka, Akinori, McKernan, Teresa L., Noguchi, Shigeru, Taya, Choji, ...
The common cytokine receptor γ chain (γc), a shared component of the receptors for IL-2, IL-4, IL-7, IL-9, and IL-15, is critical for the development and function of lymphocytes. The cytoplasmic...
A Critical Role for Cyclin C in Promotion of the Hematopoietic Cell Cycle by Cooperation with c-Myc
Liu, Zhao-Jun, Ueda, Takahiro, Miyazaki, Tadaaki, Tanaka, Nobuyuki, Mine, Shinichiro, Tanaka, Yoshiya, ...
Cyclin C, a putative G1 cyclin, was originally isolated through its ability to complement a Saccharomyces cerevisiae strain lacking the G1 cyclin gene CLN1-3. Unlike cyclins D1 and E, the other two...
Kim, Sunhwa, Koga, Takako, Isobe, Miho, Kern, Britt E., Yokochi, Taeko, Chin, Y. Eugene, ...
Bone remodeling is central to maintaining the integrity of the skeletal system, wherein the developed bone is constantly renewed by the balanced action of osteoblastic bone formation and osteoclastic...
Integral role of Noxa in p53-mediated apoptotic response
Shibue, Tsukasa, Takeda, Kiyoshi, Oda, Eri, Tanaka, Hiroshi, Murasawa, Hideki, Takaoka, Akinori, ...
The tumor suppressor p53 exerts its versatile function to maintain the genomic integrity of a cell, and the life of cancerous cells with DNA damage is often terminated by induction of apoptosis. We...
Honda, Kenya, Sakaguchi, Shinya, Nakajima, Chigusa, Watanabe, Ai, Yanai, Hideyuki, Matsumoto, Misako, ...
A complex mechanism may be operational for dendritic cell (DC) maturation, wherein Toll-like receptor and other signaling pathways may be coordinated differently depending on the nature of the...
Pyk2 is a downstream mediator of the IL-2 receptor-coupled Jak signaling pathway
Miyazaki, Tadaaki, Takaoka, Akinori, Nogueira, Leonor, Dikic, Ivan, Fujii, Hodaka, Tsujino, Shiho, ...
Many cytokines transmit signals to the cell interior through activation of receptor-associated, Janus family protein tyrosine kinases (Jak PTKs). The interleukin-2 receptor (IL-2R) is associated with...
Nozawa, Hiroaki, Oda, Eri, Nakao, Kazuki, Ishihara, Masahiko, Ueda, Seiji, Yokochi, Taeko, ...
The transcription factor IRF-1 has been implicated in tumor suppression: IRF-1 suppresses cell transformation and mediates apoptosis in vitro. Here we show that the loss of IRF-1 alleles per se has...
Structure of a chromosomal gene for human interferon β
Ohno, Shigeo, Taniguchi, Tadatsugu
We have cloned and analyzed a chromosomal DNA segment containing the human interferon β1 gene from a human gene library. The nucleotide sequence of the protein-coding and the noncoding regions of...
Honda, Kenya, Mizutani, Tatsuaki, Taniguchi, Tadatsugu
The development and cooperation of distinct subsets of antigen-presenting cells, particularly dendritic cells (DCs), may be critical for maintaining homeostatic immune responses. Recently, much...
Honda, Kenya, Yanai, Hideyuki, Mizutani, Tatsuaki, Negishi, Hideo, Shimada, Naoya, Suzuki, Nobutaka, ...
Toll-like receptor (TLR) activation is central to immunity, wherein the activation of the TLR9 subfamily members TLR9 and TLR7 results in the robust induction of type I IFNs (IFN-α/β) by means of...
Negative regulation of Toll-like-receptor signaling by IRF-4
Negishi, Hideo, Ohba, Yusuke, Yanai, Hideyuki, Takaoka, Akinori, Honma, Kiri, Yui, Katsuyuki, ...
The recognition of microbial components by Toll-like receptors (TLRs) is an event central to the activation of innate and adaptive immune systems. TLR activation triggers the induction of downstream...
