Takahasi, Kiyohiro, Kumeta, Hiroyuki, Tsuduki, Natsuko, Narita, Ryo, Shigemoto, Taeko, Hirai, Reiko, ...
The RIG-I like receptor (RLR) comprises three homologues: RIG-I (retinoic acid-inducible gene I), MDA5(melanoma differentiation-associated gene 5), and LGP2 (laboratory of genetics and physiology 2)....
Monopole and Topological Electron Dynamics in Adiabatic Spintronic and Graphene Systems (2009)
Tan, S. G., Jalil, M. B. A., Fujita, Takashi
A unified theoretical treatment is presented to describe the physics of electron dynamics in semiconductor and graphene systems. Electron spin fast alignment with the Zeeman magnetic field (physical...
Terashima, Ichiro, Fujita, Takashi, Inoue, Takeshi, Chow, Wah Soon, Oguchi, Riichi
The literature and our present examinations indicate that the intra-leaf light absorption profile is in most cases steeper than the photosynthetic capacity profile. In strong white light, therefore,...
Spin Hall utilizing U(1) and SU(2) gauge fields (2007)
Tan, S. G., Jalil, M. B. A., Liu, Xiong-Jun, Fujita, Takashi
We propose a two-dimensional electron gas (2DEG) system in which an external magnetic (B) field with a small chirality is applied to provide a topological U(1) U(1) gauge field that separates...
Toyama, Tatsuya, Zhang, Zhenhuan, Iwase, Hirotaka, Yamashita, Hiroko, Ando, Yoshiaki, Hamaguchi, Maho, ...
Background: While Snail is a zinc-finger transcription factor that triggers the epithelial-mesenchymal transition, it has also been reported to be indirectly regulated by estrogen receptor α (ERα)...
Toyama, Tatsuya, Zhang, Zhenhuan, Iwase, Hirotaka, Yamashita, Hiroko, Ando, Yoshiaki, Hamaguchi, Maho, ...
Background: While Snail is a zinc-finger transcription factor that triggers the epithelial- mesenchymal transition, it has also been reported to be indirectly regulated by estrogen receptor α (ERα)...
Yoshida, Carolina A., Yamamoto, Hiromitsu, Fujita, Takashi, Furuichi, Tatsuya, Ito, Kosei, Inoue, Ken-ichi, ...
The differentiation of mesenchymal cells into chondrocytes and chondrocyte proliferation and maturation are fundamental steps in skeletal development. Runx2 is essential for osteoblast...
Sato, Shintaro, Takeuchi, Osamu, Fujita, Takashi, Tomizawa, Hideyuki, Takeda, Kiyoshi, Akira, Shizuo
Exposure of macrophages to lipopolysaccharide (LPS) induces a hypo‐responsive state to a second challenge with LPS that is termed LPS tolerance. LPS tolerance is also induced by...
Suhara, Wakako, Yoneyama, Mitsutoshi, Iwamura, Tomokatsu, Yoshimura, Shoko, Tamura, Keiko, Namiki, Hideo, ...
Cellular genes including the type I interferon genes are activated in response to viral infection. We previously reported that IRF-3 (interferon regulatory factor 3) is specifically phosphorylated on...
Biophysical characterization of human erythrocyte spectrin and its subunits (1997)
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Suhara, Wakako, Yoneyama, Mitsutoshi, Yonekawa, Hiromichi, Fujita, Takashi
Interferon stimulated gene factor 3 (ISGF3) is a trimeric transcription factor activated on treatment of cells with interferon-α and β (type I EFNs). Upon stimulation, the regulatory subunits,...
Yoneyama, Mitsutoshi, Suhara, Wakako, Fukuhara, Yukiko, Sato, Mayumi, Ozato, Keiko, Fujita, Takashi
Interferon regulatory factor (IRF)-1 and IRF-2 have been implicated for the virus-induced expression of the interferon-α and β (type I IFN) genes. However, recent gene disruption studies in mice...
Nolan, Garry P., Fujita, Takashi, Bhatia, Kishor, Huppi, Conrad, Liou, Hsiou-Chi, Scott, Martin L., ...
The product of the putative proto-oncogene bcl-3 is an I kappa B-like molecule with novel binding properties specific for a subset of the rel family of transcriptional regulators. In vitro, Bcl-3...
Characterization of the DNA binding domain of the mouse IRF-2 protein (1993)
Uegaki, Koichi, Shirakawa, Masahiro, Fujita, Takashi, Taniguchi, Tadatsugu, Kyogoku, Yoshimasa
The DNA binding domain of the interferon regulatory factor-2 protein (IRF-2) has been produced and characterized, α-chymotrypsin digestion of the purified IRF-2 protein bound to a synthetic binding...
