Taizo Matsuki

Selective loss of GABAB receptors in orexin/hypocretin-producing neurons results in disrupted sleep/wakefulness architecture (2007)

Takeshi Sakurai, Taizo Matsuki, Hitomi Takahira, Noriko Hirashima, Thomas Kilduff, Satoshi Kunita, ...

We generated mice with a selective loss of GABAB receptors in orexin neurons. Orexin neurons in these GABAB1^-/-(orexin) mice showed reduced responsiveness to...

Abnormal T cell activation caused by the imbalance of the IL-1/IL-1R antagonist system is responsible for the development of experimental autoimmune encephalomyelitis (2006)

Matsuki, Taizo, Nakae, Susumu, Sudo, Katsuko, Horai, Reiko, Iwakura, Yoichiro

IL-1 is a pro-inflammatory cytokine that plays an important role in inflammation and host responses to infection. We have previously shown that imbalances in the IL-1 and IL-1R antagonist (IL-1Ra)...

Abnormal T cell activation caused by the imbalance of the IL-1/IL-1R antagonist system is responsible for the development of experimental autoimmune encephalomyelitis (2006)

Matsuki, Taizo, Nakae, Susumu, Sudo, Katsuko, Horai, Reiko, Iwakura, Yoichiro

IL-1 is a pro-inflammatory cytokine that plays an important role in inflammation and host responses to infection. We have previously shown that imbalances in the IL-1 and IL-1R antagonist (IL-1Ra)...

TNF-α is crucial for the development of autoimmune arthritis in IL-1 receptor antagonist–deficient mice

Horai, Reiko, Nakajima, Akiko, Habiro, Katsuyoshi, Kotani, Motoko, Nakae, Susumu, Matsuki, Taizo, ...

IL-1 receptor antagonist–deficient (IL-1Ra–/–) mice spontaneously develop autoimmune arthritis. We demonstrate here that T cells are required for the induction of arthritis; T cell–deficient...

TNF-α is crucial for the development of autoimmune arthritis in IL-1 receptor antagonist–deficient mice

Horai, Reiko, Nakajima, Akiko, Habiro, Katsuyoshi, Kotani, Motoko, Nakae, Susumu, Matsuki, Taizo, ...

IL-1 receptor antagonist–deficient (IL-1Ra–/–) mice spontaneously develop autoimmune arthritis. We demonstrate here that T cells are required for the induction of arthritis; T cell–deficient...

IL-1 Plays an Important Role in Lipid Metabolism by Regulating Insulin Levels under Physiological Conditions

Matsuki, Taizo, Horai, Reiko, Sudo, Katsuko, Iwakura, Yoichiro

IL-1 is a proinflammatory cytokine that plays important roles in inflammation. However, the role of this cytokine under physiological conditions is not known completely. In this paper, we analyzed...

Selective loss of GABAB receptors in orexin-producing neurons results in disrupted sleep/wakefulness architecture

Matsuki, Taizo, Nomiyama, Mika, Takahira, Hitomi, Hirashima, Noriko, Kunita, Satoshi, Takahashi, Satoru, ...

Hypothalamic neurons that contain the neuropeptide orexin (hypocretin) play important roles in the regulation of sleep/wake. Here we analyze the in vivo and in vitro phenotype of mice lacking the...