Kuramoto, Taiju, Fukuda, Katsutoshi, Ohshima, Akira, Kihira, Kenji, Hoshita, Takahiko
This paper describes the determination of the glucurono-conjugated position in two bile alcohol glucuronides excreted in urine of a patient with cerebrotendinous xanthomatosis by a nuclear magnetic...
Une, Mizuho, Izumi, Noboru, Hoshita, Takahiko
We have investigated the stereochemistry of the side chain of the intermediates, 3α, 7α,12α-trihydroxy-5β-cholest-24-enoic acid and 3α,7α,12α,24-tetrahydroxy-5β-cholestanoic acid, in the...
Une, Mizuho, Izumi, Noboru, Imanaka, Tsuneo, Hoshita, Takahiko
Whether 3α,7α,12α-trihydroxy-5β-cholestanoic acid (THCA) was converted into cholic acid in human skin fibroblasts was examined. THCA was incubated with subcellular fractions of cultured skin...
Metabolism of Sodium 3{alpha},7{alpha}lydroxy-5{beta}9-Cholane-24-Sulfonate in Hamsters (1991)
Kihira, Kenji, Okamoto, Akira, Ikawa, Seiichiro, Mikami, Takahiro, Yoshii, Michiko, Mosbach, Erwin H., ...
Metabolism of sodium 3α,7α-dihydroxy-5β-cholane-24-sulfonate, the sulfonate derivative of chenodeoxycholic acid, was studied in hamsters. In bile fistula hamsters, the sulfonate analogue was...
Une, Mizuho, Kisaka, Nobuko, Yoshii, Michiko, Hoshita, Takahiko
In order to confirm the occurrence of 3α, 6α, 7α, 12α-tetrahydroxy-5β-cholestanoic acid in Zellweger's syndrome, the nature of tetrahydroxycholestanoic acids present in a patient with this...
UNE, Mizuho, TAZAWA, Yusaku, TADA, Keiya, HOSHITA, Takahiko
Urine from a patient with Zellweger's syndrome was examined for bile acids after fractionation into three groups according to mode of conjugation. 3αa,7α,12α-Trihydroxy-5β-cholestanoic acid was...
Identification of New C27 and C24 Bile Acids in the Bile of Alligator mississippiensis (1987)
KIHIRA, Kenji, OKAMOTO, Akira, HOSHITA, Takahiko
Biliary bile acids of Alligator mississippiensis were analyzed by gas-liquid chromatography-mass spectrometry after fractionation by silica gel column chromatography. It was shown that the alligator...
SHIMAZU, Kazuhiro, KUWABARA, Miho, YOSHII, Michiko, KIHIRA, Kenji, TAKEUCHI, Haruo, NAKANO, Ikuta, ...
Bile alcohols in bile, urine, and feces of a patient with cerebrotendinous xanthomatosis have been analyzed by a combination of capillary gas-liquid chromatography and mass spectrometry after...
UNE, Mizuho, MORIGAMI, Izumi, KIHIRA, Kenji, HOSHITA, Takahiko
Studies of the stereochemistry of the intermediates, 3α,7α,12α-trihydroxy-5β-cholest-24-en-26-oic acid and 3α,7α, 12α, 24-tetrahydroxy-5β-cholestan-26-oic acid, in the biosynthetic sequence...
Intestinal Absorption of Bile Alcohols (1981)
HOSHITA, Takahiko, HARADA, Nobue, MORITA, Itsuko, KIHTRA, Kenji
The absorption of bile alcohols by rat small intestine was studied using in vivo and in vitro preparations. In bile duct cannulated rats, intraduodenal administered bile alcohols were certainly...
KURAMOTO, Taiju, ITAKURA, Seiko, HOSHITA, Takahiko
1. When mevalonate-2-14C was injected intraperitoneally into toad, radioactive cholic acid* and 5β-bufol were isolated from the gall-bladder bile, while the main bile acids of this Anura, 3α, 7α,...