Watanabe, Nobumasa, Sakakibara, Jun, Hovanessian, Ara G., Taniguchi, Tadatsugu, Fujita, Takashi
Expression of the Type I IFN (i.e., IFN-αs and IFN-β) genes is efficiently induced by viruses at the transcriptional level. This induction is mediated by at least two types of positive regulatory...
Sequence of a cDNA coding for human IRF-2 (1989)
Itoh, Susumu, Harada, Hisashi, Fujita, Takashi, Mimura, Tsutomu, Taniguchi, Tadatsugu
Fujita, Takashi, Miyamoto, Masaaki, Kimura, Yoko, Hammer, Jürgen, Taniguchi, Tadatsuga
Interferon-β (IFN-β) gene is transcriptionally activated following virus infection of various cell types such as fibroblasts. In the previous studies, regulatory DNA sequences that mediate the...
Cloning and Expression of a Novel Variant of Human Interferon-{gamma} cDNA (1985)
NISHI, Tatsunari, FUJITA, Takashi, NISHI-TAKAOKA, Chikako, SAITO, Akiko, MATSUMOTO, Tadashi, SATO, Moriyuki, ...
A cDNA library was prepared from the poly(A) mRNA isolated from human peripheral blood lymphocytes which were induced by combined treatment with phytohemagglutinin and a phorbol ester. Recombinant...
Organization and structure of the mouse interleukin-2 gene (1984)
Fuse, Akira, Fujita, Takashi, Yasumitsu, Hidetaro, Kashima, Nobukazu, Hasegawa, Katsushige, Taniguchi, Tadatsugu
We have cloned a chromosomal DNA segment which covers the entire sequence for the murine interleukin-2 gene and analysed the structure of the gene. The coding regions are separated into four blocks...
Sequential Grouping of Nonhistone Chromosomal Protein from Pig Thymus (1980)
YOSHIDA, Michiteru, OHTAKI, Yoshihiro, FUJITA, Takashi, SHIMURA, Kensuke
1. To establish a practical method to prepare nonhistone chromosomal proteins (NHP's) in substantial quantity, a sequential group fractionation procedure for NHP's from pig thymus chromatin has been...
Yoshida, Carolina A., Yamamoto, Hiromitsu, Fujita, Takashi, Furuichi, Tatsuya, Ito, Kosei, Inoue, Ken-ichi, ...
The differentiation of mesenchymal cells into chondrocytes and chondrocyte proliferation and maturation are fundamental steps in skeletal development. Runx2 is essential for osteoblast...
Sumpter, Rhea, Loo, Yueh-Ming, Foy, Eileen, Li, Kui, Yoneyama, Mitsutoshi, Fujita, Takashi, ...
Virus-responsive signaling pathways that induce alpha/beta interferon production and engage intracellular immune defenses influence the outcome of many viral infections. The processes that trigger...
Foy, Eileen, Li, Kui, Sumpter, Rhea, Loo, Yueh-Ming, Johnson, Cynthia L., Wang, Chunfu, ...
Hepatitis C virus (HCV) is a major human pathogen that infects 170 million people. A hallmark of HCV is its ability to establish persistent infections reflecting the evasion of host immunity and...
Breiman, Adrien, Grandvaux, Nathalie, Lin, Rongtuan, Ottone, Catherine, Akira, Shizuo, Yoneyama, Mitsutoshi, ...
Interferon (IFN) is one important effector of the innate immune response, induced by different viral or bacterial components through Toll-like receptor (TLR)-dependent and -independent mechanisms. As...
The Alpha/Beta Interferon Response Controls Tissue Tropism and Pathogenicity of Poliovirus
Ida-Hosonuma, Miki, Iwasaki, Takuya, Yoshikawa, Tomoki, Nagata, Noriyo, Sato, Yuko, Sata, Tetsutaro, ...
Poliovirus selectively replicates in neurons in the spinal cord and brainstem, although poliovirus receptor (PVR) expression is observed in both the target and nontarget tissues in humans and...
Yoshikawa, Tomoki, Iwasaki, Takuya, Ida-Hosonuma, Miki, Yoneyama, Mitsutoshi, Fujita, Takashi, Horie, Hitoshi, ...
Replication of poliovirus (PV) is restricted to a few sites, including the brain and spinal cord. However, this neurotropism is not conserved in cultured cells. Monkey kidney cells become susceptible...
Viral and therapeutic control of IFN-β promoter stimulator 1 during hepatitis C virus infection
Loo, Yueh-Ming, Owen, David M., Li, Kui, Erickson, Andrea K., Johnson, Cynthia L., Fish, Penny M., ...