Chen, Min, Cheng, Alan, Chen, Yi-Qing, Hymel, Anka, Hanson, Eric P., Kimmel, Lida, ...
JAK3 is a protein tyrosine kinase that specifically associates with the common γ chain (γc), a shared subunit of receptors for interleukin (IL) 2, 4, 7, 9, and 15. Patients deficient in either JAK3...
Tsujino, Shiho, Di Santo, James P., Takaoka, Akinori, McKernan, Teresa L., Noguchi, Shigeru, Taya, Choji, ...
The common cytokine receptor γ chain (γc), a shared component of the receptors for IL-2, IL-4, IL-7, IL-9, and IL-15, is critical for the development and function of lymphocytes. The cytoplasmic...
A Critical Role for Cyclin C in Promotion of the Hematopoietic Cell Cycle by Cooperation with c-Myc
Liu, Zhao-Jun, Ueda, Takahiro, Miyazaki, Tadaaki, Tanaka, Nobuyuki, Mine, Shinichiro, Tanaka, Yoshiya, ...
Cyclin C, a putative G1 cyclin, was originally isolated through its ability to complement a Saccharomyces cerevisiae strain lacking the G1 cyclin gene CLN1-3. Unlike cyclins D1 and E, the other two...
Kim, Sunhwa, Koga, Takako, Isobe, Miho, Kern, Britt E., Yokochi, Taeko, Chin, Y. Eugene, ...
Bone remodeling is central to maintaining the integrity of the skeletal system, wherein the developed bone is constantly renewed by the balanced action of osteoblastic bone formation and osteoclastic...
Integral role of Noxa in p53-mediated apoptotic response
Shibue, Tsukasa, Takeda, Kiyoshi, Oda, Eri, Tanaka, Hiroshi, Murasawa, Hideki, Takaoka, Akinori, ...
The tumor suppressor p53 exerts its versatile function to maintain the genomic integrity of a cell, and the life of cancerous cells with DNA damage is often terminated by induction of apoptosis. We...
Honda, Kenya, Sakaguchi, Shinya, Nakajima, Chigusa, Watanabe, Ai, Yanai, Hideyuki, Matsumoto, Misako, ...
A complex mechanism may be operational for dendritic cell (DC) maturation, wherein Toll-like receptor and other signaling pathways may be coordinated differently depending on the nature of the...
Pyk2 is a downstream mediator of the IL-2 receptor-coupled Jak signaling pathway
Miyazaki, Tadaaki, Takaoka, Akinori, Nogueira, Leonor, Dikic, Ivan, Fujii, Hodaka, Tsujino, Shiho, ...
Many cytokines transmit signals to the cell interior through activation of receptor-associated, Janus family protein tyrosine kinases (Jak PTKs). The interleukin-2 receptor (IL-2R) is associated with...
Nozawa, Hiroaki, Oda, Eri, Nakao, Kazuki, Ishihara, Masahiko, Ueda, Seiji, Yokochi, Taeko, ...
The transcription factor IRF-1 has been implicated in tumor suppression: IRF-1 suppresses cell transformation and mediates apoptosis in vitro. Here we show that the loss of IRF-1 alleles per se has...
Structure of a chromosomal gene for human interferon β
Ohno, Shigeo, Taniguchi, Tadatsugu
We have cloned and analyzed a chromosomal DNA segment containing the human interferon β1 gene from a human gene library. The nucleotide sequence of the protein-coding and the noncoding regions of...
Honda, Kenya, Mizutani, Tatsuaki, Taniguchi, Tadatsugu
The development and cooperation of distinct subsets of antigen-presenting cells, particularly dendritic cells (DCs), may be critical for maintaining homeostatic immune responses. Recently, much...
Honda, Kenya, Yanai, Hideyuki, Mizutani, Tatsuaki, Negishi, Hideo, Shimada, Naoya, Suzuki, Nobutaka, ...
Toll-like receptor (TLR) activation is central to immunity, wherein the activation of the TLR9 subfamily members TLR9 and TLR7 results in the robust induction of type I IFNs (IFN-α/β) by means of...