The formation of 5α-cyprinol from 7α, 12α-dihydroxycholest-4-en-3-one was investigated in vitro with a carp liver preparation. 1. The results indicate that a major pathway in this conversion is:...
Stero-bile Acids and Bile Alcohols: XGVII. Metabolism of Epicoprostanol in the Japanese Eel (1967)
HOSHITA, TAKAHIKO, HIROFUJI, SHIGEO, ENOMOTO, SHOICHI
Epicoprostanol-4-14C was synthesized chemically and administered intraperitoneally to Japanese eels. About 20% and 10%, respectively, of the administered radioactivity were recovered in the gall...
Stero-bile Acids and Bile Alcohols XGIV. Synthesis of Allochenodeoxycholic Acid (1967)
HOSHITA, TAKAHIKO, AMIMOTO, KAZUO, NAKAGAWA, TOSHIHIKO, KAZUNO, TARO
1. The new bile acid, allochenodeoxycholic acid was synthesized from the anhydro-5α-cyprinol. 2. Thin layer and gas chromatographic analyses using the synthetic allochenodeoxycholic acid as the...
HOSHITA, TAKAHIKO, OKUDA, KUICHIRO, KAZUNO, TARO
1. 3α, 7α, 12α-Trihydroxy-5β-cholestane-24-carboxylic acid was synthesized. 2. It was verified synthetically that trihydroxybufosterocholenic acid isolated from toad bile is 3α, 7α,...
The fate of tritium during the conversion of 4β-3H-4-14C-cholesterol to 5α-bile alcohols in the carp was investigated. The labeled 5α-cyprinol and 27-deoxy-5α-cyprinol isolated from the gall...
The in vivo conversion of cholestanol and 7α-hydroxycholesterol to bile salts was studied in the carp. 1. When cholestanol-5, 6-3H was injected intraperitoneally into carp, radioactive 5α-cyprinol,...
HOSHITA, TAKAHIKO, HIROFUJI, SHIGEO, NAKAGAWA, TOSHIHIKO, KAZUNO, TARO
1. A new bile alcohol, 5α-cholestane-3α, 7α, 12α, 25, 26-pentol (5α- bufol) was synthesized from 5α-cholestane-3α, 7α, 12α, 26-tetrol. 2. It was verified by column, paper, thin layer and gas...
HOSHITA, TAKAHIKO, HIROFUJI, SHIGEO, SASAKI, TAKESHI, KAZUNO, TARO
i new bile acid, haemulcholic acid was isolated from the bile of Parapristipoma trilineatum. The acid was revealed to have the chemical constitution of 3α, 7α, 22β-trihydroxy-5β-cholanic acid.
Stero-bile Acids and Bile Alcohols: LXXV. Studies on Bile of Rana nigromaculata (1965)
KAZUNO, TARO, BETSUKI, SETSUO, TANAKA, YASUO, HOSHITA, TAKAHIKO
Stero-Bile Acids and Bile Sterols: LXIII. Studies on the Bile of the Family Cyprinidae (1964)
HOSHITA, TAKAHIKO, NAGAYOSHI, SADAO, KOUCHI, MINORU, KAZUNO, TARO
The occurence of cholic acid is confirmed in the bile of all species of the family Cyprinidae examined, the chief constituent of which is cyprinol.
Isolation of a New Bile Acid, Bufonic Acid I, from Toad Bile (1963)
OKUDA, KYUICHIRO, MASUI, TAKAKO, HOSHITA, TAKAHIKO, KAZUNO, TARO
Isolation of Two Bile Acids from Bile of Eel (1962)
OKADA, SHOZO, MASUI, TAKAKO, HOSHITA, TAKAHIKO, KAZUNO, TARO
OKUDA, KYUICHIRO, HOSHITA, TAKAHIKO, KAZUNO, TARO
Two new and one already known bile sterols were isolated from toad bile by use of reversed phase partition chromatography. It was verified that chemical constitution of one of the new bile sterols...