Takao Takahashi

「患者」から「患者様」へ : ケアの論理 (2009)

高橋, 隆雄, タカハシ, タカオ, Takahashi, Takao

Recently the concept of care has been attracting more and more attention in the fields of medicine and welfare. It is sometimes underlined that the act of care is an interaction, i.e. not only the...

医療現場の行為論 (2008)

高橋, 隆雄, Takahashi, Takao, タカハシ, タカオ

Acts by medical staff and patients in clinical settings are performed under great uncertainty and therefore possess features of gambling. In fact, self-determination has some features of gambling...

Polymorphisms, Mutations, and Amplification of the EGFR Gene in Non-Small Cell Lung Cancers (2007)

Masaharu Nomura, Hisayuki Shigematsu, Lin Li, Makoto Suzuki, Takao Takahashi, Pila Estess, ...

BackgroundThe epidermal growth factor receptor (EGFR) gene is the prototype member of the type I receptor tyrosine kinase (TK) family and plays a pivotal role in cell proliferation and...

治療義務・医学的無益性・自己決定・患者の最善の利益 (2007)

高橋, 隆雄, タカハシ, タカオ, Takahashi, Takao

When we talk about withholding and withdrawal of life-sustaining treatments at the end of life, ‘treatment duty’, ‘medical futility’, ‘self-determination’, and ‘best interest of a...

道元『典座教訓』 : 言葉を理解するとはどういうことか (2006)

高橋, 隆雄, タカハシ, タカオ, Takahashi, Takao

本稿では、言葉を理解するとはいかなることであるかという観点から、『典座教訓』を読み直してみたい。それは、世に数多くある解釈とは異なる...

自然のスピリチュアリティ (2005)

高橋, 隆雄, 吉田, 李佳, タカハシ, タカオ, ヨシダ, リカ, Takahashi, Takao, Yoshida, Rika

Many people spirituality in nature, and at the same time understand nature as gentle and mild. However, it is important to know that it is also furious and awe-inspiring. Yet to consider spirituality...

Clinical and Biological Features Associated With Epidermal Growth Factor Receptor Gene Mutations in Lung Cancers (2005)

Shigematsu, Hisayuki, Lin, Li, Takahashi, Takao, Nomura, Masaharu, Suzuki, Makoto, Wistuba, Ignacio I., ...

Background: Mutations in the tyrosine kinase (TK) domain of the epidermal growth factor receptor (EGFR) gene in lung cancers are associated with increased sensitivity of these cancers to drugs that...

Clinical and Biological Features Associated With Epidermal Growth Factor Receptor Gene Mutations in Lung Cancers (2005)

Shigematsu, Hisayuki, Lin, Li, Takahashi, Takao, Nomura, Masaharu, Suzuki, Makoto, Wistuba, Ignacio I., ...

Background: Mutations in the tyrosine kinase (TK) domain of the epidermal growth factor receptor (EGFR) gene in lung cancers are associated with increased sensitivity of these cancers to drugs that...

The Carboxyl Terminal Sequence of Nucleolar Protein B23.1 Is Important in Its DNA Polymerase {alpha}-Stimulatory Activity (2001)

Umekawa, Hayato, Sato, Keiji, Takemura, Masaharu, Watanabe, Yoshinori, Usui, Satomi, Takahashi, Takao, ...

The protein B23 is a major nucleolar phosphoprotein comprising two isoforms, B23.1 and B23.2, which differ only in their carboxyl-terminal short sequences, the N-terminal 255 residues being identical...

The Alignment of Migrating Neural Cells in Relation to the Murine Neopallial Radial Glial Fiber System (1991)

Mission, Jean-Paul, Austin, Christopher P., Takahashi, Takao, Cepko, Constance L., Caviness, Verne S.

The direction of neural cell migration in relation to the pattern of alignment of adjacent radial glial fibers has been studied in the developing neopallium of emhryonic days 16-18 mouse embryos. The...

規則と原理 (1987)

高橋, 隆雄, タカハシ, タカオ, Takahashi, Takao

法哲学と言語哲学の接点の一つにある問題について考察する。...

アスペクト再考 (1986)

高橋, 隆雄, タカハシ, タカオ, Takahashi, Takao

「アスペクトの知覚」と「体験・感じとしての意味」、両者の「類似」を「比喩」に関するヴィトゲンシュタインの叙述を手掛かりとしつつ考察す...

行為と知覚の説明 (1983)

高橋, 隆雄, タカハシ, タカオ, Takahashi, Takao

行為と知覚の説明のうち、特に知覚の因果的説明に重点を置いた考察

Biochemical Studies on Ricin: II. Molecular Weight and Some Physicochemical Properties of Crystalline Ricin D (1964)

ISHIGURO, MASATSUNE, TAKAHASHI, TAKAO, HAYASHI, KATSUYA, FUNATSU, MASARU

Investigation of molecular weight and some physicochemical properties of ricin D was carried out. Sedimentation constant, s20, was calculated to be 4.64×10−13 in acetate buffer solution...