Negative regulation of Toll-like-receptor signaling by IRF-4
Negishi, Hideo, Ohba, Yusuke, Yanai, Hideyuki, Takaoka, Akinori, Honma, Kiri, Yui, Katsuyuki, ...
The recognition of microbial components by Toll-like receptors (TLRs) is an event central to the activation of innate and adaptive immune systems. TLR activation triggers the induction of downstream...
An official site of the Department of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo. The department conducts research on cytokine genes, mainly the genes...
Negishi, Hideo, Fujita, Yasuyuki, Yanai, Hideyuki, Sakaguchi, Shinya, Ouyang, Xinshou, Shinohara, Masahiro, ...
The recognition of microbial components by Toll-like receptors (TLRs) initiates signal transduction pathways, which trigger the expression of a series of target genes. It has been reported that TLR...
Role of IFN regulatory factor 5 transcription factor in antiviral immunity and tumor suppression
Yanai, Hideyuki, Chen, Hui-min, Inuzuka, Takayuki, Kondo, Seiji, Mak, Tak W., Takaoka, Akinori, ...
Host defense consists of two main aspects, namely, immune response to invading pathogens and suppression of tumor development. A family of transcription factors, IFN regulatory factors (IRFs), has...
Differential contribution of Puma and Noxa in dual regulation of p53-mediated apoptotic pathways
Shibue, Tsukasa, Suzuki, Saori, Okamoto, Hideaki, Yoshida, Hiroki, Ohba, Yusuke, Takaoka, Akinori, ...
The activation of tumor suppressor p53 induces apoptosis or cell cycle arrest depending on the state and type of cell, but it is not fully understood how these different responses are regulated....
Type I Interferon Production Enhances Susceptibility to Listeria monocytogenes Infection
O'Connell, Ryan M., Saha, Supriya K., Vaidya, Sagar A., Bruhn, Kevin W., Miranda, Gustavo A., Zarnegar, Brian, ...
Numerous bacterial products such as lipopolysaccharide potently induce type I interferons (IFNs); however, the contribution of this innate response to host defense against bacterial infection remains...
Okabe, Yasutaka, Kawane, Kohki, Akira, Shizuo, Taniguchi, Tadatsugu, Nagata, Shigekazu
Deoxyribonuclease (DNase) II in macrophages cleaves the DNA of engulfed apoptotic cells and of nuclei expelled from erythroid precursor cells. DNase II–deficient mouse embryos accumulate undigested...
A cell-type-specific requirement for IFN regulatory factor 5 (IRF5) in Fas-induced apoptosis
Couzinet, Arnaud, Tamura, Kaoru, Chen, Hui-min, Nishimura, Keishiro, Wang, ZhiChao, Morishita, Yasuyuki, ...
Apoptosis is a highly regulated process of cell suicide that occurs during development, host defense, and pathophysiology. The transcription factor IFN regulatory factor 5 (IRF5), known to be...
Regulation of innate immune responses by DAI (DLM-1/ZBP1) and other DNA-sensing molecules
Wang, ZhiChao, Choi, Myoung Kwon, Ban, Tatsuma, Yanai, Hideyuki, Negishi, Hideo, Lu, Yan, ...
DNA, whether it is microbe-derived or host-derived, evokes immune responses when exposed to the cytosol of a cell. We previously reported that DNA-dependent activator of IFN regulatory factors (DAI),...
Characterization of the Interferon-Producing Cell in Mice Infected with Listeria monocytogenes
Stockinger, Silvia, Kastner, Renate, Kernbauer, Elisabeth, Pilz, Andreas, Westermayer, Sandra, Reutterer, Benjamin, ...
Production of type I interferons (IFN-I, mainly IFNα and IFNβ) is a hallmark of innate immune responses to all classes of pathogens. When viral infection spreads to lymphoid organs, the majority of...
Negishi, Hideo, Osawa, Tomoko, Ogami, Kentaro, Ouyang, Xinshou, Sakaguchi, Shinya, Koshiba, Ryuji, ...
A conundrum of innate antiviral immunity is how nucleic acid-sensing Toll-like receptors (TLRs) and RIG-I/MDA5 receptors cooperate during virus infection. The conventional wisdom has been that the...