Development of a TT Virus DNA Quantification System Using Real-Time Detection PCR
Kato, Takanobu, Mizokami, Masashi, Mukaide, Motokazu, Orito, Etsuro, Ohno, Tomoyoshi, Nakano, Tatsunori, ...
Although TT virus (TTV) was isolated from a cryptogenic posttransfusion hepatitis patient, its pathogenic role remains unclear. It has been reported that the majority of the healthy population is...
Hasegawa, Izumi, Tanaka, Yasuhito, Kramvis, Anna, Kato, Takanobu, Sugauchi, Fuminaka, Acharya, Subrat K., ...
The eight genotypes of hepatitis B virus (HBV) have different geographical distributions, virological characteristics, and clinical manifestations. A unique subtype of HBV genotype A (HBV/A) was...
Regulation of Hepatitis C Virus Replication by Interferon Regulatory Factor 1
Kanazawa, Nobuhiko, Kurosaki, Masayuki, Sakamoto, Naoya, Enomoto, Nobuyuki, Itsui, Yasuhiro, Yamashiro, Tsuyoshi, ...
Cellular antiviral responses are mediated partly by the expression of interferon-stimulated genes, triggered by viral genomes, their transcripts and replicative intermediates. Persistent replication...
Yuen, Man-Fung, Fung, Scott K., Tanaka, Yasuhito, Kato, Takanobu, Mizokami, Masashi, Yuen, John Chi-Hang, ...
The aims of this study were to compare chronic hepatitis B (CHB) patients with genotypes B and C for the probability of HBeAg seroconversion, hepatitis activity, and viral replication before and...
Kato, Takanobu, Date, Tomoko, Miyamoto, Michiko, Zhao, Zijiang, Mizokami, Masashi, Wakita, Takaji
The hepatitis C virus (HCV) genotype 2a subgenomic replicon can replicate in two human non-hepatocyte-derived cell lines, HeLa and 293, with in vitro-transcribed replicon RNA. Sequencing analysis...
Robust hepatitis C virus infection in vitro
Zhong, Jin, Gastaminza, Pablo, Cheng, Guofeng, Kapadia, Sharookh, Kato, Takanobu, Burton, Dennis R., ...
The absence of a robust cell culture model of hepatitis C virus (HCV) infection has severely limited analysis of the HCV life cycle and the development of effective antivirals and vaccines. Here we...
Kato, Takanobu, Date, Tomoko, Miyamoto, Michiko, Sugiyama, Masaya, Tanaka, Yasuhito, Orito, Etsuro, ...
Although combination therapy with interferon and ribavirin has improved the treatment for chronic hepatitis C virus (HCV) infection, the detailed anti-HCV effect of ribavirin in clinical...
Virus-induced type I IFN stimulates generation of immunoproteasomes at the site of infection
Shin, Eui-Cheol, Seifert, Ulrike, Kato, Takanobu, Rice, Charles M., Feinstone, Stephen M., Kloetzel, Peter-M., ...
IFN-γ is known as the initial and primary inducer of immunoproteasomes during viral infections. We now report that type I IFN induced the transcription and translation of immunoproteasome subunits,...
Development of a TT Virus DNA Quantification System Using Real-Time Detection PCR
Kato, Takanobu, Mizokami, Masashi, Mukaide, Motokazu, Orito, Etsuro, Ohno, Tomoyoshi, Nakano, Tatsunori, ...
Although TT virus (TTV) was isolated from a cryptogenic posttransfusion hepatitis patient, its pathogenic role remains unclear. It has been reported that the majority of the healthy population is...
Hasegawa, Izumi, Tanaka, Yasuhito, Kramvis, Anna, Kato, Takanobu, Sugauchi, Fuminaka, Acharya, Subrat K., ...
The eight genotypes of hepatitis B virus (HBV) have different geographical distributions, virological characteristics, and clinical manifestations. A unique subtype of HBV genotype A (HBV/A) was...
Regulation of Hepatitis C Virus Replication by Interferon Regulatory Factor 1
Kanazawa, Nobuhiko, Kurosaki, Masayuki, Sakamoto, Naoya, Enomoto, Nobuyuki, Itsui, Yasuhiro, Yamashiro, Tsuyoshi, ...
Cellular antiviral responses are mediated partly by the expression of interferon-stimulated genes, triggered by viral genomes, their transcripts and replicative intermediates. Persistent replication...
Yuen, Man-Fung, Fung, Scott K., Tanaka, Yasuhito, Kato, Takanobu, Mizokami, Masashi, Yuen, John Chi-Hang, ...
The aims of this study were to compare chronic hepatitis B (CHB) patients with genotypes B and C for the probability of HBeAg seroconversion, hepatitis activity, and viral replication before and...
Kato, Takanobu, Date, Tomoko, Miyamoto, Michiko, Zhao, Zijiang, Mizokami, Masashi, Wakita, Takaji
The hepatitis C virus (HCV) genotype 2a subgenomic replicon can replicate in two human non-hepatocyte-derived cell lines, HeLa and 293, with in vitro-transcribed replicon RNA. Sequencing analysis...
Robust hepatitis C virus infection in vitro
Zhong, Jin, Gastaminza, Pablo, Cheng, Guofeng, Kapadia, Sharookh, Kato, Takanobu, Burton, Dennis R., ...
The absence of a robust cell culture model of hepatitis C virus (HCV) infection has severely limited analysis of the HCV life cycle and the development of effective antivirals and vaccines. Here we...
Kato, Takanobu, Date, Tomoko, Miyamoto, Michiko, Sugiyama, Masaya, Tanaka, Yasuhito, Orito, Etsuro, ...
Although combination therapy with interferon and ribavirin has improved the treatment for chronic hepatitis C virus (HCV) infection, the detailed anti-HCV effect of ribavirin in clinical...
Virus-induced type I IFN stimulates generation of immunoproteasomes at the site of infection
Shin, Eui-Cheol, Seifert, Ulrike, Kato, Takanobu, Rice, Charles M., Feinstone, Stephen M., Kloetzel, Peter-M., ...
IFN-γ is known as the initial and primary inducer of immunoproteasomes during viral infections. We now report that type I IFN induced the transcription and translation of immunoproteasome subunits,...
Production of Infectious Hepatitis C Virus of Various Genotypes in Cell Cultures▿
Kato, Takanobu, Matsumura, Takuya, Heller, Theo, Saito, Satoru, Sapp, Ronda K., Murthy, Krishna, ...
A unique hepatitis C virus (HCV) strain JFH-1 has been shown to replicate efficiently in cell culture with production of infectious HCV. We previously developed a DNA expression system containing HCV...
Murayama, Asako, Date, Tomoko, Morikawa, Kenichi, Akazawa, Daisuke, Miyamoto, Michiko, Kaga, Minako, ...
The JFH-1 strain of hepatitis C virus (HCV) is a genotype 2a strain that can replicate autonomously in Huh7 cells. The J6 strain is also a genotype 2a strain, but its full genomic RNA does not...