Viral signaling through retinoic acid-inducible gene-I (RIG-I) and its adaptor protein, IFN promoter-stimulator 1 (IPS-1), activates IFN regulatory factor-3 (IRF-3) and the host IFN-α/β response...
Yoshida, Carolina A., Yamamoto, Hiromitsu, Fujita, Takashi, Furuichi, Tatsuya, Ito, Kosei, Inoue, Ken-ichi, ...
The differentiation of mesenchymal cells into chondrocytes and chondrocyte proliferation and maturation are fundamental steps in skeletal development. Runx2 is essential for osteoblast...
Sumpter, Rhea, Loo, Yueh-Ming, Foy, Eileen, Li, Kui, Yoneyama, Mitsutoshi, Fujita, Takashi, ...
Virus-responsive signaling pathways that induce alpha/beta interferon production and engage intracellular immune defenses influence the outcome of many viral infections. The processes that trigger...
Foy, Eileen, Li, Kui, Sumpter, Rhea, Loo, Yueh-Ming, Johnson, Cynthia L., Wang, Chunfu, ...
Hepatitis C virus (HCV) is a major human pathogen that infects 170 million people. A hallmark of HCV is its ability to establish persistent infections reflecting the evasion of host immunity and...
Breiman, Adrien, Grandvaux, Nathalie, Lin, Rongtuan, Ottone, Catherine, Akira, Shizuo, Yoneyama, Mitsutoshi, ...
Interferon (IFN) is one important effector of the innate immune response, induced by different viral or bacterial components through Toll-like receptor (TLR)-dependent and -independent mechanisms. As...
The Alpha/Beta Interferon Response Controls Tissue Tropism and Pathogenicity of Poliovirus
Ida-Hosonuma, Miki, Iwasaki, Takuya, Yoshikawa, Tomoki, Nagata, Noriyo, Sato, Yuko, Sata, Tetsutaro, ...
Poliovirus selectively replicates in neurons in the spinal cord and brainstem, although poliovirus receptor (PVR) expression is observed in both the target and nontarget tissues in humans and...
Viral and therapeutic control of IFN-β promoter stimulator 1 during hepatitis C virus infection
Loo, Yueh-Ming, Owen, David M., Li, Kui, Erickson, Andrea K., Johnson, Cynthia L., Fish, Penny M., ...
Viral signaling through retinoic acid-inducible gene-I (RIG-I) and its adaptor protein, IFN promoter-stimulator 1 (IPS-1), activates IFN regulatory factor-3 (IRF-3) and the host IFN-α/β response...
Yoshikawa, Tomoki, Iwasaki, Takuya, Ida-Hosonuma, Miki, Yoneyama, Mitsutoshi, Fujita, Takashi, Horie, Hitoshi, ...
Replication of poliovirus (PV) is restricted to a few sites, including the brain and spinal cord. However, this neurotropism is not conserved in cultured cells. Monkey kidney cells become susceptible...
Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2
Saito, Takeshi, Hirai, Reiko, Loo, Yueh-Ming, Owen, David, Johnson, Cynthia L., Sinha, Sangita C., ...
RIG-I is an RNA helicase containing caspase activation and recruitment domains (CARDs). RNA binding and signaling by RIG-I are implicated in pathogen recognition and triggering of IFN-α/β immune...
Negative regulation of the RIG-I signaling by the ubiquitin ligase RNF125
Arimoto, Kei-ichiro, Takahashi, Hitoshi, Hishiki, Takayuki, Konishi, Hideyuki, Fujita, Takashi, Shimotohno, Kunitada
Retinoic acid-inducible gene I (RIG-I) plays a pivotal role in the regulation of cytokine production induced by pathogens. The RIG-I also augments the production of IFN and other cytokines via an...
Fujita, Takashi, Azuma, Yasutaka, Fukuyama, Ryo, Hattori, Yuji, Yoshida, Carolina, Koida, Masao, ...
Runx2 and phosphatidylinositol 3-kinase (PI3K)–Akt signaling play important roles in osteoblast and chondrocyte differentiation. We investigated the relationship between Runx2 and PI3K-Akt...
Kato, Hiroki, Takeuchi, Osamu, Mikamo-Satoh, Eriko, Hirai, Reiko, Kawai, Tomoji, Matsushita, Kazufumi, ...
The ribonucleic acid (RNA) helicases retinoic acid-inducible gene-I (RIG-I) and melanoma differentiation–associated gene 5 (MDA5) recognize distinct viral and synthetic RNAs, leading to the...
Shigemoto, Taeko, Kageyama, Maiko, Hirai, Reiko, Zheng, JiPing, Yoneyama, Mitsutoshi, Fujita, Takashi
Retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated gene 5 (MDA5) are essential for detecting viral RNA and triggering antiviral responses, including production of type I...