Takaaki Ito

Early development of human hematopoietic and acquired immune systems in new born NOD/Scid/Jak3null mice intrahepatic engrafted with cord blood-derived CD34+ cells (2008)

Okada, Seiji, Harada, Hideki, Ito, Takaaki, Saito, Takashi, Suzu, Shinya, オカダ, セイジ, ...

An animal model in which the human immune system can be reconstituted is necessary to study acquired immunity in vivo. We report here a novel model, the NOD/SCID/JAK3null mouse, for the human immune...

Quantitative analysis of survivin mRNA expression in bladder transitional cell carcinomas (2008)

Kitsukawa, Shin-ichi, Aoyagi, Teiichiro, Noda, Kenjiro, Ito, Takaaki, Yamamoto, Yutaka, Hosoda, Satoru, ...

膀胱移行上皮癌患者におけるサバイビンmRNA発現の診断・予後因子としての有用性を検討した。リアルタイムPCR法を用い膀胱移行上皮癌患者21例の膀...

Preneoplastic changes of xenotransplanted human distal airway epithelium induced by systemic administration of 4-nitroquinoline-1-oxide to host nude mice (1991)

Kitamura, Hitoshi, Inayama, Yoshiaki, Shibagaki, Tokuhiko, Hayashi, Yasufumi, Tsubakihara, Motofumi, Ito, Takaaki, ...

To elucidate a possible role of hematogeneously transported carcinogens in pathogenesis of peripheral lung carcinoma in humans, we investigated whether the bronchiolar and alveolar epithelial cells...

Lectin Binding to the Luminal Surface of Distal Airway Epithelial Cells of Rodents (1985)

ITo, Takaaki, NAGAHARA, Noriyuki, OGAWA, Takehiko, INAYAMA, Yoshiaki, KANISAWA, Masayoshi

Lectin binding sites on the luminal surface of alveoli and bronchioles of inbred A/J and Bath/C mice and F344/N rats were studied electron microscopically using 7 ferritln-conjugated...

An Electron Microscopic Observation of Rat Peritoneal Cells Processed by Rapid Freezing and Freeze-Substitution Fixation (1982)

ITO, Takaaki, ICHIKAWA, Atsushi

The ultrastructure of rat peritoneal free cells processed by rapid freezing followed by freeze-substitution fixation was compared with that of routinely prepared materials. The present cryofixation...

Mammalian Rcd1 is a novel transcriptional cofactor that mediates retinoic acid-induced cell differentiation

Hiroi, Noriko, Ito, Takaaki, Yamamoto, Hanako, Ochiya, Takahiro, Jinno, Shigeki, Okayama, Hiroto

Rcd1, initially identified as a factor essential for the commitment to nitrogen starvation-invoked differentiation in fission yeast, is one of the most conserved proteins found across eukaryotes, and...

Mammalian Rcd1 is a novel transcriptional cofactor that mediates retinoic acid-induced cell differentiation

Hiroi, Noriko, Ito, Takaaki, Yamamoto, Hanako, Ochiya, Takahiro, Jinno, Shigeki, Okayama, Hiroto

Rcd1, initially identified as a factor essential for the commitment to nitrogen starvation-invoked differentiation in fission yeast, is one of the most conserved proteins found across eukaryotes, and...

K-ras Gene Mutation Enhances Motility of Immortalized Airway Cells and Lung Adenocarcinoma Cells via Akt Activation: Possible Contribution to Non-Invasive Expansion of Lung Adenocarcinoma

Okudela, Koji, Hayashi, Hiroyuki, Ito, Takaaki, Yazawa, Takuya, Suzuki, Takehisa, Nakane, Yuko, ...

Point mutations of the K-ras gene, which are found in 10 to 30% of lung adenocarcinomas, are regarded as being an early event during the carcinogenesis. Autonomous vigorous motility of neoplastic...

The Role of p53 in Bleomycin-Induced DNA Damage in the Lung : A Comparative Study with the Small Intestine

Okudela, Koji, Ito, Takaaki, Mitsui, Hideaki, Hayashi, Hiroyuki, Udaka, Naoko, Kanisawa, Masayoshi, ...

To elucidate the role of p53 and apoptosis in the pathogenesis of lung injury, we examined histological changes, expressions of p53 and p21waf1/cip1 (p21), apoptosis, DNA double strand breaks, cell...

Complicated Mechanisms of Class II Transactivator Transcription Deficiency in Small Cell Lung Cancer and Neuroblastoma

Yazawa, Takuya, Ito, Takaaki, Kamma, Hiroshi, Suzuki, Takehisa, Okudela, Koji, Hayashi, Hiroyuki, ...

Small cell lung cancer (SCLC) and neuroblastoma (NB), the most aggressive adult and infant neuroendocrine cancers, respectively, are immunologically characterized by a severe reduction in major...