Biochemical Studies on Castor Bean Hemagglutinin: I. Separation and Purification (1962)

TAKAHASHI, TAKAO, FUNATSU, GUNKI, FUNATSU, MASARU

The Purification of castor been hemagglutinin has been accomplished first by fractional precipitation with ammonium sulfate then, by hydroxyl apatite column chromatography, and finally, by...

Overexpression of p27Kip1 lengthens the G1 phase in a mouse model that targets inducible gene expression to central nervous system progenitor cells

Mitsuhashi, Takayuki, Aoki, Yoko, Eksioglu, Yaman Z., Takahashi, Takao, Bhide, Pradeep G., Reeves, Steven A., ...

We describe a mouse model in which p27Kip1 transgene expression is spatially restricted to the central nervous system neuroepithelium and temporally controlled with doxycycline. Transgene-specific...

The RNA-binding protein HuD regulates neuronal cell identity and maturation

Akamatsu, Wado, Fujihara, Hiroaki, Mitsuhashi, Takayuki, Yano, Masato, Shibata, Shinsuke, Hayakawa, Yoshika, ...

Neural Hu proteins (HuB/C/D) are RNA-binding proteins that have been shown to induce neuronal differentiation activity when overexpressed in immature neural progenitor cells or undifferentiated...

Overexpression of p27Kip1 lengthens the G1 phase in a mouse model that targets inducible gene expression to central nervous system progenitor cells

Mitsuhashi, Takayuki, Aoki, Yoko, Eksioglu, Yaman Z., Takahashi, Takao, Bhide, Pradeep G., Reeves, Steven A., ...

We describe a mouse model in which p27Kip1 transgene expression is spatially restricted to the central nervous system neuroepithelium and temporally controlled with doxycycline. Transgene-specific...

The RNA-binding protein HuD regulates neuronal cell identity and maturation

Akamatsu, Wado, Fujihara, Hiroaki, Mitsuhashi, Takayuki, Yano, Masato, Shibata, Shinsuke, Hayakawa, Yoshika, ...

Neural Hu proteins (HuB/C/D) are RNA-binding proteins that have been shown to induce neuronal differentiation activity when overexpressed in immature neural progenitor cells or undifferentiated...

Deficiency of BLNK hampers PLC-γ2 phosphorylation and Ca2+ influx induced by the pre-B-cell receptor in human pre-B cells

Taguchi, Tomoko, Kiyokawa, Nobutaka, Takenouch, Hisami, Matsui, Jun, Tang, Wei-Ran, Nakajima, Hideki, ...

B-cell linker protein (BLNK) is a component of the B-cell receptor (BCR) as well as of the pre-BCR signalling pathway, and BLNK–/– mice have a block in B lymphopoiesis at the pro-B/pre-B cell...

Partial tolerance of subcutaneously transplanted xenogeneic tumour cell graft by Fas-mediated immunosuppression

SAWADA, TAKAHIRO, KOJI, TAKEHIKO, HISHIKAWA, YOSHITAKA, KISHIMOTO, KOJI, NAGAYASU, TAKESHI, TAKAHASHI, TAKAO, ...

Certain anti-Fas antibodies, such as RMF2, induce apoptosis of Fas-expressing cells. We applied the Fas/anti-Fas system to induce killing of Fas-expressing immunocytes with resultant...

Pathways to Acute Humoral Rejection

Saadi, Soheyla, Takahashi, Takao, Holzknecht, Robert A., Platt, Jeffrey L.

Acute humoral rejection, also known as acute vascular rejection, is a devastating condition of organ transplants and a major barrier to clinical application of organ xenotransplantation. Although...

Polymorphisms, Mutations, and Amplification of the EGFR Gene in Non-Small Cell Lung Cancers

Nomura, Masaharu, Shigematsu, Hisayuki, Li, Lin, Suzuki, Makoto, Takahashi, Takao, Estess, Pila, ...

Masaharu Nomura and colleagues examine the distribution ofEGFR polymorphisms in different populations and find differences that might explain different responses to tyrosine kinase inhibitors in lung...

Protective Function of p27KIP1 against Apoptosis in Small Cell Lung Cancer Cells in Unfavorable Microenvironments

Masuda, Akira, Osada, Hirotaka, Yatabe, Yasushi, Kozaki, Ken-ichi, Tatematsu, Yoshio, Takahashi, Takao, ...

A previous study of ours unexpectedly found that in contrast to frequent reductions in non-small cell lung cancer, high expression of the p27KIP1 cyclin-dependent kinase (CDK) inhibitor was retained...

Persistent Increase in Chromosome Instability in Lung Cancer : Possible Indirect Involvement of p53 Inactivation

Haruki, Nobuhiro, Harano, Tomoko, Masuda, Akira, Kiyono, Tohru, Takahashi, Takao, Tatematsu, Yoshio, ...

Karyotype and fluorescence in situ hybridization analyses have demonstrated the frequent presence of an altered static state of the number of chromosomes (ie, aneuploidy) in lung cancer, but it has...